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Items: 1 to 50 of 58

1.

Antioxidative CXXC Peptide Motif From Mesencephalic Astrocyte-Derived Neurotrophic Factor Antagonizes Programmed Cell Death.

Božok V, Yu LY, Palgi J, Arumäe U.

Front Cell Dev Biol. 2018 Sep 4;6:106. doi: 10.3389/fcell.2018.00106. eCollection 2018.

2.

Poststroke delivery of MANF promotes functional recovery in rats.

Mätlik K, Anttila JE, Kuan-Yin T, Smolander OP, Pakarinen E, Lehtonen L, Abo-Ramadan U, Lindholm P, Zheng C, Harvey B, Arumäe U, Lindahl M, Airavaara M.

Sci Adv. 2018 May 23;4(5):eaap8957. doi: 10.1126/sciadv.aap8957. eCollection 2018 May.

3.

Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra.

Mätlik K, Vihinen H, Bienemann A, Palgi J, Voutilainen MH, Booms S, Lindahl M, Jokitalo E, Saarma M, Huttunen HJ, Airavaara M, Arumäe U.

eNeuro. 2017 Feb 20;4(1). pii: ENEURO.0128-16.2017. doi: 10.1523/ENEURO.0128-16.2017. eCollection 2017 Jan-Feb.

4.
5.

p75 Neurotrophin Receptor Signaling Activates Sterol Regulatory Element-binding Protein-2 in Hepatocyte Cells via p38 Mitogen-activated Protein Kinase and Caspase-3.

Pham DD, Do HT, Bruelle C, Kukkonen JP, Eriksson O, Mogollón I, Korhonen LT, Arumäe U, Lindholm D.

J Biol Chem. 2016 May 13;291(20):10747-58. doi: 10.1074/jbc.M116.722272. Epub 2016 Mar 16.

6.

Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity.

Mätlik K, Yu LY, Eesmaa A, Hellman M, Lindholm P, Peränen J, Galli E, Anttila J, Saarma M, Permi P, Airavaara M, Arumäe U.

Cell Death Dis. 2015 Dec 31;6:e2032. doi: 10.1038/cddis.2015.371.

7.

Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease.

Voutilainen MH, Arumäe U, Airavaara M, Saarma M.

FEBS Lett. 2015 Dec 21;589(24 Pt A):3739-48. doi: 10.1016/j.febslet.2015.09.031. Epub 2015 Oct 9. Review.

8.

AAV-mediated targeting of gene expression to the peri-infarct region in rat cortical stroke model.

Mätlik K, Abo-Ramadan U, Harvey BK, Arumäe U, Airavaara M.

J Neurosci Methods. 2014 Oct 30;236:107-13. doi: 10.1016/j.jneumeth.2014.08.014. Epub 2014 Aug 23.

9.

The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment.

Ichim G, Genevois AL, Ménard M, Yu LY, Coelho-Aguiar JM, Llambi F, Jarrosson-Wuilleme L, Lefebvre J, Tulasne D, Dupin E, Le Douarin N, Arumäe U, Tauszig-Delamasure S, Mehlen P.

Mol Cell. 2013 Sep 12;51(5):632-46. doi: 10.1016/j.molcel.2013.08.021.

10.

Characterization of the structural and functional determinants of MANF/CDNF in Drosophila in vivo model.

Lindström R, Lindholm P, Kallijärvi J, Yu LY, Piepponen TP, Arumäe U, Saarma M, Heino TI.

PLoS One. 2013 Sep 3;8(9):e73928. doi: 10.1371/journal.pone.0073928. eCollection 2013.

11.

Multiple mechanisms repress N-Bak mRNA translation in the healthy and apoptotic neurons.

Jakobson M, Jakobson M, Llano O, Palgi J, Arumäe U.

Cell Death Dis. 2013 Aug 22;4:e777. doi: 10.1038/cddis.2013.297.

12.

Glia cell line-derived neurotrophic factor mediates survival of murine sympathetic precursors.

Heermann S, Mätlik K, Hinz U, Fey J, Arumae U, Krieglstein K.

J Neurosci Res. 2013 Jun;91(6):780-5. doi: 10.1002/jnr.23188. Epub 2013 Feb 21.

PMID:
23426908
13.

PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling.

Kysenius K, Muggalla P, Mätlik K, Arumäe U, Huttunen HJ.

Cell Mol Life Sci. 2012 Jun;69(11):1903-16. doi: 10.1007/s00018-012-0977-6. Epub 2012 Apr 6.

PMID:
22481440
14.

The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons.

Shulga A, Magalhães AC, Autio H, Plantman S, di Lieto A, Nykjær A, Carlstedt T, Risling M, Arumäe U, Castrén E, Rivera C.

J Neurosci. 2012 Feb 1;32(5):1757-70. doi: 10.1523/JNEUROSCI.3282-11.2012.

15.
16.

Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus.

Autio H, Mätlik K, Rantamäki T, Lindemann L, Hoener MC, Chao M, Arumäe U, Castrén E.

Neuropharmacology. 2011 Dec;61(8):1291-6. doi: 10.1016/j.neuropharm.2011.07.033. Epub 2011 Jul 30.

17.

Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons.

Hellman M, Arumäe U, Yu LY, Lindholm P, Peränen J, Saarma M, Permi P.

J Biol Chem. 2011 Jan 28;286(4):2675-80. doi: 10.1074/jbc.M110.146738. Epub 2010 Nov 3.

18.

Persephin signaling through GFRalpha1: the potential for the treatment of Parkinson's disease.

Sidorova YA, Mätlik K, Paveliev M, Lindahl M, Piranen E, Milbrandt J, Arumäe U, Saarma M, Bespalov MM.

Mol Cell Neurosci. 2010 Jul;44(3):223-32. doi: 10.1016/j.mcn.2010.03.009. Epub 2010 Mar 27.

PMID:
20350599
19.

Death receptors and caspases but not mitochondria are activated in the GDNF- or BDNF-deprived dopaminergic neurons.

Yu LY, Saarma M, Arumäe U.

J Neurosci. 2008 Jul 23;28(30):7467-75. doi: 10.1523/JNEUROSCI.1877-08.2008.

20.

Survival assay of transiently transfected dopaminergic neurons.

Yu LY, Arumäe U.

J Neurosci Methods. 2008 Mar 30;169(1):8-15. doi: 10.1016/j.jneumeth.2007.11.018. Epub 2007 Nov 29.

PMID:
18191457
21.

The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm.

Tauszig-Delamasure S, Yu LY, Cabrera JR, Bouzas-Rodriguez J, Mermet-Bouvier C, Guix C, Bordeaux MC, Arumäe U, Mehlen P.

Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13361-6. Epub 2007 Aug 8.

22.

Neurotrophic factors switch between two signaling pathways that trigger axonal growth.

Paveliev M, Lume M, Velthut A, Phillips M, Arumäe U, Saarma M.

J Cell Sci. 2007 Aug 1;120(Pt 15):2507-16.

23.

Large-scale production of dsRNA and siRNA pools for RNA interference utilizing bacteriophage phi6 RNA-dependent RNA polymerase.

Aalto AP, Sarin LP, van Dijk AA, Saarma M, Poranen MM, Arumäe U, Bamford DH.

RNA. 2007 Mar;13(3):422-9. Epub 2007 Jan 19.

24.

Cell differentiation: reciprocal regulation of Apaf-1 and the inhibitor of apoptosis proteins.

Lindholm D, Arumäe U.

J Cell Biol. 2004 Oct 25;167(2):193-5. Review.

25.

GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway.

Yu LY, Jokitalo E, Sun YF, Mehlen P, Lindholm D, Saarma M, Arumae U.

J Cell Biol. 2003 Dec 8;163(5):987-97. Epub 2003 Dec 1.

26.
27.

Regulation of sympathetic neuron and neuroblastoma cell death by XIAP and its association with proteasomes in neural cells.

Yu LY, Korhonen L, Martinez R, Jokitalo E, Chen Y, Arumäe U, Lindholm D.

Mol Cell Neurosci. 2003 Mar;22(3):308-18.

PMID:
12691733
28.

Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF-dependent sympathetic neurons.

Lindholm D, Mercer EA, Yu LY, Chen Y, Kukkonen J, Korhonen L, Arumäe U.

Biochim Biophys Acta. 2002 Nov 4;1600(1-2):138-47.

PMID:
12445469
29.

[Neurotrophic growth factors in the development and plasticity of nervous system].

Airaksinen MS, Arumäe U, Rauvala H, Saarma M.

Duodecim. 1999;115(5):595-605. Review. Finnish. No abstract available.

PMID:
11830910
30.

Expression of GFR alpha-1, GFR alpha-2, and c-Ret mRNAs in rat adrenal gland.

Schober A, Arumäe U, Saarma M, Unsicker K.

J Neurocytol. 2000 Mar;29(3):209-13.

PMID:
11428050
31.

Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells.

Sun YF, Yu LY, Saarma M, Timmusk T, Arumae U.

J Biol Chem. 2001 May 11;276(19):16240-7. Epub 2001 Jan 29.

32.

Functional characterization of two splice variants of rat bad and their interaction with Bcl-w in sympathetic neurons.

Hamnér S, Arumäe U, Li-Ying Y, Sun YF, Saarma M, Lindholm D.

Mol Cell Neurosci. 2001 Jan;17(1):97-106.

PMID:
11161472
33.

Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells.

Lindahl M, Poteryaev D, Yu L, Arumae U, Timmusk T, Bongarzone I, Aiello A, Pierotti MA, Airaksinen MS, Saarma M.

J Biol Chem. 2001 Mar 23;276(12):9344-51. Epub 2000 Dec 14.

34.

Neurturin is a neurotrophic factor for penile parasympathetic neurons in adult rat.

Laurikainen A, Hiltunen JO, Thomas-Crusells J, Vanhatalo S, Arumäe U, Airaksinen MS, Klinge E, Saarma M.

J Neurobiol. 2000 May;43(2):198-205.

35.

GDNF triggers a novel ret-independent Src kinase family-coupled signaling via a GPI-linked GDNF receptor alpha1.

Poteryaev D, Titievsky A, Sun YF, Thomas-Crusells J, Lindahl M, Billaud M, Arumäe U, Saarma M.

FEBS Lett. 1999 Dec 10;463(1-2):63-6.

36.

Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor.

Rossi J, Luukko K, Poteryaev D, Laurikainen A, Sun YF, Laakso T, Eerikäinen S, Tuominen R, Lakso M, Rauvala H, Arumäe U, Pasternack M, Saarma M, Airaksinen MS.

Neuron. 1999 Feb;22(2):243-52.

37.

Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-beta as cofactor in vivo.

Schober A, Hertel R, Arumäe U, Farkas L, Jaszai J, Krieglstein K, Saarma M, Unsicker K.

J Neurosci. 1999 Mar 15;19(6):2008-15.

38.

Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells.

Haapasalo A, Saarelainen T, Moshnyakov M, Arumäe U, Kiema TR, Saarma M, Wong G, Castrén E.

Oncogene. 1999 Feb 11;18(6):1285-96.

39.

Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium.

Sainio K, Suvanto P, Davies J, Wartiovaara J, Wartiovaara K, Saarma M, Arumäe U, Meng X, Lindahl M, Pachnis V, Sariola H.

Development. 1997 Oct;124(20):4077-87.

40.

Neurotrophin mRNA expression in the developing tooth suggests multiple roles in innervation and organogenesis.

Luukko K, Arumäe U, Karavanov A, Moshnyakov M, Sainio K, Sariola H, Saarma M, Thesleff I.

Dev Dyn. 1997 Oct;210(2):117-29.

41.

Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha.

Suvanto P, Wartiovaara K, Lindahl M, Arumae U, Moshnyakov M, Horelli-Kuitunen N, Airaksinen MS, Palotie A, Sariola H, Saarma M.

Hum Mol Genet. 1997 Aug;6(8):1267-73.

PMID:
9259272
42.

[Apoptosis during development of the nervous system and in degenerative diseases].

Arumäe U, Sariola H, Haltia M.

Duodecim. 1997;113(16):1590-6. Review. Finnish. No abstract available.

PMID:
10650626
43.

mRNAS for one, two or three members of trk receptor family are expressed in single rat trigeminal ganglion neurons.

Moshnyakov M, Arumäe U, Saarma M.

Brain Res Mol Brain Res. 1996 Dec 31;43(1-2):141-8.

PMID:
9037527
44.

Expression of mRNAs for neurotrophins and their receptors in developing rat heart.

Hiltunen JO, Arumäe U, Moshnyakov M, Saarma M.

Circ Res. 1996 Nov;79(5):930-9.

PMID:
8888685
45.

Functional receptor for GDNF encoded by the c-ret proto-oncogene.

Trupp M, Arenas E, Fainzilber M, Nilsson AS, Sieber BA, Grigoriou M, Kilkenny C, Salazar-Grueso E, Pachnis V, Arumäe U.

Nature. 1996 Jun 27;381(6585):785-9.

PMID:
8657281
46.

Localization of glial cell line-derived neurotrophic factor (GDNF) mRNA in embryonic rat by in situ hybridization.

Suvanto P, Hiltunen JO, Arumäe U, Moshnyakov M, Sariola H, Sainio K, Saarma M.

Eur J Neurosci. 1996 Apr;8(4):816-22.

PMID:
9081633
47.

The hsp150 delta-carrier confers secretion competence to the rat nerve growth factor receptor ectodomain in Saccharomyces cerevisiae.

Simonen M, Vihinen H, Jämsä E, Arumäe U, Kalkkinen N, Makarow M.

Yeast. 1996 Apr;12(5):457-66.

48.

Neurotrophins and ciliary neurotrophic factor: their biology and pathology.

Sariola H, Sainio K, Arumäe U, Saarma M.

Ann Med. 1994 Oct;26(5):355-63. Review.

PMID:
7826597
49.

Coordinated expression and function of neurotrophins and their receptors in the rat inner ear during target innervation.

Pirvola U, Arumäe U, Moshnyakov M, Palgi J, Saarma M, Ylikoski J.

Hear Res. 1994 May;75(1-2):131-44.

PMID:
8071140
50.

Neurotrophins and their receptors in rat peripheral trigeminal system during maxillary nerve growth.

Arumäe U, Pirvola U, Palgi J, Kiema TR, Palm K, Moshnyakov M, Ylikoski J, Saarma M.

J Cell Biol. 1993 Sep;122(5):1053-65.

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