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Items: 48

1.

Design, synthesis and biological evaluation of trinary benzocoumarin-thiazoles-azomethines derivatives as effective and selective inhibitors of alkaline phosphatase.

Channar PA, Irum H, Mahmood A, Shabir G, Zaib S, Saeed A, Ashraf Z, Larik FA, Lecka J, Sévigny J, Iqbal J.

Bioorg Chem. 2019 Jul 23;91:103137. doi: 10.1016/j.bioorg.2019.103137. [Epub ahead of print]

PMID:
31400554
2.

4-Aminocoumarin based aroylthioureas as potential jack bean urease inhibitors; Synthesis, enzyme inhibitory kinetics and docking studies.

Fattah TA, Saeed A, Ashraf Z, Abbas Q, Channar PA, Larik FA, Hassan M.

Med Chem. 2019 Jul 15. doi: 10.2174/1573406415666190715164834. [Epub ahead of print]

PMID:
31309895
3.

Substituted phenyl[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetates/acetamides as alkaline phosphatase inhibitors: Synthesis, computational studies, enzyme inhibitory kinetics and DNA binding studies.

Iqbal Z, Ashraf Z, Hassan M, Abbas Q, Jabeen E.

Bioorg Chem. 2019 Sep;90:103108. doi: 10.1016/j.bioorg.2019.103108. Epub 2019 Jul 3.

PMID:
31284102
4.

Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation.

Ashraf Z, Mahmood T, Hassan M, Afzal S, Rafique H, Afzal K, Latip J.

Drug Des Devel Ther. 2019 May 14;13:1643-1657. doi: 10.2147/DDDT.S178595. eCollection 2019.

5.

Synthesis and docking studies of N-(5-(alkylthio)-1,3,4-oxadiazol-2-yl)methyl)benzamide analogues as potential alkaline phosphatase inhibitors.

Iqbal Z, Iqbal A, Ashraf Z, Latif M, Hassan M, Nadeem H.

Drug Dev Res. 2019 Aug;80(5):646-654. doi: 10.1002/ddr.21542. Epub 2019 Apr 29.

PMID:
31032540
6.

Novel amide derivatives as potent tyrosinase inhibitors; in-vitro, in-vivo antimelanogenic activity and computational studies.

Ali A, Ashraf Z, Rafiq M, Kumar A, Jabeen F, Lee GJ, Nazir F, Ahmed M, Rhee M, Choi EH.

Med Chem. 2019 Mar 18. doi: 10.2174/1573406415666190319101329. [Epub ahead of print]

PMID:
30892163
7.

42-Year-Old Man with Worsening Headache.

Ashraf Z, Todnam N, Morgan J, Rojiani AM.

Brain Pathol. 2019 Mar;29(2):305-306. doi: 10.1111/bpa.12706. No abstract available.

PMID:
30821027
8.

GDH and toxin immunoassay for the diagnosis of Clostridioides (Clostridium) difficile infection is not a 'one size fit all' screening test.

Ashraf Z, Rahmati E, Bender JM, Nanda N, She RC.

Diagn Microbiol Infect Dis. 2019 Jun;94(2):109-112. doi: 10.1016/j.diagmicrobio.2018.12.010. Epub 2018 Dec 29.

PMID:
30696609
9.

Synthesis, carbonic anhydrase inhibitory activity and antioxidant activity of some 1,3-oxazine derivatives.

Qamar R, Saeed A, Saeed M, Ashraf Z, Abbas Q, Hassan M, Albericio F.

Drug Dev Res. 2018 Nov;79(7):352-361. doi: 10.1002/ddr.21464. Epub 2018 Oct 10.

PMID:
30302774
10.

Antihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches.

Aqeel MT, Ur-Rahman N, Khan AU, Ashraf Z, Latif M, Rafique H, Rasheed U.

Drug Des Devel Ther. 2018 Aug 9;12:2443-2453. doi: 10.2147/DDDT.S158554. eCollection 2018.

11.

Synthesis of aryl pyrazole via Suzuki coupling reaction, in vitro mushroom tyrosinase enzyme inhibition assay and in silico comparative molecular docking analysis with Kojic acid.

Channar PA, Saeed A, Larik FA, Batool B, Kalsoom S, Hasan MM, Erben MF, El-Seedi HR, Ali M, Ashraf Z.

Bioorg Chem. 2018 Sep;79:293-300. doi: 10.1016/j.bioorg.2018.04.026. Epub 2018 Apr 30.

PMID:
29793142
12.

Finding Novel Anti-carcinomas Compounds by Targeting SFRP4 Through Molecular Modeling, Docking and Dynamic Simulation Studies.

Hassan M, Azhar M, Abbas Q, Raza H, Moustafa AA, Shahzadi S, Ashraf Z, Seo SY.

Curr Comput Aided Drug Des. 2018;14(2):160-173. doi: 10.2174/1573409914666180112100122.

PMID:
29332600
13.

Synthesis, computational studies and enzyme inhibitory kinetics of substituted methyl[2-(4-dimethylamino-benzylidene)-hydrazono)-4-oxo-thiazolidin-5-ylidene]acetates as mushroom tyrosinase inhibitors.

Channar PA, Saeed A, Larik FA, Rafiq M, Ashraf Z, Jabeen F, Fattah TA.

Bioorg Med Chem. 2017 Nov 1;25(21):5929-5938. doi: 10.1016/j.bmc.2017.09.009. Epub 2017 Sep 18.

PMID:
28988751
14.

Synthesis, enzyme inhibitory kinetics, and computational studies of novel 1-(2-(4-isobutylphenyl) propanoyl)-3-arylthioureas as Jack bean urease inhibitors.

Abdul Fattah T, Saeed A, Channar PA, Ashraf Z, Abbas Q, Hassan M, Larik FA.

Chem Biol Drug Des. 2018 Feb;91(2):434-447. doi: 10.1111/cbdd.13090. Epub 2017 Nov 7.

PMID:
28834266
15.

Development of highly potent melanogenesis inhibitor by in vitro, in vivo and computational studies.

Abbas Q, Ashraf Z, Hassan M, Nadeem H, Latif M, Afzal S, Seo SY.

Drug Des Devel Ther. 2017 Jul 5;11:2029-2046. doi: 10.2147/DDDT.S137550. eCollection 2017.

16.

Carvacrol derivatives as mushroom tyrosinase inhibitors; synthesis, kinetics mechanism and molecular docking studies.

Ashraf Z, Rafiq M, Nadeem H, Hassan M, Afzal S, Waseem M, Afzal K, Latip J.

PLoS One. 2017 May 23;12(5):e0178069. doi: 10.1371/journal.pone.0178069. eCollection 2017.

17.

First macrocyclic 3rd-generation ALK inhibitor for treatment of ALK/ROS1 cancer: Clinical and designing strategy update of lorlatinib.

Basit S, Ashraf Z, Lee K, Latif M.

Eur J Med Chem. 2017 Jul 7;134:348-356. doi: 10.1016/j.ejmech.2017.04.032. Epub 2017 Apr 13. Review.

PMID:
28431340
18.

Pharmacoinformatics exploration of polyphenol oxidases leading to novel inhibitors by virtual screening and molecular dynamic simulation study.

Hassan M, Abbas Q, Ashraf Z, Moustafa AA, Seo SY.

Comput Biol Chem. 2017 Jun;68:131-142. doi: 10.1016/j.compbiolchem.2017.02.012. Epub 2017 Mar 15.

PMID:
28340400
19.

Synthesis, characterization of amide substituted dexibuprofen derivatives and their spectral, voltammetric and docking investigations for DNA binding interactions.

Arshad N, Zafran M, Ashraf Z, Perveen F.

J Photochem Photobiol B. 2017 Apr;169:134-147. doi: 10.1016/j.jphotobiol.2017.02.021. Epub 2017 Mar 3.

PMID:
28319868
20.

Synthesis, Bioevaluation and Molecular Dynamic Simulation Studies of Dexibuprofen-Antioxidant Mutual Prodrugs.

Ashraf Z, Alamgeer, Rasool R, Hassan M, Ahsan H, Afzal S, Afzal K, Cho H, Kim SJ.

Int J Mol Sci. 2016 Dec 21;17(12). pii: E2151. doi: 10.3390/ijms17122151.

21.

Isolation, characterization, and in silico, in vitro and in vivo antiulcer studies of isoimperatorin crystallized from Ostericum koreanum.

Raza H, Abbas Q, Hassan M, Eo SH, Ashraf Z, Kim D, Phull AR, Kim SJ, Kang SK, Seo SY.

Pharm Biol. 2017 Dec;55(1):218-226.

22.

Crystal structure of 2-(4-acetyl-anilino)-2-oxoethyl 3-(4-hy-droxy-phen-yl)propionate.

Ashraf Z, Kim D, Seo SY, Kang SK.

Acta Crystallogr E Crystallogr Commun. 2016 Jun 10;72(Pt 7):933-6. doi: 10.1107/S205698901600894X. eCollection 2016 Jul 1.

23.

Flurbiprofen-antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling.

Ashraf Z, Alamgeer, Kanwal M, Hassan M, Abdullah S, Waheed M, Ahsan H, Kim SJ.

Drug Des Devel Ther. 2016 Jul 27;10:2401-19. doi: 10.2147/DDDT.S109318. eCollection 2016.

24.

The Prokinetic, Laxative, and Antidiarrheal Effects of Morus nigra: Possible Muscarinic, Ca(2+) Channel Blocking, and Antimuscarinic Mechanisms.

Akhlaq A, Mehmood MH, Rehman A, Ashraf Z, Syed S, Bawany SA, Gilani AH, Ilyas M, Siddiqui BS.

Phytother Res. 2016 Aug;30(8):1362-76. doi: 10.1002/ptr.5641. Epub 2016 May 27.

PMID:
27230535
25.

Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological diversification.

Khan I, Zaib S, Batool S, Abbas N, Ashraf Z, Iqbal J, Saeed A.

Bioorg Med Chem. 2016 Jun 1;24(11):2361-81. doi: 10.1016/j.bmc.2016.03.031. Epub 2016 Mar 18. Review.

PMID:
27112448
26.

Exploration of Novel Human Tyrosinase Inhibitors by Molecular Modeling, Docking and Simulation Studies.

Hassan M, Ashraf Z, Abbas Q, Raza H, Seo SY.

Interdiscip Sci. 2018 Mar;10(1):68-80. doi: 10.1007/s12539-016-0171-x. Epub 2016 Apr 21.

PMID:
27098808
27.

Influence of plasma-activated compounds on melanogenesis and tyrosinase activity.

Ali A, Ashraf Z, Kumar N, Rafiq M, Jabeen F, Park JH, Choi KH, Lee S, Seo SY, Choi EH, Attri P.

Sci Rep. 2016 Mar 2;6:21779. doi: 10.1038/srep21779.

28.

Synthesis and crystal structures of the potential tyrosinase inhibitors N-(4-acetylphenyl)-2-chloroacetamide and 2-(4-acetylanilino)-2-oxoethyl cinnamate.

Ashraf Z, Kim D, Seo SY, Kang SK.

Acta Crystallogr C Struct Chem. 2016 Feb;72(Pt 2):94-8. doi: 10.1107/S205322961502433X. Epub 2016 Jan 13.

PMID:
26846491
29.

Iminothiazoline-Sulfonamide Hybrids as Jack Bean Urease Inhibitors; Synthesis, Kinetic Mechanism and Computational Molecular Modeling.

Saeed A, Mahmood SU, Rafiq M, Ashraf Z, Jabeen F, Seo SY.

Chem Biol Drug Des. 2016 Mar;87(3):434-43. doi: 10.1111/cbdd.12675. Epub 2015 Nov 26.

PMID:
26496515
30.

Crystal structure of 5-hy-droxy-methyl-2-meth-oxy-phenol.

Hassan M, Ashraf Z, Seo SY, Kim D, Kang SK.

Acta Crystallogr E Crystallogr Commun. 2015 Jul 4;71(Pt 8):o540-1. doi: 10.1107/S205698901501230X. eCollection 2015 Aug 1.

31.

Novel Penicillin Analogues as Potential Antimicrobial Agents; Design, Synthesis and Docking Studies.

Ashraf Z, Bais A, Manir MM, Niazi U.

PLoS One. 2015 Aug 12;10(8):e0135293. doi: 10.1371/journal.pone.0135293. eCollection 2015.

32.

Synthesis, kinetic mechanism and docking studies of vanillin derivatives as inhibitors of mushroom tyrosinase.

Ashraf Z, Rafiq M, Seo SY, Babar MM, Zaidi NU.

Bioorg Med Chem. 2015 Sep 1;23(17):5870-80. doi: 10.1016/j.bmc.2015.06.068. Epub 2015 Jul 2.

PMID:
26204890
33.

Kinetic and in silico studies of novel hydroxy-based thymol analogues as inhibitors of mushroom tyrosinase.

Ashraf Z, Rafiq M, Seo SY, Kwon KS, Babar MM, Zaidi NU.

Eur J Med Chem. 2015 Jun 15;98:203-11. doi: 10.1016/j.ejmech.2015.05.031. Epub 2015 May 21.

PMID:
26025140
34.

Mortality patterns among critically ill children in a Pediatric Intensive Care Unit of a developing country.

Siddiqui NU, Ashraf Z, Jurair H, Haque A.

Indian J Crit Care Med. 2015 Mar;19(3):147-50. doi: 10.4103/0972-5229.152756.

35.

Design, synthesis and bioevaluation of novel umbelliferone analogues as potential mushroom tyrosinase inhibitors.

Ashraf Z, Rafiq M, Seo SY, Babar MM, Zaidi NU.

J Enzyme Inhib Med Chem. 2015 Dec;30(6):874-83. doi: 10.3109/14756366.2014.979346. Epub 2015 Feb 3.

PMID:
25643758
36.

Influenza virus-specific neutralizing IgM antibodies persist for a lifetime.

Skountzou I, Satyabhama L, Stavropoulou A, Ashraf Z, Esser ES, Vassilieva E, Koutsonanos D, Compans R, Jacob J.

Clin Vaccine Immunol. 2014 Nov;21(11):1481-9. doi: 10.1128/CVI.00374-14. Epub 2014 Aug 27.

37.

Evaluation and management of acquired methemoglobinemia associated with topical benzocaine use.

Taleb M, Ashraf Z, Valavoor S, Tinkel J.

Am J Cardiovasc Drugs. 2013 Oct;13(5):325-30. doi: 10.1007/s40256-013-0027-2. Review.

PMID:
23696166
38.

Thalassemia and premarital screening: potential for implementation of a screening program among young people in Pakistan.

Mirza A, Ghani A, Pal A, Sami A, Hannan S, Ashraf Z, Iqbal S, Malik UZ, Hayat U, Fatmi Z.

Hemoglobin. 2013;37(2):160-70. doi: 10.3109/03630269.2013.773260.

PMID:
23470149
39.

Synthesis and antibacterial evaluation of typharin analog: 6,8-dihydroxy-7-methyl-3-styryl-3,4-dihydroisocoumarin.

Saeed A, Rafique H, Ashraf Z.

J Asian Nat Prod Res. 2013;15(2):130-5. doi: 10.1080/10286020.2012.751978. Epub 2013 Jan 17.

PMID:
23323839
40.

Synthesis, in vitro antibacterial and antifungal activity of some n-acetylated and non-acetylated pyrazolines.

Baseer M, Ansari FL, Ashraf Z.

Pak J Pharm Sci. 2013 Jan;26(1):67-73.

PMID:
23261729
41.

Conservative management of post-transplant central nervous system lymphoma.

Valavoor SH, Ashraf Z, Narwal R, Ratnam S.

Int Urol Nephrol. 2013 Aug;45(4):1219-22. doi: 10.1007/s11255-012-0146-8. Epub 2012 Apr 3. Review.

PMID:
22476860
42.

Synthesis, characterization, anti-inflammatory and in vitro antimicrobial activity of some novel alkyl/aryl substituted tertiary alcohols.

Baseer M, Ansari FL, Ashraf Z, SaeedulHaq R.

Molecules. 2011 Dec 14;16(12):10337-46. doi: 10.3390/molecules161210337.

43.

Quantification of human sebum on skin and human meibum on the eye lid margin using Sebutape®, spectroscopy and chemical analysis.

Ashraf Z, Pasha U, Greenstone V, Akbar J, Apenbrinck E, Foulks GN, Borchman D.

Curr Eye Res. 2011 Jun;36(6):553-62. doi: 10.3109/02713683.2011.574331.

PMID:
21591865
44.

Total synthesis and cytotoxic activity of stellatin.

Saeed A, Ashraf Z, Rafique H.

J Asian Nat Prod Res. 2011 Feb;13(2):97-104. doi: 10.1080/10286020.2010.544654.

PMID:
21279872
45.

Methyl 3,5-dibromo-4-methyl-benzoate.

Saeed A, Rafique H, Simpson J, Ashraf Z.

Acta Crystallogr Sect E Struct Rep Online. 2010 Mar 31;66(Pt 4):o982-3. doi: 10.1107/S1600536810011062.

46.

2-Chloro-5-nitro-aniline.

Saeed A, Ashraf Z, Batool M, Bolte M.

Acta Crystallogr Sect E Struct Rep Online. 2009 May 29;65(Pt 6):o1417. doi: 10.1107/S160053680901945X.

47.

Mapping changes in surgical mortality over 9 years by peer review audit.

Thompson AM, Ashraf Z, Burton H, Stonebridge PA.

Br J Surg. 2005 Nov;92(11):1449-52.

PMID:
15997442
48.

Risk assessment of hemorrhagic complications associated with nonsteroidal antiinflammatory medications in ambulatory pain clinic patients undergoing epidural steroid injection.

Horlocker TT, Bajwa ZH, Ashraf Z, Khan S, Wilson JL, Sami N, Peeters-Asdourian C, Powers CA, Schroeder DR, Decker PA, Warfield CA.

Anesth Analg. 2002 Dec;95(6):1691-7, table of contents.

PMID:
12456441

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