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Items: 1 to 50 of 111

1.

IFN-β signalling regulates RAW 264.7 macrophage activation, cytokine production, and killing activity.

Karimi Y, Giles EC, Vahedi F, Chew MV, Nham T, Loukov D, Lee AJ, Bowdish DM, Ashkar AA.

Innate Immun. 2019 Oct 15:1753425919878839. doi: 10.1177/1753425919878839. [Epub ahead of print] No abstract available.

PMID:
31615311
2.

Medroxyprogesterone acetate alters the vaginal microbiota and microenvironment in women and increases susceptibility to HIV-1 in humanized mice.

Wessels JM, Lajoie J, Cooper MIJH, Omollo K, Felker AM, Vitali D, Dupont HA, Nguyen PV, Mueller K, Vahedi F, Kimani J, Oyugi J, Cheruiyot J, Mungai JN, Deshiere A, Tremblay MJ, Mazzulli T, Stearns JC, Ashkar AA, Fowke KR, Surette MG, Kaushic C.

Dis Model Mech. 2019 Oct 23;12(10). pii: dmm039669. doi: 10.1242/dmm.039669.

3.

What Defines NK Cell Functional Fate: Phenotype or Metabolism?

Poznanski SM, Ashkar AA.

Front Immunol. 2019 Jun 19;10:1414. doi: 10.3389/fimmu.2019.01414. eCollection 2019. Review.

4.

Type I Interferon Receptor on NK Cells Negatively Regulates Interferon-γ Production.

Lee AJ, Mian F, Poznanski SM, Stackaruk M, Chan T, Chew MV, Ashkar AA.

Front Immunol. 2019 Jun 4;10:1261. doi: 10.3389/fimmu.2019.01261. eCollection 2019.

5.

Statins Promote Interleukin-1β-Dependent Adipocyte Insulin Resistance Through Lower Prenylation, Not Cholesterol.

Henriksbo BD, Tamrakar AK, Xu J, Duggan BM, Cavallari JF, Phulka J, Stampfli MR, Ashkar AA, Schertzer JD.

Diabetes. 2019 Jul;68(7):1441-1448. doi: 10.2337/db18-0999. Epub 2019 Apr 22.

PMID:
31010959
6.

TLR2 Plays a Pivotal Role in Mediating Mucosal Serotonin Production in the Gut.

Wang H, Kwon YH, Dewan V, Vahedi F, Syed S, Fontes ME, Ashkar AA, Surette MG, Khan WI.

J Immunol. 2019 May 15;202(10):3041-3052. doi: 10.4049/jimmunol.1801034. Epub 2019 Apr 5.

PMID:
30952815
7.

Shining light on the significance of NK cell CD56 brightness.

Poznanski SM, Ashkar AA.

Cell Mol Immunol. 2018 Dec;15(12):1071-1073. doi: 10.1038/s41423-018-0163-3. Epub 2018 Oct 1. No abstract available.

PMID:
30275534
8.

The Dual Nature of Type I and Type II Interferons.

Lee AJ, Ashkar AA.

Front Immunol. 2018 Sep 11;9:2061. doi: 10.3389/fimmu.2018.02061. eCollection 2018. Review.

9.

Immunometabolism of T cells and NK cells: metabolic control of effector and regulatory function.

Poznanski SM, Barra NG, Ashkar AA, Schertzer JD.

Inflamm Res. 2018 Oct;67(10):813-828. doi: 10.1007/s00011-018-1174-3. Epub 2018 Jul 31. Review.

PMID:
30066126
10.

Expanded CD56superbrightCD16+ NK Cells from Ovarian Cancer Patients Are Cytotoxic against Autologous Tumor in a Patient-Derived Xenograft Murine Model.

Poznanski SM, Nham T, Chew MV, Lee AJ, Hammill JA, Fan IY, Butcher M, Bramson JL, Lee DA, Hirte HW, Ashkar AA.

Cancer Immunol Res. 2018 Oct;6(10):1174-1185. doi: 10.1158/2326-6066.CIR-18-0144. Epub 2018 Jul 17.

11.

IL-15 and IFN-γ signal through the ERK pathway to inhibit HCV replication, independent of type I IFN signaling.

Vahedi F, Lee AJ, Collins SE, Chew MV, Lusty E, Chen B, Dubey A, Richards CD, Feld JJ, Russell RS, Mossman KL, Ashkar AA.

Cytokine. 2019 Dec;124:154439. doi: 10.1016/j.cyto.2018.06.006. Epub 2018 Jun 19.

PMID:
29908921
12.

Transforming the prostatic tumor microenvironment with oncolytic virotherapy.

Atherton MJ, Stephenson KB, Tzelepis F, Bakhshinyan D, Nikota JK, Son HH, Jirovec A, Lefebvre C, Dvorkin-Gheva A, Ashkar AA, Wan Y, Stojdl DF, Belanger EC, Breau RH, Bell JC, Saad F, Singh SK, Diallo JS, Lichty BD.

Oncoimmunology. 2018 Mar 27;7(7):e1445459. doi: 10.1080/2162402X.2018.1445459. eCollection 2018.

13.

Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier.

Nazli A, Dizzell S, Zahoor MA, Ferreira VH, Kafka J, Woods MW, Ouellet M, Ashkar AA, Tremblay MJ, Bowdish DM, Kaushic C.

Cell Mol Immunol. 2019 Feb;16(2):178-194. doi: 10.1038/cmi.2017.168. Epub 2018 Mar 19.

14.

High Intensity Interval Training Increases Natural Killer Cell Number and Function in Obese Breast Cancer-challenged Mice and Obese Women.

Barra NG, Fan IY, Gillen JB, Chew M, Marcinko K, Steinberg GR, Gibala MJ, Ashkar AA.

J Cancer Prev. 2017 Dec;22(4):260-266. doi: 10.15430/JCP.2017.22.4.260. Epub 2017 Dec 30.

15.

Ex vivo-expanded NK cells from blood and ascites of ovarian cancer patients are cytotoxic against autologous primary ovarian cancer cells.

Nham T, Poznanski SM, Fan IY, Shenouda MM, Chew MV, Lee AJ, Vahedi F, Karimi Y, Butcher M, Lee DA, Hirte H, Ashkar AA.

Cancer Immunol Immunother. 2018 Apr;67(4):575-587. doi: 10.1007/s00262-017-2112-x. Epub 2018 Jan 3.

PMID:
29299659
16.

Ex Vivo-expanded Natural Killer Cells Derived From Long-term Cryopreserved Cord Blood are Cytotoxic Against Primary Breast Cancer Cells.

Nham T, Poznanski SM, Fan IY, Vahedi F, Shenouda MM, Lee AJ, Chew MV, Hogg RT, Lee DA, Ashkar AA.

J Immunother. 2018 Feb/Mar;41(2):64-72. doi: 10.1097/CJI.0000000000000192.

PMID:
29189387
17.

Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice.

Nguyen PV, Wessels JM, Mueller K, Vahedi F, Anipindi V, Verschoor CP, Chew M, Deshiere A, Karniychuk U, Mazzulli T, Tremblay MJ, Ashkar AA, Kaushic C.

Sci Rep. 2017 Nov 10;7(1):15263. doi: 10.1038/s41598-017-15630-z.

18.

Ex Vivo Expanded Human NK Cells Survive and Proliferate in Humanized Mice with Autologous Human Immune Cells.

Vahedi F, Nham T, Poznanski SM, Chew MV, Shenouda MM, Lee D, Ashkar AA.

Sci Rep. 2017 Sep 21;7(1):12083. doi: 10.1038/s41598-017-12223-8.

19.

The Application of Humanized Mouse Models for the Study of Human Exclusive Viruses.

Vahedi F, Giles EC, Ashkar AA.

Methods Mol Biol. 2017;1656:1-56. doi: 10.1007/978-1-4939-7237-1_1.

PMID:
28808960
20.

Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours.

Shenouda MM, Gillgrass A, Nham T, Hogg R, Lee AJ, Chew MV, Shafaei M, Aarts C, Lee DA, Hassell J, Bane A, Dhesy-Thind S, Ashkar AA.

Breast Cancer Res. 2017 Jul 1;19(1):76. doi: 10.1186/s13058-017-0867-9.

21.

IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-γ production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation.

Lusty E, Poznanski SM, Kwofie K, Mandur TS, Lee DA, Richards CD, Ashkar AA.

Mol Immunol. 2017 Aug;88:138-147. doi: 10.1016/j.molimm.2017.06.025. Epub 2017 Jun 20.

PMID:
28644973
22.

Combined Stimulation with Interleukin-18 and Interleukin-12 Potently Induces Interleukin-8 Production by Natural Killer Cells.

Poznanski SM, Lee AJ, Nham T, Lusty E, Larché MJ, Lee DA, Ashkar AA.

J Innate Immun. 2017;9(5):511-525. doi: 10.1159/000477172. Epub 2017 Jun 21.

23.

Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine.

Yao Y, Lai R, Afkhami S, Haddadi S, Zganiacz A, Vahedi F, Ashkar AA, Kaushic C, Jeyanathan M, Xing Z.

J Infect Dis. 2017 Jul 1;216(1):135-145. doi: 10.1093/infdis/jix252.

24.

Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection.

Lee AJ, Chen B, Chew MV, Barra NG, Shenouda MM, Nham T, van Rooijen N, Jordana M, Mossman KL, Schreiber RD, Mack M, Ashkar AA.

J Exp Med. 2017 Apr 3;214(4):1153-1167. doi: 10.1084/jem.20160880. Epub 2017 Mar 6.

25.

Type I interferon signalling is not required for the induction of endotoxin tolerance.

Karimi Y, Poznanski SM, Vahedi F, Chen B, Chew MV, Lee AJ, Ashkar AA.

Cytokine. 2017 Jul;95:7-11. doi: 10.1016/j.cyto.2017.01.017. Epub 2017 Feb 9.

PMID:
28189043
26.

NK cells require antigen-specific memory CD4+ T cells to mediate superior effector functions during HSV-2 recall responses in vitro.

Chen B, Lee AJ, Chew MV, Ashkar AA.

J Leukoc Biol. 2017 Apr;101(4):1045-1052. doi: 10.1189/jlb.4A0416-192R. Epub 2016 Dec 14.

PMID:
27974365
27.

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus.

He W, Tan GS, Mullarkey CE, Lee AJ, Lam MM, Krammer F, Henry C, Wilson PC, Ashkar AA, Palese P, Miller MS.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11931-11936. Epub 2016 Oct 3.

28.

M2-polarized and tumor-associated macrophages alter NK cell phenotype and function in a contact-dependent manner.

Krneta T, Gillgrass A, Poznanski S, Chew M, Lee AJ, Kolb M, Ashkar AA.

J Leukoc Biol. 2017 Jan;101(1):285-295. doi: 10.1189/jlb.3A1215-552R. Epub 2016 Aug 4.

PMID:
27493241
29.

Reconstitution of immune cell in liver and lymph node of adult- and newborn-engrafted humanized mice.

Dykstra C, Lee AJ, Lusty EJ, Shenouda MM, Shafai M, Vahedi F, Chew MV, Collins S, Ashkar AA.

BMC Immunol. 2016 Jun 16;17(1):18. doi: 10.1186/s12865-016-0157-9.

30.

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria C, Chen L, Rangwala Z, Hesch A, Chan ESY, Tuinman C, Suthar MS, Jiang Z, Ashkar AA, Thomas G, Kozma SC, Gale M Jr, Fitzgerald KA, Diamond MS, Mossman K, Sonenberg N, Wan Y, Lichty BD.

Nat Immunol. 2016 May;17(5):514-522. doi: 10.1038/ni.3433. Epub 2016 Apr 4.

31.

The breast tumor microenvironment alters the phenotype and function of natural killer cells.

Krneta T, Gillgrass A, Chew M, Ashkar AA.

Cell Mol Immunol. 2016 Sep;13(5):628-39. doi: 10.1038/cmi.2015.42. Epub 2015 Aug 17.

32.

Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model.

Gillgrass AE, Chew MV, Krneta T, Ashkar AA.

BMC Cancer. 2015 Apr 16;15:293. doi: 10.1186/s12885-015-1264-3.

33.

Vitamin D3 modulates the function of chicken macrophages.

Shojadoost B, Behboudi S, Villanueva AI, Brisbin JT, Ashkar AA, Sharif S.

Res Vet Sci. 2015 Jun;100:45-51. doi: 10.1016/j.rvsc.2015.03.009. Epub 2015 Mar 9.

PMID:
25814176
34.

Type I IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity.

Karimi K, Karimi Y, Chan J, Boudreau JE, Basset J, Chew MV, Reid S, Bramson JL, Wan Y, Ashkar AA.

Innate Immun. 2015 Aug;21(6):626-34. doi: 10.1177/1753425915575078. Epub 2015 Mar 5.

PMID:
25749844
35.

Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance.

Denou E, Lolmède K, Garidou L, Pomie C, Chabo C, Lau TC, Fullerton MD, Nigro G, Zakaroff-Girard A, Luche E, Garret C, Serino M, Amar J, Courtney M, Cavallari JF, Henriksbo BD, Barra NG, Foley KP, McPhee JB, Duggan BM, O'Neill HM, Lee AJ, Sansonetti P, Ashkar AA, Khan WI, Surette MG, Bouloumié A, Steinberg GR, Burcelin R, Schertzer JD.

EMBO Mol Med. 2015 Mar;7(3):259-74. doi: 10.15252/emmm.201404169.

36.

Interleukin-15 modulates adipose tissue by altering mitochondrial mass and activity.

Barra NG, Palanivel R, Denou E, Chew MV, Gillgrass A, Walker TD, Kong J, Richards CD, Jordana M, Collins SM, Trigatti BL, Holloway AC, Raha S, Steinberg GR, Ashkar AA.

PLoS One. 2014 Dec 17;9(12):e114799. doi: 10.1371/journal.pone.0114799. eCollection 2014.

37.

The absence or overexpression of IL-15 drastically alters breast cancer metastasis via effects on NK cells, CD4 T cells, and macrophages.

Gillgrass A, Gill N, Babian A, Ashkar AA.

J Immunol. 2014 Dec 15;193(12):6184-91. doi: 10.4049/jimmunol.1303175. Epub 2014 Oct 29.

38.
39.

T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes.

Chu DK, Mohammed-Ali Z, Jiménez-Saiz R, Walker TD, Goncharova S, Llop-Guevara A, Kong J, Gordon ME, Barra NG, Gillgrass AE, Van Seggelen H, Khan WI, Ashkar AA, Bramson JL, Humbles AA, Kolbeck R, Waserman S, Jordana M.

Mucosal Immunol. 2014 Nov;7(6):1395-404. doi: 10.1038/mi.2014.29. Epub 2014 Apr 30.

PMID:
24781052
40.

Restoration of innate immune activation accelerates Th1-cell priming and protection following pulmonary mycobacterial infection.

Lai R, Jeyanathan M, Shaler CR, Damjanovic D, Khera A, Horvath C, Ashkar AA, Xing Z.

Eur J Immunol. 2014 May;44(5):1375-86. doi: 10.1002/eji.201344300. Epub 2014 Apr 4.

41.

HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium.

Nazli A, Kafka JK, Ferreira VH, Anipindi V, Mueller K, Osborne BJ, Dizzell S, Chauvin S, Mian MF, Ouellet M, Tremblay MJ, Mossman KL, Ashkar AA, Kovacs C, Bowdish DM, Snider DP, Kaul R, Kaushic C.

J Immunol. 2013 Oct 15;191(8):4246-58. doi: 10.4049/jimmunol.1301482. Epub 2013 Sep 16.

42.

Type I interferon regulation of natural killer cell function in primary and secondary infections.

Stackaruk ML, Lee AJ, Ashkar AA.

Expert Rev Vaccines. 2013 Aug;12(8):875-84. doi: 10.1586/14760584.2013.814871. Review.

PMID:
23984959
43.

Length of dsRNA (poly I:C) drives distinct innate immune responses, depending on the cell type.

Mian MF, Ahmed AN, Rad M, Babaian A, Bowdish D, Ashkar AA.

J Leukoc Biol. 2013 Nov;94(5):1025-36. doi: 10.1189/jlb.0312125. Epub 2013 Aug 2.

PMID:
23911868
44.

Interleukin-15 is required for maximal lipopolysaccharide-induced abortion.

Lee AJ, Kandiah N, Karimi K, Clark DA, Ashkar AA.

J Leukoc Biol. 2013 Jun;93(6):905-12. doi: 10.1189/jlb.0912442. Epub 2013 Mar 15.

PMID:
23505315
45.

Immunity to ocular and genital herpes simplex viruses infections.

Chentoufi AA, BenMohamed L, Van De Perre P, Ashkar AA.

Clin Dev Immunol. 2012;2012:732546. doi: 10.1155/2012/732546. Epub 2012 Dec 26. No abstract available.

46.

The influence of macrophages and the tumor microenvironment on natural killer cells.

Krneta T, Gillgrass A, Ashkar AA.

Curr Mol Med. 2013 Jan;13(1):68-79. Review.

PMID:
22834841
47.

Interleukin-15 treatment induces weight loss independent of lymphocytes.

Barra NG, Chew MV, Reid S, Ashkar AA.

PLoS One. 2012;7(6):e39553. doi: 10.1371/journal.pone.0039553. Epub 2012 Jun 29.

48.

Critical role of natural killer cells in lung immunopathology during influenza infection in mice.

Abdul-Careem MF, Mian MF, Yue G, Gillgrass A, Chenoweth MJ, Barra NG, Chew MV, Chan T, Al-Garawi AA, Jordana M, Ashkar AA.

J Infect Dis. 2012 Jul 15;206(2):167-77. doi: 10.1093/infdis/jis340. Epub 2012 May 4.

PMID:
22561366
49.

Genital HSV-2 infection induces short-term NK cell memory.

Abdul-Careem MF, Lee AJ, Pek EA, Gill N, Gillgrass AE, Chew MV, Reid S, Ashkar AA.

PLoS One. 2012;7(3):e32821. doi: 10.1371/journal.pone.0032821. Epub 2012 Mar 22.

50.

IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.

Chenoweth MJ, Mian MF, Barra NG, Alain T, Sonenberg N, Bramson J, Lichty BD, Richards CD, Ma A, Ashkar AA.

J Immunol. 2012 May 1;188(9):4149-57. doi: 10.4049/jimmunol.1101883. Epub 2012 Mar 23.

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