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Items: 1 to 50 of 443

1.

Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.

Toshiyama R, Konno M, Eguchi H, Takemoto H, Noda T, Asai A, Koseki J, Haraguchi N, Ueda Y, Matsushita K, Asukai K, Ohashi T, Iwagami Y, Yamada D, Sakai D, Asaoka T, Kudo T, Kawamoto K, Gotoh K, Kobayashi S, Satoh T, Doki Y, Nishiyama N, Mori M, Ishii H.

Oncogene. 2018 Aug 8. doi: 10.1038/s41388-018-0406-x. [Epub ahead of print]

PMID:
30089817
2.

Cyclic analogue of S-benzylisothiourea that suppresses kynurenine production without inhibiting indoleamine 2,3-dioxygenase activity.

Fukuda M, Sasaki T, Hashimoto T, Miyachi H, Waki M, Asai A, Takikawa O, Ohno O, Matsuno K.

Bioorg Med Chem Lett. 2018 Jul 20. pii: S0960-894X(18)30614-0. doi: 10.1016/j.bmcl.2018.07.034. [Epub ahead of print]

PMID:
30055888
3.

A novel mutation causing type 1 Gaucher disease found in a Japanese patient with gastric cancer: A case report.

Hosoba S, Kito K, Teramoto Y, Adachi K, Nakanishi R, Asai A, Iwasa M, Nishimura R, Moritani S, Kawahara M, Minamiguchi H, Nanba E, Kushima R, Andoh A.

Medicine (Baltimore). 2018 Jul;97(27):e11361. doi: 10.1097/MD.0000000000011361.

4.

Effects of Surgery With Salvage Stereotactic Radiosurgery Versus Surgery With Whole-Brain Radiation Therapy in Patients With One to Four Brain Metastases (JCOG0504): A Phase III, Noninferiority, Randomized Controlled Trial.

Kayama T, Sato S, Sakurada K, Mizusawa J, Nishikawa R, Narita Y, Sumi M, Miyakita Y, Kumabe T, Sonoda Y, Arakawa Y, Miyamoto S, Beppu T, Sugiyama K, Nakamura H, Nagane M, Nakasu Y, Hashimoto N, Terasaki M, Matsumura A, Ishikawa E, Wakabayashi T, Iwadate Y, Ohue S, Kobayashi H, Kinoshita M, Asano K, Mukasa A, Tanaka K, Asai A, Nakamura H, Abe T, Muragaki Y, Iwasaki K, Aoki T, Watanabe T, Sasaki H, Izumoto S, Mizoguchi M, Matsuo T, Takeshima H, Hayashi M, Jokura H, Mizowaki T, Shimizu E, Shirato H, Tago M, Katayama H, Fukuda H, Shibui S; Japan Clinical Oncology Group.

J Clin Oncol. 2018 Jun 20:JCO2018786186. doi: 10.1200/JCO.2018.78.6186. [Epub ahead of print]

PMID:
29924704
5.

Peripheral Nerve Block Provides Effective Analgesia for a Patient With Peripheral Nerve Hyperexcitability Syndrome: Isaacs Syndrome Case Report.

Asai A, Kako E, Hasegawa T, Sobue K.

A A Pract. 2018 Jun 11. doi: 10.1213/XAA.0000000000000804. [Epub ahead of print]

PMID:
29894344
6.

What deserves our respect? Reexamination of respect for autonomy in the context of the management of chronic conditions.

Enzo A, Okita T, Asai A.

Med Health Care Philos. 2018 May 29. doi: 10.1007/s11019-018-9844-z. [Epub ahead of print]

PMID:
29845419
7.

Survival of Mice with Gastrointestinal Acute Radiation Syndrome through Control of Bacterial Translocation.

Suzuki F, Loucas BD, Ito I, Asai A, Suzuki S, Kobayashi M.

J Immunol. 2018 Jul 1;201(1):77-86. doi: 10.4049/jimmunol.1701515. Epub 2018 May 9.

PMID:
29743312
8.

Association of iron metabolic enzyme hepcidin expression levels with the prognosis of patients with pancreatic cancer.

Toshiyama R, Konno M, Eguchi H, Asai A, Noda T, Koseki J, Asukai K, Ohashi T, Matsushita K, Iwagami Y, Yamada D, Asaoka T, Wada H, Kawamoto K, Gotoh K, Kudo T, Satoh T, Doki Y, Mori M, Ishii H.

Oncol Lett. 2018 May;15(5):8125-8133. doi: 10.3892/ol.2018.8357. Epub 2018 Mar 26.

9.

[Indwelling of Full-Length Metallic Ureteral Stents as an Initial Treatment for Patients with Untreated Malignant Ureteral Obstruction].

Tsurusaki T, Asai A, Imasato Y.

Hinyokika Kiyo. 2018 Feb;64(2):35-39. doi: 10.14989/ActaUrolJap_64_2_35. Japanese.

PMID:
29684946
10.

JCOG0911 INTEGRA study: a randomized screening phase II trial of interferonβ plus temozolomide in comparison with temozolomide alone for newly diagnosed glioblastoma.

Wakabayashi T, Natsume A, Mizusawa J, Katayama H, Fukuda H, Sumi M, Nishikawa R, Narita Y, Muragaki Y, Maruyama T, Ito T, Beppu T, Nakamura H, Kayama T, Sato S, Nagane M, Mishima K, Nakasu Y, Kurisu K, Yamasaki F, Sugiyama K, Onishi T, Iwadate Y, Terasaki M, Kobayashi H, Matsumura A, Ishikawa E, Sasaki H, Mukasa A, Matsuo T, Hirano H, Kumabe T, Shinoura N, Hashimoto N, Aoki T, Asai A, Abe T, Yoshino A, Arakawa Y, Asano K, Yoshimoto K, Shibui S; Members of Japan Clinical Oncology Group Brain Tumor Study Group (JCOG-BTSG).

J Neurooncol. 2018 Jul;138(3):627-636. doi: 10.1007/s11060-018-2831-7. Epub 2018 Mar 20.

11.

Delta-like 3 is silenced by HBx via histone acetylation in HBV-associated HCCs.

Hamamoto H, Maemura K, Matsuo K, Taniguchi K, Tanaka Y, Futaki S, Takeshita A, Asai A, Hayashi M, Hirose Y, Kondo Y, Uchiyama K.

Sci Rep. 2018 Mar 19;8(1):4842. doi: 10.1038/s41598-018-23318-1.

12.

[Agreement in the responses to self-reported and proxy-reported versions of QOL-HC: a new quality-of-life scale for patients receiving home-based medical care].

Kamitani H, Umegaki H, Okamoto K, Kanda S, Asai A, Shimojima T, Nomura H, Hattori A, Kimata T, Suzuki Y, Ohshima H, Kuzuya M.

Nihon Ronen Igakkai Zasshi. 2018;55(1):98-105. doi: 10.3143/geriatrics.55.98. Japanese.

13.

Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer.

Nishizawa Y, Konno M, Asai A, Koseki J, Kawamoto K, Miyoshi N, Takahashi H, Nishida N, Haraguchi N, Sakai D, Kudo T, Hata T, Matsuda C, Mizushima T, Satoh T, Doki Y, Mori M, Ishii H.

Oncotarget. 2017 Dec 21;9(7):7476-7486. doi: 10.18632/oncotarget.23554. eCollection 2018 Jan 26.

15.

Visualization and quantification of dynamic STAT3 homodimerization in living cells using homoFluoppi.

Okada Y, Watanabe T, Shoji T, Taguchi K, Ogo N, Asai A.

Sci Rep. 2018 Feb 5;8(1):2385. doi: 10.1038/s41598-018-20234-2.

16.

Efficacy and safety of sunitinib alternate day regimen in patients with metastatic renal cell carcinoma in Japan: Comparison with standard 4/2 schedule.

Ohba K, Miyata Y, Yasuda T, Asai A, Mitsunari K, Matsuo T, Mochizuki Y, Matsunaga N, Sakai H.

Asia Pac J Clin Oncol. 2018 Jun;14(3):153-158. doi: 10.1111/ajco.12849. Epub 2018 Jan 31.

PMID:
29383843
17.

Hypoxia stimulates the cytoplasmic localization of oncogenic long noncoding RNA LINC00152 in colorectal cancer.

Nishizawa Y, Konno M, Asai A, Koseki J, Kawamoto K, Miyoshi N, Takahashi H, Nishida N, Haraguchi N, Sakai D, Kudo T, Hata T, Matsuda C, Mizushima T, Satoh T, Doki Y, Mori M, Ishii H.

Int J Oncol. 2018 Feb;52(2):453-460. doi: 10.3892/ijo.2017.4218. Epub 2017 Dec 7.

PMID:
29345294
18.

The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells.

Taketo K, Konno M, Asai A, Koseki J, Toratani M, Satoh T, Doki Y, Mori M, Ishii H, Ogawa K.

Int J Oncol. 2018 Feb;52(2):621-629. doi: 10.3892/ijo.2017.4219. Epub 2017 Dec 7.

PMID:
29345285
19.

Computational trans-omics approach characterised methylomic and transcriptomic involvements and identified novel therapeutic targets for chemoresistance in gastrointestinal cancer stem cells.

Konno M, Matsui H, Koseki J, Asai A, Kano Y, Kawamoto K, Nishida N, Sakai D, Kudo T, Satoh T, Doki Y, Mori M, Ishii H.

Sci Rep. 2018 Jan 17;8(1):899. doi: 10.1038/s41598-018-19284-3.

20.

Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis.

Koseki J, Konno M, Asai A, Colvin H, Kawamoto K, Nishida N, Sakai D, Kudo T, Satoh T, Doki Y, Mori M, Ishii H.

Sci Rep. 2018 Jan 10;8(1):303. doi: 10.1038/s41598-017-18456-x.

21.

Mitochondrial pyruvate carrier modulates the epithelial-mesenchymal transition in cholangiocarcinoma.

Ohashi T, Eguchi H, Kawamoto K, Konno M, Asai A, Colvin H, Ueda Y, Takaoka H, Iwagami Y, Yamada D, Asaoka T, Noda T, Wada H, Gotoh K, Kobayashi S, Koseki J, Satoh T, Ogawa K, Doki Y, Mori M, Ishii H.

Oncol Rep. 2018 Mar;39(3):1276-1282. doi: 10.3892/or.2017.6172. Epub 2017 Dec 20.

PMID:
29286150
22.

The preventive effect of the impaired liver function for antiemetic therapy against chemotherapy-induced nausea and vomiting in hepatocellular carcinoma patients.

Nishikawa T, Asai A, Okamoto N, Yasuoka H, Nakamura K, Yokohama K, Ohama H, Tsuchimoto Y, Fukunishi S, Tsuda Y, Yamamoto K, Higuchi K.

J Clin Biochem Nutr. 2017 Nov;61(3):222-227. doi: 10.3164/jcbn.17-57. Epub 2017 Oct 19.

23.

Severity and multiplicity of microvascular complications are associated with QT interval prolongation in patients with type 2 diabetes.

Kobayashi S, Nagao M, Asai A, Fukuda I, Oikawa S, Sugihara H.

J Diabetes Investig. 2018 Jul;9(4):946-951. doi: 10.1111/jdi.12772. Epub 2017 Dec 13.

24.

Pathological significance and prognostic significance of FES expression in bladder cancer vary according to tumor grade.

Asai A, Miyata Y, Takehara K, Kanda S, Watanabe SI, Greer PA, Sakai H.

J Cancer Res Clin Oncol. 2018 Jan;144(1):21-31. doi: 10.1007/s00432-017-2524-1. Epub 2017 Sep 26.

25.
26.

M2b macrophage polarization accompanied with reduction of long noncoding RNA GAS5.

Ito I, Asai A, Suzuki S, Kobayashi M, Suzuki F.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):170-175. doi: 10.1016/j.bbrc.2017.09.053. Epub 2017 Sep 13.

PMID:
28917839
27.

Direct inhibition of STAT signaling by platinum drugs contributes to their anti-cancer activity.

Hato SV, Figdor CG, Takahashi S, Pen AE, Halilovic A, Bol KF, Vasaturo A, Inoue Y, de Haas N, Verweij D, Van Herpen CML, Kaanders JH, van Krieken JHJM, Van Laarhoven HWM, Hooijer GKJ, Punt CJA, Asai A, de Vries IJM, Lesterhuis WJ.

Oncotarget. 2017 May 7;8(33):54434-54443. doi: 10.18632/oncotarget.17661. eCollection 2017 Aug 15.

28.

Enlarging pediatric ectopic Rathke's cleft cyst in the prepontine cistern: case report.

Kamei T, Nonaka M, Uemura Y, Yamanouchi Y, Komori Y, Iwata R, Takeda J, Hashiba T, Yoshimura K, Asai A.

J Neurosurg Pediatr. 2017 Nov;20(5):480-484. doi: 10.3171/2017.6.PEDS1727. Epub 2017 Sep 8.

PMID:
28885086
29.

MicroRNA profiles involved in trifluridine resistance.

Tsunekuni K, Konno M, Asai A, Koseki J, Kobunai T, Takechi T, Doki Y, Mori M, Ishii H.

Oncotarget. 2017 May 23;8(32):53017-53027. doi: 10.18632/oncotarget.18078. eCollection 2017 Aug 8.

30.

Factors associated with polypharmacy in elderly home-care patients.

Komiya H, Umegaki H, Asai A, Kanda S, Maeda K, Shimojima T, Nomura H, Kuzuya M.

Geriatr Gerontol Int. 2018 Jan;18(1):33-41. doi: 10.1111/ggi.13132. Epub 2017 Aug 8.

PMID:
28786554
31.

High purity tocotrienols attenuate atherosclerotic lesion formation in apoE-KO mice.

Shibata A, Kobayashi T, Asai A, Eitsuka T, Oikawa S, Miyazawa T, Nakagawa K.

J Nutr Biochem. 2017 Oct;48:44-50. doi: 10.1016/j.jnutbio.2017.06.009. Epub 2017 Jun 24.

PMID:
28759786
32.

New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF-κB transcription factors.

Gabriele E, Brambilla D, Ricci C, Regazzoni L, Taguchi K, Ferri N, Asai A, Sparatore A.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):1012-1028. doi: 10.1080/14756366.2017.1350658.

33.

The anti-tumor activity of the STAT3 inhibitor STX-0119 occurs via promotion of tumor-infiltrating lymphocyte accumulation in temozolomide-resistant glioblastoma cell line.

Akiyama Y, Nonomura C, Ashizawa T, Iizuka A, Kondou R, Miyata H, Sugino T, Mitsuya K, Hayashi N, Nakasu Y, Asai A, Ito M, Kiyohara Y, Yamaguchi K.

Immunol Lett. 2017 Oct;190:20-25. doi: 10.1016/j.imlet.2017.07.005. Epub 2017 Jul 15.

PMID:
28716484
34.

Misuse of emergent healthcare in contemporary Japan.

Kadooka Y, Asai A, Enzo A, Okita T.

BMC Emerg Med. 2017 Jul 14;17(1):23. doi: 10.1186/s12873-017-0135-4.

35.

Short-Term Alcohol Abstinence Improves Antibacterial Defenses of Chronic Alcohol-Consuming Mice against Gut Bacteria-Associated Sepsis Caused by Enterococcus faecalis Oral Infection.

Kobayashi M, Asai A, Ito I, Suzuki S, Higuchi K, Suzuki F.

Am J Pathol. 2017 Sep;187(9):1998-2007. doi: 10.1016/j.ajpath.2017.05.013. Epub 2017 Jul 11.

PMID:
28708971
36.

Micro-RNA-130a-3p Regulates Gemcitabine Resistance via PPARG in Cholangiocarcinoma.

Asukai K, Kawamoto K, Eguchi H, Konno M, Asai A, Iwagami Y, Yamada D, Asaoka T, Noda T, Wada H, Gotoh K, Nishida N, Satoh T, Doki Y, Mori M, Ishii H.

Ann Surg Oncol. 2017 Aug;24(8):2344-2352. doi: 10.1245/s10434-017-5871-x. Epub 2017 May 30.

PMID:
28560603
37.

Levels of glucose-regulatory hormones in patients with non-islet cell tumor hypoglycemia: including a review of the literature.

Fukuda I, Asai A, Nagamine T, Harada T, Tanimura-Inagaki K, Hizuka N, Sugihara H.

Endocr J. 2017 Jul 28;64(7):719-726. doi: 10.1507/endocrj.EJ17-0072. Epub 2017 May 19. Review.

38.

5-ALA fluorescence-guided endoscopic surgery for mixed germ cell tumors.

Takeda J, Nonaka M, Li Y, Komori Y, Kamei T, Iwata R, Hashiba T, Yoshimura K, Asai A.

J Neurooncol. 2017 Aug;134(1):119-124. doi: 10.1007/s11060-017-2494-9. Epub 2017 May 20.

PMID:
28528422
39.

Establishment of a tumor sphere cell line from a metastatic brain neuroendocrine tumor.

Iwata R, Maruyama M, Ito T, Nakano Y, Kanemura Y, Koike T, Oe S, Yoshimura K, Nonaka M, Nomura S, Sugimoto T, Yamada H, Asai A.

Med Mol Morphol. 2017 Dec;50(4):211-219. doi: 10.1007/s00795-017-0160-0. Epub 2017 May 17.

PMID:
28516286
40.

Host antitumor resistance improved by the macrophage polarization in a chimera model of patients with HCC.

Asai A, Tsuchimoto Y, Ohama H, Fukunishi S, Tsuda Y, Kobayashi M, Higuchi K, Suzuki F.

Oncoimmunology. 2017 Mar 3;6(4):e1299301. doi: 10.1080/2162402X.2017.1299301. eCollection 2017.

41.

Stromal expression of Fer suppresses tumor progression in renal cell carcinoma and is a predictor of survival.

Mitsunari K, Miyata Y, Watanabe SI, Asai A, Yasuda T, Kanda S, Sakai H.

Oncol Lett. 2017 Feb;13(2):834-840. doi: 10.3892/ol.2016.5481. Epub 2016 Dec 12.

42.

An in vivo active 1,2,5-oxadiazole Pt(II) complex: A promising anticancer agent endowed with STAT3 inhibitory properties.

Porta F, Facchetti G, Ferri N, Gelain A, Meneghetti F, Villa S, Barlocco D, Masciocchi D, Asai A, Miyoshi N, Marchianò S, Kwon BM, Jin Y, Gandin V, Marzano C, Rimoldi I.

Eur J Med Chem. 2017 May 5;131:196-206. doi: 10.1016/j.ejmech.2017.03.017. Epub 2017 Mar 15.

PMID:
28324784
43.

Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells.

Asai A, Aihara E, Watson C, Mourya R, Mizuochi T, Shivakumar P, Phelan K, Mayhew C, Helmrath M, Takebe T, Wells J, Bezerra JA.

Development. 2017 Mar 15;144(6):1056-1064. doi: 10.1242/dev.142794.

44.

A long-lasting dipeptidyl peptidase-4 inhibitor, teneligliptin, as a preventive drug for the development of hepatic steatosis in high-fructose diet-fed ob/ob mice.

Nakamura K, Fukunishi S, Yokohama K, Ohama H, Tsuchimoto Y, Asai A, Tsuda Y, Higuchi K.

Int J Mol Med. 2017 Apr;39(4):969-983. doi: 10.3892/ijmm.2017.2899. Epub 2017 Feb 20.

PMID:
28260070
45.

The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review).

Konno M, Asai A, Kawamoto K, Nishida N, Satoh T, Doki Y, Mori M, Ishii H.

Int J Oncol. 2017 Apr;50(4):1057-1063. doi: 10.3892/ijo.2017.3885. Epub 2017 Feb 20. Review.

PMID:
28259896
46.

Green Tea Polyphenol Induces Changes in Cancer-Related Factors in an Animal Model of Bladder Cancer.

Matsuo T, Miyata Y, Asai A, Sagara Y, Furusato B, Fukuoka J, Sakai H.

PLoS One. 2017 Jan 31;12(1):e0171091. doi: 10.1371/journal.pone.0171091. eCollection 2017.

47.

Multicomponent Assembly of the Kinesin Spindle Protein Inhibitor CPUYJ039 and Analogues as Antimitotic Agents.

Carbajales C, Sawada JI, Marzaro G, Sotelo E, Escalante L, Sánchez-Díaz Marta A, García-Mera X, Asai A, Coelho A.

ACS Comb Sci. 2017 Mar 13;19(3):153-160. doi: 10.1021/acscombsci.6b00166. Epub 2017 Feb 17.

PMID:
28135059
48.

Inhibition of STAT3 by Anticancer Drug Bendamustine.

Iwamoto K, Uehara Y, Inoue Y, Taguchi K, Muraoka D, Ogo N, Matsuno K, Asai A.

PLoS One. 2017 Jan 26;12(1):e0170709. doi: 10.1371/journal.pone.0170709. eCollection 2017.

49.

Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain.

Gabriele E, Ricci C, Meneghetti F, Ferri N, Asai A, Sparatore A.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):337-344. doi: 10.1080/14756366.2016.1252757.

50.

Alpha-Based Multiplexed Assay for Identifying SH2 Domain Antagonists.

Asai A, Takakuma K.

Methods Mol Biol. 2017;1555:351-356. doi: 10.1007/978-1-4939-6762-9_19.

PMID:
28092042

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