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Items: 1 to 50 of 197

1.

A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes.

Ölander M, Wiśniewski JR, Flörkemeier I, Handin N, Urdzik J, Artursson P.

Arch Toxicol. 2018 Dec 17. doi: 10.1007/s00204-018-2375-9. [Epub ahead of print]

PMID:
30560367
2.

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.

Visnes T, Cázares-Körner A, Hao W, Wallner O, Masuyer G, Loseva O, Mortusewicz O, Wiita E, Sarno A, Manoilov A, Astorga-Wells J, Jemth AS, Pan L, Sanjiv K, Karsten S, Gokturk C, Grube M, Homan EJ, Hanna BMF, Paulin CBJ, Pham T, Rasti A, Berglund UW, von Nicolai C, Benitez-Buelga C, Koolmeister T, Ivanic D, Iliev P, Scobie M, Krokan HE, Baranczewski P, Artursson P, Altun M, Jensen AJ, Kalderén C, Ba X, Zubarev RA, Stenmark P, Boldogh I, Helleday T.

Science. 2018 Nov 16;362(6416):834-839. doi: 10.1126/science.aar8048.

PMID:
30442810
3.
4.

CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box.

Karlgren M, Simoff I, Keiser M, Oswald S, Artursson P.

Drug Metab Dispos. 2018 Nov;46(11):1776-1786. doi: 10.1124/dmd.118.082842. Epub 2018 Aug 20.

PMID:
30126863
5.

Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines.

Llona-Minguez S, Ghassemian A, Baranczewski P, Desroses M, Koolmeister T, Artursson P, Scobie M, Helleday T.

Medchemcomm. 2017 Jul 4;8(7):1553-1560. doi: 10.1039/c7md00230k. eCollection 2017 Jul 1.

6.

Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids.

Treyer A, Mateus A, Wiśniewski JR, Boriss H, Matsson P, Artursson P.

Mol Pharm. 2018 Jun 4;15(6):2224-2233. doi: 10.1021/acs.molpharmaceut.8b00064. Epub 2018 May 11.

7.

Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound.

Islam MK, Strand M, Saleeb M, Svensson R, Baranczewski P, Artursson P, Wadell G, Ahlm C, Elofsson M, Evander M.

Sci Rep. 2018 Jan 31;8(1):1925. doi: 10.1038/s41598-018-20362-9.

8.

Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates.

Weiß F, Hammer HS, Klein K, Planatscher H, Zanger UM, Norén A, Wegler C, Artursson P, Joos TO, Poetz O.

Drug Metab Dispos. 2018 Apr;46(4):387-396. doi: 10.1124/dmd.117.078626. Epub 2018 Jan 17.

PMID:
29343608
9.

Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells.

Kundu S, Ali MA, Handin N, Padhan N, Larsson J, Karoutsou M, Ban K, Wiśniewski JR, Artursson P, He L, Hellström M, Sjöblom T.

Genome Med. 2018 Jan 4;10(1):2. doi: 10.1186/s13073-017-0511-4.

10.

The stimulation of GLP-1 secretion and delivery of GLP-1 agonists via nanostructured lipid carriers.

Shrestha N, Bouttefeux O, Vanvarenberg K, Lundquist P, Cunarro J, Tovar S, Khodus G, Andersson E, Keita ÅV, Gonzalez Dieguez C, Artursson P, Préat V, Beloqui A.

Nanoscale. 2018 Jan 3;10(2):603-613. doi: 10.1039/c7nr07736j.

PMID:
29235598
11.

Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.

Llona-Minguez S, Höglund A, Ghassemian A, Desroses M, Calderón-Montaño JM, Burgos Morón E, Valerie NCK, Wiita E, Almlöf I, Koolmeister T, Mateus A, Cazares-Körner C, Sanjiv K, Homan E, Loseva O, Baranczewski P, Darabi M, Mehdizadeh A, Fayezi S, Jemth AS, Warpman Berglund U, Sigmundsson K, Lundbäck T, Jenmalm Jensen A, Artursson P, Scobie M, Helleday T.

J Med Chem. 2017 Sep 14;60(17):7614. doi: 10.1021/acs.jmedchem.7b01137. Epub 2017 Sep 1. No abstract available.

PMID:
28862438
12.

Erratum: Structural and conformational determinants of macrocycle cell permeability.

Over B, Matsson P, Tyrchan C, Artursson P, Doak BC, Foley MA, Hilgendorf C, Johnston SE, Lee MD 4th, Lewis RJ, McCarren P, Muncipinto G, Norinder U, Perry MWD, Duvall JR, Kihlberg J.

Nat Chem Biol. 2017 Jul 18;13(8):922. doi: 10.1038/nchembio0817-922a. No abstract available.

PMID:
28853740
13.

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes.

Wegler C, Gaugaz FZ, Andersson TB, Wiśniewski JR, Busch D, Gröer C, Oswald S, Norén A, Weiss F, Hammer HS, Joos TO, Poetz O, Achour B, Rostami-Hodjegan A, van de Steeg E, Wortelboer HM, Artursson P.

Mol Pharm. 2017 Sep 5;14(9):3142-3151. doi: 10.1021/acs.molpharmaceut.7b00364. Epub 2017 Aug 16.

14.

Retraction Notice to: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule.

Kitambi SS, Toledo EM, Usoskin D, Wee S, Harisankar A, Svensson R, Sigmundsson K, Kalderén C, Niklasson M, Kundu S, Aranda S, Westermark B, Uhrbom L, Andäng M, Damberg P, Nelander S, Arenas E, Artursson P, Walfridsson J, Nilsson KF, Hammarström LGJ, Ernfors P.

Cell. 2017 Jul 13;170(2):407. doi: 10.1016/j.cell.2017.06.044. No abstract available.

15.

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery.

Mateus A, Gordon LJ, Wayne GJ, Almqvist H, Axelsson H, Seashore-Ludlow B, Treyer A, Matsson P, Lundbäck T, West A, Hann MM, Artursson P.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6231-E6239. doi: 10.1073/pnas.1701848114. Epub 2017 Jul 12.

16.

A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation.

Beloqui A, Brayden DJ, Artursson P, Préat V, des Rieux A.

Nat Protoc. 2017 Jul;12(7):1387-1399. doi: 10.1038/nprot.2017.041. Epub 2017 Jun 15.

PMID:
28617450
17.

Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.

Llona-Minguez S, Höglund A, Ghassemian A, Desroses M, Calderón-Montaño JM, Burgos Morón E, Valerie NCK, Wiita E, Almlöf I, Koolmeister T, Mateus A, Cazares-Körner C, Sanjiv K, Homan E, Loseva O, Baranczewski P, Darabi M, Mehdizadeh A, Fayezi S, Jemth AS, Warpman Berglund U, Sigmundsson K, Lundbäck T, Jenmalm Jensen A, Artursson P, Scobie M, Helleday T.

J Med Chem. 2017 May 25;60(10):4279-4292. doi: 10.1021/acs.jmedchem.7b00182. Epub 2017 May 16. Erratum in: J Med Chem. 2017 Sep 14;60(17):7614.

PMID:
28508636
18.

Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist.

Kusuhara H, Obach RS, Rostami-Hodjegan A, Pang KS, Hammarlund-Udenaes M, Derendorf H, Artursson P, Huang SM, Suzuki H, Terasaki T.

J Pharm Sci. 2017 Sep;106(9):2188-2194. doi: 10.1016/j.xphs.2017.04.072. Epub 2017 May 4. No abstract available.

PMID:
28479350
19.

A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.

Karlgren M, Simoff I, Backlund M, Wegler C, Keiser M, Handin N, Müller J, Lundquist P, Jareborg AC, Oswald S, Artursson P.

J Pharm Sci. 2017 Sep;106(9):2909-2913. doi: 10.1016/j.xphs.2017.04.018. Epub 2017 Apr 24.

PMID:
28450237
20.

Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, Desroses M, Gustavsson AL, Olofsson R, Johansson F, Homan EJ, Loseva O, Bräutigam L, Johansson L, Höglund A, Hagenkort A, Pham T, Altun M, Gaugaz FZ, Vikingsson S, Evers B, Henriksson M, Vallin KSA, Wallner OA, Hammarström LGJ, Wiita E, Almlöf I, Kalderén C, Axelsson H, Djureinovic T, Carreras Puigvert J, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jenmalm Jensen A, Artursson P, Nilsson JA, Stenmark P, Scobie M; Ulrika Warpman Berglund &Thomas Helleday.

Nature. 2017 Apr 26;544(7651):508. doi: 10.1038/nature22083. No abstract available.

PMID:
28447629
21.

Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2).

Pedersen JM, Khan EK, Bergström CAS, Palm J, Hoogstraate J, Artursson P.

Eur J Pharm Sci. 2017 May 30;103:70-76. doi: 10.1016/j.ejps.2017.03.002. Epub 2017 Mar 2.

PMID:
28263911
22.

Global Proteome Changes in Liver Tissue 6 Weeks after FOLFOX Treatment of Colorectal Cancer Liver Metastases.

Urdzik J, Vildhede A, Wiśniewski JR, Duraj F, Haglund U, Artursson P, Norén A.

Proteomes. 2016 Oct 14;4(4). pii: E30. doi: 10.3390/proteomes4040030.

23.

Intracellular drug bioavailability: a new predictor of system dependent drug disposition.

Mateus A, Treyer A, Wegler C, Karlgren M, Matsson P, Artursson P.

Sci Rep. 2017 Feb 22;7:43047. doi: 10.1038/srep43047.

24.

Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1.

Llona-Minguez S, Höglund A, Wiita E, Almlöf I, Mateus A, Calderón-Montaño JM, Cazares-Körner C, Homan E, Loseva O, Baranczewski P, Jemth AS, Häggblad M, Martens U, Lundgren B, Artursson P, Lundbäck T, Jenmalm Jensen A, Warpman Berglund U, Scobie M, Helleday T.

J Med Chem. 2017 Mar 9;60(5):2148-2154. doi: 10.1021/acs.jmedchem.6b01786. Epub 2017 Feb 15.

PMID:
28145708
25.

Validation and development of MTH1 inhibitors for treatment of cancer.

Warpman Berglund U, Sanjiv K, Gad H, Kalderén C, Koolmeister T, Pham T, Gokturk C, Jafari R, Maddalo G, Seashore-Ludlow B, Chernobrovkin A, Manoilov A, Pateras IS, Rasti A, Jemth AS, Almlöf I, Loseva O, Visnes T, Einarsdottir BO, Gaugaz FZ, Saleh A, Platzack B, Wallner OA, Vallin KS, Henriksson M, Wakchaure P, Borhade S, Herr P, Kallberg Y, Baranczewski P, Homan EJ, Wiita E, Nagpal V, Meijer T, Schipper N, Rudd SG, Bräutigam L, Lindqvist A, Filppula A, Lee TC, Artursson P, Nilsson JA, Gorgoulis VG, Lehtiö J, Zubarev RA, Scobie M, Helleday T.

Ann Oncol. 2016 Dec;27(12):2275-2283. doi: 10.1093/annonc/mdw429. Epub 2016 Nov 8.

PMID:
27827301
26.

Structural and conformational determinants of macrocycle cell permeability.

Over B, Matsson P, Tyrchan C, Artursson P, Doak BC, Foley MA, Hilgendorf C, Johnston SE, Lee MD 4th, Lewis RJ, McCarren P, Muncipinto G, Norinder U, Perry MW, Duvall JR, Kihlberg J.

Nat Chem Biol. 2016 Dec;12(12):1065-1074. doi: 10.1038/nchembio.2203. Epub 2016 Oct 17. Erratum in: Nat Chem Biol. 2017 Jul 18;13(8):922.

PMID:
27748751
27.

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures.

Diwakarla S, Nylander E, Grönbladh A, Vanga SR, Khan YS, Gutiérrez-de-Terán H, Sävmarker J, Ng L, Pham V, Lundbäck T, Jenmalm-Jensen A, Svensson R, Artursson P, Zelleroth S, Engen K, Rosenström U, Larhed M, Åqvist J, Chai SY, Hallberg M.

ACS Chem Neurosci. 2016 Oct 19;7(10):1383-1392. Epub 2016 Aug 8.

PMID:
27501164
28.

Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues.

Lundquist P, Artursson P.

Adv Drug Deliv Rev. 2016 Nov 15;106(Pt B):256-276. doi: 10.1016/j.addr.2016.07.007. Epub 2016 Aug 3. Review.

29.

Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions.

Wiśniewski JR, Wegler C, Artursson P.

Anal Biochem. 2016 Sep 15;509:82-88. doi: 10.1016/j.ab.2016.06.006. Epub 2016 Jun 14.

30.

The Pro-inflammatory Cytokine Interleukin-6 Regulates Nanoparticle Transport Across Model Follicle-Associated Epithelium Cells.

Miyake M, Ragnarsson E, Nakai D, Artursson P.

J Pharm Sci. 2016 Jul;105(7):2099-104. doi: 10.1016/j.xphs.2016.03.043. Epub 2016 Jun 1.

PMID:
27262206
31.

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.

Almqvist H, Axelsson H, Jafari R, Dan C, Mateus A, Haraldsson M, Larsson A, Martinez Molina D, Artursson P, Lundbäck T, Nordlund P.

Nat Commun. 2016 Mar 24;7:11040. doi: 10.1038/ncomms11040.

32.

The Need for Speed-Kinetic Limits of Drug Transporters.

Matsson P, Lundquist P, Artursson P.

Trends Pharmacol Sci. 2016 Apr;37(4):243-245. doi: 10.1016/j.tips.2016.02.002. Epub 2016 Feb 24. No abstract available.

PMID:
26922253
33.

Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9.

Simoff I, Karlgren M, Backlund M, Lindström AC, Gaugaz FZ, Matsson P, Artursson P.

J Pharm Sci. 2016 Feb;105(2):1017-1021. doi: 10.1016/S0022-3549(15)00171-9.

PMID:
26869442
34.

The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition.

Ölander M, Wiśniewski JR, Matsson P, Lundquist P, Artursson P.

J Pharm Sci. 2016 Feb;105(2):817-827. doi: 10.1016/j.xphs.2015.10.030. Epub 2016 Jan 9.

PMID:
26869432
35.

Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity.

Good JA, Silver J, Núñez-Otero C, Bahnan W, Krishnan KS, Salin O, Engström P, Svensson R, Artursson P, Gylfe Å, Bergström S, Almqvist F.

J Med Chem. 2016 Mar 10;59(5):2094-108. doi: 10.1021/acs.jmedchem.5b01759. Epub 2016 Feb 22.

PMID:
26849778
36.

Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach.

Vildhede A, Mateus A, Khan EK, Lai Y, Karlgren M, Artursson P, Kjellsson MC.

Drug Metab Dispos. 2016 Apr;44(4):505-16. doi: 10.1124/dmd.115.066746. Epub 2016 Feb 3.

PMID:
26842596
37.

In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes.

Wiśniewski JR, Vildhede A, Norén A, Artursson P.

J Proteomics. 2016 Mar 16;136:234-47. doi: 10.1016/j.jprot.2016.01.016. Epub 2016 Jan 26.

38.

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.

Llona-Minguez S, Höglund A, Jacques SA, Johansson L, Calderón-Montaño JM, Claesson M, Loseva O, Valerie NCK, Lundbäck T, Piedrafita J, Maga G, Crespan E, Meijer L, Morón EB, Baranczewski P, Hagbjörk AL, Svensson R, Wiita E, Almlöf I, Visnes T, Jeppsson F, Sigmundsson K, Jensen AJ, Artursson P, Jemth AS, Stenmark P, Berglund UW, Scobie M, Helleday T.

J Med Chem. 2016 Feb 11;59(3):1140-1148. doi: 10.1021/acs.jmedchem.5b01741. Epub 2016 Jan 27.

39.

A Tribute to Ronald T. Borchardt--Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man.

Schowen KB, Schowen RL, Borchardt SE, Borchardt PM, Artursson P, Audus KL, Augustijns P, Nicolazzo JA, Raub TJ, Schöneich C, Siahaan TJ, Takakura Y, Thakker DR, Wolfe MS.

J Pharm Sci. 2016 Feb;105(2):370-385. doi: 10.1002/jps.24687. Epub 2016 Jan 29. No abstract available.

PMID:
26453244
40.

Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo.

Caraballo R, Larsson M, Nilsson SK, Ericsson M, Qian W, Nguyen Tran NP, Kindahl T, Svensson R, Saar V, Artursson P, Olivecrona G, Enquist PA, Elofsson M.

Eur J Med Chem. 2015 Oct 20;103:191-209. doi: 10.1016/j.ejmech.2015.08.058. Epub 2015 Sep 2.

41.

Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability.

Gordon LJ, Allen M, Artursson P, Hann MM, Leavens BJ, Mateus A, Readshaw S, Valko K, Wayne GJ, West A.

J Biomol Screen. 2016 Feb;21(2):156-64. doi: 10.1177/1087057115604141. Epub 2015 Sep 3.

PMID:
26336900
42.

Addendum to 'Quantifying the impact of transporters on cellular drug permeability'.

Matsson P, Fenu LA, Lundquist P, Wiśniewski JR, Kansy M, Artursson P.

Trends Pharmacol Sci. 2015 Sep;36(9):559. doi: 10.1016/j.tips.2015.06.009. Epub 2015 Jul 24. No abstract available.

PMID:
26216247
43.

Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure.

Vildhede A, Wiśniewski JR, Norén A, Karlgren M, Artursson P.

J Proteome Res. 2015 Aug 7;14(8):3305-14. doi: 10.1021/acs.jproteome.5b00334. Epub 2015 Jul 20.

44.

Quantifying the impact of transporters on cellular drug permeability.

Matsson P, Fenu LA, Lundquist P, Wiśniewski JR, Kansy M, Artursson P.

Trends Pharmacol Sci. 2015 May;36(5):255-62. doi: 10.1016/j.tips.2015.02.009. Epub 2015 Mar 19. Review. Erratum in: Trends Pharmacol Sci. 2015 Sep;36(9):559.

PMID:
25799456
45.

Structural biology. Breaking the intestinal barrier to deliver drugs.

Artursson P, Knight SD.

Science. 2015 Feb 13;347(6223):716-7. doi: 10.1126/science.aaa6124. No abstract available.

PMID:
25678646
46.

Preclinical characterization of acyl sulfonimidamides: potential carboxylic acid bioisosteres with tunable properties.

Borhade SR, Svensson R, Brandt P, Artursson P, Arvidsson PI, Sandström A.

ChemMedChem. 2015 Mar;10(3):455-60. doi: 10.1002/cmdc.201402497. Epub 2015 Jan 28.

PMID:
25630705
47.

Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues.

Fransson R, Nordvall G, Bylund J, Carlsson-Jonsson A, Kratz JM, Svensson R, Artursson P, Hallberg M, Sandström A.

ACS Med Chem Lett. 2014 Oct 29;5(12):1272-7. doi: 10.1021/ml5002954. eCollection 2014 Dec 11.

48.

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles.

Lampa A, Alogheli H, Ehrenberg AE, Åkerblom E, Svensson R, Artursson P, Danielson UH, Karlén A, Sandström A.

Bioorg Med Chem. 2014 Dec 1;22(23):6595-6615. doi: 10.1016/j.bmc.2014.10.010.

PMID:
25456385
49.

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2-P1' Region.

Lampa AK, Bergman SM, Gustafsson SS, Alogheli H, Akerblom EB, Lindeberg GG, Svensson RM, Artursson P, Danielson UH, Karlén A, Sandström A.

ACS Med Chem Lett. 2013 Aug 2;5(3):249-54. doi: 10.1021/ml400217r. eCollection 2014 Mar 13.

50.

Hepatic uptake of atorvastatin: influence of variability in transporter expression on uptake clearance and drug-drug interactions.

Vildhede A, Karlgren M, Svedberg EK, Wisniewski JR, Lai Y, Norén A, Artursson P.

Drug Metab Dispos. 2014 Jul;42(7):1210-8. doi: 10.1124/dmd.113.056309. Epub 2014 May 5. Erratum in: Drug Metab Dispos. 2015 May;43(5):786-7.

PMID:
24799396

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