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Items: 1 to 50 of 143

1.

Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes.

Xu B, Allard C, Alvarez-Mercado AI, Fuselier T, Kim JH, Coons LA, Hewitt SC, Urano F, Korach KS, Levin ER, Arvan P, Floyd ZE, Mauvais-Jarvis F.

Cell Rep. 2018 Jul 3;24(1):181-196. doi: 10.1016/j.celrep.2018.06.019.

2.

Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells.

Taneera J, Prasad RB, Dhaiban S, Mohammed AK, Haataja L, Arvan P, Hamad M, Groop L, Wollheim CB.

Mol Cell Endocrinol. 2018 Sep 5;472:10-17. doi: 10.1016/j.mce.2018.06.003. Epub 2018 Jun 8.

PMID:
29890211
3.

Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress.

Knupp J, Arvan P, Chang A.

Cell Death Differ. 2018 May 23. doi: 10.1038/s41418-018-0133-4. [Epub ahead of print]

PMID:
29795335
4.

Control of insulin granule formation and function by the ABC transporters ABCG1 and ABCA1 and by oxysterol binding protein OSBP.

Hussain SS, Harris MT, Kreutzberger AJB, Inouye CM, Doyle CA, Castle AM, Arvan P, Castle JD.

Mol Biol Cell. 2018 May 15;29(10):1238-1257. doi: 10.1091/mbc.E17-08-0519. Epub 2018 Mar 22.

PMID:
29540530
5.

Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity.

Kim GH, Shi G, Somlo DR, Haataja L, Song S, Long Q, Nillni EA, Low MJ, Arvan P, Myers MG Jr, Qi L.

J Clin Invest. 2018 Mar 1;128(3):1125-1140. doi: 10.1172/JCI96420. Epub 2018 Feb 19.

6.

Relationship between the dimerization of thyroglobulin and its ability to form triiodothyronine.

Citterio CE, Morishita Y, Dakka N, Veluswamy B, Arvan P.

J Biol Chem. 2018 Mar 30;293(13):4860-4869. doi: 10.1074/jbc.RA118.001786. Epub 2018 Feb 12.

PMID:
29440273
7.

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.

Arunagiri A, Haataja L, Cunningham CN, Shrestha N, Tsai B, Qi L, Liu M, Arvan P.

Ann N Y Acad Sci. 2018 Apr;1418(1):5-19. doi: 10.1111/nyas.13531. Epub 2018 Jan 28. Review.

PMID:
29377149
8.

Positive charge in the n-region of the signal peptide contributes to efficient post-translational translocation of small secretory preproteins.

Guo H, Sun J, Li X, Xiong Y, Wang H, Shu H, Zhu R, Liu Q, Huang Y, Madley R, Wang Y, Cui J, Arvan P, Liu M.

J Biol Chem. 2018 Feb 9;293(6):1899-1907. doi: 10.1074/jbc.RA117.000922. Epub 2017 Dec 11.

9.

ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis.

Shi G, Somlo DRM, Kim GH, Prescianotto-Baschong C, Sun S, Beuret N, Long Q, Rutishauser J, Arvan P, Spiess M, Qi L.

J Clin Invest. 2017 Oct 2;127(10):3897-3912. doi: 10.1172/JCI94771. Epub 2017 Sep 18.

10.

Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.

Wasserfall C, Nick HS, Campbell-Thompson M, Beachy D, Haataja L, Kusmartseva I, Posgai A, Beery M, Rhodes C, Bonifacio E, Arvan P, Atkinson M.

Cell Metab. 2017 Sep 5;26(3):568-575.e3. doi: 10.1016/j.cmet.2017.08.013.

PMID:
28877460
11.

De novo triiodothyronine formation from thyrocytes activated by thyroid-stimulating hormone.

Citterio CE, Veluswamy B, Morgan SJ, Galton VA, Banga JP, Atkins S, Morishita Y, Neumann S, Latif R, Gershengorn MC, Smith TJ, Arvan P.

J Biol Chem. 2017 Sep 15;292(37):15434-15444. doi: 10.1074/jbc.M117.784447. Epub 2017 Jul 25.

PMID:
28743746
12.

New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation.

Qi L, Tsai B, Arvan P.

Trends Cell Biol. 2017 Jun;27(6):430-440. doi: 10.1016/j.tcb.2016.12.002. Epub 2017 Feb 9. Review.

13.

Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion.

Cunningham CN, He K, Arunagiri A, Paton AW, Paton JC, Arvan P, Tsai B.

Diabetes. 2017 Mar;66(3):741-753. doi: 10.2337/db16-1338. Epub 2016 Dec 27.

14.

86th Annual Meeting of the American Thyroid Association.

Arvan P, Fish S.

Thyroid. 2016 Sep;26(9):1154-5. doi: 10.1089/thy.2016.29024.ata. Epub 2016 Aug 17. No abstract available.

15.

Thyroglobulin Represents a Novel Molecular Architecture of Vertebrates.

Holzer G, Morishita Y, Fini JB, Lorin T, Gillet B, Hughes S, Tohmé M, Deléage G, Demeneix B, Arvan P, Laudet V.

J Biol Chem. 2016 Aug 5;291(32):16553-66. doi: 10.1074/jbc.M116.719047. Epub 2016 Jun 16.

16.

Erratum to: Autophagy is a major regulator of beta cell insulin homeostasis.

Riahi Y, Wikstrom JD, Bachar-Wikstrom E, Polin N, Zucker H, Lee MS, Quan W, Haataja L, Liu M, Arvan P, Cerasi E, Leibowitz G.

Diabetologia. 2016 Jul;59(7):1575-1576. doi: 10.1007/s00125-016-3986-4. No abstract available.

PMID:
27189065
17.

Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?

Barbetti F, Colombo C, Haataja L, Cras-Méneur C, Bernardini S, Arvan P.

Clin Diabetes Endocrinol. 2016 May 2;2:11. doi: 10.1186/s40842-016-0029-5. eCollection 2016.

18.

Autophagy is a major regulator of beta cell insulin homeostasis.

Riahi Y, Wikstrom JD, Bachar-Wikstrom E, Polin N, Zucker H, Lee MS, Quan W, Haataja L, Liu M, Arvan P, Cerasi E, Leibowitz G.

Diabetologia. 2016 Jul;59(7):1480-1491. doi: 10.1007/s00125-016-3868-9. Epub 2016 Jan 30. Erratum in: Diabetologia. 2016 Jul;59(7):1575-6.

19.

Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum.

Haataja L, Manickam N, Soliman A, Tsai B, Liu M, Arvan P.

Diabetes. 2016 Apr;65(4):1050-60. doi: 10.2337/db15-1345. Epub 2016 Jan 28.

20.

Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure.

Alejandro EU, Bozadjieva N, Kumusoglu D, Abdulhamid S, Levine H, Haataja L, Vadrevu S, Satin LS, Arvan P, Bernal-Mizrachi E.

Cell Rep. 2015 Dec 22;13(11):2527-2538. doi: 10.1016/j.celrep.2015.11.020. Epub 2015 Dec 8.

21.

Monitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo.

Zhu S, Larkin D, Lu S, Inouye C, Haataja L, Anjum A, Kennedy R, Castle D, Arvan P.

Diabetes. 2016 Mar;65(3):699-709. doi: 10.2337/db15-1264. Epub 2015 Dec 8.

22.

Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response.

Gao XH, Krokowski D, Guan BJ, Bederman I, Majumder M, Parisien M, Diatchenko L, Kabil O, Willard B, Banerjee R, Wang B, Bebek G, Evans CR, Fox PL, Gerson SL, Hoppel CL, Liu M, Arvan P, Hatzoglou M.

Elife. 2015 Nov 23;4:e10067. doi: 10.7554/eLife.10067.

23.

Thyroglobulin From Molecular and Cellular Biology to Clinical Endocrinology.

Di Jeso B, Arvan P.

Endocr Rev. 2016 Feb;37(1):2-36. doi: 10.1210/er.2015-1090. Epub 2015 Nov 23. Review.

24.

Competitive Inhibition of the Endoplasmic Reticulum Signal Peptidase by Non-cleavable Mutant Preprotein Cargos.

Cui J, Chen W, Sun J, Guo H, Madley R, Xiong Y, Pan X, Wang H, Tai AW, Weiss MA, Arvan P, Liu M.

J Biol Chem. 2015 Nov 20;290(47):28131-40. doi: 10.1074/jbc.M115.692350. Epub 2015 Oct 7.

25.

Insulin demand regulates β cell number via the unfolded protein response.

Sharma RB, O'Donnell AC, Stamateris RE, Ha B, McCloskey KM, Reynolds PR, Arvan P, Alonso LC.

J Clin Invest. 2015 Oct 1;125(10):3831-46. doi: 10.1172/JCI79264. Epub 2015 Sep 21.

26.

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.

Alarcon C, Boland BB, Uchizono Y, Moore PC, Peterson B, Rajan S, Rhodes OS, Noske AB, Haataja L, Arvan P, Marsh BJ, Austin J, Rhodes CJ.

Diabetes. 2016 Feb;65(2):438-50. doi: 10.2337/db15-0792. Epub 2015 Aug 25.

27.

PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis.

He K, Cunningham CN, Manickam N, Liu M, Arvan P, Tsai B.

Mol Biol Cell. 2015 Oct 1;26(19):3413-23. doi: 10.1091/mbc.E15-01-0034. Epub 2015 Aug 12.

28.

Better care for people with diabetes and endocrine diseases.

Tan MH, Arvan P.

Clin Diabetes Endocrinol. 2015 Jun 4;1:1. doi: 10.1186/s40842-015-0003-7. eCollection 2015. No abstract available.

29.

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro.

Russ HA, Parent AV, Ringler JJ, Hennings TG, Nair GG, Shveygert M, Guo T, Puri S, Haataja L, Cirulli V, Blelloch R, Szot GL, Arvan P, Hebrok M.

EMBO J. 2015 Jul 2;34(13):1759-72. doi: 10.15252/embj.201591058. Epub 2015 Apr 23.

30.

Molecular aspects of pancreatic beta cell failure and diabetes.

Arvan P, Bernal-Mizrachi E, Liu M, Pietropaolo M, Satin L, Schnell S, Soleimanpour SA.

Mol Aspects Med. 2015 Apr;42:1-2. doi: 10.1016/j.mam.2015.01.002. Epub 2015 Jan 14. No abstract available.

PMID:
25596327
31.

Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.

Sun J, Cui J, He Q, Chen Z, Arvan P, Liu M.

Mol Aspects Med. 2015 Apr;42:105-18. doi: 10.1016/j.mam.2015.01.001. Epub 2015 Jan 8. Review.

32.

INS-gene mutations: from genetics and beta cell biology to clinical disease.

Liu M, Sun J, Cui J, Chen W, Guo H, Barbetti F, Arvan P.

Mol Aspects Med. 2015 Apr;42:3-18. doi: 10.1016/j.mam.2014.12.001. Epub 2014 Dec 24. Review.

33.

Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring.

Alejandro EU, Gregg B, Wallen T, Kumusoglu D, Meister D, Chen A, Merrins MJ, Satin LS, Liu M, Arvan P, Bernal-Mizrachi E.

J Clin Invest. 2014 Oct;124(10):4395-410. doi: 10.1172/JCI74237. Epub 2014 Sep 2.

34.

Sox17 regulates insulin secretion in the normal and pathologic mouse β cell.

Jonatan D, Spence JR, Method AM, Kofron M, Sinagoga K, Haataja L, Arvan P, Deutsch GH, Wells JM.

PLoS One. 2014 Aug 21;9(8):e104675. doi: 10.1371/journal.pone.0104675. eCollection 2014.

35.

Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function.

Prabhu Y, Blanco EH, Liu M, Peinado JR, Wheeler MC, Gekakis N, Arvan P, Lindberg I.

Endocrinology. 2014 Jul;155(7):2391-401. doi: 10.1210/en.2013-1985. Epub 2014 May 14.

36.

Inefficient translocation of preproinsulin contributes to pancreatic β cell failure and late-onset diabetes.

Guo H, Xiong Y, Witkowski P, Cui J, Wang LJ, Sun J, Lara-Lemus R, Haataja L, Hutchison K, Shan SO, Arvan P, Liu M.

J Biol Chem. 2014 Jun 6;289(23):16290-302. doi: 10.1074/jbc.M114.562355. Epub 2014 Apr 25.

37.

Transient covalent interactions of newly synthesized thyroglobulin with oxidoreductases of the endoplasmic reticulum.

Di Jeso B, Morishita Y, Treglia AS, Lofrumento DD, Nicolardi G, Beguinot F, Kellogg AP, Arvan P.

J Biol Chem. 2014 Apr 18;289(16):11488-96. doi: 10.1074/jbc.M113.520767. Epub 2014 Mar 5.

38.

Proinsulin entry and transit through the endoplasmic reticulum in pancreatic beta cells.

Liu M, Wright J, Guo H, Xiong Y, Arvan P.

Vitam Horm. 2014;95:35-62. doi: 10.1016/B978-0-12-800174-5.00002-8. Review.

PMID:
24559913
39.

A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth.

Gualeni B, Rajpar MH, Kellogg A, Bell PA, Arvan P, Boot-Handford RP, Briggs MD.

Dis Model Mech. 2013 Nov;6(6):1414-25. doi: 10.1242/dmm.013342. Epub 2013 Sep 12.

40.

Endoplasmic reticulum oxidoreductin-1α (Ero1α) improves folding and secretion of mutant proinsulin and limits mutant proinsulin-induced endoplasmic reticulum stress.

Wright J, Birk J, Haataja L, Liu M, Ramming T, Weiss MA, Appenzeller-Herzog C, Arvan P.

J Biol Chem. 2013 Oct 25;288(43):31010-8. doi: 10.1074/jbc.M113.510065. Epub 2013 Sep 10.

41.

UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum.

Ferris SP, Jaber NS, Molinari M, Arvan P, Kaufman RJ.

Mol Biol Cell. 2013 Sep;24(17):2597-608. doi: 10.1091/mbc.E13-02-0101. Epub 2013 Jul 17.

42.

Neuroendocrinology: regulated secretory cells go to the BAR for a bud.

Arvan P, Castle D.

Nat Rev Endocrinol. 2013 Aug;9(8):443-4. doi: 10.1038/nrendo.2013.121. Epub 2013 Jun 25.

PMID:
23797817
43.

Dominant protein interactions that influence the pathogenesis of conformational diseases.

Wright J, Wang X, Haataja L, Kellogg AP, Lee J, Liu M, Arvan P.

J Clin Invest. 2013 Jul;123(7):3124-34. doi: 10.1172/JCI67260. Epub 2013 Jun 3.

44.

A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux.

Krokowski D, Han J, Saikia M, Majumder M, Yuan CL, Guan BJ, Bevilacqua E, Bussolati O, Bröer S, Arvan P, Tchórzewski M, Snider MD, Puchowicz M, Croniger CM, Kimball SR, Pan T, Koromilas AE, Kaufman RJ, Hatzoglou M.

J Biol Chem. 2013 Jun 14;288(24):17202-13. doi: 10.1074/jbc.M113.466920. Epub 2013 May 3.

45.

Proinsulin intermolecular interactions during secretory trafficking in pancreatic β cells.

Haataja L, Snapp E, Wright J, Liu M, Hardy AB, Wheeler MB, Markwardt ML, Rizzo M, Arvan P.

J Biol Chem. 2013 Jan 18;288(3):1896-906. doi: 10.1074/jbc.M112.420018. Epub 2012 Dec 6.

46.

Islet autoantigens: structure, function, localization, and regulation.

Arvan P, Pietropaolo M, Ostrov D, Rhodes CJ.

Cold Spring Harb Perspect Med. 2012 Aug 1;2(8). pii: a007658. doi: 10.1101/cshperspect.a007658. Review.

47.

Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes.

Liu M, Lara-Lemus R, Shan SO, Wright J, Haataja L, Barbetti F, Guo H, Larkin D, Arvan P.

Diabetes. 2012 Apr;61(4):828-37. doi: 10.2337/db11-0878. Epub 2012 Feb 22.

48.

Action of protein disulfide isomerase on proinsulin exit from endoplasmic reticulum of pancreatic β-cells.

Rajpal G, Schuiki I, Liu M, Volchuk A, Arvan P.

J Biol Chem. 2012 Jan 2;287(1):43-7. doi: 10.1074/jbc.C111.279927. Epub 2011 Nov 21.

49.

Maturation of thyroglobulin protein region I.

Lee J, Di Jeso B, Arvan P.

J Biol Chem. 2011 Sep 23;286(38):33045-52. doi: 10.1074/jbc.M111.281337. Epub 2011 Aug 4.

50.

In vivo misfolding of proinsulin below the threshold of frank diabetes.

Hodish I, Absood A, Liu L, Liu M, Haataja L, Larkin D, Al-Khafaji A, Zaki A, Arvan P.

Diabetes. 2011 Aug;60(8):2092-101. doi: 10.2337/db10-1671. Epub 2011 Jun 15.

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