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Items: 1 to 50 of 162

1.

CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism.

Thomas LW, Esposito C, Stephen JM, Costa ASH, Frezza C, Blacker TS, Szabadkai G, Ashcroft M.

Cancer Metab. 2019 Jul 16;7:7. doi: 10.1186/s40170-019-0200-4. eCollection 2019.

2.

CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain.

Thomas LW, Stephen JM, Esposito C, Hoer S, Antrobus R, Ahmed A, Al-Habib H, Ashcroft M.

Cancer Metab. 2019 Mar 6;7:2. doi: 10.1186/s40170-019-0194-y. eCollection 2019.

3.

Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria.

Thomas LW, Ashcroft M.

Cell Mol Life Sci. 2019 May;76(9):1759-1777. doi: 10.1007/s00018-019-03039-y. Epub 2019 Feb 14. Review.

4.

Corrigendum: CHCHD4 Regulates Intracellular Oxygenation and Perinuclear Distribution of Mitochondria.

Thomas LW, Staples O, Turmaine M, Ashcroft M.

Front Oncol. 2019 Jan 23;9:23. doi: 10.3389/fonc.2019.00023. eCollection 2019.

5.

Percutaneous treatment of a massive saphenous vein graft aneurysm.

Knoery C, Ashcroft M, Smith JA, Leslie SJ.

Catheter Cardiovasc Interv. 2019 Apr 1;93(5):923-926. doi: 10.1002/ccd.28040. Epub 2018 Dec 27.

PMID:
30592136
6.

VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function.

Briston T, Stephen JM, Thomas LW, Esposito C, Chung YL, Syafruddin SE, Turmaine M, Maddalena LA, Greef B, Szabadkai G, Maxwell PH, Vanharanta S, Ashcroft M.

Front Oncol. 2018 Oct 4;8:388. doi: 10.3389/fonc.2018.00388. eCollection 2018.

7.

Metabolic Profiling of Human Eosinophils.

Porter L, Toepfner N, Bashant KR, Guck J, Ashcroft M, Farahi N, Chilvers ER.

Front Immunol. 2018 Jun 21;9:1404. doi: 10.3389/fimmu.2018.01404. eCollection 2018.

8.

Which is more biased: Standardized weather stations or microclimatic sensors?

Ashcroft MB.

Ecol Evol. 2018 May 7;8(11):5231-5232. doi: 10.1002/ece3.3965. eCollection 2018 Jun.

9.

The mitochondrial oxidoreductase CHCHD4 is present in a semi-oxidized state in vivo.

Erdogan AJ, Ali M, Habich M, Salscheider SL, Schu L, Petrungaro C, Thomas LW, Ashcroft M, Leichert LI, Roma LP, Riemer J.

Redox Biol. 2018 Jul;17:200-206. doi: 10.1016/j.redox.2018.03.014. Epub 2018 Mar 24.

10.

Remote monitoring of dynamic canopy photosynthesis with high time resolution light-induced fluorescence transients.

Wyber R, Osmond B, Ashcroft MB, Malenovský Z, Robinson SA.

Tree Physiol. 2018 Sep 1;38(9):1302-1318. doi: 10.1093/treephys/tpx161.

PMID:
29301044
11.

Iatrogenic Arteriovenous Fistula of the breast following core-biopsy presenting in pregnancy.

Barker S, Ashcroft M, Abbott N.

Breast J. 2018 May;24(3):388-390. doi: 10.1111/tbj.12958. Epub 2017 Nov 15.

PMID:
29139607
12.

Genetic variation in IRF4 expression modulates growth characteristics, tyrosinase expression and interferon-gamma response in melanocytic cells.

Chhabra Y, Yong HXL, Fane ME, Soogrim A, Lim W, Mahiuddin DN, Kim RSQ, Ashcroft M, Beatson SA, Ainger SA, Smit DJ, Jagirdar K, Walker GJ, Sturm RA, Smith AG.

Pigment Cell Melanoma Res. 2018 Jan;31(1):51-63. doi: 10.1111/pcmr.12620. Epub 2017 Oct 23.

PMID:
28755520
13.

CHCHD4 Regulates Intracellular Oxygenation and Perinuclear Distribution of Mitochondria.

Thomas LW, Staples O, Turmaine M, Ashcroft M.

Front Oncol. 2017 Apr 27;7:71. doi: 10.3389/fonc.2017.00071. eCollection 2017. Erratum in: Front Oncol. 2019 Jan 23;9:23.

14.

Mutations in mitochondrial DNA causing tubulointerstitial kidney disease.

Connor TM, Hoer S, Mallett A, Gale DP, Gomez-Duran A, Posse V, Antrobus R, Moreno P, Sciacovelli M, Frezza C, Duff J, Sheerin NS, Sayer JA, Ashcroft M, Wiesener MS, Hudson G, Gustafsson CM, Chinnery PF, Maxwell PH.

PLoS Genet. 2017 Mar 7;13(3):e1006620. doi: 10.1371/journal.pgen.1006620. eCollection 2017 Mar.

15.

Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication.

Farquhar MJ, Humphreys IS, Rudge SA, Wilson GK, Bhattacharya B, Ciaccia M, Hu K, Zhang Q, Mailly L, Reynolds GM, Ashcroft M, Balfe P, Baumert TF, Roessler S, Wakelam MJO, McKeating JA.

J Hepatol. 2017 May;66(5):919-929. doi: 10.1016/j.jhep.2017.01.009. Epub 2017 Jan 23.

PMID:
28126468
16.

Moving beyond presence and absence when examining changes in species distributions.

Ashcroft MB, King DH, Raymond B, Turnbull JD, Wasley J, Robinson SA.

Glob Chang Biol. 2017 Aug;23(8):2929-2940. doi: 10.1111/gcb.13628. Epub 2017 Feb 15. Review.

PMID:
28100027
17.

Preparing for community development practice: A Delphi study of Canadian occupational therapists

Leclair LL, Ashcroft ML, Canning TL, Lisowski MA.

Can J Occup Ther. 2016 Oct;83(4):226-236. Epub 2016 Feb 26.

PMID:
26919933
18.

Direct Measurements of Unimolecular and Bimolecular Reaction Kinetics of the Criegee Intermediate (CH3)2COO.

Chhantyal-Pun R, Welz O, Savee JD, Eskola AJ, Lee EP, Blacker L, Hill HR, Ashcroft M, Khan MA, Lloyd-Jones GC, Evans L, Rotavera B, Huang H, Osborn DL, Mok DK, Dyke JM, Shallcross DE, Percival CJ, Orr-Ewing AJ, Taatjes CA.

J Phys Chem A. 2017 Jan 12;121(1):4-15. doi: 10.1021/acs.jpca.6b07810. Epub 2016 Dec 22.

PMID:
27755879
19.

Erratum for Ben Zakour et al., Sequential Acquisition of Virulence and Fluoroquinolone Resistance Has Shaped the Evolution of Escherichia coli ST131.

Ben Zakour NL, Alsheikh-Hussain AS, Ashcroft MM, Khanh Nhu NT, Roberts LW, Stanton-Cook M, Schembri MA, Beatson SA.

MBio. 2016 Jun 28;7(3). pii: e00958-16. doi: 10.1128/mBio.00958-16. No abstract available.

20.

Sequential Acquisition of Virulence and Fluoroquinolone Resistance Has Shaped the Evolution of Escherichia coli ST131.

Ben Zakour NL, Alsheikh-Hussain AS, Ashcroft MM, Khanh Nhu NT, Roberts LW, Stanton-Cook M, Schembri MA, Beatson SA.

MBio. 2016 Apr 26;7(2):e00347-16. doi: 10.1128/mBio.00347-16. Erratum in: MBio. 2016 Jun 28;7(3):null.

21.

Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20).

Burrows N, Cane G, Robson M, Gaude E, Howat WJ, Szlosarek PW, Pedley RB, Frezza C, Ashcroft M, Maxwell PH.

Sci Rep. 2016 Mar 14;6:22950. doi: 10.1038/srep22950.

22.

Lineage-Specific Methyltransferases Define the Methylome of the Globally Disseminated Escherichia coli ST131 Clone.

Forde BM, Phan MD, Gawthorne JA, Ashcroft MM, Stanton-Cook M, Sarkar S, Peters KM, Chan KG, Chong TM, Yin WF, Upton M, Schembri MA, Beatson SA.

MBio. 2015 Nov 17;6(6):e01602-15. doi: 10.1128/mBio.01602-15.

23.

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.

Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ, Peso LD, Landazuri MO, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton DC, Haider S, Buffa FM, Harris AL, Scozzafava A, Supuran CT, Moser I, Jobst G, Busk M, Toustrup K, Overgaard J, Alsner J, Pouyssegur J, Chiche J, Mazure N, Marchiq I, Parks S, Ahmed A, Ashcroft M, Pastorekova S, Cao Y, Rouschop KM, Wouters BG, Koritzinsky M, Mujcic H, Cojocari D.

J Enzyme Inhib Med Chem. 2015;30(5):689-721. doi: 10.3109/14756366.2014.966704. Epub 2014 Oct 27. Review.

PMID:
25347767
24.

HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore.

Ong SG, Lee WH, Theodorou L, Kodo K, Lim SY, Shukla DH, Briston T, Kiriakidis S, Ashcroft M, Davidson SM, Maxwell PH, Yellon DM, Hausenloy DJ.

Cardiovasc Res. 2014 Oct 1;104(1):24-36. doi: 10.1093/cvr/cvu172. Epub 2014 Jul 25.

PMID:
25063991
25.

Climate refugia: joint inference from fossil records, species distribution models and phylogeography.

Gavin DG, Fitzpatrick MC, Gugger PF, Heath KD, Rodríguez-Sánchez F, Dobrowski SZ, Hampe A, Hu FS, Ashcroft MB, Bartlein PJ, Blois JL, Carstens BC, Davis EB, de Lafontaine G, Edwards ME, Fernandez M, Henne PD, Herring EM, Holden ZA, Kong WS, Liu J, Magri D, Matzke NJ, McGlone MS, Saltré F, Stigall AL, Tsai YH, Williams JW.

New Phytol. 2014 Oct;204(1):37-54. doi: 10.1111/nph.12929. Epub 2014 Jul 16. Review.

26.

Assessing the distribution and protection status of two types of cool environment to facilitate their conservation under climate change.

Gollan JR, Ramp D, Ashcroft MB.

Conserv Biol. 2014 Apr;28(2):456-66. doi: 10.1111/cobi.12212. Epub 2014 Jan 14.

PMID:
24423229
27.

The synthesis and structure revision of NSC-134754.

Hickin JA, Ahmed A, Fucke K, Ashcroft M, Jones K.

Chem Commun (Camb). 2014 Feb 7;50(10):1238-40. doi: 10.1039/c3cc48189a.

PMID:
24336320
28.

Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways.

Selvarajah J, Nathawat K, Moumen A, Ashcroft M, Carroll VA.

Cell Death Dis. 2013 Oct 17;4:e865. doi: 10.1038/cddis.2013.395.

29.

Evaluation and immunohistochemical qualification of carbogen-induced ΔR₂ as a noninvasive imaging biomarker of improved tumor oxygenation.

Baker LC, Boult JK, Jamin Y, Gilmour LD, Walker-Samuel S, Burrell JS, Ashcroft M, Howe FA, Griffiths JR, Raleigh JA, van der Kogel AJ, Robinson SP.

Int J Radiat Oncol Biol Phys. 2013 Sep 1;87(1):160-7. doi: 10.1016/j.ijrobp.2013.04.051. Epub 2013 Jul 9.

PMID:
23849692
30.

Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.

Luong le A, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JL, Harten S, Ashcroft M, Walmsley SR, Haskard DO, Maxwell PH, Walczak H, Pusey C, Evans PC.

Circ Res. 2013 Jun 7;112(12):1583-91. doi: 10.1161/CIRCRESAHA.111.300119. Epub 2013 Apr 5.

PMID:
23564640
31.

The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function.

Baker LC, Boult JK, Walker-Samuel S, Chung YL, Jamin Y, Ashcroft M, Robinson SP.

Br J Cancer. 2012 May 8;106(10):1638-47. doi: 10.1038/bjc.2012.131. Epub 2012 Apr 12.

32.

A practical critique of antifungal treatment guidelines for haemato-oncologists.

Agrawal S, Jones B, Barnes R, Kibbler C, Millen M, Ashcroft M, Jain S, Last A, Lewis D, Lewis T, Patel M, Pagliuca A.

Crit Rev Microbiol. 2012 Aug;38(3):203-16. doi: 10.3109/1040841X.2011.645521. Epub 2012 Feb 11. Review.

PMID:
22324737
33.

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression.

Yang J, Staples O, Thomas LW, Briston T, Robson M, Poon E, Simões ML, El-Emir E, Buffa FM, Ahmed A, Annear NP, Shukla D, Pedley BR, Maxwell PH, Harris AL, Ashcroft M.

J Clin Invest. 2012 Feb;122(2):600-11. doi: 10.1172/JCI58780. Epub 2012 Jan 3.

34.

A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migration.

Wilson GK, Brimacombe CL, Rowe IA, Reynolds GM, Fletcher NF, Stamataki Z, Bhogal RH, Simões ML, Ashcroft M, Afford SC, Mitry RR, Dhawan A, Mee CJ, Hübscher SG, Balfe P, McKeating JA.

J Hepatol. 2012 Apr;56(4):803-9. doi: 10.1016/j.jhep.2011.11.018. Epub 2011 Dec 16.

35.

HIF-1α localization with mitochondria: a new role for an old favorite?

Briston T, Yang J, Ashcroft M.

Cell Cycle. 2011 Dec 1;10(23):4170-1. doi: 10.4161/cc.10.23.18565. Epub 2011 Dec 1. No abstract available.

36.

Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells.

Harten SK, Esteban MA, Shukla D, Ashcroft M, Maxwell PH.

Mol Cancer. 2011 Jul 26;10:89. doi: 10.1186/1476-4598-10-89.

37.

Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1.

Ahmed A, Yang J, Maya-Mendoza A, Jackson DA, Ashcroft M.

Cell Death Dis. 2011 May 19;2:e160. doi: 10.1038/cddis.2011.42.

38.

Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis.

Khan MN, Bhattacharyya T, Andrikopoulos P, Esteban MA, Barod R, Connor T, Ashcroft M, Maxwell PH, Kiriakidis S.

Br J Cancer. 2011 Mar 29;104(7):1151-9. doi: 10.1038/bjc.2011.73. Epub 2011 Mar 8.

39.

Successful treatment of coronary artery steal with an Amplatzer Vascular Plug 4.

Ashcroft M, Miller J, Smith JA, Leslie SJ.

Int J Cardiol. 2011 May 19;149(1):117-8. doi: 10.1016/j.ijcard.2011.01.056. Epub 2011 Feb 12. No abstract available.

PMID:
21316773
40.

TRP-ing off the p53 apoptotic switch.

Ahmed A, Ashcroft M.

Pigment Cell Melanoma Res. 2010 Oct;23(5):581-2. doi: 10.1111/j.1755-148X.2010.00747.x. No abstract available.

PMID:
20840120
41.

TRP-ing off the p53 apoptotic switch.

Ahmed A, Ashcroft M.

Pigment Cell Melanoma Res. 2010 Jul 29. [Epub ahead of print] No abstract available.

PMID:
20673277
42.

Diminished macrophage apoptosis and reactive oxygen species generation after phorbol ester stimulation in Crohn's disease.

Palmer CD, Rahman FZ, Sewell GW, Ahmed A, Ashcroft M, Bloom SL, Segal AW, Smith AM.

PLoS One. 2009 Nov 12;4(11):e7787. doi: 10.1371/journal.pone.0007787.

43.

Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection.

Harten SK, Ashcroft M, Maxwell PH.

Antioxid Redox Signal. 2010 Apr;12(4):459-80. doi: 10.1089/ars.2009.2870. Review.

PMID:
19737089
44.

Targeting the hypoxia-inducible factor (HIF) pathway in cancer.

Poon E, Harris AL, Ashcroft M.

Expert Rev Mol Med. 2009 Aug 27;11:e26. doi: 10.1017/S1462399409001173. Review.

PMID:
19709449
45.

Activation of a unique p53-dependent DNA damage response.

Yang J, Ahmed A, Ashcroft M.

Cell Cycle. 2009 May 15;8(10):1630-2. Epub 2009 May 2. No abstract available.

PMID:
19372763
46.

Ertapenem resistance and the Enterobacteriaceae.

Ashcroft M, Weinbren M.

Int J Antimicrob Agents. 2009 Aug;34(2):194-5. doi: 10.1016/j.ijantimicag.2009.02.020. Epub 2009 Apr 10. No abstract available.

PMID:
19362451
47.

Biliary inflammatory pseudotumour: report of two cases and review of the literature.

Ashcroft MW, Ng CS, Frost RA, Freeman AH.

Clin Radiol. 2009 Apr;64(4):449-55. doi: 10.1016/j.crad.2008.12.004. Epub 2009 Feb 5. Review. No abstract available.

PMID:
19264191
48.

Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia.

Yang J, Ahmed A, Poon E, Perusinghe N, de Haven Brandon A, Box G, Valenti M, Eccles S, Rouschop K, Wouters B, Ashcroft M.

Mol Cell Biol. 2009 Apr;29(8):2243-53. doi: 10.1128/MCB.00959-08. Epub 2009 Feb 17.

50.

Regulation of angiogenic factors by HDM2 in renal cell carcinoma.

Carroll VA, Ashcroft M.

Cancer Res. 2008 Jan 15;68(2):545-52. doi: 10.1158/0008-5472.CAN-06-4738.

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