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Items: 46


Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2.

Wang Q, Corey RA, Hedger G, Aryal P, Grieben M, Nasrallah C, Baronina A, Pike ACW, Shi J, Carpenter EP, Sansom MSP.

Structure. 2019 Nov 27. pii: S0969-2126(19)30389-2. doi: 10.1016/j.str.2019.11.005. [Epub ahead of print]


Antipyretic, Antinociceptive, and Anti-Inflammatory Activities from Pogostemon benghalensis Leaf Extract in Experimental Wister Rats.

Aryal S, Adhikari B, Panthi K, Aryal P, Mallik SK, Bhusal RP, Salehi B, Setzer WN, Sharifi-Rad J, Koirala N.

Medicines (Basel). 2019 Sep 20;6(4). pii: E96. doi: 10.3390/medicines6040096.


Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.

Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB.

Cell Metab. 2018 Feb 6;27(2):419-427.e4. doi: 10.1016/j.cmet.2018.01.001.


Real Time Spectroscopic Ellipsometry Analysis of First Stage CuIn1-xGaxSe₂ Growth: Indium-Gallium Selenide Co-Evaporation.

Pradhan P, Aryal P, Attygalle D, Ibdah AR, Koirala P, Li J, Bhandari KP, Liyanage GK, Ellingson RJ, Heben MJ, Marsillac S, Collins RW, Podraza NJ.

Materials (Basel). 2018 Jan 16;11(1). pii: E145. doi: 10.3390/ma11010145.


Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport.

Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB.

Cell Rep. 2017 Oct 24;21(4):1021-1035. doi: 10.1016/j.celrep.2017.09.091.


The effects of stretch activation on ionic selectivity of the TREK-2 K2P K+ channel.

Nematian-Ardestani E, Jarerattanachat V, Aryal P, Sansom MSP, Tucker SJ.

Channels (Austin). 2017 Sep 3;11(5):482-486. doi: 10.1080/19336950.2017.1356955. Epub 2017 Jul 19.


Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channel.

Lacin E, Aryal P, Glaaser IW, Bodhinathan K, Tsai E, Marsh N, Tucker SJ, Sansom MSP, Slesinger PA.

J Gen Physiol. 2017 Jul 18. pii: jgp.201711801. doi: 10.1085/jgp.201711801. [Epub ahead of print]


Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

Aryal P, Jarerattanachat V, Clausen MV, Schewe M, McClenaghan C, Argent L, Conrad LJ, Dong YY, Pike ACW, Carpenter EP, Baukrowitz T, Sansom MSP, Tucker SJ.

Structure. 2017 May 2;25(5):708-718.e2. doi: 10.1016/j.str.2017.03.006. Epub 2017 Apr 6.


Outpatient template-guided permanent interstitial brachytherapy using 131Cs in gynecologic malignancies: Initial report.

Feddock J, Aryal P, Steber C, Edwards J, Cheek D, Randall M.

Brachytherapy. 2017 Mar - Apr;16(2):393-401. doi: 10.1016/j.brachy.2016.12.008. Epub 2017 Jan 27.


Functional Annotation of Ion Channel Structures by Molecular Simulation.

Trick JL, Chelvaniththilan S, Klesse G, Aryal P, Wallace EJ, Tucker SJ, Sansom MSP.

Structure. 2016 Dec 6;24(12):2207-2216. doi: 10.1016/j.str.2016.10.005. Epub 2016 Nov 17.


Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses.

Lee J, Moraes-Vieira PM, Castoldi A, Aryal P, Yee EU, Vickers C, Parnas O, Donaldson CJ, Saghatelian A, Kahn BB.

J Biol Chem. 2016 Oct 14;291(42):22207-22217. Epub 2016 Aug 29.


A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons.

Kong D, Dagon Y, Campbell JN, Guo Y, Yang Z, Yi X, Aryal P, Wellenstein K, Kahn BB, Sabatini BL, Lowell BB.

Neuron. 2016 Jul 6;91(1):25-33. doi: 10.1016/j.neuron.2016.05.025. Epub 2016 Jun 16.


Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.

McClenaghan C, Schewe M, Aryal P, Carpenter EP, Baukrowitz T, Tucker SJ.

J Gen Physiol. 2016 Jun;147(6):497-505. doi: 10.1085/jgp.201611601.


Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance.

Moraes-Vieira PM, Castoldi A, Aryal P, Wellenstein K, Peroni OD, Kahn BB.

Diabetes. 2016 May;65(5):1317-27. doi: 10.2337/db15-1696. Epub 2016 Mar 2.


Erratum: "Independent dosimetric assessment of the model EP917 episcleral brachytherapy plaque" [Med. Phys. 41, 092102 (11pp.) (2014)].

Aryal P, Molloy JA, Rivard MJ.

Med Phys. 2015 Jun;42(6):3085. doi: 10.1118/1.4919619. No abstract available.


Molecular simulation studies of hydrophobic gating in nanopores and ion channels.

Trick JL, Aryal P, Tucker SJ, Sansom MS.

Biochem Soc Trans. 2015 Apr;43(2):146-50. doi: 10.1042/BST20140256. Review.


K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.

Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP.

Science. 2015 Mar 13;347(6227):1256-9. doi: 10.1126/science.1261512.


Evaluation of antibacterial activity of some traditionally used medicinal plants against human pathogenic bacteria.

Marasini BP, Baral P, Aryal P, Ghimire KR, Neupane S, Dahal N, Singh A, Ghimire L, Shrestha K.

Biomed Res Int. 2015;2015:265425. doi: 10.1155/2015/265425. Epub 2015 Feb 9.


Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel.

Aryal P, Abd-Wahab F, Bucci G, Sansom MS, Tucker SJ.

Channels (Austin). 2015;9(1):44-9. doi: 10.4161/19336950.2014.981987.


Independent dosimetric assessment of the model EP917 episcleral brachytherapy plaque.

Aryal P, Molloy JA, Rivard MJ.

Med Phys. 2014 Sep;41(9):092102. doi: 10.1118/1.4892603. Erratum in: Med Phys. 2015 Jun;42(6):3085.


Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells.

Aryal P, Kim K, Park PH, Ham S, Cho J, Song K.

FEBS J. 2014 Oct;281(20):4644-58. doi: 10.1111/febs.12969. Epub 2014 Sep 11.


Hydrophobic gating in ion channels.

Aryal P, Sansom MS, Tucker SJ.

J Mol Biol. 2015 Jan 16;427(1):121-30. doi: 10.1016/j.jmb.2014.07.030. Epub 2014 Aug 12. Review.


A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel.

Aryal P, Abd-Wahab F, Bucci G, Sansom MS, Tucker SJ.

Nat Commun. 2014 Jul 8;5:4377. doi: 10.1038/ncomms5377.


RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance.

Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P, Kahn BB.

Cell Metab. 2014 Mar 4;19(3):512-26. doi: 10.1016/j.cmet.2014.01.018.


Implementation and early clinical results utilizing Cs-131 permanent interstitial implants for gynecologic malignancies.

Wooten CE, Randall M, Edwards J, Aryal P, Luo W, Feddock J.

Gynecol Oncol. 2014 May;133(2):268-73. doi: 10.1016/j.ygyno.2014.02.015. Epub 2014 Feb 17.


Determination of prescription dose for Cs-131 permanent implants using the BED formalism including resensitization correction.

Luo W, Molloy J, Aryal P, Feddock J, Randall M.

Med Phys. 2014 Feb;41(2):024101. doi: 10.1118/1.4860255.


A modern Monte Carlo investigation of the TG-43 dosimetry parameters for an 125I seed already having AAPM consensus data.

Aryal P, Molloy JA, Rivard MJ.

Med Phys. 2014 Feb;41(2):021702. doi: 10.1118/1.4860135.


Identification of the variants in PARL, the nuclear modifier gene, responsible for the expression of LHON patients in Thailand.

Istikharah R, Tun AW, Kaewsutthi S, Aryal P, Kunhapan B, Katanyoo W, Chuenkongkaew W, Lertrit P.

Exp Eye Res. 2013 Nov;116:55-7. doi: 10.1016/j.exer.2013.08.007. Epub 2013 Aug 22. Review.


Liver retinol transporter and receptor for serum retinol-binding protein (RBP4).

Alapatt P, Guo F, Komanetsky SM, Wang S, Cai J, Sargsyan A, Rodríguez Díaz E, Bacon BT, Aryal P, Graham TE.

J Biol Chem. 2013 Jan 11;288(2):1250-65. doi: 10.1074/jbc.M112.369132. Epub 2012 Oct 26.


SU-E-T-13: Comparison of Dose Rates with and without Gold Backing of USC #9 Radioactive Eye Plaque Using MCNP5.

Aryal P, Molloy J.

Med Phys. 2012 Jun;39(6Part9):3705. doi: 10.1118/1.4735067.


SU-E-T-462: Calculation of Prescribed Dose for Permanent Implant with Cs-131 Using LQ Equation including Resensitization.

Luo W, Aryal P, Randall M.

Med Phys. 2012 Jun;39(6Part17):3811. doi: 10.1118/1.4735551.


Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism.

Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, Usheva A, Davis RJ, Smith U, Kahn BB.

Mol Cell Biol. 2012 May;32(10):2010-9. doi: 10.1128/MCB.06193-11. Epub 2012 Mar 19.


Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.

Almeida MC, Hew-Butler T, Soriano RN, Rao S, Wang W, Wang J, Tamayo N, Oliveira DL, Nucci TB, Aryal P, Garami A, Bautista D, Gavva NR, Romanovsky AA.

J Neurosci. 2012 Feb 8;32(6):2086-99. doi: 10.1523/JNEUROSCI.5606-11.2012.


Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms.

An MC, Lin W, Yang J, Dominguez B, Padgett D, Sugiura Y, Aryal P, Gould TW, Oppenheim RW, Hester ME, Kaspar BK, Ko CP, Lee KF.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10702-7. doi: 10.1073/pnas.1004956107. Epub 2010 May 24.


A discrete alcohol pocket involved in GIRK channel activation.

Aryal P, Dvir H, Choe S, Slesinger PA.

Nat Neurosci. 2009 Aug;12(8):988-95. doi: 10.1038/nn.2358. Epub 2009 Jun 28.


Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6.

Wu ZL, Aryal P, Lozach O, Meijer L, Guengerich FP.

Chem Biodivers. 2005 Jan;2(1):51-65.


Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.

Fowler CE, Aryal P, Suen KF, Slesinger PA.

J Physiol. 2007 Apr 1;580(Pt 1):51-65. Epub 2006 Dec 21.


Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism.

Lin W, Dominguez B, Yang J, Aryal P, Brandon EP, Gage FH, Lee KF.

Neuron. 2005 May 19;46(4):569-79.


Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo.

Martindale JJ, Wall JA, Martinez-Longoria DM, Aryal P, Rockman HA, Guo Y, Bolli R, Glembotski CC.

J Biol Chem. 2005 Jan 7;280(1):669-76. Epub 2004 Oct 18.


Regulation of myosin-VI targeting to endocytic compartments.

Dance AL, Miller M, Seragaki S, Aryal P, White B, Aschenbrenner L, Hasson T.

Traffic. 2004 Oct;5(10):798-813.


Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis.

Guengerich FP, Sorrells JL, Schmitt S, Krauser JA, Aryal P, Meijer L.

J Med Chem. 2004 Jun 3;47(12):3236-41.


Use of heterologously-expressed cytochrome P450 and glutathione transferase enzymes in toxicity assays.

Guengerich FP, Wheeler JB, Chun YJ, Kim D, Shimada T, Aryal P, Oda Y, Gillam EM.

Toxicology. 2002 Dec 27;181-182:261-4.


Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy.

Lucas DT, Aryal P, Szweda LI, Koch WJ, Leinwand LA.

Am J Physiol Heart Circ Physiol. 2003 Feb;284(2):H575-83. Epub 2002 Oct 31.


Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase.

Aryal P, Yoshikawa K, Terashita T, Guengerich FP, Shimada T, Oda Y.

Mutat Res. 1999 Jun 25;442(2):113-20.


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