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Items: 1 to 50 of 99

1.

Reversible fold-switching controls the functional cycle of the antitermination factor RfaH.

Zuber PK, Schweimer K, Rösch P, Artsimovitch I, Knauer SH.

Nat Commun. 2019 Feb 11;10(1):702. doi: 10.1038/s41467-019-08567-6.

2.

Ligand Modulates Cross-Coupling between Riboswitch Folding and Transcriptional Pausing.

Widom JR, Nedialkov YA, Rai V, Hayes RL, Brooks CL 3rd, Artsimovitch I, Walter NG.

Mol Cell. 2018 Nov 1;72(3):541-552.e6. doi: 10.1016/j.molcel.2018.08.046.

PMID:
30388413
3.

Mechanism for the Regulated Control of Bacterial Transcription Termination by a Universal Adaptor Protein.

Lawson MR, Ma W, Bellecourt MJ, Artsimovitch I, Martin A, Landick R, Schulten K, Berger JM.

Mol Cell. 2018 Sep 20;71(6):911-922.e4. doi: 10.1016/j.molcel.2018.07.014. Epub 2018 Aug 16.

PMID:
30122535
4.

In silico discovery of small molecules that inhibit RfaH recruitment to RNA polymerase.

Svetlov D, Shi D, Twentyman J, Nedialkov Y, Rosen DA, Abagyan R, Artsimovitch I.

Mol Microbiol. 2018 Oct;110(1):128-142. doi: 10.1111/mmi.14093. Epub 2018 Oct 2.

PMID:
30069925
5.

Global DNA Compaction in Stationary-Phase Bacteria Does Not Affect Transcription.

Janissen R, Arens MMA, Vtyurina NN, Rivai Z, Sunday ND, Eslami-Mossallam B, Gritsenko AA, Laan L, de Ridder D, Artsimovitch I, Dekker NH, Abbondanzieri EA, Meyer AS.

Cell. 2018 Aug 23;174(5):1188-1199.e14. doi: 10.1016/j.cell.2018.06.049. Epub 2018 Jul 26.

PMID:
30057118
6.

Structural Basis for Transcript Elongation Control by NusG Family Universal Regulators.

Kang JY, Mooney RA, Nedialkov Y, Saba J, Mishanina TV, Artsimovitch I, Landick R, Darst SA.

Cell. 2018 Jun 14;173(7):1650-1662.e14. doi: 10.1016/j.cell.2018.05.017. Epub 2018 Jun 7.

PMID:
29887376
7.

Locking the nontemplate DNA to control transcription.

Nedialkov Y, Svetlov D, Belogurov GA, Artsimovitch I.

Mol Microbiol. 2018 Aug;109(4):445-457. doi: 10.1111/mmi.13983.

PMID:
29758107
8.

The universally-conserved transcription factor RfaH is recruited to a hairpin structure of the non-template DNA strand.

Zuber PK, Artsimovitch I, NandyMazumdar M, Liu Z, Nedialkov Y, Schweimer K, Rösch P, Knauer SH.

Elife. 2018 May 9;7. pii: e36349. doi: 10.7554/eLife.36349.

9.

Rebuilding the bridge between transcription and translation.

Artsimovitch I.

Mol Microbiol. 2018 Jun;108(5):467-472. doi: 10.1111/mmi.13964. Epub 2018 Apr 27.

PMID:
29608805
10.

Uneven Braking Spins RNA Polymerase into a Pause.

Artsimovitch I, Belogurov GA.

Mol Cell. 2018 Mar 1;69(5):723-725. doi: 10.1016/j.molcel.2018.02.013.

PMID:
29499129
11.

Flipping states: a few key residues decide the winning conformation of the only universally conserved transcription factor.

Shi D, Svetlov D, Abagyan R, Artsimovitch I.

Nucleic Acids Res. 2017 Sep 6;45(15):8835-8843. doi: 10.1093/nar/gkx523.

12.

A Screen for rfaH Suppressors Reveals a Key Role for a Connector Region of Termination Factor Rho.

Hu K, Artsimovitch I.

MBio. 2017 May 30;8(3). pii: e00753-17. doi: 10.1128/mBio.00753-17.

13.

Distributed biotin-streptavidin transcription roadblocks for mapping cotranscriptional RNA folding.

Strobel EJ, Watters KE, Nedialkov Y, Artsimovitch I, Lucks JB.

Nucleic Acids Res. 2017 Jul 7;45(12):e109. doi: 10.1093/nar/gkx233.

14.

RNA polymerase gate loop guides the nontemplate DNA strand in transcription complexes.

NandyMazumdar M, Nedialkov Y, Svetlov D, Sevostyanova A, Belogurov GA, Artsimovitch I.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):14994-14999. doi: 10.1073/pnas.1613673114. Epub 2016 Dec 12.

15.

Maintenance of Transcription-Translation Coupling by Elongation Factor P.

Elgamal S, Artsimovitch I, Ibba M.

MBio. 2016 Sep 13;7(5). pii: e01373-16. doi: 10.1128/mBio.01373-16.

16.

Fluorescence Resonance Energy Transfer Characterization of DNA Wrapping in Closed and Open Escherichia coli RNA Polymerase-λP(R) Promoter Complexes.

Sreenivasan R, Heitkamp S, Chhabra M, Saecker R, Lingeman E, Poulos M, McCaslin D, Capp MW, Artsimovitch I, Record MT Jr.

Biochemistry. 2016 Apr 12;55(14):2174-86. doi: 10.1021/acs.biochem.6b00125. Epub 2016 Mar 31.

17.

Interdomain Contacts Control Native State Switching of RfaH on a Dual-Funneled Landscape.

Ramírez-Sarmiento CA, Noel JK, Valenzuela SL, Artsimovitch I.

PLoS Comput Biol. 2015 Jul 31;11(7):e1004379. doi: 10.1371/journal.pcbi.1004379. eCollection 2015 Jul.

18.

Regulation of Transcript Elongation.

Belogurov GA, Artsimovitch I.

Annu Rev Microbiol. 2015;69:49-69. doi: 10.1146/annurev-micro-091014-104047. Epub 2015 Jun 24. Review.

19.

Creative Math of RNA Polymerase III Termination: Sense Plus Antisense Makes More Sense.

Artsimovitch I, Belogurov GA.

Mol Cell. 2015 Jun 18;58(6):974-6. doi: 10.1016/j.molcel.2015.06.003.

20.

E. coli RNA Polymerase Determinants of Open Complex Lifetime and Structure.

Ruff EF, Drennan AC, Capp MW, Poulos MA, Artsimovitch I, Record MT Jr.

J Mol Biol. 2015 Jul 31;427(15):2435-2450. doi: 10.1016/j.jmb.2015.05.024. Epub 2015 Jun 6.

21.

Initial events in bacterial transcription initiation.

Ruff EF, Record MT Jr, Artsimovitch I.

Biomolecules. 2015 May 27;5(2):1035-62. doi: 10.3390/biom5021035. Review.

22.

Preface. Bacterial transcriptional control.

Artsimovitch I, Santangelo TJ.

Methods Mol Biol. 2015;1276:v. No abstract available.

PMID:
25811056
23.

pH dependence of the stress regulator DksA.

Furman R, Danhart EM, NandyMazumdar M, Yuan C, Foster MP, Artsimovitch I.

PLoS One. 2015 Mar 23;10(3):e0120746. doi: 10.1371/journal.pone.0120746. eCollection 2015.

24.

Purification of bacterial RNA polymerase: tools and protocols.

Svetlov V, Artsimovitch I.

Methods Mol Biol. 2015;1276:13-29. doi: 10.1007/978-1-4939-2392-2_2.

25.

Mapping the Escherichia coli transcription elongation complex with exonuclease III.

Liu Z, Artsimovitch I.

Methods Mol Biol. 2015;1276:1-12. doi: 10.1007/978-1-4939-2392-2_1.

26.

Ubiquitous transcription factors display structural plasticity and diverse functions: NusG proteins - Shifting shapes and paradigms.

NandyMazumdar M, Artsimovitch I.

Bioessays. 2015 Mar;37(3):324-34. doi: 10.1002/bies.201400177. Epub 2015 Jan 15. Review.

27.

CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase.

Malinen AM, Nandymazumdar M, Turtola M, Malmi H, Grocholski T, Artsimovitch I, Belogurov GA.

Nat Commun. 2014 Mar 6;5:3408. doi: 10.1038/ncomms4408.

28.

Molecular biology: The tug of DNA repair.

Artsimovitch I.

Nature. 2014 Jan 16;505(7483):298-9. doi: 10.1038/nature12850. Epub 2014 Jan 8. No abstract available.

PMID:
24402229
29.

Interplay between the trigger loop and the F loop during RNA polymerase catalysis.

Miropolskaya N, Esyunina D, Klimasauskas S, Nikiforov V, Artsimovitch I, Kulbachinskiy A.

Nucleic Acids Res. 2014 Jan;42(1):544-52. doi: 10.1093/nar/gkt877. Epub 2013 Oct 1.

30.

Interdomain contacts control folding of transcription factor RfaH.

Tomar SK, Knauer SH, Nandymazumdar M, Rösch P, Artsimovitch I.

Nucleic Acids Res. 2013 Dec;41(22):10077-85. doi: 10.1093/nar/gkt779. Epub 2013 Aug 29.

31.

NusG-Spt5 proteins-Universal tools for transcription modification and communication.

Tomar SK, Artsimovitch I.

Chem Rev. 2013 Nov 13;113(11):8604-19. doi: 10.1021/cr400064k. Epub 2013 May 2. Review. No abstract available.

32.

DksA2, a zinc-independent structural analog of the transcription factor DksA.

Furman R, Biswas T, Danhart EM, Foster MP, Tsodikov OV, Artsimovitch I.

FEBS Lett. 2013 Mar 18;587(6):614-9. doi: 10.1016/j.febslet.2013.01.073. Epub 2013 Feb 14.

33.

A novel non-radioactive primase-pyrophosphatase activity assay and its application to the discovery of inhibitors of Mycobacterium tuberculosis primase DnaG.

Biswas T, Resto-Roldán E, Sawyer SK, Artsimovitch I, Tsodikov OV.

Nucleic Acids Res. 2013 Feb 1;41(4):e56. doi: 10.1093/nar/gks1292. Epub 2012 Dec 24.

34.

The RNA polymerase bridge helix YFI motif in catalysis, fidelity and translocation.

Nedialkov YA, Opron K, Assaf F, Artsimovitch I, Kireeva ML, Kashlev M, Cukier RI, Nudler E, Burton ZF.

Biochim Biophys Acta. 2013 Feb;1829(2):187-98. doi: 10.1016/j.bbagrm.2012.11.005. Epub 2012 Nov 30.

35.

An insertion in the catalytic trigger loop gates the secondary channel of RNA polymerase.

Furman R, Tsodikov OV, Wolf YI, Artsimovitch I.

J Mol Biol. 2013 Jan 9;425(1):82-93. doi: 10.1016/j.jmb.2012.11.008. Epub 2012 Nov 9.

36.

Transformation: the next level of regulation.

Knauer SH, Rösch P, Artsimovitch I.

RNA Biol. 2012 Dec;9(12):1418-23. doi: 10.4161/rna.22724. Epub 2012 Nov 6.

37.

Key roles of the downstream mobile jaw of Escherichia coli RNA polymerase in transcription initiation.

Drennan A, Kraemer M, Capp M, Gries T, Ruff E, Sheppard C, Wigneshweraraj S, Artsimovitch I, Record MT Jr.

Biochemistry. 2012 Nov 27;51(47):9447-59. doi: 10.1021/bi301260u. Epub 2012 Nov 14.

38.

Transformer proteins.

Knauer SH, Artsimovitch I, Rösch P.

Cell Cycle. 2012 Dec 1;11(23):4289-90. doi: 10.4161/cc.22468. Epub 2012 Oct 24. No abstract available.

39.

Interplay of DNA repair with transcription: from structures to mechanisms.

Deaconescu AM, Artsimovitch I, Grigorieff N.

Trends Biochem Sci. 2012 Dec;37(12):543-52. doi: 10.1016/j.tibs.2012.09.002. Epub 2012 Oct 17. Review.

40.

An α helix to β barrel domain switch transforms the transcription factor RfaH into a translation factor.

Burmann BM, Knauer SH, Sevostyanova A, Schweimer K, Mooney RA, Landick R, Artsimovitch I, Rösch P.

Cell. 2012 Jul 20;150(2):291-303. doi: 10.1016/j.cell.2012.05.042.

41.

Fidaxomicin is an inhibitor of the initiation of bacterial RNA synthesis.

Artsimovitch I, Seddon J, Sears P.

Clin Infect Dis. 2012 Aug;55 Suppl 2:S127-31. doi: 10.1093/cid/cis358.

42.

Response to Klyuyev and Vassylyev: on the mechanism of tagetitoxin inhibition of transcription.

Svetlov V, Artsimovitch I, Nudler E.

Transcription. 2012 Mar-Apr;3(2):51-5. doi: 10.4161/trns.19749. Epub 2012 Mar 1.

43.

Nucleotide excision repair (NER) machinery recruitment by the transcription-repair coupling factor involves unmasking of a conserved intramolecular interface.

Deaconescu AM, Sevostyanova A, Artsimovitch I, Grigorieff N.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3353-8. doi: 10.1073/pnas.1115105109. Epub 2012 Feb 13.

44.

Transcriptional pausing coordinates folding of the aptamer domain and the expression platform of a riboswitch.

Perdrizet GA 2nd, Artsimovitch I, Furman R, Sosnick TR, Pan T.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3323-8. doi: 10.1073/pnas.1113086109. Epub 2012 Feb 13.

45.

Transcription initiation factor DksA has diverse effects on RNA chain elongation.

Furman R, Sevostyanova A, Artsimovitch I.

Nucleic Acids Res. 2012 Apr;40(8):3392-402. doi: 10.1093/nar/gkr1273. Epub 2011 Dec 30.

46.

Tagetitoxin inhibits RNA polymerase through trapping of the trigger loop.

Artsimovitch I, Svetlov V, Nemetski SM, Epshtein V, Cardozo T, Nudler E.

J Biol Chem. 2011 Nov 18;286(46):40395-400. doi: 10.1074/jbc.M111.300889. Epub 2011 Oct 5.

47.

The β subunit gate loop is required for RNA polymerase modification by RfaH and NusG.

Sevostyanova A, Belogurov GA, Mooney RA, Landick R, Artsimovitch I.

Mol Cell. 2011 Jul 22;43(2):253-62. doi: 10.1016/j.molcel.2011.05.026.

48.

Termination and antitermination: RNA polymerase runs a stop sign.

Santangelo TJ, Artsimovitch I.

Nat Rev Microbiol. 2011 May;9(5):319-29. doi: 10.1038/nrmicro2560. Epub 2011 Apr 11. Review.

49.

Modulation of RNA polymerase activity through the trigger loop folding.

Miropolskaya N, Nikiforov V, Klimasauskas S, Artsimovitch I, Kulbachinskiy A.

Transcription. 2010 Sep-Oct;1(2):89-94. doi: 10.4161/trns.1.2.12544.

50.

Role of a Zn-independent DksA in Zn homeostasis and stringent response.

Blaby-Haas CE, Furman R, Rodionov DA, Artsimovitch I, de Crécy-Lagard V.

Mol Microbiol. 2011 Feb;79(3):700-15. doi: 10.1111/j.1365-2958.2010.07475.x. Epub 2010 Dec 7.

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