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Items: 41

1.

Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis.

Barrows NJ, Anglero-Rodriguez Y, Kim B, Jamison SF, Le Sommer C, McGee CE, Pearson JL, Dimopoulos G, Ascano M, Bradrick SS, Garcia-Blanco MA.

Sci Rep. 2019 Jul 4;9(1):9711. doi: 10.1038/s41598-019-45910-9.

2.

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy.

Shae D, Becker KW, Christov P, Yun DS, Lytton-Jean AKR, Sevimli S, Ascano M, Kelley M, Johnson DB, Balko JM, Wilson JT.

Nat Nanotechnol. 2019 Mar;14(3):269-278. doi: 10.1038/s41565-018-0342-5. Epub 2019 Jan 21.

3.

G3BP1 enhances cytoplasmic DNA pattern recognition.

Wiser C, Kim B, Ascano M.

Nat Immunol. 2019 Jan;20(1):5-7. doi: 10.1038/s41590-018-0279-8. No abstract available.

PMID:
30538338
4.

Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin.

Mok-Lin E, Ascano M Jr, Serganov A, Rosenwaks Z, Tuschl T, Williams Z.

Sci Rep. 2018 Jan 12;8(1):588. doi: 10.1038/s41598-017-18598-y.

5.

Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.

Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M.

Nat Commun. 2017 Nov 23;8(1):1827. doi: 10.1038/s41467-017-01770-3.

6.

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.

Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M.

Nat Commun. 2017 Sep 29;8(1):750. doi: 10.1038/s41467-017-00833-9. Erratum in: Nat Commun. 2017 Nov 23;8(1):1827.

7.

Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.

Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A.

Sci Signal. 2016 Jun 7;9(431):ra58. doi: 10.1126/scisignal.aaf6060.

8.

RCAN1 links impaired neurotrophin trafficking to aberrant development of the sympathetic nervous system in Down syndrome.

Patel A, Yamashita N, Ascaño M, Bodmer D, Boehm E, Bodkin-Clarke C, Ryu YK, Kuruvilla R.

Nat Commun. 2015 Dec 14;6:10119. doi: 10.1038/ncomms10119.

9.

Enhancer of Rudimentary Homolog Affects the Replication Stress Response through Regulation of RNA Processing.

Kavanaugh G, Zhao R, Guo Y, Mohni KN, Glick G, Lacy ME, Hutson MS, Ascano M, Cortez D.

Mol Cell Biol. 2015 Sep 1;35(17):2979-90. doi: 10.1128/MCB.01276-14. Epub 2015 Jun 22.

10.

Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease.

Gerstberger S, Hafner M, Ascano M, Tuschl T.

Adv Exp Med Biol. 2014;825:1-55. doi: 10.1007/978-1-4939-1221-6_1. Review.

11.

Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.

Gao P, Zillinger T, Wang W, Ascano M, Dai P, Hartmann G, Tuschl T, Deng L, Barchet W, Patel DJ.

Cell Rep. 2014 Sep 25;8(6):1668-1676. doi: 10.1016/j.celrep.2014.08.010. Epub 2014 Sep 4.

12.

PAR-CLIP (Photoactivatable Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation): a step-by-step protocol to the transcriptome-wide identification of binding sites of RNA-binding proteins.

Spitzer J, Hafner M, Landthaler M, Ascano M, Farazi T, Wardle G, Nusbaum J, Khorshid M, Burger L, Zavolan M, Tuschl T.

Methods Enzymol. 2014;539:113-61. doi: 10.1016/B978-0-12-420120-0.00008-6.

13.

A novel computational biostatistics approach implies impaired dephosphorylation of growth factor receptors as associated with severity of autism.

Wittkowski KM, Sonakya V, Bigio B, Tonn MK, Shic F, Ascano M, Nasca C, Gold-Von Simson G.

Transl Psychiatry. 2014 Jan 28;4:e354. doi: 10.1038/tp.2013.124.

14.

Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA.

Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov AA, Gaffney BL, Shuman S, Jones RA, Deng L, Hartmann G, Barchet W, Tuschl T, Patel DJ.

Cell. 2013 Aug 15;154(4):748-62. doi: 10.1016/j.cell.2013.07.023. Epub 2013 Aug 1.

15.

Eukaryote-specific insertion elements control human ARGONAUTE slicer activity.

Nakanishi K, Ascano M, Gogakos T, Ishibe-Murakami S, Serganov AA, Briskin D, Morozov P, Tuschl T, Patel DJ.

Cell Rep. 2013 Jun 27;3(6):1893-900. doi: 10.1016/j.celrep.2013.06.010.

16.

Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

Gao P, Ascano M, Wu Y, Barchet W, Gaffney BL, Zillinger T, Serganov AA, Liu Y, Jones RA, Hartmann G, Tuschl T, Patel DJ.

Cell. 2013 May 23;153(5):1094-107. doi: 10.1016/j.cell.2013.04.046. Epub 2013 May 3.

17.

BDNF regulates Rab11-mediated recycling endosome dynamics to induce dendritic branching.

Lazo OM, Gonzalez A, Ascaño M, Kuruvilla R, Couve A, Bronfman FC.

J Neurosci. 2013 Apr 3;33(14):6112-22. doi: 10.1523/JNEUROSCI.4630-12.2013.

18.

Multi-disciplinary methods to define RNA-protein interactions and regulatory networks.

Ascano M, Gerstberger S, Tuschl T.

Curr Opin Genet Dev. 2013 Feb;23(1):20-8. doi: 10.1016/j.gde.2013.01.003. Epub 2013 Feb 28. Review.

19.

FMRP targets distinct mRNA sequence elements to regulate protein expression.

Ascano M Jr, Mukherjee N, Bandaru P, Miller JB, Nusbaum JD, Corcoran DL, Langlois C, Munschauer M, Dewell S, Hafner M, Williams Z, Ohler U, Tuschl T.

Nature. 2012 Dec 20;492(7429):382-6. doi: 10.1038/nature11737. Epub 2012 Dec 12.

20.

Endocytic trafficking of neurotrophins in neural development.

Ascano M, Bodmer D, Kuruvilla R.

Trends Cell Biol. 2012 May;22(5):266-73. doi: 10.1016/j.tcb.2012.02.005. Epub 2012 Mar 21. Review.

21.

Identification of RNA-protein interaction networks using PAR-CLIP.

Ascano M, Hafner M, Cekan P, Gerstberger S, Tuschl T.

Wiley Interdiscip Rev RNA. 2012 Mar-Apr;3(2):159-77. doi: 10.1002/wrna.1103. Epub 2011 Dec 27. Review.

22.

New insights in the mechanism of microRNA-mediated target repression.

Hafner M, Ascano M Jr, Tuschl T.

Nat Struct Mol Biol. 2011 Nov 4;18(11):1181-2. doi: 10.1038/nsmb.2170. No abstract available.

23.

Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability.

Mukherjee N, Corcoran DL, Nusbaum JD, Reid DW, Georgiev S, Hafner M, Ascano M Jr, Tuschl T, Ohler U, Keene JD.

Mol Cell. 2011 Aug 5;43(3):327-39. doi: 10.1016/j.molcel.2011.06.007. Epub 2011 Jun 30.

24.

Isoform-specific dephosphorylation of dynamin1 by calcineurin couples neurotrophin receptor endocytosis to axonal growth.

Bodmer D, Ascaño M, Kuruvilla R.

Neuron. 2011 Jun 23;70(6):1085-99. doi: 10.1016/j.neuron.2011.04.025.

25.

Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex.

Tian Y, Simanshu DK, Ascano M, Diaz-Avalos R, Park AY, Juranek SA, Rice WJ, Yin Q, Robinson CV, Tuschl T, Patel DJ.

Nat Struct Mol Biol. 2011 Jun;18(6):658-64. doi: 10.1038/nsmb.2069. Epub 2011 May 8.

26.

PAR-CliP--a method to identify transcriptome-wide the binding sites of RNA binding proteins.

Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T.

J Vis Exp. 2010 Jul 2;(41). pii: 2034. doi: 10.3791/2034.

27.

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.

Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M Jr, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T.

Cell. 2010 Apr 2;141(1):129-41. doi: 10.1016/j.cell.2010.03.009.

28.

The full-length unprocessed hedgehog protein is an active signaling molecule.

Tokhunts R, Singh S, Chu T, D'Angelo G, Baubet V, Goetz JA, Huang Z, Yuan Z, Ascano M, Zavros Y, Thérond PP, Kunes S, Dahmane N, Robbins DJ.

J Biol Chem. 2010 Jan 22;285(4):2562-8. doi: 10.1074/jbc.M109.078626. Epub 2009 Nov 17.

29.

Axonal targeting of Trk receptors via transcytosis regulates sensitivity to neurotrophin responses.

Ascaño M, Richmond A, Borden P, Kuruvilla R.

J Neurosci. 2009 Sep 16;29(37):11674-85. doi: 10.1523/JNEUROSCI.1542-09.2009.

30.

A quantification of pathway components supports a novel model of Hedgehog signal transduction.

Farzan SF, Stegman MA, Ogden SK, Ascano M Jr, Black KE, Tacchelly O, Robbins DJ.

J Biol Chem. 2009 Oct 16;284(42):28874-84. doi: 10.1074/jbc.M109.041608. Epub 2009 Aug 28.

31.

Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway.

Farzan SF, Ascano M Jr, Ogden SK, Sanial M, Brigui A, Plessis A, Robbins DJ.

Curr Biol. 2008 Aug 26;18(16):1215-20. doi: 10.1016/j.cub.2008.07.026. Epub 2008 Aug 7.

32.

Arrestin residues involved in the functional binding of arrestin to phosphorylated, photolyzed rhodopsin.

Ascano MT, Smith WC, Gregurick SK, Robinson PR.

Mol Vis. 2006 Dec 5;12:1516-25.

33.
34.

Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms.

Ogden SK, Casso DJ, Ascano M Jr, Yore MM, Kornberg TB, Robbins DJ.

J Biol Chem. 2006 Mar 17;281(11):7237-43. Epub 2006 Jan 19.

35.
36.

Regulation of Hedgehog signaling: a complex story.

Ogden SK, Ascano M Jr, Stegman MA, Robbins DJ.

Biochem Pharmacol. 2004 Mar 1;67(5):805-14. Review.

37.
38.

The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner.

Stegman MA, Goetz JA, Ascano M Jr, Ogden SK, Nybakken KE, Robbins DJ.

J Biol Chem. 2004 Feb 20;279(8):7064-71. Epub 2003 Nov 28.

39.

Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2.

Ogden SK, Ascano M Jr, Stegman MA, Suber LM, Hooper JE, Robbins DJ.

Curr Biol. 2003 Nov 11;13(22):1998-2003.

40.

The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling.

Ascano M Jr, Nybakken KE, Sosinski J, Stegman MA, Robbins DJ.

Mol Cell Biol. 2002 Mar;22(5):1555-66.

41.

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