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Items: 31

1.

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.

Dwivedi OP, Lehtovirta M, Hastoy B, Chandra V, Krentz NAJ, Kleiner S, Jain D, Richard AM, Abaitua F, Beer NL, Grotz A, Prasad RB, Hansson O, Ahlqvist E, Krus U, Artner I, Suoranta A, Gomez D, Baras A, Champon B, Payne AJ, Moralli D, Thomsen SK, Kramer P, Spiliotis I, Ramracheya R, Chabosseau P, Theodoulou A, Cheung R, van de Bunt M, Flannick J, Trombetta M, Bonora E, Wolheim CB, Sarelin L, Bonadonna RC, Rorsman P, Davies B, Brosnan J, McCarthy MI, Otonkoski T, Lagerstedt JO, Rutter GA, Gromada J, Gloyn AL, Tuomi T, Groop L.

Nat Genet. 2019 Nov;51(11):1596-1606. doi: 10.1038/s41588-019-0513-9. Epub 2019 Nov 1.

PMID:
31676859
2.

Loss of MafA and MafB expression promotes islet inflammation.

Singh T, Colberg JK, Sarmiento L, Chaves P, Hansen L, Bsharat S, Cataldo LR, Dudenhöffer-Pfeifer M, Fex M, Bryder D, Holmberg D, Sitnicka E, Cilio C, Prasad RB, Artner I.

Sci Rep. 2019 Jun 24;9(1):9074. doi: 10.1038/s41598-019-45528-x.

3.

The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification.

Luan C, Ye Y, Singh T, Barghouth M, Eliasson L, Artner I, Zhang E, Renström E.

Commun Biol. 2019 Mar 15;2:106. doi: 10.1038/s42003-019-0351-4. eCollection 2019.

4.

Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors.

Sonntag Y, Gena P, Maggio A, Singh T, Artner I, Oklinski MK, Johanson U, Kjellbom P, Nieland JD, Nielsen S, Calamita G, Rützler M.

J Biol Chem. 2019 May 3;294(18):7377-7387. doi: 10.1074/jbc.RA118.006083. Epub 2019 Mar 11.

PMID:
30862673
5.

MafA Expression Preserves Immune Homeostasis in Human and Mouse Islets.

Singh T, Sarmiento L, Luan C, Prasad RB, Johansson J, Cataldo LR, Renström E, Soneji S, Cilio C, Artner I.

Genes (Basel). 2018 Dec 18;9(12). pii: E644. doi: 10.3390/genes9120644.

6.

Serotonergic regulation of insulin secretion.

Cataldo Bascuñan LR, Lyons C, Bennet H, Artner I, Fex M.

Acta Physiol (Oxf). 2019 Jan;225(1):e13101. doi: 10.1111/apha.13101. Epub 2018 Jun 20. Review.

PMID:
29791774
7.

Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.

Axelsson AS, Mahdi T, Nenonen HA, Singh T, Hänzelmann S, Wendt A, Bagge A, Reinbothe TM, Millstein J, Yang X, Zhang B, Gusmao EG, Shu L, Szabat M, Tang Y, Wang J, Salö S, Eliasson L, Artner I, Fex M, Johnson JD, Wollheim CB, Derry JMJ, Mecham B, Spégel P, Mulder H, Costa IG, Zhang E, Rosengren AH.

Nat Commun. 2017 Jun 6;8:15652. doi: 10.1038/ncomms15652.

8.

Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling.

Arregi I, Climent M, Iliev D, Strasser J, Gouignard N, Johansson JK, Singh T, Mazur M, Semb H, Artner I, Minichiello L, Pera EM.

Endocrinology. 2016 Dec;157(12):4615-4631. Epub 2016 Oct 14.

PMID:
27740873
9.

The putative tumor suppressor gene EphA7 is a novel BMI-1 target.

Prost G, Braun S, Hertwig F, Winkler M, Jagemann L, Nolbrant S, Leefa IV, Offen N, Miharada K, Lang S, Artner I, Nuber UA.

Oncotarget. 2016 Sep 6;7(36):58203-58217. doi: 10.18632/oncotarget.11279.

10.

MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes.

Ganic E, Singh T, Luan C, Fadista J, Johansson JK, Cyphert HA, Bennet H, Storm P, Prost G, Ahlenius H, Renström E, Stein R, Groop L, Fex M, Artner I.

Cell Rep. 2016 Mar 1;14(8):1991-2002. doi: 10.1016/j.celrep.2016.02.002. Epub 2016 Feb 18.

11.

Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.

Bennet H, Mollet IG, Balhuizen A, Medina A, Nagorny C, Bagge A, Fadista J, Ottosson-Laakso E, Vikman P, Dekker-Nitert M, Eliasson L, Wierup N, Artner I, Fex M.

Diabetologia. 2016 Apr;59(4):744-54. doi: 10.1007/s00125-015-3847-6. Epub 2016 Jan 6.

PMID:
26733006
12.

Islet-specific monoamine oxidase A and B expression depends on MafA transcriptional activity and is compromised in type 2 diabetes.

Ganic E, Johansson JK, Bennet H, Fex M, Artner I.

Biochem Biophys Res Commun. 2015 Dec 25;468(4):629-35. doi: 10.1016/j.bbrc.2015.11.002. Epub 2015 Nov 10.

PMID:
26546820
13.

Microphthalmia transcription factor regulates pancreatic β-cell function.

Mazur MA, Winkler M, Ganic E, Colberg JK, Johansson JK, Bennet H, Fex M, Nuber UA, Artner I.

Diabetes. 2013 Aug;62(8):2834-42. doi: 10.2337/db12-1464. Epub 2013 Apr 22.

14.

Definition of genetic events directing the development of distinct types of brain tumors from postnatal neural stem/progenitor cells.

Hertwig F, Meyer K, Braun S, Ek S, Spang R, Pfenninger CV, Artner I, Prost G, Chen X, Biegel JA, Judkins AR, Englund E, Nuber UA.

Cancer Res. 2012 Jul 1;72(13):3381-92. doi: 10.1158/0008-5472.CAN-11-3525. Epub 2012 Jun 20.

15.

MafA and MafB regulate genes critical to beta-cells in a unique temporal manner.

Artner I, Hang Y, Mazur M, Yamamoto T, Guo M, Lindner J, Magnuson MA, Stein R.

Diabetes. 2010 Oct;59(10):2530-9. doi: 10.2337/db10-0190. Epub 2010 Jul 13.

16.

Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.

Raum JC, Hunter CS, Artner I, Henderson E, Guo M, Elghazi L, Sosa-Pineda B, Ogihara T, Mirmira RG, Sussel L, Stein R.

Mol Cell Biol. 2010 Sep;30(17):4234-44. doi: 10.1128/MCB.01396-09. Epub 2010 Jun 28.

17.

FGF2 specifies hESC-derived definitive endoderm into foregut/midgut cell lineages in a concentration-dependent manner.

Ameri J, Ståhlberg A, Pedersen J, Johansson JK, Johannesson MM, Artner I, Semb H.

Stem Cells. 2010 Jan;28(1):45-56. doi: 10.1002/stem.249.

18.

Lasp1 misexpression influences chondrocyte differentiation in the vertebral column.

Hermann-Kleiter N, Ghaffari-Tabrizi N, Blumer MJ, Schwarzer C, Mazur MA, Artner I.

Int J Dev Biol. 2009;53(7):983-91. doi: 10.1387/ijdb.072435nh.

19.

MafA and MafB regulate Pdx1 transcription through the Area II control region in pancreatic beta cells.

Vanhoose AM, Samaras S, Artner I, Henderson E, Hang Y, Stein R.

J Biol Chem. 2008 Aug 15;283(33):22612-9. doi: 10.1074/jbc.M802902200. Epub 2008 Jun 3.

20.

MafA is a dedicated activator of the insulin gene in vivo.

Artner I, Hang Y, Guo M, Gu G, Stein R.

J Endocrinol. 2008 Aug;198(2):271-9. doi: 10.1677/JOE-08-0063. Epub 2008 May 30.

21.

MafB is required for islet beta cell maturation.

Artner I, Blanchi B, Raum JC, Guo M, Kaneko T, Cordes S, Sieweke M, Stein R.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3853-8. Epub 2007 Feb 22.

22.

Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells.

Tweedie E, Artner I, Crawford L, Poffenberger G, Thorens B, Stein R, Powers AC, Gannon M.

Diabetes. 2006 Dec;55(12):3264-70.

23.

FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.

Raum JC, Gerrish K, Artner I, Henderson E, Guo M, Sussel L, Schisler JC, Newgard CB, Stein R.

Mol Cell Biol. 2006 Aug;26(15):5735-43.

24.

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.

Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM, Peters JL, Shackman JG, Zhang M, Artner I, Satin LS, Stein R, Holzenberger M, Kennedy RT, Kahn CR, Kulkarni RN.

Nat Genet. 2006 May;38(5):583-8. Epub 2006 Apr 23.

PMID:
16642022
25.

Regulation of the insulin gene by glucose and fatty acids.

Poitout V, Hagman D, Stein R, Artner I, Robertson RP, Harmon JS.

J Nutr. 2006 Apr;136(4):873-6. Review.

26.

MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.

Artner I, Le Lay J, Hang Y, Elghazi L, Schisler JC, Henderson E, Sosa-Pineda B, Stein R.

Diabetes. 2006 Feb;55(2):297-304.

27.

Interactions between areas I and II direct pdx-1 expression specifically to islet cell types of the mature and developing pancreas.

Van Velkinburgh JC, Samaras SE, Gerrish K, Artner I, Stein R.

J Biol Chem. 2005 Nov 18;280(46):38438-44. Epub 2005 Sep 7.

28.

The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.

Matsuoka TA, Artner I, Henderson E, Means A, Sander M, Stein R.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2930-3. Epub 2004 Feb 18.

29.

Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells.

Matsuoka TA, Zhao L, Artner I, Jarrett HW, Friedman D, Means A, Stein R.

Mol Cell Biol. 2003 Sep;23(17):6049-62.

30.

Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11.

Kleiter N, Artner I, Gmachl N, Ghaffari-Tabrizi N, Kratochwil K.

Cytogenet Genome Res. 2002;97(1-2):100-5.

PMID:
12438746
31.

Genomic organization and chromosome location of the murine Rpl23 gene.

Kleiter N, Artner I, Copeland NG, Gilbert DJ, Jenkins NA, Kratochwil K.

Cytogenet Cell Genet. 2000;90(3-4):227-30.

PMID:
11124519

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