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Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.

György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, Holt JR, Corey DP.

Nat Med. 2019 Jul;25(7):1123-1130. doi: 10.1038/s41591-019-0500-9. Epub 2019 Jul 3.


A phase II study of the combination of docetaxel and bevacizumab for previously treated non-small cell lung cancer.

Shimizu T, Nakagawa Y, Asai Y, Tsujino I, Takahashi N, Gon Y.

J Int Med Res. 2019 Jun 10:300060519852202. doi: 10.1177/0300060519852202. [Epub ahead of print]


Genetic and environmental susceptibility to food allergy in a registry of twins.

Kivistö JE, Clarke A, Dery A, De Schryver S, Shand G, Huhtala H, Mäkelä MJ, Asai Y, Nadeau K, Harada L, Chan ES, Ben-Shoshan M.

J Allergy Clin Immunol Pract. 2019 May 24. pii: S2213-2198(19)30471-4. doi: 10.1016/j.jaip.2019.05.016. [Epub ahead of print] No abstract available.


Quantifying the seasonal drivers of transmission for Lassa fever in Nigeria.

Akhmetzhanov AR, Asai Y, Nishiura H.

Philos Trans R Soc Lond B Biol Sci. 2019 Jun 24;374(1775):20180268. doi: 10.1098/rstb.2018.0268.


Patients With Refractory Out-of-Cardiac Arrest and Sustained Ventricular Fibrillation as Candidates for Extracorporeal Cardiopulmonary Resuscitation - Prospective Multi-Center Observational Study.

Nakashima T, Noguchi T, Tahara Y, Nishimura K, Ogata S, Yasuda S, Onozuka D, Morimura N, Nagao K, Gaieski DF, Asai Y, Yokota H, Nara S, Hase M, Atsumi T, Sakamoto T; SAVE-J Group.

Circ J. 2019 Apr 25;83(5):1011-1018. doi: 10.1253/circj.CJ-18-1257. Epub 2019 Mar 20.


Quantifying heterogeneous contact patterns in Japan: a social contact survey.

Munasinghe L, Asai Y, Nishiura H.

Theor Biol Med Model. 2019 Mar 20;16(1):6. doi: 10.1186/s12976-019-0102-8.


Filaggrin gene loss-of-function mutations constitute a factor in patients with multiple contact allergies.

Elhaji Y, Sasseville D, Pratt M, Asai Y, Matheson K, McLean WHI, Hull PR.

Contact Dermatitis. 2019 Jun;80(6):354-358. doi: 10.1111/cod.13268. Epub 2019 Apr 10.


Integrative and theoretical research on the architecture of a biological system and its disorder.

Uchida S, Asai Y, Kariya Y, Tsumoto K, Hibino H, Honma M, Abe T, Nin F, Kurata Y, Furutani K, Suzuki H, Kitano H, Inoue R, Kurachi Y.

J Physiol Sci. 2019 May;69(3):433-451. doi: 10.1007/s12576-019-00667-8. Epub 2019 Mar 13. Review.


Dynamic Stretching Has Sustained Effects on Range of Motion and Passive Stiffness of the Hamstring Muscles.

Iwata M, Yamamoto A, Matsuo S, Hatano G, Miyazaki M, Fukaya T, Fujiwara M, Asai Y, Suzuki S.

J Sports Sci Med. 2019 Feb 11;18(1):13-20. eCollection 2019 Mar.


Differences in postural stability and dynamic visual acuity among healthy young adults in relation to sports activity: a cross sectional study.

Koide Y, Ueki Y, Asai Y, Morimoto H, Asai H, Johnson EG, Lohman EB, Sakuma E, Mizutani J, Ueki T, Wada I.

J Phys Ther Sci. 2019 Jan;31(1):53-56. doi: 10.1589/jpts.31.53. Epub 2019 Jan 10.


Gate controlling of quantum interference and direct observation of anti-resonances in single molecule charge transport.

Li Y, Buerkle M, Li G, Rostamian A, Wang H, Wang Z, Bowler DR, Miyazaki T, Xiang L, Asai Y, Zhou G, Tao N.

Nat Mater. 2019 Apr;18(4):357-363. doi: 10.1038/s41563-018-0280-5. Epub 2019 Feb 11.


Publisher Correction: Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.

Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR.

Nat Commun. 2019 Feb 8;10(1):734. doi: 10.1038/s41467-019-08716-x.


[A Case of Colon Metastasis from Invasive Lobular Carcinoma of the Breast].

Sazuka T, Kimura M, Ikeda Y, Kamata T, Isozaki T, Urahama R, Tasaki K, Sugamoto Y, Watanabe Y, Asai Y, Fukunaga T, Matsubara H.

Gan To Kagaku Ryoho. 2018 Dec;45(13):2473-2475. Japanese.


[A Case of HER2 Positive Locally Advanced Breast Cancer Successfully Treated with a Combination Therapy of Eribulin, Trastuzumab and Pertuzumab].

Sazuka T, Kimura M, Kamata T, Isozaki T, Urahama R, Tasaki K, Sugamoto Y, Watanabe Y, Asai Y, Fukunaga T, Matsubara H.

Gan To Kagaku Ryoho. 2018 Dec;45(13):2470-2472. Japanese.


[Pulmonary Metastasis Resection Twice after Curative Resection of Esophageal Cancer-A Long-Term Survival Case].

Urahama R, Murakami K, Kamata T, Isozaki T, Sazuka T, Asai Y, Kuboshima M, Tasaki K, Sugamoto Y, Fukunaga T, Kimura M, Matsubara H.

Gan To Kagaku Ryoho. 2018 Dec;45(13):2456-2457. Japanese.


[Long-Term Survival of a Rectal Cancer Patient with Virchow Lymph Node Metastasis, Liver Metastasis, and Para-Aortic Lymph Node Metastasis].

Urahama R, Toyozumi T, Kamata T, Isozaki T, Sazuka T, Asai Y, Kuboshima M, Tasaki K, Sugamoto Y, Fukunaga T, Kimura M, Matsubara H.

Gan To Kagaku Ryoho. 2018 Dec;45(13):1875-1876. Japanese.


[A Case of Gallbladder Jejunal Anastomosis and Duodenal Jejunal Anastomosis to Maintain QOL for an Elderly Patient with Pancreatic Cancer].

Isozaki T, Tasaki K, Kimura M, Fukunaga T, Sugamoto Y, Kuboshima M, Asai Y, Sazuka T, Watanabe Y, Urahama R, Kamata T, Matsubara H.

Gan To Kagaku Ryoho. 2018 Dec;45(13):1818-1820. Japanese.


Objective measures of physical activity in patients with chronic unilateral vestibular hypofunction, and its relationship to handicap, anxiety and postural stability.

Morimoto H, Asai Y, Johnson EG, Koide Y, Niki J, Sakai S, Nakayama M, Kabaya K, Fukui A, Mizutani Y, Mizutani T, Ueki Y, Mizutani J, Ueki T, Wada I.

Auris Nasus Larynx. 2019 Feb;46(1):70-77. doi: 10.1016/j.anl.2018.06.010. Epub 2018 Jun 30.


Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.

Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR.

Nat Commun. 2019 Jan 22;10(1):236. doi: 10.1038/s41467-018-08264-w. Erratum in: Nat Commun. 2019 Feb 8;10(1):734.


Mathematical Analysis of a Transformed ODE from a PDE Multiscale Model of Hepatitis C Virus Infection.

Kitagawa K, Kuniya T, Nakaoka S, Asai Y, Watashi K, Iwami S.

Bull Math Biol. 2019 May;81(5):1427-1441. doi: 10.1007/s11538-018-00564-y. Epub 2019 Jan 14.


Enhancement of postprandial endogenous insulin secretion rather than exogenous insulin injection ameliorated insulin antibody-induced unstable diabetes: a case report.

Kaneko K, Satake C, Izumi T, Tanaka M, Yamamoto J, Asai Y, Sawada S, Imai J, Yamada T, Katagiri H.

BMC Endocr Disord. 2019 Jan 8;19(1):5. doi: 10.1186/s12902-018-0326-3.


Differences in prevalence and associated factors between mild and severe vertebral fractures in Japanese men and women: the third survey of the ROAD study.

Horii C, Asai Y, Iidaka T, Muraki S, Oka H, Tsutsui S, Hashizume H, Yamada H, Yoshida M, Kawaguchi H, Nakamura K, Akune T, Tanaka S, Yoshimura N.

J Bone Miner Metab. 2019 Jan 3. doi: 10.1007/s00774-018-0981-5. [Epub ahead of print]


Successful Treatment of Acute Fulminant Eosinophilic Myocarditis in a Patient with Ulcerative Colitis Using Steroid Therapy and Percutaneous Cardiopulmonary Support.

Tagawa M, Nakamura Y, Okura Y, Nanba H, Kishi K, Akashi E, Ochiai Y, Asai Y, Chinushi M.

Intern Med. 2019 Apr 15;58(8):1111-1118. doi: 10.2169/internalmedicine.1528-18. Epub 2018 Dec 18.


Clinical Impact of Piecemeal Resection Concerning the Lateral Spread of Ampullary Adenomas.

Yamamoto K, Sofuni A, Tsuchiya T, Ishii K, Tsuji S, Tanaka R, Tonozuka R, Honjo M, Mukai S, Fujita M, Asai Y, Matsunami Y, Nagakawa Y, Yamaguchi H, Itoi T.

Intern Med. 2019 Apr 1;58(7):901-906. doi: 10.2169/internalmedicine.1147-18. Epub 2018 Dec 18.


Suvorexant (Belsomra® Tablets 10, 15, and 20 mg): Japanese Drug-Use Results Survey.

Asai Y, Sano H, Miyazaki M, Iwakura M, Maeda Y, Hara M.

Drugs R D. 2019 Mar;19(1):27-46. doi: 10.1007/s40268-018-0256-6.


Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation.

Izumi T, Imai J, Yamamoto J, Kawana Y, Endo A, Sugawara H, Kohata M, Asai Y, Takahashi K, Kodama S, Kaneko K, Gao J, Uno K, Sawada S, Kalinichenko VV, Ishigaki Y, Yamada T, Katagiri H.

Nat Commun. 2018 Dec 13;9(1):5300. doi: 10.1038/s41467-018-07747-0.


EUS-guided antegrade metal stenting with hepaticoenterostomy using a dedicated plastic stent with a review of the literature (with video).

Yamamoto K, Itoi T, Tsuchiya T, Tanaka R, Tonozuka R, Honjo M, Mukai S, Fujita M, Asai Y, Matsunami Y, Kurosawa T, Sofuni A, Nagakawa Y.

Endosc Ultrasound. 2018 Nov-Dec;7(6):404-412. doi: 10.4103/eus.eus_51_18.


Novel peroral direct digital cholangioscopy-assisted lithotripsy using a monorail technique through the overtube in patients with surgically altered anatomy (with video).

Tonozuka R, Itoi T, Sofuni A, Tsuchiya T, Ishii K, Tanaka R, Honjo M, Mukai S, Yamamoto K, Fujita M, Asai Y, Mastunami Y, Kurosawa T, Kojima H, Kogure H, Nagakawa Y.

Dig Endosc. 2019 Mar;31(2):203-208. doi: 10.1111/den.13310. Epub 2019 Jan 18.


[Medicine in New Era with Artificial Intelligence and Systems Biology].

Asai Y, Abe T, Hayano T.

Nihon Hoshasen Gijutsu Gakkai Zasshi. 2018;74(11):1343-1351. doi: 10.6009/jjrt.2018_JSRT_74.11.1343. Japanese. No abstract available.


Occult ovarian clear-cell carcinoma diagnosed as primary adenocarcinoma of the lung: A case report of a diagnostic pitfall for clinicians and pathologists.

Kubo T, Hirohashi Y, Fujita H, Sugita S, Kikuchi Y, Shinkawa T, Nakatsugawa M, Tsujiwaki M, Sudo Y, Asai Y, Umeda Y, Takahashi H, Hasegawa T, Torigoe T.

Respir Med Case Rep. 2018 Oct 18;25:306-308. doi: 10.1016/j.rmcr.2018.10.013. eCollection 2018.


Disparities in diagnosis of advanced melanoma: a population-based cohort study.

Mavor ME, Richardson H, Miao Q, Asai Y, Hanna TP.

CMAJ Open. 2018 Oct 31;6(4):E502-E512. doi: 10.9778/cmajo.20180089. Print 2018 Oct-Dec.


How To Probe the Limits of the Wiedemann-Franz Law at Nanoscale.

Bürkle M, Asai Y.

Nano Lett. 2018 Nov 14;18(11):7358-7361. doi: 10.1021/acs.nanolett.8b03651. Epub 2018 Oct 18.


Low resolution rates of seafood allergy.

Zotova V, Clarke AE, Chan ES, Asai Y, Chin R, Van Lambalgen C, Harada L, Ben-Shoshan M.

J Allergy Clin Immunol Pract. 2019 Feb;7(2):690-692. doi: 10.1016/j.jaip.2018.09.011. Epub 2018 Sep 22. No abstract available.


Expanding the indication of endoscopic papillectomy for T1a ampullary carcinoma.

Yamamoto K, Itoi T, Sofuni A, Tsuchiya T, Tanaka R, Tonozuka R, Honjo M, Mukai S, Fujita M, Asai Y, Matsunami Y, Kurosawa T, Yamaguchi H, Nagakawa Y.

Dig Endosc. 2019 Mar;31(2):188-196. doi: 10.1111/den.13265. Epub 2018 Oct 3.


Psychosocial factors at work and inflammatory markers: protocol for a systematic review and meta-analysis.

Eguchi H, Watanabe K, Kawakami N, Ando E, Arima H, Asai Y, Inoue A, Inoue R, Iwanaga M, Imamura K, Kobayashi Y, Nishida N, Otsuka Y, Sakuraya A, Tsuno K, Shimazu A, Tsutsumi A.

BMJ Open. 2018 Aug 29;8(8):e022612. doi: 10.1136/bmjopen-2018-022612.


Farming habit, light exposure, physical activity, and depressive symptoms. A cross-sectional study of the HEIJO-KYO cohort.

Asai Y, Obayashi K, Oume M, Ogura M, Takeuchi K, Yamagami Y, Tai Y, Kurumatani N, Saeki K.

J Affect Disord. 2018 Dec 1;241:235-240. doi: 10.1016/j.jad.2018.08.003. Epub 2018 Aug 10.


TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells.

Pan B, Akyuz N, Liu XP, Asai Y, Nist-Lund C, Kurima K, Derfler BH, György B, Limapichat W, Walujkar S, Wimalasena LN, Sotomayor M, Corey DP, Holt JR.

Neuron. 2018 Aug 22;99(4):736-753.e6. doi: 10.1016/j.neuron.2018.07.033.


Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1.

Asai Y, Pan B, Nist-Lund C, Galvin A, Lukashkin AN, Lukashkina VA, Chen T, Zhou W, Zhu H, Russell IJ, Holt JR, Géléoc GSG.

Sci Rep. 2018 Aug 14;8(1):12124. doi: 10.1038/s41598-018-28958-x.


Prediction of glandularity and breast radiation dose from mammography results in Japanese women.

Yamamuro M, Asai Y, Yamada K, Ozaki Y, Matsumoto M, Murakami T.

Med Biol Eng Comput. 2019 Jan;57(1):289-298. doi: 10.1007/s11517-018-1882-4. Epub 2018 Aug 11.


Work-related psychosocial factors and metabolic syndrome onset among workers: a systematic review and meta-analysis.

Watanabe K, Sakuraya A, Kawakami N, Imamura K, Ando E, Asai Y, Eguchi H, Kobayashi Y, Nishida N, Arima H, Shimazu A, Tsutsumi A.

Obes Rev. 2018 Nov;19(11):1557-1568. doi: 10.1111/obr.12725. Epub 2018 Jul 25.


Regenerating hair cells in vestibular sensory epithelia from humans.

Taylor RR, Filia A, Paredes U, Asai Y, Holt JR, Lovett M, Forge A.

Elife. 2018 Jul 18;7. pii: e34817. doi: 10.7554/eLife.34817.


Ex vivo assessment of anchoring force of covered biflanged metal stent and covered self-expandable metal stent for interventional endoscopic ultrasound.

Tonozuka R, Yunoki S, Itoi T, Sofuni A, Tsuchiya T, Ishii K, Tanaka R, Honjo M, Mukai S, Fujita M, Yamamoto K, Asai Y, Matsunami Y, Kurosawa T, Kojima H, Nagakawa Y, Nagakawa Y.

J Gastroenterol Hepatol. 2019 Jan;34(1):194-201. doi: 10.1111/jgh.14307. Epub 2018 Jun 28.


A retrospective histological comparison of EUS-guided fine-needle biopsy using a novel franseen needle and a conventional end-cut type needle.

Mukai S, Itoi T, Yamaguchi H, Sofuni A, Tsuchiya T, Tanaka R, Tonozuka R, Honjo M, Fujita M, Yamamoto K, Matsunami Y, Asai Y, Kurosawa T, Nagakawa Y.

Endosc Ultrasound. 2019 Jan-Feb;8(1):50-57. doi: 10.4103/eus.eus_11_18.


Effect of single-walled carbon nanotubes on cytochrome P450 activity in human liver microsomes in vitro.

Asai Y, Sakakibara Y, Inoue R, Inoue R, Nadai M, Katoh M.

Biopharm Drug Dispos. 2018 May;39(5):275-279. doi: 10.1002/bdd.2133.


Brief Report: Increase in Melanoma Incidence in Ontario.

Langley A, Levesque L, Baetz T, Asai Y.

J Cutan Med Surg. 2018 Sep/Oct;22(5):476-478. doi: 10.1177/1203475418773360. Epub 2018 May 1.


Evaluation of a new stent for EUS-guided pancreatic duct drainage: long-term follow-up outcome.

Matsunami Y, Itoi T, Sofuni A, Tsuchiya T, Kamada K, Tanaka R, Tonozuka R, Honjo M, Mukai S, Fujita M, Yamamoto K, Asai Y, Kurosawa T, Tachibana S, Nagakawa Y.

Endosc Int Open. 2018 May;6(5):E505-E512. doi: 10.1055/s-0044-101753. Epub 2018 Apr 18.


Effect of the National Stress Check Program on mental health among workers in Japan: A 1-year retrospective cohort study.

Imamura K, Asai Y, Watanabe K, Tsutsumi A, Shimazu A, Inoue A, Hiro H, Odagiri Y, Yoshikawa T, Yoshikawa E, Kawakami N.

J Occup Health. 2018 Jul 25;60(4):298-306. doi: 10.1539/joh.2017-0314-OA. Epub 2018 Apr 18.


Development of EUS-guided gallbladder drainage and current indications.

Itoi T, Tsuchiya T, Sofuni A, Tanaka R, Tonozuka R, Honjo M, Mukai S, Fujita M, Yamamoto K, Asai Y, Kurosawa T, Tachibana S, Nagakawa Y.

Endosc Ultrasound. 2018 Mar-Apr;7(2):76-78. doi: 10.4103/eus.eus_4_18. No abstract available.


Adverse Events Caused by Aspiration Implemented for Death Rattle in Patients in the Terminal Stage of Cancer: A Retrospective Observational Study.

Watanabe H, Taniguchi A, Yamamoto C, Odagiri T, Asai Y.

J Pain Symptom Manage. 2018 Jul;56(1):e6-e8. doi: 10.1016/j.jpainsymman.2018.04.001. Epub 2018 Apr 11. No abstract available.


A PDE multiscale model of hepatitis C virus infection can be transformed to a system of ODEs.

Kitagawa K, Nakaoka S, Asai Y, Watashi K, Iwami S.

J Theor Biol. 2018 Jul 7;448:80-85. doi: 10.1016/j.jtbi.2018.04.006. Epub 2018 Apr 7.


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