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Items: 1 to 50 of 311

1.

Pneumococcal Carriage, Serotype Distribution, and Risk Factors in Children With Community-Acquired Pneumonia, 5 Years After Introduction of the 10-Valent Pneumococcal Conjugate Vaccine in Ethiopia.

Negash AA, Asrat D, Abebe W, Hailemariam T, Gebre M, Verhaegen J, Aseffa A, Vaneechoutte M.

Open Forum Infect Dis. 2019 May 31;6(6):ofz259. doi: 10.1093/ofid/ofz259. eCollection 2019 Jun.

2.

CYP2J27 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients.

Ahmed JH, Makonnen E, Yimer G, Seifu D, Bekele A, Assefa M, Aseffa A, Howe R, Fotoohi A, Hassan M, Aklillu E.

Front Pharmacol. 2019 May 14;10:481. doi: 10.3389/fphar.2019.00481. eCollection 2019.

3.

Evaluation of the tuberculosis culture color plate test for rapid detection of drug susceptible and drug-resistant Mycobacterium tuberculosis in a resource-limited setting, Addis Ababa, Ethiopia.

Mekonnen B, Mihret A, Getahun M, Hailu T, Sidiki S, V Kelley H, Scordo JM, Hunt WG, Pan X, Balada-Llasat JM, Gebreyes W, Evans CA, Aseffa A, Torrelles JB, Wang SH, Abebe T.

PLoS One. 2019 May 28;14(5):e0215679. doi: 10.1371/journal.pone.0215679. eCollection 2019.

4.

Serotype and molecular diversity of nasopharyngeal Streptococcus pneumoniae isolates from children before and after vaccination with the ten-valent pneumococcal conjugate vaccine (PCV10) in Ethiopia.

Sime WT, Aseffa A, Woldeamanuel Y, Brovall S, Morfeldt E, Henriques-Normark B.

BMC Infect Dis. 2019 May 10;19(1):409. doi: 10.1186/s12879-019-4024-1.

5.

Epidemiology of tuberculous lymphadenitis in Africa: A systematic review and meta-analysis.

Mekonnen D, Derbie A, Abeje A, Shumet A, Nibret E, Biadglegne F, Munshae A, Bobosha K, Wassie L, Berg S, Aseffa A.

PLoS One. 2019 Apr 19;14(4):e0215647. doi: 10.1371/journal.pone.0215647. eCollection 2019.

6.

Risk factors for tuberculosis: A case-control study in Addis Ababa, Ethiopia.

Shimeles E, Enquselassie F, Aseffa A, Tilahun M, Mekonen A, Wondimagegn G, Hailu T.

PLoS One. 2019 Apr 2;14(4):e0214235. doi: 10.1371/journal.pone.0214235. eCollection 2019.

7.

Serological evidence for a decline in malaria transmission following major scale-up of control efforts in a setting selected for Plasmodium vivax and Plasmodium falciparum malaria elimination in Babile district, Oromia, Ethiopia.

Keffale M, Shumie G, Behaksra SW, Chali W, Hoogen LLVD, Hailemeskel E, Mekonnen D, Chanyalew M, Damte D, Fanta T, Ashine T, Chali S, Tetteh KKA, Birhanu DD, Balcha TT, Aseffa A, Drakeley C, Tessema TS, Adamu H, Bousema T, Gadisa E, Tadesse FG.

Trans R Soc Trop Med Hyg. 2019 Jun 1;113(6):305-311. doi: 10.1093/trstmh/trz005.

8.

Homing defects of B cells in HIV-1 infected children impair vaccination responses.

Bekele Y, Lemma M, Bobosha K, Yibeltal D, Nasi A, Gebre M, Nilsson A, Aseffa A, Howe R, Chiodi F.

Vaccine. 2019 Apr 17;37(17):2348-2355. doi: 10.1016/j.vaccine.2019.03.027. Epub 2019 Mar 23.

9.

Molecular studies of meningococcal and pneumococcal meningitis patients in Ethiopia.

Mihret W, Sletbakk Brusletto B, Øvstebø R, Siebke Troseid AM, Norheim G, Merid Y, Kassu A, Abebe W, Ayele S, Silamsaw Asres M, Yamuah L, Aseffa A, Petros B, Caugant DA, Brandtzaeg P.

Innate Immun. 2019 Apr;25(3):158-167. doi: 10.1177/1753425918806363.

PMID:
30894090
10.

Vitamin D Deficiency is Associated with Increased Use of Antimicrobials among Preschool Girls in Ethiopia.

Bodin J, Mihret A, Holm-Hansen C, Dembinski JL, Trieu MC, Tessema B, Tarekegne A, Yimer SA, Cox R, Aseffa A, Haneberg B, Mjaaland S.

Nutrients. 2019 Mar 7;11(3). pii: E575. doi: 10.3390/nu11030575.

11.

Bacteremic Community-Acquired Pneumonia in Ethiopian Children: Etiology, Antibiotic Resistance, Risk Factors, and Clinical Outcome.

Negash AA, Asrat D, Abebe W, Hailemariam T, Hailu T, Aseffa A, Vaneechoutte M.

Open Forum Infect Dis. 2019 Jan 23;6(3):ofz029. doi: 10.1093/ofid/ofz029. eCollection 2019 Mar.

12.

Ample glycosylation in membrane and cell envelope proteins may explain the phenotypic diversity and virulence in the Mycobacterium tuberculosis complex.

Birhanu AG, Yimer SA, Kalayou S, Riaz T, Zegeye ED, Holm-Hansen C, Norheim G, Aseffa A, Abebe M, Tønjum T.

Sci Rep. 2019 Feb 27;9(1):2927. doi: 10.1038/s41598-019-39654-9.

13.

Risk factors for acquisition of meningococcal carriage in the African meningitis belt.

Cooper LV, Robson A, Trotter CL, Aseffa A, Collard JM, Daugla DM, Diallo A, Hodgson A, Jusot JF, Omotara B, Sow S, Hassan-King M, Manigart O, Nascimento M, Woukeu A, Chandramohan D, Borrow R, Maiden MCJ, Greenwood B, Stuart JM; MenAfriCar Consortium.

Trop Med Int Health. 2019 Apr;24(4):392-400. doi: 10.1111/tmi.13203. Epub 2019 Feb 6.

14.

Vitamin D Status and Association of VDR Genetic Polymorphism to Risk of Breast Cancer in Ethiopia.

Ahmed JH, Makonnen E, Fotoohi A, Yimer G, Seifu D, Assefa M, Tigeneh W, Aseffa A, Howe R, Aklillu E.

Nutrients. 2019 Jan 29;11(2). pii: E289. doi: 10.3390/nu11020289.

15.

Genomic analysis of Plasmodium vivax in southern Ethiopia reveals selective pressures in multiple parasite mechanisms.

Auburn S, Getachew S, Pearson RD, Amato R, Miotto O, Trimarsanto H, Zhu SJ, Rumaseb A, Marfurt J, Noviyanti R, Grigg MJ, Barber B, William T, Goncalves SM, Drury E, Sriprawat K, Anstey NM, Nosten F, Petros B, Aseffa A, McVean G, Kwiatkowski DP, Price RN.

J Infect Dis. 2019 Jan 21. doi: 10.1093/infdis/jiz016. [Epub ahead of print]

PMID:
30668735
16.

Daily Nutritional Supplementation with Vitamin D₃ and Phenylbutyrate to Treatment-Naïve HIV Patients Tested in a Randomized Placebo-Controlled Trial.

Ashenafi S, Amogne W, Kassa E, Gebreselassie N, Bekele A, Aseffa G, Getachew M, Aseffa A, Worku A, Hammar U, Bergman P, Aderaye G, Andersson J, Brighenti S.

Nutrients. 2019 Jan 10;11(1). pii: E133. doi: 10.3390/nu11010133.

17.

The effects of prednisolone treatment on serological responses and lipid profiles in Ethiopian leprosy patients with Erythema Nodosum Leprosum reactions.

Negera E, Tilahun M, Bobosha K, Lambert SM, Walker SL, Spencer JS, Aseffa A, Dockrell HM, Lockwood DN.

PLoS Negl Trop Dis. 2018 Dec 28;12(12):e0007035. doi: 10.1371/journal.pntd.0007035. eCollection 2018 Dec.

18.

Line-probe assay and molecular typing reveal a potential drug resistant clone of Mycobacterium tuberculosis in Ethiopia.

Bekele S, Derese Y, Hailu E, Mihret A, Dagne K, Yamuah L, Hailu T, Ayele S, Beyene D, Berg S, Aseffa A.

Trop Dis Travel Med Vaccines. 2018 Dec 4;4:15. doi: 10.1186/s40794-018-0075-3. eCollection 2018.

19.

The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.

Park SE, Pham DT, Boinett C, Wong VK, Pak GD, Panzner U, Espinoza LMC, von Kalckreuth V, Im J, Schütt-Gerowitt H, Crump JA, Breiman RF, Adu-Sarkodie Y, Owusu-Dabo E, Rakotozandrindrainy R, Soura AB, Aseffa A, Gasmelseed N, Keddy KH, May J, Sow AG, Aaby P, Biggs HM, Hertz JT, Montgomery JM, Cosmas L, Olack B, Fields B, Sarpong N, Razafindrabe TJL, Raminosoa TM, Kabore LP, Sampo E, Teferi M, Yeshitela B, El Tayeb MA, Sooka A, Meyer CG, Krumkamp R, Dekker DM, Jaeger A, Poppert S, Tall A, Niang A, Bjerregaard-Andersen M, Løfberg SV, Seo HJ, Jeon HJ, Deerin JF, Park J, Konings F, Ali M, Clemens JD, Hughes P, Sendagala JN, Vudriko T, Downing R, Ikumapayi UN, Mackenzie GA, Obaro S, Argimon S, Aanensen DM, Page A, Keane JA, Duchene S, Dyson Z, Holt KE, Dougan G, Marks F, Baker S.

Nat Commun. 2018 Nov 30;9(1):5094. doi: 10.1038/s41467-018-07370-z.

20.

A study of clinical, hematological, and biochemical profiles of patients with dengue viral infections in Northwest Ethiopia: implications for patient management.

Ferede G, Tiruneh M, Abate E, Wondimeneh Y, Gadisa E, Howe R, Aseffa A, Tessema B.

BMC Infect Dis. 2018 Dec 4;18(1):616. doi: 10.1186/s12879-018-3557-z.

21.

Narrative review of methods and findings of recent studies on the carriage of meningococci and other Neisseria species in the African Meningitis Belt.

Greenwood BM, Aseffa A, Caugant DA, Diallo K, Kristiansen PA, Maiden MCJ, Stuart JM, Trotter CL.

Trop Med Int Health. 2019 Feb;24(2):143-154. doi: 10.1111/tmi.13185. Epub 2018 Dec 6. Review.

22.

Prevalence of pulmonary tuberculosis among students in three eastern Ethiopian universities.

Mekonnen A, Collins JM, Aseffa A, Ameni G, Petros B.

Int J Tuberc Lung Dis. 2018 Oct 1;22(10):1210-1215. doi: 10.5588/ijtld.18.0029.

PMID:
30236190
23.

Molecular epidemiology and drug resistance patterns of Mycobacterium tuberculosis complex isolates from university students and the local community in Eastern Ethiopia.

Mekonnen A, Merker M, Collins JM, Addise D, Aseffa A, Petros B, Ameni G, Niemann S.

PLoS One. 2018 Sep 17;13(9):e0198054. doi: 10.1371/journal.pone.0198054. eCollection 2018.

24.

Evaluation of Auramine O staining and conventional PCR for leprosy diagnosis: A comparative cross-sectional study from Ethiopia.

Girma S, Avanzi C, Bobosha K, Desta K, Idriss MH, Busso P, Tsegaye Y, Nigusse S, Hailu T, Cole ST, Aseffa A.

PLoS Negl Trop Dis. 2018 Sep 4;12(9):e0006706. doi: 10.1371/journal.pntd.0006706. eCollection 2018 Sep.

25.

Views and perceptions about locally manufactured medicines in Ethiopia: a qualitative study of physicians, patients and regulatory authorities.

Alemayehu C, Mitchell G, Nikles J, Aseffa A, Clavarino A.

BMC Health Serv Res. 2018 Aug 8;18(1):624. doi: 10.1186/s12913-018-3410-5.

26.

Low and heterogeneous prevalence of glucose-6-phosphate dehydrogenase deficiency in different settings in Ethiopia using phenotyping and genotyping approaches.

Shitaye G, Gadisa E, Grignard L, Shumie G, Chali W, Menberu T, Belachew M, Tegegn G, Challi S, Curry J, Mahey L, Hailu T, Mamo H, Menon M, Balcha T, Aseffa A, Drakeley C, Bousema T, Tadesse FG.

Malar J. 2018 Aug 2;17(1):281. doi: 10.1186/s12936-018-2437-8.

27.

Associations of gender and serum total cholesterol with CD4+ T cell count and HIV RNA load in antiretroviral-naïve individuals in Addis Ababa.

Adal M, Howe R, Kassa D, Aseffa A, Petros B.

BMC Public Health. 2018 Jul 31;18(1):943. doi: 10.1186/s12889-018-5852-4.

28.

Mentoring in Global Health: Formative Evaluation of Tuberculosis Research Training Programs in Ethiopia and Georgia.

Comeau DL, Mishkin K, Tukvadze N, Avaliani Z, Kempker RR, Sthreshley L, Magee MJ, Eisen H, Mariam DH, Aseffa A, Blumberg HM.

Am J Trop Med Hyg. 2018 Sep;99(3):565-577. doi: 10.4269/ajtmh.17-0746. Epub 2018 Jul 12.

PMID:
30014815
29.

In vitro analysis of antigen induced T cell-monocyte conjugates by imaging flow cytometry.

Habtamu M, Abebe M, Aseffa A, Dyrhol-Riise AM, Spurkland A, Abrahamsen G.

J Immunol Methods. 2018 Sep;460:93-100. doi: 10.1016/j.jim.2018.06.014. Epub 2018 Jul 4.

PMID:
29981305
30.

Vitamin D₃ Status and the Association with Human Cathelicidin Expression in Patients with Different Clinical Forms of Active Tuberculosis.

Ashenafi S, Mazurek J, Rehn A, Lemma B, Aderaye G, Bekele A, Assefa G, Chanyalew M, Aseffa A, Andersson J, Bergman P, Brighenti S.

Nutrients. 2018 Jun 4;10(6). pii: E721. doi: 10.3390/nu10060721.

31.

A serologic study of dengue in northwest Ethiopia: Suggesting preventive and control measures.

Ferede G, Tiruneh M, Abate E, Wondimeneh Y, Damtie D, Gadisa E, Howe R, Aseffa A, Tessema B.

PLoS Negl Trop Dis. 2018 May 31;12(5):e0006430. doi: 10.1371/journal.pntd.0006430. eCollection 2018 May.

32.

Serological investigation of visceral Leishmania infection in human and its associated risk factors in Welkait District, Western Tigray, Ethiopia.

Bsrat A, Berhe M, Gadissa E, Taddele H, Tekle Y, Hagos Y, Abera A, G/Micael M, Alemayhu T, Gugsa G, Aseffa A.

Parasite Epidemiol Control. 2017 Nov 4;3(1):13-20. doi: 10.1016/j.parepi.2017.10.004. eCollection 2018 Feb.

33.

Determining the Best Immunization Strategy for Protecting African Children Against Invasive Salmonella Disease.

Jeon HJ, Pak GD, Im J, Owusu-Dabo E, Adu-Sarkodie Y, Gassama Sow A, Bassiahi Soura A, Gasmelseed N, Keddy KH, Bjerregaard-Andersen M, Konings F, Aseffa A, Crump JA, Chon Y, Breiman RF, Park SE, Cruz Espinoza LM, Seo HJ, May J, Meyer CG, Andrews JR, Panzner U, von Kalckreuth V, Wierzba TF, Rakotozandrindrainy R, Dougan G, Levine MM, Hombach J, Kim JH, Clemens JD, Baker S, Marks F.

Clin Infect Dis. 2018 Nov 28;67(12):1824-1830. doi: 10.1093/cid/ciy386.

34.

Correction to: Polymorphisms in chloroquine resistance-associated genes in Plasmodium vivax in Ethiopia.

Golassa L, Erko B, Baliraine FN, Aseffa A, Swedberg G.

Malar J. 2018 May 2;17(1):188. doi: 10.1186/s12936-018-2338-x.

35.

Daily adjunctive therapy with vitamin D3 and phenylbutyrate supports clinical recovery from pulmonary tuberculosis: a randomized controlled trial in Ethiopia.

Bekele A, Gebreselassie N, Ashenafi S, Kassa E, Aseffa G, Amogne W, Getachew M, Aseffa A, Worku A, Raqib R, Agerberth B, Hammar U, Bergman P, Aderaye G, Andersson J, Brighenti S.

J Intern Med. 2018 Sep;284(3):292-306. doi: 10.1111/joim.12767. Epub 2018 May 23.

PMID:
29696707
36.

Malnutrition and lipid abnormalities in antiretroviral naïve HIV-infected adults in Addis Ababa: A cross-sectional study.

Adal M, Howe R, Kassa D, Aseffa A, Petros B.

PLoS One. 2018 Apr 19;13(4):e0195942. doi: 10.1371/journal.pone.0195942. eCollection 2018.

37.

High utility of active tuberculosis case finding in an Ethiopian prison.

Merid Y, Woldeamanuel Y, Abebe M, Datiko DG, Hailu T, Habtamu G, Assefa G, Kempker RR, Blumberg HM, Aseffa A.

Int J Tuberc Lung Dis. 2018 May 1;22(5):524-529. doi: 10.5588/ijtld.17.0635.

38.

Taking forward the Stop TB Partnership and World Health Organization Joint Theme for World TB Day March 24th 2018 - "Wanted: Leaders for a TB-Free World. You can make history. End TB".

Tiberi S, Petersen E, Maeurer M, Ntoumi F, Yeboa-Manu D, Mwaba P, Vilaplana C, Dar O, Bates M, Corrah T, Rao M, Kapata N, Azhar EI, Memish ZA, Mfinanga S, Aseffa A, Ippolito G, Migliori GB, Zumla A.

Int J Infect Dis. 2018 Mar;68:122-124. doi: 10.1016/j.ijid.2018.03.002. Epub 2018 Mar 22. No abstract available.

39.

Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development.

Zimara N, Chanyalew M, Aseffa A, van Zandbergen G, Lepenies B, Schmid M, Weiss R, Rascle A, Wege AK, Jantsch J, Schatz V, Brown GD, Ritter U.

Front Immunol. 2018 Feb 26;9:263. doi: 10.3389/fimmu.2018.00263. eCollection 2018.

40.

Complement C1q expression in Erythema nodosum leprosum.

Negera E, Walker SL, Lema T, Aseffa A, Lockwood DN, Dockrell HM.

PLoS Negl Trop Dis. 2018 Mar 2;12(3):e0006321. doi: 10.1371/journal.pntd.0006321. eCollection 2018 Mar.

41.

The Effects of Prednisolone Treatment on Cytokine Expression in Patients with Erythema Nodosum Leprosum Reactions.

Negera E, Walker SL, Bobosha K, Bekele Y, Endale B, Tarekegn A, Abebe M, Aseffa A, Dockrell HM, Lockwood DN.

Front Immunol. 2018 Feb 9;9:189. doi: 10.3389/fimmu.2018.00189. eCollection 2018.

42.

Molecular epidemiology and drug sensitivity pattern of Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients in and around Ambo Town, Central Ethiopia.

Tilahun M, Ameni G, Desta K, Zewude A, Yamuah L, Abebe M, Aseffa A.

PLoS One. 2018 Feb 15;13(2):e0193083. doi: 10.1371/journal.pone.0193083. eCollection 2018.

43.

Molecular epidemiology of fluoroquinolone resistant Salmonella in Africa: A systematic review and meta-analysis.

Tadesse G, Tessema TS, Beyene G, Aseffa A.

PLoS One. 2018 Feb 12;13(2):e0192575. doi: 10.1371/journal.pone.0192575. eCollection 2018. Review.

44.

Cost-effectiveness of WHO-Recommended Algorithms for TB Case Finding at Ethiopian HIV Clinics.

Adelman MW, McFarland DA, Tsegaye M, Aseffa A, Kempker RR, Blumberg HM.

Open Forum Infect Dis. 2017 Dec 23;5(1):ofx269. doi: 10.1093/ofid/ofx269. eCollection 2018 Jan.

45.

Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae.

Benjak A, Avanzi C, Singh P, Loiseau C, Girma S, Busso P, Fontes ANB, Miyamoto Y, Namisato M, Bobosha K, Salgado CG, da Silva MB, Bouth RC, Frade MAC, Filho FB, Barreto JG, Nery JAC, Bührer-Sékula S, Lupien A, Al-Samie AR, Al-Qubati Y, Alkubati AS, Bretzel G, Vera-Cabrera L, Sakho F, Johnson CR, Kodio M, Fomba A, Sow SO, Gado M, Konaté O, Stefani MMA, Penna GO, Suffys PN, Sarno EN, Moraes MO, Rosa PS, Baptista IMFD, Spencer JS, Aseffa A, Matsuoka M, Kai M, Cole ST.

Nat Commun. 2018 Jan 24;9(1):352. doi: 10.1038/s41467-017-02576-z.

46.

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa.

Taylor WR, Naw HK, Maitland K, Williams TN, Kapulu M, D'Alessandro U, Berkley JA, Bejon P, Okebe J, Achan J, Amambua AN, Affara M, Nwakanma D, van Geertruyden JP, Mavoko M, Lutumba P, Matangila J, Brasseur P, Piola P, Randremanana R, Lasry E, Fanello C, Onyamboko M, Schramm B, Yah Z, Jones J, Fairhurst RM, Diakite M, Malenga G, Molyneux M, Rwagacondo C, Obonyo C, Gadisa E, Aseffa A, Loolpapit M, Henry MC, Dorsey G, John C, Sirima SB, Barnes KI, Kremsner P, Day NP, White NJ, Mukaka M.

BMC Med. 2018 Jan 18;16(1):11. doi: 10.1186/s12916-017-0990-6.

47.

Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle.

Villarreal-Ramos B, Berg S, Whelan A, Holbert S, Carreras F, Salguero FJ, Khatri BL, Malone K, Rue-Albrecht K, Shaughnessy R, Smyth A, Ameni G, Aseffa A, Sarradin P, Winter N, Vordermeier M, Gordon SV.

Sci Rep. 2018 Jan 17;8(1):894. doi: 10.1038/s41598-017-18575-5.

48.

A phase I, open-label trial on the safety and immunogenicity of the adjuvanted tuberculosis subunit vaccine H1/IC31® in people living in a TB-endemic area.

Hussein J, Zewdie M, Yamuah L, Bedru A, Abebe M, Dagnew AF, Chanyalew M, Yohannes AG, Ahmed J, Engers H, Doherty TM, Bang P, Kromann I, Hoff ST, Aseffa A.

Trials. 2018 Jan 10;19(1):24. doi: 10.1186/s13063-017-2354-0.

49.

The Relative Contribution of Symptomatic and Asymptomatic Plasmodium vivax and Plasmodium falciparum Infections to the Infectious Reservoir in a Low-Endemic Setting in Ethiopia.

Tadesse FG, Slater HC, Chali W, Teelen K, Lanke K, Belachew M, Menberu T, Shumie G, Shitaye G, Okell LC, Graumans W, van Gemert GJ, Kedir S, Tesfaye A, Belachew F, Abebe W, Mamo H, Sauerwein R, Balcha T, Aseffa A, Yewhalaw D, Gadisa E, Drakeley C, Bousema T.

Clin Infect Dis. 2018 Jun 1;66(12):1883-1891. doi: 10.1093/cid/cix1123.

50.

Glucose-6-Phosphate Dehydrogenase Deficiency Genetic Variants in Malaria Patients in Southwestern Ethiopia.

Carter TE, Mekonnen SK, Lopez K, Bonnell V, Damodaran L, Aseffa A, Janies DA.

Am J Trop Med Hyg. 2018 Jan;98(1):83-87. doi: 10.4269/ajtmh.17-0557. Epub 2018 Jan 1.

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