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Items: 1 to 50 of 51

1.

Topical photodynamic therapy following excisional wounding of human skin increases production of transforming growth factor-β3 and matrix metalloproteinases 1 and 9, with associated improvement in dermal matrix organization.

Mills SJ, Farrar MD, Ashcroft GS, Griffiths CE, Hardman MJ, Rhodes LE.

Br J Dermatol. 2014 Jul;171(1):55-62. doi: 10.1111/bjd.12843. Epub 2014 Jun 24.

PMID:
24471979
2.

Insulin-like growth factor-1 promotes wound healing in estrogen-deprived mice: new insights into cutaneous IGF-1R/ERα cross talk.

Emmerson E, Campbell L, Davies FC, Ross NL, Ashcroft GS, Krust A, Chambon P, Hardman MJ.

J Invest Dermatol. 2012 Dec;132(12):2838-48. doi: 10.1038/jid.2012.228. Epub 2012 Jul 19.

3.

Tumor necrosis factor-alpha (TNF-α) is a therapeutic target for impaired cutaneous wound healing.

Ashcroft GS, Jeong MJ, Ashworth JJ, Hardman M, Jin W, Moutsopoulos N, Wild T, McCartney-Francis N, Sim D, McGrady G, Song XY, Wahl SM.

Wound Repair Regen. 2012 Jan-Feb;20(1):38-49. doi: 10.1111/j.1524-475X.2011.00748.x. Epub 2011 Dec 8.

4.

Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities.

Campbell L, Emmerson E, Davies F, Gilliver SC, Krust A, Chambon P, Ashcroft GS, Hardman MJ.

J Exp Med. 2010 Aug 30;207(9):1825-33. doi: 10.1084/jem.20100500. Epub 2010 Aug 23.

5.

17beta-estradiol inhibits wound healing in male mice via estrogen receptor-alpha.

Gilliver SC, Emmerson E, Campbell L, Chambon P, Hardman MJ, Ashcroft GS.

Am J Pathol. 2010 Jun;176(6):2707-21. doi: 10.2353/ajpath.2010.090432. Epub 2010 May 6.

6.

Clinically relevant doses of lidocaine and bupivacaine do not impair cutaneous wound healing in mice.

Waite A, Gilliver SC, Masterson GR, Hardman MJ, Ashcroft GS.

Br J Anaesth. 2010 Jun;104(6):768-73. doi: 10.1093/bja/aeq093. Epub 2010 Apr 24.

7.

The phytoestrogen genistein promotes wound healing by multiple independent mechanisms.

Emmerson E, Campbell L, Ashcroft GS, Hardman MJ.

Mol Cell Endocrinol. 2010 Jun 10;321(2):184-93. doi: 10.1016/j.mce.2010.02.026. Epub 2010 Mar 1.

PMID:
20193736
8.

Novel locally active estrogens accelerate cutaneous wound healing. A preliminary study.

Brufani M, Ceccacci F, Filocamo L, Garofalo B, Joudioux R, La Bella A, Leonelli F, Migneco LM, Bettolo RM, Farina PM, Ashcroft GS, Routley C, Hardman M, Meda C, Rando G, Maggi A.

Mol Pharm. 2009 Mar-Apr;6(2):543-56. doi: 10.1021/mp800206b.

PMID:
19718805
9.

Unique and synergistic roles for 17beta-estradiol and macrophage migration inhibitory factor during cutaneous wound closure are cell type specific.

Emmerson E, Campbell L, Ashcroft GS, Hardman MJ.

Endocrinology. 2009 Jun;150(6):2749-57. doi: 10.1210/en.2008-1569. Epub 2009 Feb 5.

PMID:
19196797
10.

Effect of estrogen and progesterone on macrophage activation during wound healing.

Routley CE, Ashcroft GS.

Wound Repair Regen. 2009 Jan-Feb;17(1):42-50. doi: 10.1111/j.1524-475X.2008.00440.x.

PMID:
19152650
11.

5alpha-dihydrotestosterone (DHT) retards wound closure by inhibiting re-epithelialization.

Gilliver SC, Ruckshanthi JP, Hardman MJ, Zeef LA, Ashcroft GS.

J Pathol. 2009 Jan;217(1):73-82. doi: 10.1002/path.2444.

PMID:
18855875
12.

Sex dimorphism in wound healing: the roles of sex steroids and macrophage migration inhibitory factor.

Gilliver SC, Ruckshanthi JP, Hardman MJ, Nakayama T, Ashcroft GS.

Endocrinology. 2008 Nov;149(11):5747-57. doi: 10.1210/en.2008-0355. Epub 2008 Jul 24.

PMID:
18653719
13.

Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly.

Hardman MJ, Ashcroft GS.

Genome Biol. 2008;9(5):R80. doi: 10.1186/gb-2008-9-5-r80. Epub 2008 May 13.

14.

Polymorphisms spanning the 0N exon and promoter of the estrogen receptor-beta (ERbeta) gene ESR2 are associated with venous ulceration.

Ashworth JJ, Smyth JV, Pendleton N, Horan M, Payton A, Worthington J, Ollier WE, Ashcroft GS.

Clin Genet. 2008 Jan;73(1):55-61. Epub 2007 Nov 29.

PMID:
18070128
15.

Selective estrogen receptor modulators accelerate cutaneous wound healing in ovariectomized female mice.

Hardman MJ, Emmerson E, Campbell L, Ashcroft GS.

Endocrinology. 2008 Feb;149(2):551-7. Epub 2007 Nov 1.

PMID:
17974625
16.

Sex steroids and cutaneous wound healing: the contrasting influences of estrogens and androgens.

Gilliver SC, Ashcroft GS.

Climacteric. 2007 Aug;10(4):276-88. Review.

PMID:
17653954
17.

Androgens influence expression of matrix proteins and proteolytic factors during cutaneous wound healing.

Gilliver SC, Ruckshanthi JP, Atkinson SJ, Ashcroft GS.

Lab Invest. 2007 Sep;87(9):871-81. Epub 2007 Jul 2.

18.

The hormonal regulation of cutaneous wound healing.

Gilliver SC, Ashworth JJ, Ashcroft GS.

Clin Dermatol. 2007 Jan-Feb;25(1):56-62. Review.

PMID:
17276202
19.

Androgens modulate the inflammatory response during acute wound healing.

Gilliver SC, Ashworth JJ, Mills SJ, Hardman MJ, Ashcroft GS.

J Cell Sci. 2006 Feb 15;119(Pt 4):722-32. Epub 2006 Jan 31.

20.

Macrophage migration inhibitory factor: a central regulator of wound healing.

Hardman MJ, Waite A, Zeef L, Burow M, Nakayama T, Ashcroft GS.

Am J Pathol. 2005 Dec;167(6):1561-74.

21.

The sex steroid precursor DHEA accelerates cutaneous wound healing via the estrogen receptors.

Mills SJ, Ashworth JJ, Gilliver SC, Hardman MJ, Ashcroft GS.

J Invest Dermatol. 2005 Nov;125(5):1053-62.

22.

The dinucleotide (CA) repeat polymorphism of estrogen receptor beta but not the dinucleotide (TA) repeat polymorphism of estrogen receptor alpha is associated with venous ulceration.

Ashworth JJ, Smyth JV, Pendleton N, Horan M, Payton A, Worthington J, Ollier WE, Ashcroft GS.

J Steroid Biochem Mol Biol. 2005 Nov;97(3):266-70. Epub 2005 Sep 8.

PMID:
16153823
23.

Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.

Jackson B, Tilli CM, Hardman MJ, Avilion AA, MacLeod MC, Ashcroft GS, Byrne C.

J Invest Dermatol. 2005 May;124(5):1062-70.

24.

Regulatory roles of androgens in cutaneous wound healing.

Gilliver SC, Wu F, Ashcroft GS.

Thromb Haemost. 2003 Dec;90(6):978-85. Review.

PMID:
14652627
25.

Role of Smad3 in the hormonal modulation of in vivo wound healing responses.

Ashcroft GS, Mills SJ, Flanders KC, Lyakh LA, Anzano MA, Gilliver SC, Roberts AB.

Wound Repair Regen. 2003 Nov-Dec;11(6):468-73.

PMID:
14617288
26.

Potential role of estrogens in wound healing.

Ashcroft GS, Ashworth JJ.

Am J Clin Dermatol. 2003;4(11):737-43. Review.

PMID:
14572296
27.

Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor.

Ashcroft GS, Mills SJ, Lei K, Gibbons L, Jeong MJ, Taniguchi M, Burow M, Horan MA, Wahl SM, Nakayama T.

J Clin Invest. 2003 May;111(9):1309-18.

28.

Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair.

Zhu J, Nathan C, Jin W, Sim D, Ashcroft GS, Wahl SM, Lacomis L, Erdjument-Bromage H, Tempst P, Wright CD, Ding A.

Cell. 2002 Dec 13;111(6):867-78.

29.

Ageing and wound healing.

Ashcroft GS, Mills SJ, Ashworth JJ.

Biogerontology. 2002;3(6):337-45. Review.

PMID:
12510172
30.

Androgen receptor-mediated inhibition of cutaneous wound healing.

Ashcroft GS, Mills SJ.

J Clin Invest. 2002 Sep;110(5):615-24.

31.

Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing.

Ashcroft GS, Lei K, Jin W, Longenecker G, Kulkarni AB, Greenwell-Wild T, Hale-Donze H, McGrady G, Song XY, Wahl SM.

Nat Med. 2000 Oct;6(10):1147-53.

PMID:
11017147
32.

Incisional wound healing in transforming growth factor-beta1 null mice.

Koch RM, Roche NS, Parks WT, Ashcroft GS, Letterio JJ, Roberts AB.

Wound Repair Regen. 2000 May-Jun;8(3):179-91.

PMID:
10886809
33.

Loss of Smad3 modulates wound healing.

Ashcroft GS, Roberts AB.

Cytokine Growth Factor Rev. 2000 Mar-Jun;11(1-2):125-31. Review.

PMID:
10708960
34.

Bidirectional regulation of macrophage function by TGF-beta.

Ashcroft GS.

Microbes Infect. 1999 Dec;1(15):1275-82. Review.

PMID:
10611755
35.

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response.

Ashcroft GS, Yang X, Glick AB, Weinstein M, Letterio JL, Mizel DE, Anzano M, Greenwell-Wild T, Wahl SM, Deng C, Roberts AB.

Nat Cell Biol. 1999 Sep;1(5):260-6.

PMID:
10559937
36.

Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response.

Ashcroft GS, Greenwell-Wild T, Horan MA, Wahl SM, Ferguson MW.

Am J Pathol. 1999 Oct;155(4):1137-46.

37.

An elastin gene mutation producing abnormal tropoelastin and abnormal elastic fibres in a patient with autosomal dominant cutis laxa.

Tassabehji M, Metcalfe K, Hurst J, Ashcroft GS, Kielty C, Wilmot C, Donnai D, Read AP, Jones CJ.

Hum Mol Genet. 1998 Jun;7(6):1021-8.

PMID:
9580666
38.

Ageing, defence mechanisms and the immune system.

Horan MA, Ashcroft GS.

Age Ageing. 1997 Dec;26 Suppl 4:15-9. Review. No abstract available.

PMID:
9506428
39.
40.

Age-related differences in the temporal and spatial regulation of matrix metalloproteinases (MMPs) in normal skin and acute cutaneous wounds of healthy humans.

Ashcroft GS, Horan MA, Herrick SE, Tarnuzzer RW, Schultz GS, Ferguson MW.

Cell Tissue Res. 1997 Dec;290(3):581-91.

PMID:
9369533
41.

Human ageing impairs injury-induced in vivo expression of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and -2 proteins and mRNA.

Ashcroft GS, Herrick SE, Tarnuzzer RW, Horan MA, Schultz GS, Ferguson MW.

J Pathol. 1997 Oct;183(2):169-76.

PMID:
9390029
42.
43.

Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels.

Ashcroft GS, Dodsworth J, van Boxtel E, Tarnuzzer RW, Horan MA, Schultz GS, Ferguson MW.

Nat Med. 1997 Nov;3(11):1209-15.

PMID:
9359694
44.
47.

Re-epithelialization of normal human excisional wounds is associated with a switch from alpha v beta 5 to alpha v beta 6 integrins.

Clark RA, Ashcroft GS, Spencer MJ, Larjava H, Ferguson MW.

Br J Dermatol. 1996 Jul;135(1):46-51.

PMID:
8776358
48.

The effects of ageing on cutaneous wound healing in mammals.

Ashcroft GS, Horan MA, Ferguson MW.

J Anat. 1995 Aug;187 ( Pt 1):1-26. Review.

49.

Factors important in determining trainee anaesthetists' quality of life.

Masterson GR, Ashcroft GS, Shah R.

Anaesthesia. 1994 Nov;49(11):991-5.

50.

Interleukin-6 and wound healing.

Ashcroft GS, Masterson GR.

Br J Anaesth. 1994 Sep;73(3):426. No abstract available.

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