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Items: 16


Local and Systemic Immunity against Respiratory Syncytial Virus Induced by a Novel Intranasal Vaccine. A Randomized, Double-Blind, Placebo-controlled Clinical Trial.

Ascough S, Vlachantoni I, Kalyan M, Haijema BJ, Wallin-Weber S, Dijkstra-Tiekstra M, Ahmed MS, van Roosmalen M, Grimaldi R, Zhang Q, Leenhouts K, Openshaw PJ, Chiu C.

Am J Respir Crit Care Med. 2019 Aug 15;200(4):481-492. doi: 10.1164/rccm.201810-1921OC.


Induction and Subversion of Human Protective Immunity: Contrasting Influenza and Respiratory Syncytial Virus.

Ascough S, Paterson S, Chiu C.

Front Immunol. 2018 Mar 2;9:323. doi: 10.3389/fimmu.2018.00323. eCollection 2018. Review.


Host genetics determine susceptibility to avian influenza infection and transmission dynamics.

Ruiz-Hernandez R, Mwangi W, Peroval M, Sadeyen JR, Ascough S, Balkissoon D, Staines K, Boyd A, McCauley J, Smith A, Butter C.

Sci Rep. 2016 Jun 9;6:26787. doi: 10.1038/srep26787.


CD4+ T Cells Targeting Dominant and Cryptic Epitopes from Bacillus anthracis Lethal Factor.

Ascough S, Ingram RJ, Chu KK, Musson JA, Moore SJ, Gallagher T, Baillie L, Williamson ED, Robinson JH, Maillere B, Boyton RJ, Altmann DM.

Front Microbiol. 2016 Jan 5;6:1506. doi: 10.3389/fmicb.2015.01506. eCollection 2015.


Natural cutaneous anthrax infection, but not vaccination, induces a CD4(+) T cell response involving diverse cytokines.

Ingram RJ, Ascough S, Reynolds CJ, Metan G, Doganay M, Baillie L, Williamson DE, Robinson JH, Maillere B, Boyton RJ, Altmann DM.

Cell Biosci. 2015 Apr 26;5:20. doi: 10.1186/s13578-015-0011-4. eCollection 2015.


Anthrax in injecting drug users: the need for increased vigilance in the clinic.

Ascough S, Altmann DM.

Expert Rev Anti Infect Ther. 2015 Jun;13(6):681-4. doi: 10.1586/14787210.2015.1032255. Epub 2015 Apr 1.


Anthrax lethal factor as an immune target in humans and transgenic mice and the impact of HLA polymorphism on CD4+ T cell immunity.

Ascough S, Ingram RJ, Chu KK, Reynolds CJ, Musson JA, Doganay M, Metan G, Ozkul Y, Baillie L, Sriskandan S, Moore SJ, Gallagher TB, Dyson H, Williamson ED, Robinson JH, Maillere B, Boyton RJ, Altmann DM.

PLoS Pathog. 2014 May 1;10(5):e1004085. doi: 10.1371/journal.ppat.1004085. eCollection 2014 May.


Injectional anthrax infection due to heroin use induces strong immunological memory.

Ascough S, Ingram RJ, Abarra A, Holmes AJ, Maillere B, Altmann DM, Boyton RJ.

J Infect. 2014 Feb;68(2):200-3. No abstract available.


Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response.

Lowther DE, Chong DL, Ascough S, Ettorre A, Ingram RJ, Boyton RJ, Altmann DM.

Acta Neuropathol. 2013 Oct;126(4):501-15. doi: 10.1007/s00401-013-1159-9. Epub 2013 Aug 10.


Exposure to anthrax toxin alters human leucocyte expression of anthrax toxin receptor 1.

Ingram RJ, Harris A, Ascough S, Metan G, Doganay M, Ballie L, Williamson ED, Dyson H, Robinson JH, Sriskandan S, Altmann DM.

Clin Exp Immunol. 2013 Jul;173(1):84-91. doi: 10.1111/cei.12090.


Anthrax lethal toxin and the induction of CD4 T cell immunity.

Ascough S, Ingram RJ, Altmann DM.

Toxins (Basel). 2012 Oct;4(10):878-99. doi: 10.3390/toxins4100878. Epub 2012 Oct 19. Review.


Comment on "Frequency of epitope-specific naive CD4+ T cells correlates with immunodominance in the human memory repertoire".

Ascough S, Ingram RJ, Metan G, Maillere B, Doganay M, Ozkul Y, Kim LU, Ballie L, Moore S, Huwar TB, Sriskandan S, Altmann DM.

J Immunol. 2012 Jun 1;188(11):5205-6; author reply 5206. doi: 10.4049/jimmunol.1290018. No abstract available.


Repertoire of HLA-DR1-restricted CD4 T-cell responses to capsular Caf1 antigen of Yersinia pestis in human leukocyte antigen transgenic mice.

Musson JA, Ingram R, Durand G, Ascough S, Waters EL, Hartley MG, Robson T, Maillere B, Williamson ED, Sriskandan S, Altmann D, Robinson JH.

Infect Immun. 2010 Oct;78(10):4356-62. doi: 10.1128/IAI.00195-10. Epub 2010 Jul 26.


An epitope of Bacillus anthracis protective antigen that is cryptic in rabbits may be immunodominant in humans.

Ingram RJ, Chu KK, Metan G, Maillere B, Doganay M, Ozkul Y, Dyson H, Williamson ED, Baillie L, Kim LU, Ascough S, Sriskandan S, Altmann DM.

Infect Immun. 2010 May;78(5):2353; author reply 2353-4. doi: 10.1128/IAI.00072-10. No abstract available.


Natural exposure to cutaneous anthrax gives long-lasting T cell immunity encompassing infection-specific epitopes.

Ingram RJ, Metan G, Maillere B, Doganay M, Ozkul Y, Kim LU, Baillie L, Dyson H, Williamson ED, Chu KK, Ascough S, Moore S, Huwar TB, Robinson JH, Sriskandan S, Altmann DM.

J Immunol. 2010 Apr 1;184(7):3814-21. doi: 10.4049/jimmunol.0901581. Epub 2010 Mar 5.


HLA-DQB1*0602 determines disease susceptibility in a new "humanized" multiple sclerosis model in HLA-DR15 (DRB1*1501;DQB1*0602) transgenic mice.

Kaushansky N, Altmann DM, Ascough S, David CS, Lassmann H, Ben-Nun A.

J Immunol. 2009 Sep 1;183(5):3531-41. doi: 10.4049/jimmunol.0900784. Epub 2009 Jul 31.

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