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Items: 1 to 50 of 105

1.

Rapid Degradation of Caenorhabditis elegans Proteins at Single-Cell Resolution with a Synthetic Auxin.

Martinez MAQ, Kinney BA, Medwig-Kinney TN, Ashley G, Ragle JM, Johnson L, Aguilera J, Hammell CM, Ward JD, Matus DQ.

G3 (Bethesda). 2019 Nov 14. pii: g3.400781.2019. doi: 10.1534/g3.119.400781. [Epub ahead of print]

PMID:
31727633
2.

PLX038: a PEGylated prodrug of SN-38 independent of UGT1A1 activity.

Fontaine SD, Santi AD, Reid R, Smith PC, Ashley GW, Santi DV.

Cancer Chemother Pharmacol. 2019 Nov 9. doi: 10.1007/s00280-019-03987-z. [Epub ahead of print]

PMID:
31707444
3.

A once-monthly GLP-1 receptor agonist for treatment of diabetic cats.

Schneider EL, Reid R, Parkes DG, Lutz TA, Ashley GW, Santi DV.

Domest Anim Endocrinol. 2019 Jul 8;70:106373. doi: 10.1016/j.domaniend.2019.07.001. [Epub ahead of print]

PMID:
31479925
4.

Species-specific optimization of PEG~SN-38 prodrug pharmacokinetics and antitumor effects in a triple-negative BRCA1-deficient xenograft.

Fontaine SD, Hann B, Reid R, Ashley GW, Santi DV.

Cancer Chemother Pharmacol. 2019 Oct;84(4):729-738. doi: 10.1007/s00280-019-03903-5. Epub 2019 Jul 18.

PMID:
31321449
5.

A Controlled Release System for Long-Acting Intravitreal Delivery of Small Molecules.

Machinaga N, Ashley GW, Reid R, Yamasaki A, Tanaka K, Nakamura K, Yabe Y, Yoshigae Y, Santi DV.

Transl Vis Sci Technol. 2018 Aug 28;7(4):21. doi: 10.1167/tvst.7.4.21. eCollection 2018 Jul.

6.

Primary deuterium kinetic isotope effects prolong drug release and polymer biodegradation in a drug delivery system.

Hearn BR, Fontaine SD, Pfaff SJ, Schneider EL, Henise J, Ashley GW, Santi DV.

J Control Release. 2018 May 28;278:74-79. doi: 10.1016/j.jconrel.2018.03.021. Epub 2018 Mar 22.

PMID:
29577950
7.

A Hydrogel-Microsphere Drug Delivery System That Supports Once-Monthly Administration of a GLP-1 Receptor Agonist.

Schneider EL, Hearn BR, Pfaff SJ, Reid R, Parkes DG, Vrang N, Ashley GW, Santi DV.

ACS Chem Biol. 2017 Aug 18;12(8):2107-2116. doi: 10.1021/acschembio.7b00218. Epub 2017 Jun 29.

PMID:
28605180
8.

Modelling the role of groundwater hydro-refugia in East African hominin evolution and dispersal.

Cuthbert MO, Gleeson T, Reynolds SC, Bennett MR, Newton AC, McCormack CJ, Ashley GM.

Nat Commun. 2017 May 30;8:15696. doi: 10.1038/ncomms15696.

9.

Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake.

Schneider EL, Hearn BR, Pfaff SJ, Fontaine SD, Reid R, Ashley GW, Grabulovski S, Strassberger V, Vogt L, Jung T, Santi DV.

Bioconjug Chem. 2016 Oct 19;27(10):2534-2539. doi: 10.1021/acs.bioconjchem.6b00469. Epub 2016 Oct 7.

PMID:
27657443
10.

Synaptonemal Complex Components Are Required for Meiotic Checkpoint Function in Caenorhabditis elegans.

Bohr T, Ashley G, Eggleston E, Firestone K, Bhalla N.

Genetics. 2016 Nov;204(3):987-997. doi: 10.1534/genetics.116.191494. Epub 2016 Sep 7.

11.

Subcutaneously Administered Self-Cleaving Hydrogel-Octreotide Conjugates Provide Very Long-Acting Octreotide.

Schneider EL, Henise J, Reid R, Ashley GW, Santi DV.

Bioconjug Chem. 2016 Jul 20;27(7):1638-44. doi: 10.1021/acs.bioconjchem.6b00188. Epub 2016 Jun 20.

PMID:
27253622
12.

Surgical sealants with tunable swelling, burst pressures, and biodegradation rates.

Henise J, Hearn BR, Santi DV, Kamata H, Sakai T, Ashley GW.

J Biomed Mater Res B Appl Biomater. 2017 Aug;105(6):1602-1611. doi: 10.1002/jbm.b.33701. Epub 2016 May 5.

PMID:
27149244
13.

Hydrogel Drug Delivery System Using Self-Cleaving Covalent Linkers for Once-a-Week Administration of Exenatide.

Schneider EL, Henise J, Reid R, Ashley GW, Santi DV.

Bioconjug Chem. 2016 May 18;27(5):1210-5. doi: 10.1021/acs.bioconjchem.5b00690. Epub 2016 Mar 22.

PMID:
26930186
14.

Dietary options and behavior suggested by plant biomarker evidence in an early human habitat.

Magill CR, Ashley GM, Domínguez-Rodrigo M, Freeman KH.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2874-9. doi: 10.1073/pnas.1507055113. Epub 2016 Feb 22.

15.

Half-life extension of the HIV-fusion inhibitor peptide TRI-1144 using a novel linker technology.

Schneider EL, Ashley GW, Dillen L, Stoops B, Austin NE, Malcolm BA, Santi DV.

Eur J Pharm Biopharm. 2015 Jun;93:254-9. doi: 10.1016/j.ejpb.2015.04.003. Epub 2015 Apr 18.

PMID:
25900863
16.

Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system.

Henise J, Hearn BR, Ashley GW, Santi DV.

Bioconjug Chem. 2015 Feb 18;26(2):270-8. doi: 10.1021/bc5005476. Epub 2015 Jan 13.

PMID:
25584814
17.

Long-term stabilization of maleimide-thiol conjugates.

Fontaine SD, Reid R, Robinson L, Ashley GW, Santi DV.

Bioconjug Chem. 2015 Jan 21;26(1):145-52. doi: 10.1021/bc5005262. Epub 2014 Dec 26.

PMID:
25494821
18.

A spring forward for hominin evolution in East Africa.

Cuthbert MO, Ashley GM.

PLoS One. 2014 Sep 10;9(9):e107358. doi: 10.1371/journal.pone.0107358. eCollection 2014.

19.

Macromolecular prodrug that provides the irinotecan (CPT-11) active-metabolite SN-38 with ultralong half-life, low C(max), and low glucuronide formation.

Santi DV, Schneider EL, Ashley GW.

J Med Chem. 2014 Mar 27;57(6):2303-14. doi: 10.1021/jm401644v. Epub 2014 Mar 6.

PMID:
24494988
20.

First partial skeleton of a 1.34-million-year-old Paranthropus boisei from Bed II, Olduvai Gorge, Tanzania.

Domínguez-Rodrigo M, Pickering TR, Baquedano E, Mabulla A, Mark DF, Musiba C, Bunn HT, Uribelarrea D, Smith V, Diez-Martin F, Pérez-González A, Sánchez P, Santonja M, Barboni D, Gidna A, Ashley G, Yravedra J, Heaton JL, Arriaza MC.

PLoS One. 2013 Dec 5;8(12):e80347. doi: 10.1371/journal.pone.0080347. eCollection 2013.

21.

The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.

Czudnochowski N, Ashley GW, Santi DV, Alian A, Finer-Moore J, Stroud RM.

Nucleic Acids Res. 2014 Feb;42(3):2037-48. doi: 10.1093/nar/gkt1050. Epub 2013 Nov 7.

22.

β-Eliminative releasable linkers adapted for bioconjugation of macromolecules to phenols.

Schneider EL, Robinson L, Reid R, Ashley GW, Santi DV.

Bioconjug Chem. 2013 Dec 18;24(12):1990-7. doi: 10.1021/bc4002882. Epub 2013 Nov 20.

PMID:
24171387
23.

Hydrogel drug delivery system with predictable and tunable drug release and degradation rates.

Ashley GW, Henise J, Reid R, Santi DV.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2318-23. doi: 10.1073/pnas.1215498110. Epub 2013 Jan 23.

24.

Water, plants, and early human habitats in eastern Africa.

Magill CR, Ashley GM, Freeman KH.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1175-80. doi: 10.1073/pnas.1209405109. Epub 2012 Dec 24.

25.

Ecosystem variability and early human habitats in eastern Africa.

Magill CR, Ashley GM, Freeman KH.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1167-74. doi: 10.1073/pnas.1206276110. Epub 2012 Dec 24.

26.

Earliest porotic hyperostosis on a 1.5-million-year-old hominin, olduvai gorge, Tanzania.

Domínguez-Rodrigo M, Pickering TR, Diez-Martín F, Mabulla A, Musiba C, Trancho G, Baquedano E, Bunn HT, Barboni D, Santonja M, Uribelarrea D, Ashley GM, Martínez-Ávila Mdel S, Barba R, Gidna A, Yravedra J, Arriaza C.

PLoS One. 2012;7(10):e46414. doi: 10.1371/journal.pone.0046414. Epub 2012 Oct 3.

27.

Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer.

Henke A, Grace OC, Ashley GR, Stewart GD, Riddick AC, Yeun H, O'Donnell M, Anderson RA, Thomson AA.

PLoS One. 2012;7(8):e42516. doi: 10.1371/journal.pone.0042516. Epub 2012 Aug 3.

28.

Dual-mode thin film bulk acoustic wave resonators for parallel sensing of temperature and mass loading.

García-Gancedo L, Pedrós J, Zhao XB, Ashley GM, Flewitt AJ, Milne WI, Ford CJ, Lu JR, Luo JK.

Biosens Bioelectron. 2012 Oct-Dec;38(1):369-74. doi: 10.1016/j.bios.2012.06.023. Epub 2012 Jun 21.

PMID:
22784500
29.

Interfacial recognition of human prostate-specific antigen by immobilized monoclonal antibody: effects of solution conditions and surface chemistry.

Zhao X, Pan F, Garcia-Gancedo L, Flewitt AJ, Ashley GM, Luo J, Lu JR.

J R Soc Interface. 2012 Oct 7;9(75):2457-67. doi: 10.1098/rsif.2012.0148. Epub 2012 May 2.

30.

Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates.

Santi DV, Schneider EL, Reid R, Robinson L, Ashley GW.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6211-6. doi: 10.1073/pnas.1117147109. Epub 2012 Apr 2.

31.

ZnO-based FBAR resonators with carbon nanotube electrodes.

García-Gancedo L, Al-Naimi F, Flewitt AJ, Milne WI, Ashley GM, Luo JK, Zhao X, Lu JR.

IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Nov;58(11):2438-45. doi: 10.1109/TUFFC.2011.2100.

PMID:
22083776
32.

Interfacial immobilization of monoclonal antibody and detection of human prostate-specific antigen.

Zhao X, Pan F, Cowsill B, Lu JR, Garcia-Gancedo L, Flewitt AJ, Ashley GM, Luo J.

Langmuir. 2011 Jun 21;27(12):7654-62. doi: 10.1021/la201245q. Epub 2011 May 25.

PMID:
21612249
33.

The bovine chemokine receptors and their mRNA abundance in mononuclear phagocytes.

Widdison S, Siddiqui N, Easton V, Lawrence F, Ashley G, Werling D, Watson M, Coffey TJ.

BMC Genomics. 2010 Jul 19;11:439. doi: 10.1186/1471-2164-11-439.

34.

Identification of EphrinB1 expression in prostatic mesenchyme and a role for EphB-EphrinB signalling in prostate development.

Ashley GR, Grace OC, Vanpoucke G, Thomson AA.

Differentiation. 2010 Sep-Oct;80(2-3):89-98. doi: 10.1016/j.diff.2010.06.003. Epub 2010 Jul 15.

PMID:
20633976
35.

Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.

Menzella HG, Tran TT, Carney JR, Lau-Wee J, Galazzo J, Reeves CD, Carreras C, Mukadam S, Eng S, Zhong Z, Timmermans PB, Murli S, Ashley GW.

J Med Chem. 2009 Mar 26;52(6):1518-21. doi: 10.1021/jm900012a.

PMID:
19231864
36.

A role for notch signaling in stromal survival and differentiation during prostate development.

Orr B, Grace OC, Vanpoucke G, Ashley GR, Thomson AA.

Endocrinology. 2009 Jan;150(1):463-72. doi: 10.1210/en.2008-0383. Epub 2008 Sep 18.

PMID:
18801907
37.

Transcriptional profiling of inductive mesenchyme to identify molecules involved in prostate development and disease.

Vanpoucke G, Orr B, Grace OC, Chan R, Ashley GR, Williams K, Franco OE, Hayward SW, Thomson AA.

Genome Biol. 2007;8(10):R213.

39.

Characterisation of bovine inducible nitric oxide synthase.

Widdison S, Ashley GR, Howard CJ, Coffey TJ.

Vet Immunol Immunopathol. 2007 Jun 15;117(3-4):302-9. Epub 2007 Jan 31.

PMID:
17336395
40.

Preparation of erythromycin analogs having functional groups at C-15.

Ashley GW, Burlingame M, Desai R, Fu H, Leaf T, Licari PJ, Tran C, Abbanat D, Bush K, Macielag M.

J Antibiot (Tokyo). 2006 Jul;59(7):392-401.

PMID:
17025015
41.

Structure elucidation of new ascomycins produced by genetic engineering.

Carney JR, Ashley GW, Arslanian RL, Buchannan GO.

J Antibiot (Tokyo). 2005 Nov;58(11):715-21.

PMID:
16466025
42.

Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1.

Murli S, MacMillan KS, Hu Z, Ashley GW, Dong SD, Kealey JT, Reeves CD, Kennedy J.

Appl Environ Microbiol. 2005 Aug;71(8):4503-9.

43.

15-amido erythromycins: synthesis and in vitro activity of a new class of macrolide antibiotics.

Shaw SJ, Abbanat D, Ashley GW, Bush K, Foleno B, Macielag M, Zhang D, Myles DC.

J Antibiot (Tokyo). 2005 Mar;58(3):167-77.

PMID:
15895524
44.

Translation and protein synthesis: macrolides.

Katz L, Ashley GW.

Chem Rev. 2005 Feb;105(2):499-528. Review. No abstract available.

PMID:
15700954
45.
46.
47.

A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases.

Hu Z, Pfeifer BA, Chao E, Murli S, Kealey J, Carney JR, Ashley G, Khosla C, Hutchinson CR.

Microbiology. 2003 Aug;149(Pt 8):2213-25.

PMID:
12904561
48.

Late Pliocene Homo and hominid land use from Western Olduvai Gorge, Tanzania.

Blumenschine RJ, Peters CR, Masao FT, Clarke RJ, Deino AL, Hay RL, Swisher CC, Stanistreet IG, Ashley GM, McHenry LJ, Sikes NE, Van Der Merwe NJ, Tactikos JC, Cushing AE, Deocampo DM, Njau JK, Ebert JI.

Science. 2003 Feb 21;299(5610):1217-21.

49.

A model of structure and catalysis for ketoreductase domains in modular polyketide synthases.

Reid R, Piagentini M, Rodriguez E, Ashley G, Viswanathan N, Carney J, Santi DV, Hutchinson CR, McDaniel R.

Biochemistry. 2003 Jan 14;42(1):72-9.

PMID:
12515540
50.

Genetically engineered analogs of ascomycin for nerve regeneration.

Revill WP, Voda J, Reeves CR, Chung L, Schirmer A, Ashley G, Carney JR, Fardis M, Carreras CW, Zhou Y, Feng L, Tucker E, Robinson D, Gold BG.

J Pharmacol Exp Ther. 2002 Sep;302(3):1278-85.

PMID:
12183690

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