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Items: 1 to 20 of 158

1.

p.L571P in the linker domain of rat thyroglobulin causes intracellular retention.

Citterio CE, Siffo S, Moya CM, Pio MG, Molina MF, Scheps KG, Rey OA, Arvan P, Rivolta CM, Targovnik HM.

Mol Cell Endocrinol. 2020 Jan 20:110719. doi: 10.1016/j.mce.2020.110719. [Epub ahead of print]

PMID:
31972331
2.

Reticulon protects the integrity of the ER membrane during ER escape of large macromolecular protein complexes.

Chen YJ, Williams JM, Arvan P, Tsai B.

J Cell Biol. 2020 Feb 3;219(2). pii: e201908182. doi: 10.1083/jcb.201908182.

PMID:
31895406
3.

Requirement for translocon-associated protein (TRAP) α in insulin biogenesis.

Li X, Itani OA, Haataja L, Dumas KJ, Yang J, Cha J, Flibotte S, Shih HJ, Delaney CE, Xu J, Qi L, Arvan P, Liu M, Hu PJ.

Sci Adv. 2019 Dec 4;5(12):eaax0292. doi: 10.1126/sciadv.aax0292. eCollection 2019 Dec.

4.

Lessons from animal models of endocrine disorders caused by defects of protein folding in the secretory pathway.

Morishita Y, Arvan P.

Mol Cell Endocrinol. 2020 Jan 1;499:110613. doi: 10.1016/j.mce.2019.110613. Epub 2019 Oct 9.

PMID:
31605742
5.

Abnormalities in proinsulin processing in islets from individuals with longstanding T1D.

Sims EK, Syed F, Nyalwidhe J, Bahnson HT, Haataja L, Speake C, Morris MA, Balamurugan AN, Mirmira RG, Nadler J, Mastracci TL, Arvan P, Greenbaum CJ, Evans-Molina C.

Transl Res. 2019 Nov;213:90-99. doi: 10.1016/j.trsl.2019.08.001. Epub 2019 Aug 9.

PMID:
31442418
6.

PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity.

Jang I, Pottekat A, Poothong J, Yong J, Lagunas-Acosta J, Charbono A, Chen Z, Scheuner DL, Liu M, Itkin-Ansari P, Arvan P, Kaufman RJ.

Elife. 2019 Jun 11;8. pii: e44528. doi: 10.7554/eLife.44528.

7.

Proinsulin misfolding is an early event in the progression to type 2 diabetes.

Arunagiri A, Haataja L, Pottekat A, Pamenan F, Kim S, Zeltser LM, Paton AW, Paton JC, Tsai B, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P.

Elife. 2019 Jun 11;8. pii: e44532. doi: 10.7554/eLife.44532.

8.

Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates.

Cunningham CN, Williams JM, Knupp J, Arunagiri A, Arvan P, Tsai B.

Mol Cell. 2019 Aug 8;75(3):442-456.e4. doi: 10.1016/j.molcel.2019.05.011. Epub 2019 Jun 5.

PMID:
31176671
9.

Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258-264.

Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, Swensen AC, Yip-Schneider M, Schmidt CM, Considine RV, Arvan P, Greenbaum CJ, Evans-Molina C.

Diabetes Care. 2019 May;42(5):e85-e86. doi: 10.2337/dci19-0012. No abstract available.

PMID:
31010952
10.

Preservation of circadian rhythms by the protein folding chaperone, BiP.

Pickard A, Chang J, Alachkar N, Calverley B, Garva R, Arvan P, Meng QJ, Kadler KE.

FASEB J. 2019 Jun;33(6):7479-7489. doi: 10.1096/fj.201802366RR. Epub 2019 Mar 19.

11.

The role of thyroglobulin in thyroid hormonogenesis.

Citterio CE, Targovnik HM, Arvan P.

Nat Rev Endocrinol. 2019 Jun;15(6):323-338. doi: 10.1038/s41574-019-0184-8. Review.

PMID:
30886364
12.

Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease Genes.

Fang Z, Weng C, Li H, Tao R, Mai W, Liu X, Lu L, Lai S, Duan Q, Alvarez C, Arvan P, Wynshaw-Boris A, Li Y, Pei Y, Jin F, Li Y.

Cell Rep. 2019 Mar 12;26(11):3132-3144.e7. doi: 10.1016/j.celrep.2019.02.043.

13.

Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling.

Ghiasi SM, Dahlby T, Hede Andersen C, Haataja L, Petersen S, Omar-Hmeadi M, Yang M, Pihl C, Bresson SE, Khilji MS, Klindt K, Cheta O, Perone MJ, Tyrberg B, Prats C, Barg S, Tengholm A, Arvan P, Mandrup-Poulsen T, Marzec MT.

Diabetes. 2019 Apr;68(4):747-760. doi: 10.2337/db18-0671. Epub 2019 Jan 22.

14.

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes.

Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, Swensen AC, Yip-Schneider M, Schmidt CM, Considine RV, Arvan P, Greenbaum CJ, Evans-Molina C; T1D Exchange Residual C-peptide Study Group.

Diabetes Care. 2019 Feb;42(2):258-264. doi: 10.2337/dc17-2625. Epub 2018 Dec 10.

PMID:
30530850
15.

Biosynthesis, structure, and folding of the insulin precursor protein.

Liu M, Weiss MA, Arunagiri A, Yong J, Rege N, Sun J, Haataja L, Kaufman RJ, Arvan P.

Diabetes Obes Metab. 2018 Sep;20 Suppl 2:28-50. doi: 10.1111/dom.13378. Review.

16.

Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes.

Xu B, Allard C, Alvarez-Mercado AI, Fuselier T, Kim JH, Coons LA, Hewitt SC, Urano F, Korach KS, Levin ER, Arvan P, Floyd ZE, Mauvais-Jarvis F.

Cell Rep. 2018 Jul 3;24(1):181-196. doi: 10.1016/j.celrep.2018.06.019.

17.

Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells.

Taneera J, Prasad RB, Dhaiban S, Mohammed AK, Haataja L, Arvan P, Hamad M, Groop L, Wollheim CB.

Mol Cell Endocrinol. 2018 Sep 5;472:10-17. doi: 10.1016/j.mce.2018.06.003. Epub 2018 Jun 8.

18.

Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress.

Knupp J, Arvan P, Chang A.

Cell Death Differ. 2019 Mar;26(3):487-501. doi: 10.1038/s41418-018-0133-4. Epub 2018 May 23.

PMID:
29795335
19.

Control of insulin granule formation and function by the ABC transporters ABCG1 and ABCA1 and by oxysterol binding protein OSBP.

Hussain SS, Harris MT, Kreutzberger AJB, Inouye CM, Doyle CA, Castle AM, Arvan P, Castle JD.

Mol Biol Cell. 2018 May 15;29(10):1238-1257. doi: 10.1091/mbc.E17-08-0519. Epub 2018 Mar 22.

20.

Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity.

Kim GH, Shi G, Somlo DR, Haataja L, Song S, Long Q, Nillni EA, Low MJ, Arvan P, Myers MG Jr, Qi L.

J Clin Invest. 2018 Mar 1;128(3):1125-1140. doi: 10.1172/JCI96420. Epub 2018 Feb 19.

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