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Items: 1 to 50 of 490

1.

One-Carbon Metabolism for Cancer Diagnostic and Therapeutic Approaches.

Asai A, Konno M, Koseki J, Taniguchi M, Vecchione A, Ishii H.

Cancer Lett. 2019 Nov 21. pii: S0304-3835(19)30578-6. doi: 10.1016/j.canlet.2019.11.023. [Epub ahead of print]

PMID:
31759958
2.

Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation.

Kubota M, Kakimoto K, Nakagawa T, Koubayashi E, Nakazawa K, Tawa H, Hirata Y, Okada T, Kawakami K, Asai A, Hosomi S, Takeuchi T, Fukunishi S, Inoue T, Asahi M, Higuchi K.

PLoS One. 2019 Nov 8;14(11):e0225066. doi: 10.1371/journal.pone.0225066. eCollection 2019.

3.

ICOSLG-mediated regulatory T cell expansion and IL-10 production promote progression of glioblastoma.

Iwata R, Lee JH, Hayashi M, Dianzani U, Ofune K, Maruyama M, Oe S, Ito T, Hashiba T, Yoshimura K, Nonaka M, Nakano Y, Norian L, Nakano I, Asai A.

Neuro Oncol. 2019 Oct 22. pii: noz204. doi: 10.1093/neuonc/noz204. [Epub ahead of print]

PMID:
31634400
4.

CD44/CD133-Positive Colorectal Cancer Stem Cells are Sensitive to Trifluridine Exposure.

Tsunekuni K, Konno M, Haraguchi N, Koseki J, Asai A, Matsuoka K, Kobunai T, Takechi T, Doki Y, Mori M, Ishii H.

Sci Rep. 2019 Oct 16;9(1):14861. doi: 10.1038/s41598-019-50968-6.

5.

The Management of Recurrence within Six Months after Hepatic Resection for Colorectal Liver Metastasis.

Inoue Y, Fujii K, Kagota S, Tomioka A, Yamaguchi T, Ohama H, Hamamoto H, Ishii M, Osumi W, Tsuchimoto Y, Terazawa T, Ogura T, Masubuchi S, Yamamoto M, Imoto A, Asai A, Komeda K, Fukunishi S, Hirokawa F, Goto M, Tanaka K, Okuda J, Higuchi K, Uchiyama K.

Dig Surg. 2019 Oct 9:1-10. doi: 10.1159/000503420. [Epub ahead of print]

PMID:
31597148
6.

Impact of combination therapy with anti-PD-1 blockade and a STAT3 inhibitor on the tumor-infiltrating lymphocyte status.

Ashizawa T, Iizuka A, Maeda C, Tanaka E, Kondou R, Miyata H, Sugino T, Kawata T, Deguchi S, Mitsuya K, Hayashi N, Asai A, Ito M, Yamaguchi K, Akiyama Y.

Immunol Lett. 2019 Dec;216:43-50. doi: 10.1016/j.imlet.2019.10.003. Epub 2019 Oct 3.

7.

Identification of benzo[d]pyrrolo[2,1-b]thiazole derivatives as CENP-E inhibitors.

Yamane M, Sawada JI, Ogo N, Ohba M, Ando T, Asai A.

Biochem Biophys Res Commun. 2019 Nov 12;519(3):505-511. doi: 10.1016/j.bbrc.2019.09.028. Epub 2019 Sep 14.

PMID:
31530389
8.

Selective Inhibition of Spindle Microtubules by a Tubulin-Binding Quinazoline Derivative.

Sawada JI, Ishii H, Matsuno K, Sato M, Suzuki Y, Asai A.

Mol Pharmacol. 2019 Nov;96(5):609-618. doi: 10.1124/mol.119.116624. Epub 2019 Aug 30.

PMID:
31471455
9.

Distinct methylation levels of mature microRNAs in gastrointestinal cancers.

Konno M, Koseki J, Asai A, Yamagata A, Shimamura T, Motooka D, Okuzaki D, Kawamoto K, Mizushima T, Eguchi H, Takiguchi S, Satoh T, Mimori K, Ochiya T, Doki Y, Ofusa K, Mori M, Ishii H.

Nat Commun. 2019 Aug 29;10(1):3888. doi: 10.1038/s41467-019-11826-1.

10.

Structural and Thermodynamic Basis of the Enhanced Interaction between Kinesin Spindle Protein Eg5 and STLC-type Inhibitors.

Yokoyama H, Sawada JI, Sato K, Ogo N, Kamei N, Ishikawa Y, Hara K, Asai A, Hashimoto H.

ACS Omega. 2018 Sep 28;3(9):12284-12294. doi: 10.1021/acsomega.8b00778. eCollection 2018 Sep 30.

11.

Integrated Clinical, Histopathological, and Molecular Data Analysis of 190 Central Nervous System Germ Cell Tumors from the iGCT Consortium.

Takami H, Fukuoka K, Fukushima S, Nakamura T, Mukasa A, Saito N, Yanagisawa T, Nakamura H, Sugiyama K, Kanamori M, Tominaga T, Maehara T, Nakada M, Kanemura Y, Asai A, Takeshima H, Hirose Y, Iuchi T, Nagane M, Yoshimoto K, Matsumura A, Kurozumi K, Nakase H, Sakai K, Tokuyama T, Shibui S, Nakazato Y, Narita Y, Nishikawa R, Matsutani M, Ichimura K.

Neuro Oncol. 2019 Aug 16. pii: noz139. doi: 10.1093/neuonc/noz139. [Epub ahead of print]

PMID:
31420671
12.

Association between dysphagia risk and unplanned hospitalization in older patients receiving home medical care.

Watanabe K, Umegaki H, Huang CH, Arakawa Martins B, Asai A, Kanda S, Nomura H, Kuzuya M.

Geriatr Gerontol Int. 2019 Oct;19(10):977-981. doi: 10.1111/ggi.13753. Epub 2019 Aug 15.

PMID:
31415130
13.

Laparoscopic Repeat Hepatic Resection for the Management of Liver Tumors.

Inoue Y, Fujii K, Ishii M, Kagota S, Tomioka A, Hamamoto H, Osumi W, Tsuchimoto Y, Terasawa T, Ogura T, Masubuchi S, Yamamoto M, Imoto A, Asai A, Komeda K, Fukunishi S, Hirokawa F, Goto M, Tanaka K, Okuda J, Higuchi K, Uchiyama K.

J Gastrointest Surg. 2019 Nov;23(11):2314-2321. doi: 10.1007/s11605-019-04276-z. Epub 2019 Jul 16.

PMID:
31313147
14.

Evaluation of 8-week glecaprevir/pibrentasvir treatment in direct-acting antiviral-naïve noncirrhotic HCV genotype 1 and 2infected patients in a real-world setting in Japan.

Ikeda H, Watanabe T, Atsukawa M, Toyoda H, Takaguchi K, Nakamuta M, Matsumoto N, Okuse C, Tada T, Tsutsui A, Yamashita N, Kondo C, Hayama K, Kato K, Itokawa N, Arai T, Shimada N, Asano T, Uojima H, Ogawa C, Mikami S, Ikegami T, Fukunishi S, Asai A, Iio E, Tsubota A, Hiraoka A, Nozaki A, Okubo H, Tachi Y, Moriya A, Oikawa T, Matsumoto Y, Tsuruoka S, Tani J, Kikuchi K, Iwakiri K, Tanaka Y, Kumada T.

J Viral Hepat. 2019 Nov;26(11):1266-1275. doi: 10.1111/jvh.13170. Epub 2019 Aug 9.

PMID:
31278795
15.

Prospective Assessment of Ultrasound Shear Wave Elastography for Discriminating Biliary Atresia from other Causes of Neonatal Cholestasis.

Dillman JR, DiPaola FW, Smith SJ, Barth RA, Asai A, Lam S, Campbell KM, Bezerra JA, Tiao GM, Trout AT.

J Pediatr. 2019 Sep;212:60-65.e3. doi: 10.1016/j.jpeds.2019.05.048. Epub 2019 Jun 26.

PMID:
31253405
16.

A Hydrogen Peroxide Activatable Gemcitabine Prodrug for the Selective Treatment of Pancreatic Ductal Adenocarcinoma.

Matsushita K, Okuda T, Mori S, Konno M, Eguchi H, Asai A, Koseki J, Iwagami Y, Yamada D, Akita H, Asaoka T, Noda T, Kawamoto K, Gotoh K, Kobayashi S, Kasahara Y, Morihiro K, Satoh T, Doki Y, Mori M, Ishii H, Obika S.

ChemMedChem. 2019 Aug 6;14(15):1384-1391. doi: 10.1002/cmdc.201900324. Epub 2019 Jul 4.

PMID:
31207139
17.

Intratumoural immune cell landscape in germinoma reveals multipotent lineages and exhibits prognostic significance.

Takami H, Fukushima S, Aoki K, Satomi K, Narumi K, Hama N, Matsushita Y, Fukuoka K, Yamasaki K, Nakamura T, Mukasa A, Saito N, Suzuki T, Yanagisawa T, Nakamura H, Sugiyama K, Tamura K, Maehara T, Nakada M, Nonaka M, Asai A, Yokogami K, Takeshima H, Iuchi T, Kanemura Y, Kobayashi K, Nagane M, Kurozumi K, Yoshimoto K, Matsuda M, Matsumura A, Hirose Y, Tokuyama T, Kumabe T, Ueki K, Narita Y, Shibui S, Totoki Y, Shibata T, Nakazato Y, Nishikawa R, Matsutani M, Ichimura K; Intracranial Germ Cell Tumor Genome Analysis Consortium (the iGCT Consortium).

Neuropathol Appl Neurobiol. 2019 Jun 10. doi: 10.1111/nan.12570. [Epub ahead of print]

PMID:
31179566
18.

A Review of Oxidative Stress and Urinary Dysfunction Caused by Bladder Outlet Obstruction and Treatments Using Antioxidants.

Miyata Y, Matsuo T, Mitsunari K, Asai A, Ohba K, Sakai H.

Antioxidants (Basel). 2019 May 15;8(5). pii: E132. doi: 10.3390/antiox8050132. Review.

19.

The Pathological Significance and Prognostic Roles of Thrombospondin-1, and -2, and 4N1K-peptide in Bladder Cancer.

Nakamura Y, Miyata Y, Takehara K, Asai A, Mitsunari K, Araki K, Matsuo T, Ohba K, Sakai H.

Anticancer Res. 2019 May;39(5):2317-2324. doi: 10.21873/anticanres.13348.

PMID:
31092423
20.

Laparoscopic liver resection for patients with cardiac disease.

Inoue Y, Kagota S, Tsuchimoto Y, Ogura T, Asai A, Fukunishi S, Higuchi K, Uchiyama K.

Contemp Oncol (Pozn). 2019;23(1):37-42. doi: 10.5114/wo.2019.84109. Epub 2019 Apr 5.

21.

Discovery of a New STAT3 Inhibitor Acting on the Linker Domain.

Koseki T, Suehiro N, Masuda Y, Miyoshi N, Muraoka D, Ogo N, Asai A.

Biol Pharm Bull. 2019;42(5):792-800. doi: 10.1248/bpb.b18-00992.

22.

Involvement of phosphatidylinositol metabolism in aluminum-induced malate secretion in Arabidopsis.

Wu L, Sadhukhan A, Kobayashi Y, Ogo N, Tokizawa M, Agrahari RK, Ito H, Iuchi S, Kobayashi M, Asai A, Koyama H.

J Exp Bot. 2019 Jun 28;70(12):3329-3342. doi: 10.1093/jxb/erz179.

PMID:
30977815
23.

Metformin Attenuates Early-Stage Atherosclerosis in Mildly Hyperglycemic Oikawa-Nagao Mice.

Asai A, Shuto Y, Nagao M, Kawahara M, Miyazawa T, Sugihara H, Oikawa S.

J Atheroscler Thromb. 2019 Dec 1;26(12):1075-1083. doi: 10.5551/jat.48223. Epub 2019 Apr 11.

24.

Direct Analysis of Incorporation of an Anticancer Drug into DNA at Single-Molecule Resolution.

Ohshiro T, Komoto Y, Konno M, Koseki J, Asai A, Ishii H, Taniguchi M.

Sci Rep. 2019 Mar 7;9(1):3886. doi: 10.1038/s41598-019-40504-x.

25.

Group-level and functional-region analysis of electric-field shape during cerebellar transcranial direct current stimulation with different electrode montages.

Gomez-Tames J, Asai A, Mikkonen M, Laakso I, Tanaka S, Uehara S, Otaka Y, Hirata A.

J Neural Eng. 2019 Jun;16(3):036001. doi: 10.1088/1741-2552/ab0ac5. Epub 2019 Feb 26.

PMID:
30808008
26.

Mitochondrial pyruvate carrier 1 expression controls cancer epithelial-mesenchymal transition and radioresistance.

Takaoka Y, Konno M, Koseki J, Colvin H, Asai A, Tamari K, Satoh T, Mori M, Doki Y, Ogawa K, Ishii H.

Cancer Sci. 2019 Apr;110(4):1331-1339. doi: 10.1111/cas.13980.

27.

Potentially inappropriate medications according to STOPP-J criteria and risks of hospitalization and mortality in elderly patients receiving home-based medical services.

Huang CH, Umegaki H, Watanabe Y, Kamitani H, Asai A, Kanda S, Nomura H, Kuzuya M.

PLoS One. 2019 Feb 8;14(2):e0211947. doi: 10.1371/journal.pone.0211947. eCollection 2019.

28.

[(4)Treatment of Arachnoid Cysts:Endoscopic Fenestration or Cyst-Peritoneal Shunt?]

Nonaka M, Asai A.

No Shinkei Geka. 2019 Jan;47(1):39-48. doi: 10.11477/mf.1436203894. Japanese. No abstract available.

PMID:
30696790
29.

Change in quality of life and potentially associated factors in patients receiving home-based primary care: a prospective cohort study.

Huang CH, Umegaki H, Kamitani H, Asai A, Kanda S, Maeda K, Nomura H, Kuzuya M.

BMC Geriatr. 2019 Jan 24;19(1):21. doi: 10.1186/s12877-019-1040-3.

30.

Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance.

Muraoka D, Seo N, Hayashi T, Tahara Y, Fujii K, Tawara I, Miyahara Y, Okamori K, Yagita H, Imoto S, Yamaguchi R, Komura M, Miyano S, Goto M, Sawada SI, Asai A, Ikeda H, Akiyoshi K, Harada N, Shiku H.

J Clin Invest. 2019 Mar 1;129(3):1278-1294. doi: 10.1172/JCI97642. Epub 2019 Feb 11.

31.

Prevalence and risk factors of constipation and pollakisuria among older home-care patients.

Komiya H, Umegaki H, Asai A, Kanda S, Maeda K, Nomura H, Kuzuya M.

Geriatr Gerontol Int. 2019 Apr;19(4):277-281. doi: 10.1111/ggi.13610. Epub 2019 Jan 9.

PMID:
30628140
32.

[Significance of monitoring cerebrospinal fluid leukocyte counts in managing central nervous system disease of acute myeloid leukemia in patients presenting with intracerebral hemorrhage upon initial examination].

Kawahara M, Teramoto Y, Asai A, Nagai S, Iwasa M, Fujishiro A, Nishimura R, Minamiguchi H, Tsuji A, Kito K, Andoh A.

Rinsho Ketsueki. 2018;59(12):2578-2582. doi: 10.11406/rinketsu.59.2578. Japanese.

PMID:
30626792
33.

Exploring the Biological Activity of a Library of 1,2,5-Oxadiazole Derivatives Endowed With Antiproliferative Activity.

Gelain A, Mori M, Meneghetti F, Porta F, Basile L, Marverti G, Asai A, Hyeraci M, García-Argáez AN, Via LD, Guccione S, Villa S.

Anticancer Res. 2019 Jan;39(1):135-144. doi: 10.21873/anticanres.13089.

PMID:
30591450
34.

Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2.

Asai A, Koseki J, Konno M, Nishimura T, Gotoh N, Satoh T, Doki Y, Mori M, Ishii H.

Heliyon. 2018 Dec 17;4(12):e01021. doi: 10.1016/j.heliyon.2018.e01021. eCollection 2018 Dec.

35.

Dual antiplatelet therapy does not affect the incidence of low-dose aspirin-induced small intestinal mucosal injury in patients after percutaneous coronary intervention for coronary stenosis: a multicenter cross-sectional study.

Hara A, Ota K, Takeuchi T, Kojima Y, Hirata Y, Ozaki H, Kawaguchi S, Takahashi Y, Harada S, Sakanaka T, Ogura T, Nouda S, Kakimoto K, Kawakami K, Asai A, Fukunishi S, Sanomura M, Tominaga K, Higuchi K.

J Clin Biochem Nutr. 2018 Nov;63(3):224-229. doi: 10.3164/jcbn.18-16. Epub 2018 May 25.

36.

Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells.

Tamari K, Konno M, Asai A, Koseki J, Hayashi K, Kawamoto K, Murai N, Matsufuji S, Isohashi F, Satoh T, Goto N, Tanaka S, Doki Y, Mori M, Ogawa K, Ishii H.

Cell Death Discov. 2018 Nov 13;4:104. doi: 10.1038/s41420-018-0117-7. eCollection 2018.

37.

The utility of the subcuticular suture in hepatic resection.

Inoue Y, Fujii K, Ishii M, Kagota S, Hamamoto H, Osumi W, Tsuchimoto Y, Masubuchi S, Yamamoto M, Asai A, Komeda K, Fukunishi S, Hirokawa F, Higuchi K, Uchiyama K.

Contemp Oncol (Pozn). 2018;22(3):184-190. doi: 10.5114/wo.2018.78940. Epub 2018 Sep 30.

38.

Comparison of resection site of standardized laparoscopic hepatic tumor resection.

Inoue Y, Ishii M, Tsuchimoto Y, Masubuchi S, Yamamoto M, Asai A, Fukunishi S, Hirokawa F, Higuchi K, Uchiyama K.

Wideochir Inne Tech Maloinwazyjne. 2018 Sep;13(3):333-341. doi: 10.5114/wiitm.2018.75866. Epub 2018 May 21.

39.

Volumetric and Functional Regeneration of Remnant Liver after Hepatectomy.

Inoue Y, Fujii K, Ishii M, Kagota S, Tomioka A, Hamamoto H, Osumi W, Tsuchimoto Y, Masubuchi S, Yamamoto M, Asai A, Komeda K, Shimizu T, Asakuma M, Fukunishi S, Hirokawa F, Narumi Y, Higuchi K, Uchiyama K.

J Gastrointest Surg. 2019 May;23(5):914-921. doi: 10.1007/s11605-018-3985-5. Epub 2018 Sep 27.

PMID:
30264387
40.

A Convolutional Neural Network Uses Microscopic Images to Differentiate between Mouse and Human Cell Lines and Their Radioresistant Clones.

Toratani M, Konno M, Asai A, Koseki J, Kawamoto K, Tamari K, Li Z, Sakai D, Kudo T, Satoh T, Sato K, Motooka D, Okuzaki D, Doki Y, Mori M, Ogawa K, Ishii H.

Cancer Res. 2018 Dec 1;78(23):6703-6707. doi: 10.1158/0008-5472.CAN-18-0653. Epub 2018 Sep 25.

41.

[The Novel Evaluation Method of Geometric Distortion for 3D-MRI].

Fuju A, Ogura A, Asai A, Sotome H, Hayashi N.

Nihon Hoshasen Gijutsu Gakkai Zasshi. 2018;74(9):869-875. doi: 10.6009/jjrt.2018_JSRT_74.9.869. Japanese.

42.

[Capillary Blood Flow of Muscle Before and After the Exercise Used by Intravoxel Incoherent Motion].

Sotome H, Ogura A, Asai A, Fuju A.

Nihon Hoshasen Gijutsu Gakkai Zasshi. 2018;74(9):861-868. doi: 10.6009/jjrt.2018_JSRT_74.9.861. Japanese.

43.

The Relationship Between Postoperative Chemotherapy and Remnant Liver Regeneration and Outcomes After Hepatectomy for Colorectal Liver Metastasis.

Inoue Y, Fujii K, Ishii M, Kagota S, Hamamoto H, Osumi W, Terasawa T, Tsuchimoto Y, Masubuchi S, Yamamoto M, Asai A, Komeda K, Fukunishi S, Hirokawa F, Goto M, Narumi Y, Higuchi K, Uchiyama K.

J Gastrointest Surg. 2019 Oct;23(10):1973-1983. doi: 10.1007/s11605-018-3952-1. Epub 2018 Sep 5.

PMID:
30187326
44.

[Effect of Slice Thickness for Apparent Diffusion Coefficient Measurement of Mass].

Asai A, Ogura A, Sotome H, Fuju A.

Nihon Hoshasen Gijutsu Gakkai Zasshi. 2018;74(8):805-809. doi: 10.6009/jjrt.2018_JSRT_74.8.805. Japanese.

45.

Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.

Toshiyama R, Konno M, Eguchi H, Takemoto H, Noda T, Asai A, Koseki J, Haraguchi N, Ueda Y, Matsushita K, Asukai K, Ohashi T, Iwagami Y, Yamada D, Sakai D, Asaoka T, Kudo T, Kawamoto K, Gotoh K, Kobayashi S, Satoh T, Doki Y, Nishiyama N, Mori M, Ishii H.

Oncogene. 2019 Jan;38(2):244-260. doi: 10.1038/s41388-018-0406-x. Epub 2018 Aug 8.

PMID:
30089817
46.

Cyclic analogue of S-benzylisothiourea that suppresses kynurenine production without inhibiting indoleamine 2,3-dioxygenase activity.

Fukuda M, Sasaki T, Hashimoto T, Miyachi H, Waki M, Asai A, Takikawa O, Ohno O, Matsuno K.

Bioorg Med Chem Lett. 2018 Sep 15;28(17):2846-2849. doi: 10.1016/j.bmcl.2018.07.034. Epub 2018 Jul 20.

PMID:
30055888
47.

A novel mutation causing type 1 Gaucher disease found in a Japanese patient with gastric cancer: A case report.

Hosoba S, Kito K, Teramoto Y, Adachi K, Nakanishi R, Asai A, Iwasa M, Nishimura R, Moritani S, Kawahara M, Minamiguchi H, Nanba E, Kushima R, Andoh A.

Medicine (Baltimore). 2018 Jul;97(27):e11361. doi: 10.1097/MD.0000000000011361.

48.

Effects of Surgery With Salvage Stereotactic Radiosurgery Versus Surgery With Whole-Brain Radiation Therapy in Patients With One to Four Brain Metastases (JCOG0504): A Phase III, Noninferiority, Randomized Controlled Trial.

Kayama T, Sato S, Sakurada K, Mizusawa J, Nishikawa R, Narita Y, Sumi M, Miyakita Y, Kumabe T, Sonoda Y, Arakawa Y, Miyamoto S, Beppu T, Sugiyama K, Nakamura H, Nagane M, Nakasu Y, Hashimoto N, Terasaki M, Matsumura A, Ishikawa E, Wakabayashi T, Iwadate Y, Ohue S, Kobayashi H, Kinoshita M, Asano K, Mukasa A, Tanaka K, Asai A, Nakamura H, Abe T, Muragaki Y, Iwasaki K, Aoki T, Watanabe T, Sasaki H, Izumoto S, Mizoguchi M, Matsuo T, Takeshima H, Hayashi M, Jokura H, Mizowaki T, Shimizu E, Shirato H, Tago M, Katayama H, Fukuda H, Shibui S; Japan Clinical Oncology Group.

J Clin Oncol. 2018 Jun 20:JCO2018786186. doi: 10.1200/JCO.2018.78.6186. [Epub ahead of print]

PMID:
29924704
49.

Peripheral Nerve Block Provides Effective Analgesia for a Patient With Peripheral Nerve Hyperexcitability Syndrome: Isaacs Syndrome Case Report.

Asai A, Kako E, Hasegawa T, Sobue K.

A A Pract. 2018 Nov 15;11(10):268-269. doi: 10.1213/XAA.0000000000000804.

PMID:
29894344
50.

What deserves our respect? Reexamination of respect for autonomy in the context of the management of chronic conditions.

Enzo A, Okita T, Asai A.

Med Health Care Philos. 2019 Mar;22(1):85-94. doi: 10.1007/s11019-018-9844-z.

PMID:
29845419

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