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Items: 1 to 50 of 146

1.

The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells.

Kelsall IR, Zhang J, Knebel A, Arthur JSC, Cohen P.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13293-13298. doi: 10.1073/pnas.1905873116. Epub 2019 Jun 17.

2.

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism.

Nanda SK, Nagamori T, Windheim M, Amu S, Aviello G, Patterson-Kane J, Arthur JSC, Ley SC, Fallon P, Cohen P.

J Immunol. 2018 Dec 1;201(11):3373-3382. doi: 10.4049/jimmunol.1700614. Epub 2018 Oct 24.

3.

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases.

Andersen JL, Gesser B, Funder ED, Nielsen CJF, Gotfred-Rasmussen H, Rasmussen MK, Toth R, Gothelf KV, Arthur JSC, Iversen L, Nissen P.

Nat Commun. 2018 Oct 19;9(1):4344. doi: 10.1038/s41467-018-06787-w.

4.

IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3.

McCarthy PC, Phair IR, Greger C, Pardali K, McGuire VA, Clark AR, Gaestel M, Arthur JSC.

Immunol Cell Biol. 2019 Jan;97(1):54-71. doi: 10.1111/imcb.12200. Epub 2018 Oct 19.

5.

STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle.

Morgan EL, Wasson CW, Hanson L, Kealy D, Pentland I, McGuire V, Scarpini C, Coleman N, Arthur JSC, Parish JL, Roberts S, Macdonald A.

PLoS Pathog. 2018 Apr 9;14(4):e1006975. doi: 10.1371/journal.ppat.1006975. eCollection 2018 Apr.

6.

A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages.

Danne C, Ryzhakov G, Martínez-López M, Ilott NE, Franchini F, Cuskin F, Lowe EC, Bullers SJ, Arthur JSC, Powrie F.

Cell Host Microbe. 2017 Dec 13;22(6):733-745.e5. doi: 10.1016/j.chom.2017.11.002.

7.

Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases.

Sutavani RV, Phair IR, Barker R, McFarlane A, Shpiro N, Lang S, Woodland A, Arthur JSC.

J Biol Chem. 2018 Feb 16;293(7):2302-2317. doi: 10.1074/jbc.M117.805424. Epub 2017 Dec 11.

8.

Mitogen- and Stress-Activated Protein Kinase 1 Regulates Status Epilepticus-Evoked Cell Death in the Hippocampus.

Choi YS, Horning P, Aten S, Karelina K, Alzate-Correa D, Arthur JSC, Hoyt KR, Obrietan K.

ASN Neuro. 2017 Sep-Oct;9(5):1759091417726607. doi: 10.1177/1759091417726607.

9.

P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment.

Wada M, Canals D, Adada M, Coant N, Salama MF, Helke KL, Arthur JS, Shroyer KR, Kitatani K, Obeid LM, Hannun YA.

Oncogene. 2017 Nov 23;36(47):6649-6657. doi: 10.1038/onc.2017.274. Epub 2017 Aug 7.

10.

Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs).

Heap RE, Hope AG, Pearson LA, Reyskens KMSE, McElroy SP, Hastie CJ, Porter DW, Arthur JSC, Gray DW, Trost M.

SLAS Discov. 2017 Dec;22(10):1193-1202. doi: 10.1177/2472555217717473. Epub 2017 Jul 10.

11.

MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins.

Hunter CJ, Remenyi J, Correa SA, Privitera L, Reyskens KMSE, Martin KJ, Toth R, Frenguelli BG, Arthur JSC.

FEBS Open Bio. 2017 May 11;7(6):821-834. doi: 10.1002/2211-5463.12232. eCollection 2017 Jun.

12.

Mir-132/212 is required for maturation of binocular matching of orientation preference and depth perception.

Mazziotti R, Baroncelli L, Ceglia N, Chelini G, Sala GD, Magnan C, Napoli D, Putignano E, Silingardi D, Tola J, Tognini P, Arthur JSC, Baldi P, Pizzorusso T.

Nat Commun. 2017 May 23;8:15488. doi: 10.1038/ncomms15488.

13.

The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-κB by merkel polyomavirus small tumour antigen.

Abdul-Sada H, Müller M, Mehta R, Toth R, Arthur JSC, Whitehouse A, Macdonald A.

Oncotarget. 2017 Apr 11;8(15):25418-25432. doi: 10.18632/oncotarget.15836.

14.

Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling.

Strickson S, Emmerich CH, Goh ETH, Zhang J, Kelsall IR, Macartney T, Hastie CJ, Knebel A, Peggie M, Marchesi F, Arthur JSC, Cohen P.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3481-E3489. doi: 10.1073/pnas.1702367114. Epub 2017 Apr 12.

15.

The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory.

Daumas S, Hunter CJ, Mistry RB, Morè L, Privitera L, Cooper DD, Reyskens KM, Flynn HT, Morris RG, Arthur JS, Frenguelli BG.

eNeuro. 2017 Feb 20;4(1). pii: ENEURO.0212-16.2017. doi: 10.1523/ENEURO.0212-16.2017. eCollection 2017 Jan-Feb.

16.

Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.

Hayakawa M, Hayakawa H, Petrova T, Ritprajak P, Sutavani RV, Jiménez-Andrade GY, Sano Y, Choo MK, Seavitt J, Venigalla RK, Otsu K, Georgopoulos K, Arthur JS, Park JM.

J Biol Chem. 2017 Feb 3;292(5):1762-1772. doi: 10.1074/jbc.M116.764548. Epub 2016 Dec 23.

17.

The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development.

Bhat N, Park J, Zoghbi HY, Arthur JS, Zaret KS.

PLoS One. 2016 Dec 14;11(12):e0166703. doi: 10.1371/journal.pone.0166703. eCollection 2016.

18.

Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages.

Darling NJ, Toth R, Arthur JS, Clark K.

Biochem J. 2017 Feb 15;474(4):521-537. doi: 10.1042/BCJ20160646. Epub 2016 Dec 5.

19.

Stress-induced haematopoietic stem cell proliferation: new roles for p38α and purine metabolism.

McGuire VA, Arthur JS.

Stem Cell Investig. 2016 Oct 25;3:64. eCollection 2016. No abstract available.

20.
21.

Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways.

McGuire VA, Rosner D, Ananieva O, Ross EA, Elcombe SE, Naqvi S, van den Bosch MMW, Monk CE, Ruiz-Zorrilla Diez T, Clark AR, Arthur JSC.

Mol Cell Biol. 2016 Dec 19;37(1). pii: e00454-16. doi: 10.1128/MCB.00454-16. Print 2017 Jan 1.

22.

Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice.

Choi JP, Foley M, Zhou Z, Wong WY, Gokoolparsadh N, Arthur JS, Li DY, Zheng X.

PLoS One. 2016 Aug 11;11(8):e0160833. doi: 10.1371/journal.pone.0160833. eCollection 2016.

23.

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation.

McGuire VA, Ruiz-Zorrilla Diez T, Emmerich CH, Strickson S, Ritorto MS, Sutavani RV, Weiβ A, Houslay KF, Knebel A, Meakin PJ, Phair IR, Ashford ML, Trost M, Arthur JS.

Sci Rep. 2016 Aug 8;6:31159. doi: 10.1038/srep31159.

24.

Emerging Roles of the Mitogen and Stress Activated Kinases MSK1 and MSK2.

Reyskens KM, Arthur JS.

Front Cell Dev Biol. 2016 Jun 10;4:56. doi: 10.3389/fcell.2016.00056. eCollection 2016. Review.

25.

Corrigendum: Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, Kahn ML.

Nature. 2016 Aug 25;536(7617):488. doi: 10.1038/nature18311. Epub 2016 May 25. No abstract available.

PMID:
27281211
26.

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, Kahn ML.

Nature. 2016 Apr 7;532(7597):122-6. doi: 10.1038/nature17178. Epub 2016 Mar 30. Erratum in: Nature. 2016 May 25;536(7617):488.

27.

The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132.

Remenyi J, Bajan S, Fuller-Pace FV, Arthur JS, Hutvagner G.

Sci Rep. 2016 Mar 7;6:22848. doi: 10.1038/srep22848.

28.

Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome.

Hansen KF, Sakamoto K, Aten S, Snider KH, Loeser J, Hesse AM, Page CE, Pelz C, Arthur JS, Impey S, Obrietan K.

Learn Mem. 2016 Jan 15;23(2):61-71. doi: 10.1101/lm.039578.115. Print 2016 Feb.

29.

Subverting Toll-Like Receptor Signaling by Bacterial Pathogens.

McGuire VA, Arthur JS.

Front Immunol. 2015 Dec 1;6:607. doi: 10.3389/fimmu.2015.00607. eCollection 2015. Review.

30.

Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2.

Lang E, Bissinger R, Fajol A, Salker MS, Singh Y, Zelenak C, Ghashghaeinia M, Gu S, Jilani K, Lupescu A, Reyskens KM, Ackermann TF, Föller M, Schleicher E, Sheffield WP, Arthur JS, Lang F, Qadri SM.

Sci Rep. 2015 Nov 27;5:17316. doi: 10.1038/srep17316.

31.

Development of Selective Covalent Janus Kinase 3 Inhibitors.

Tan L, Akahane K, McNally R, Reyskens KM, Ficarro SB, Liu S, Herter-Sprie GS, Koyama S, Pattison MJ, Labella K, Johannessen L, Akbay EA, Wong KK, Frank DA, Marto JA, Look TA, Arthur JS, Eck MJ, Gray NS.

J Med Chem. 2015 Aug 27;58(16):6589-606. doi: 10.1021/acs.jmedchem.5b00710. Epub 2015 Aug 18.

32.

The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression.

Zhou Z, Rawnsley DR, Goddard LM, Pan W, Cao XJ, Jakus Z, Zheng H, Yang J, Arthur JS, Whitehead KJ, Li D, Zhou B, Garcia BA, Zheng X, Kahn ML.

Dev Cell. 2015 Jan 26;32(2):168-80. doi: 10.1016/j.devcel.2014.12.009.

33.

Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis.

Karelina K, Liu Y, Alzate-Correa D, Wheaton KL, Hoyt KR, Arthur JS, Obrietan K.

Neuroscience. 2015 Jan 29;285:292-302. doi: 10.1016/j.neuroscience.2014.10.053. Epub 2014 Nov 14.

34.

Transcriptional regulation of IL-10 and its cell-specific role in vivo.

MacKenzie KF, Pattison MJ, Arthur JS.

Crit Rev Immunol. 2014;34(4):315-45. Review.

PMID:
24941159
35.

The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle.

Poncet N, Mitchell FE, Ibrahim AF, McGuire VA, English G, Arthur JS, Shi YB, Taylor PM.

PLoS One. 2014 Feb 26;9(2):e89547. doi: 10.1371/journal.pone.0089547. eCollection 2014.

36.

CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling.

Naqvi S, Martin KJ, Arthur JS.

Biochem J. 2014 Mar 15;458(3):469-79. doi: 10.1042/BJ20131115.

PMID:
24438093
37.

Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases.

Castor D, Nair N, Déclais AC, Lachaud C, Toth R, Macartney TJ, Lilley DM, Arthur JS, Rouse J.

Mol Cell. 2013 Oct 24;52(2):221-33. doi: 10.1016/j.molcel.2013.08.036. Epub 2013 Sep 26.

38.

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.

Emmerich CH, Ordureau A, Strickson S, Arthur JS, Pedrioli PG, Komander D, Cohen P.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15247-52. doi: 10.1073/pnas.1314715110. Epub 2013 Aug 28.

39.

Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.

McGuire VA, Gray A, Monk CE, Santos SG, Lee K, Aubareda A, Crowe J, Ronkina N, Schwermann J, Batty IH, Leslie NR, Dean JL, O'Keefe SJ, Boothby M, Gaestel M, Arthur JS.

Mol Cell Biol. 2013 Nov;33(21):4152-65. doi: 10.1128/MCB.01691-12. Epub 2013 Aug 26.

40.

Mitogen-activated protein kinases in innate immunity.

Arthur JS, Ley SC.

Nat Rev Immunol. 2013 Sep;13(9):679-92. doi: 10.1038/nri3495. Epub 2013 Aug 19. Review.

PMID:
23954936
41.

Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.

Pauls E, Nanda SK, Smith H, Toth R, Arthur JSC, Cohen P.

J Immunol. 2013 Sep 1;191(5):2717-30. doi: 10.4049/jimmunol.1203268. Epub 2013 Aug 5. Erratum in: J Immunol. 2013 Nov 15;191(10):5317.

42.

RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.

Park J, Al-Ramahi I, Tan Q, Mollema N, Diaz-Garcia JR, Gallego-Flores T, Lu HC, Lagalwar S, Duvick L, Kang H, Lee Y, Jafar-Nejad P, Sayegh LS, Richman R, Liu X, Gao Y, Shaw CA, Arthur JSC, Orr HT, Westbrook TF, Botas J, Zoghbi HY.

Nature. 2013 Jun 20;498(7454):325-331. doi: 10.1038/nature12204. Epub 2013 May 29.

43.

miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity.

Remenyi J, van den Bosch MW, Palygin O, Mistry RB, McKenzie C, Macdonald A, Hutvagner G, Arthur JS, Frenguelli BG, Pankratov Y.

PLoS One. 2013 Apr 26;8(4):e62509. doi: 10.1371/journal.pone.0062509. Print 2013.

44.

X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor.

Elkins JM, Wang J, Deng X, Pattison MJ, Arthur JS, Erazo T, Gomez N, Lizcano JM, Gray NS, Knapp S.

J Med Chem. 2013 Jun 13;56(11):4413-21. doi: 10.1021/jm4000837. Epub 2013 May 17.

45.

IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages.

Pattison MJ, MacKenzie KF, Elcombe SE, Arthur JS.

FEBS Lett. 2013 May 21;587(10):1496-503. doi: 10.1016/j.febslet.2013.03.025. Epub 2013 Mar 28.

46.

Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers.

Elcombe SE, Naqvi S, Van Den Bosch MW, MacKenzie KF, Cianfanelli F, Brown GD, Arthur JS.

PLoS One. 2013;8(3):e60086. doi: 10.1371/journal.pone.0060086. Epub 2013 Mar 22.

47.

PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development.

Venigalla RK, McGuire VA, Clarke R, Patterson-Kane JC, Najafov A, Toth R, McCarthy PC, Simeons F, Stojanovski L, Arthur JS.

EMBO J. 2013 Apr 3;32(7):1008-22. doi: 10.1038/emboj.2013.40. Epub 2013 Mar 5.

48.

MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop.

MacKenzie KF, Van Den Bosch MW, Naqvi S, Elcombe SE, McGuire VA, Reith AD, Blackshear PJ, Dean JL, Arthur JS.

Mol Cell Biol. 2013 Apr;33(7):1456-67. doi: 10.1128/MCB.01690-12. Epub 2013 Feb 4.

49.

PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway.

MacKenzie KF, Clark K, Naqvi S, McGuire VA, Nöehren G, Kristariyanto Y, van den Bosch M, Mudaliar M, McCarthy PC, Pattison MJ, Pedrioli PG, Barton GJ, Toth R, Prescott A, Arthur JS.

J Immunol. 2013 Jan 15;190(2):565-77. doi: 10.4049/jimmunol.1202462. Epub 2012 Dec 14.

50.

Mitogen- and stress-activated protein kinase 1 modulates photic entrainment of the suprachiasmatic circadian clock.

Cao R, Butcher GQ, Karelina K, Arthur JS, Obrietan K.

Eur J Neurosci. 2013 Jan;37(1):130-40. doi: 10.1111/ejn.12028. Epub 2012 Nov 6.

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