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Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signalling.

Tual-Chalot S, Garcia-Collado M, Redgrave RE, Singh E, Davison B, Park C, Lin H, Luli S, Jin Y, Wang Y, Lawrie A, Jakobsson L, Arthur HM.

Circ Res. 2019 Dec 6. doi: 10.1161/CIRCRESAHA.119.315974. [Epub ahead of print]


Role of soluble endoglin in BMP9 signaling.

Lawera A, Tong Z, Thorikay M, Redgrave RE, Cai J, van Dinther M, Morrell NW, Afink GB, Charnock-Jones DS, Arthur HM, Ten Dijke P, Li W.

Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17800-17808. doi: 10.1073/pnas.1816661116. Epub 2019 Aug 20.


Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction.

Walaszczyk A, Dookun E, Redgrave R, Tual-Chalot S, Victorelli S, Spyridopoulos I, Owens A, Arthur HM, Passos JF, Richardson GD.

Aging Cell. 2019 Jun;18(3):e12945. doi: 10.1111/acel.12945. Epub 2019 Mar 28.


Disruption of embryonic ROCK signaling reproduces the sarcomeric phenotype of hypertrophic cardiomyopathy.

Bailey KE, MacGowan GA, Tual-Chalot S, Phillips L, Mohun TJ, Henderson DJ, Arthur HM, Bamforth SD, Phillips HM.

JCI Insight. 2019 Mar 5;5. pii: 125172. doi: 10.1172/jci.insight.125172.


Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.

Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF.

EMBO J. 2019 Mar 1;38(5). pii: e100492. doi: 10.15252/embj.2018100492. Epub 2019 Feb 8.


Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2.

Thalgott JH, Dos-Santos-Luis D, Hosman AE, Martin S, Lamandé N, Bracquart D, Srun S, Galaris G, de Boer HC, Tual-Chalot S, Kroon S, Arthur HM, Cao Y, Snijder RJ, Disch F, Mager JJ, Rabelink TJ, Mummery CL, Raymond K, Lebrin F.

Circulation. 2018 Dec 4;138(23):2698-2712. doi: 10.1161/CIRCULATIONAHA.117.033062.


Soluble endoglin regulates expression of angiogenesis-related proteins and induction of arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia.

Gallardo-Vara E, Tual-Chalot S, Botella LM, Arthur HM, Bernabeu C.

Dis Model Mech. 2018 Sep 21;11(9). pii: dmm034397. doi: 10.1242/dmm.034397.


Inhibiting DPP4 in a mouse model of HHT1 results in a shift towards regenerative macrophages and reduces fibrosis after myocardial infarction.

Dingenouts CKE, Bakker W, Lodder K, Wiesmeijer KC, Moerkamp AT, Maring JA, Arthur HM, Smits AM, Goumans MJ.

PLoS One. 2017 Dec 18;12(12):e0189805. doi: 10.1371/journal.pone.0189805. eCollection 2017.


Evaluating the feasibility of conducting a trial using a patient decision aid in implantable cardioverter defibrillator candidates: a randomized controlled feasibility trial.

Carroll SL, Stacey D, McGillion M, Healey JS, Foster G, Hutchings S, Arthur HM, Browne G, Thabane L.

Pilot Feasibility Stud. 2017 Nov 21;3:49. doi: 10.1186/s40814-017-0189-9. eCollection 2017.


Executive summary of the 12th HHT international scientific conference.

Andrejecsk JW, Hosman AE, Botella LM, Shovlin CL, Arthur HM, Dupuis-Girod S, Buscarini E, Hughes CCW, Lebrin F, Mummery CL, Post MC, Mager JJ.

Angiogenesis. 2018 Feb;21(1):169-181. doi: 10.1007/s10456-017-9585-2.


The secret life of nonclassical monocytes.

Marsh SA, Arthur HM, Spyridopoulos I.

Cytometry A. 2017 Nov;91(11):1055-1058. doi: 10.1002/cyto.a.23280. Epub 2017 Oct 27. No abstract available.


Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling.

Jin Y, Muhl L, Burmakin M, Wang Y, Duchez AC, Betsholtz C, Arthur HM, Jakobsson L.

Nat Cell Biol. 2017 Jun;19(6):639-652. doi: 10.1038/ncb3534. Epub 2017 May 22.


Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis.

Redgrave RE, Tual-Chalot S, Davison BJ, Singh E, Hall D, Amirrasouli MM, Gilchrist D, Medvinsky A, Arthur HM.

Stem Cell Reports. 2017 May 9;8(5):1287-1298. doi: 10.1016/j.stemcr.2017.04.015.


Burden, screening, and treatment of depressive and anxious symptoms among women referred to cardiac rehabilitation: a prospective study.

Hurley MC, Arthur HM, Chessex C, Oh P, Turk-Adawi K, Grace SL.

BMC Womens Health. 2017 Feb 7;17(1):11. doi: 10.1186/s12905-017-0367-1.


Microvessels of the heart: Formation, regeneration, and dysfunction.

Spyridopoulos I, Arthur HM.

Microcirculation. 2017 Jan;24(1). doi: 10.1111/micc.12338.


Using MRI to predict future adverse cardiac remodelling in a male mouse model of myocardial infarction.

Redgrave RE, Tual-Chalot S, Davison BJ, Greally E, Santibanez-Koref M, Schneider JE, Blamire AM, Arthur HM.

Int J Cardiol Heart Vasc. 2016 Mar 16;11:29-34. eCollection 2016 Jun.


Persistent infiltration and pro-inflammatory differentiation of monocytes cause unresolved inflammation in brain arteriovenous malformation.

Zhang R, Han Z, Degos V, Shen F, Choi EJ, Sun Z, Kang S, Wong M, Zhu W, Zhan L, Arthur HM, Oh SP, Faughnan ME, Su H.

Angiogenesis. 2016 Oct;19(4):451-461. doi: 10.1007/s10456-016-9519-4. Epub 2016 Jun 20.


Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response.

Ojeda-Fernández L, Recio-Poveda L, Aristorena M, Lastres P, Blanco FJ, Sanz-Rodríguez F, Gallardo-Vara E, de las Casas-Engel M, Corbí Á, Arthur HM, Bernabeu C, Botella LM.

PLoS Genet. 2016 Mar 24;12(3):e1005935. doi: 10.1371/journal.pgen.1005935. eCollection 2016 Mar.


Women's Health Behaviours and Psychosocial Well-Being by Cardiac Rehabilitation Program Model: A Randomized Controlled Trial.

Midence L, Arthur HM, Oh P, Stewart DE, Grace SL.

Can J Cardiol. 2016 Aug;32(8):956-62. doi: 10.1016/j.cjca.2015.10.007. Epub 2016 Feb 3. Erratum in: Can J Cardiol. 2017 Dec;33(12 ):1734-1735.


Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous Malformations.

Gkatzis K, Thalgott J, Dos-Santos-Luis D, Martin S, Lamandé N, Carette MF, Disch F, Snijder RJ, Westermann CJ, Mager JJ, Oh SP, Miquerol L, Arthur HM, Mummery CL, Lebrin F.

Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):707-17. doi: 10.1161/ATVBAHA.115.306719. Epub 2016 Jan 28.


Cardiac Rehabilitation Program Adherence and Functional Capacity Among Women: A Randomized Controlled Trial.

Grace SL, Midence L, Oh P, Brister S, Chessex C, Stewart DE, Arthur HM.

Mayo Clin Proc. 2016 Feb;91(2):140-8. doi: 10.1016/j.mayocp.2015.10.021. Epub 2015 Dec 10.


Endoglin is required in Pax3-derived cells for embryonic blood vessel formation.

Young K, Krebs LT, Tweedie E, Conley B, Mancini M, Arthur HM, Liaw L, Gridley T, Vary C.

Dev Biol. 2016 Jan 1;409(1):95-105. doi: 10.1016/j.ydbio.2015.10.019. Epub 2015 Oct 19.


The CREATE Method for Expressing Continuous Outcome Data in Absolute Terms for Use in Patient Treatment Decision Aids: A Validation Study.

McGillion M, Victor JC, Carroll SL, Metcalfe K, O'Keefe-McCarthy S, Jamal N, Arthur HM, McKelvie R, Jolicoeur EM, Hanlon JG, Stone J, Niznick J, Beanlands R, Svorkdal N, Coyte P, Stevens B, Stacey D.

Med Decis Making. 2015 Nov;35(8):959-66. doi: 10.1177/0272989X15598540. Epub 2015 Aug 5.


Reliability of vascular access site bruise measurement.

Cosman TL, Arthur HM, Bryant-Lukosius D, Strachan PH.

J Nurs Meas. 2015;23(1):179-200.


Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges.

Tual-Chalot S, Oh SP, Arthur HM.

Front Genet. 2015 Feb 18;6:25. doi: 10.3389/fgene.2015.00025. eCollection 2015.


Monitoring and management of patients with chronic atrial fibrillation: Is there added value in the identification of clinical phenotypes?

McGillion M, Carroll SL, Arthur HM.

Eur J Cardiovasc Nurs. 2015 Oct;14(5):382-3. doi: 10.1177/1474515115575645. Epub 2015 Feb 24. No abstract available.


Self-efficacy and outcome expectations in cardiac rehabilitation: associations with women's physical activity.

Blanchard C, Arthur HM, Gunn E.

Rehabil Psychol. 2015 Feb;60(1):59-66. doi: 10.1037/rep0000024. Epub 2015 Jan 19.


Women's preferences for cardiac rehabilitation program model: a randomized controlled trial.

Andraos C, Arthur HM, Oh P, Chessex C, Brister S, Grace SL.

Eur J Prev Cardiol. 2015 Dec;22(12):1513-22. doi: 10.1177/2047487314559275. Epub 2014 Dec 1.


Common and distinctive pathogenetic features of arteriovenous malformations in hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 animal models--brief report.

Garrido-Martin EM, Nguyen HL, Cunningham TA, Choe SW, Jiang Z, Arthur HM, Lee YJ, Oh SP.

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2232-6. doi: 10.1161/ATVBAHA.114.303984. Epub 2014 Jul 31.


Development of a patient decision aid for people with refractory angina: protocol for a three-phase pilot study.

McGillion MH, Carroll SL, Metcalfe K, Arthur HM, Victor JC, McKelvie R, Jolicoeur EM, Lessard MG, Stone J, Svorkdal N, Hanlon JG, Andrade A, Niznick J, Malysh L, McDonald W, Stevens B, Coyte P, Stacey D.

Health Qual Life Outcomes. 2014 Jun 11;12:93. doi: 10.1186/1477-7525-12-93.


Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression.

Tual-Chalot S, Mahmoud M, Allinson KR, Redgrave RE, Zhai Z, Oh SP, Fruttiger M, Arthur HM.

PLoS One. 2014 Jun 4;9(6):e98646. doi: 10.1371/journal.pone.0098646. eCollection 2014.


Results of initiatives to address women's issues in cardiovascular health: more light than heat?

Arthur HM.

Can J Cardiol. 2014 Jul;30(7):703-4. doi: 10.1016/j.cjca.2013.12.002. Epub 2013 Dec 4. No abstract available.


Living with an implantable cardiac defibrillator: a model of chronic uncertainty.

Carroll SL, McGillion M, Arthur HM.

Res Theory Nurs Pract. 2014;28(1):71-86.


Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia.

Choi EJ, Chen W, Jun K, Arthur HM, Young WL, Su H.

PLoS One. 2014 Feb 10;9(2):e88511. doi: 10.1371/journal.pone.0088511. eCollection 2014.


ENDOGLIN is dispensable for vasculogenesis, but required for vascular endothelial growth factor-induced angiogenesis.

Liu Z, Lebrin F, Maring JA, van den Driesche S, van der Brink S, van Dinther M, Thorikay M, Martin S, Kobayashi K, Hawinkels LJ, van Meeteren LA, Pardali E, Korving J, Letarte M, Arthur HM, Theuer C, Goumans MJ, Mummery C, ten Dijke P.

PLoS One. 2014 Jan 28;9(1):e86273. doi: 10.1371/journal.pone.0086273. eCollection 2014.


Impact of self-management interventions on stable angina symptoms and health-related quality of life: a meta-analysis.

McGillion M, O'Keefe-McCarthy S, Carroll SL, Victor JC, Cosman T, Cook A, Hanlon JG, Jolicoeur EM, Jamal N, McKelvie R, Arthur HM.

BMC Cardiovasc Disord. 2014 Feb 1;14:14. doi: 10.1186/1471-2261-14-14. Review.


Caregivers' contributions to heart failure self-care: a systematic review.

Buck HG, Harkness K, Wion R, Carroll SL, Cosman T, Kaasalainen S, Kryworuchko J, McGillion M, O'Keefe-McCarthy S, Sherifali D, Strachan PH, Arthur HM.

Eur J Cardiovasc Nurs. 2015 Feb;14(1):79-89. doi: 10.1177/1474515113518434. Epub 2014 Jan 6. Review.


Exercise trajectories of women from entry to a 6-month cardiac rehabilitation program to one year after discharge.

Arthur HM, Blanchard C, Gunn E, Kodis J, Walker S, Toner B.

Biomed Res Int. 2013;2013:121030. doi: 10.1155/2013/121030. Epub 2013 Sep 12.


Development and feasibility testing of decision support for patients who are candidates for a prophylactic implantable defibrillator: a study protocol for a pilot randomized controlled trial.

Carroll SL, McGillion M, Stacey D, Healey JS, Browne G, Arthur HM, Thabane L.

Trials. 2013 Oct 22;14:346. doi: 10.1186/1745-6215-14-346.


Whole mount immunofluorescent staining of the neonatal mouse retina to investigate angiogenesis in vivo.

Tual-Chalot S, Allinson KR, Fruttiger M, Arthur HM.

J Vis Exp. 2013 Jul 9;(77):e50546. doi: 10.3791/50546.


LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.

Wang X, Abraham S, McKenzie JAG, Jeffs N, Swire M, Tripathi VB, Luhmann UFO, Lange CAK, Zhai Z, Arthur HM, Bainbridge J, Moss SE, Greenwood J.

Nature. 2013 Jul 18;499(7458):306-11. doi: 10.1038/nature12345.


The tissue-specific RNA binding protein T-STAR controls regional splicing patterns of neurexin pre-mRNAs in the brain.

Ehrmann I, Dalgliesh C, Liu Y, Danilenko M, Crosier M, Overman L, Arthur HM, Lindsay S, Clowry GJ, Venables JP, Fort P, Elliott DJ.

PLoS Genet. 2013 Apr;9(4):e1003474. doi: 10.1371/journal.pgen.1003474. Epub 2013 Apr 25.


Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination.

Anderberg C, Cunha SI, Zhai Z, Cortez E, Pardali E, Johnson JR, Franco M, Páez-Ribes M, Cordiner R, Fuxe J, Johansson BR, Goumans MJ, Casanovas O, ten Dijke P, Arthur HM, Pietras K.

J Exp Med. 2013 Mar 11;210(3):563-79. doi: 10.1084/jem.20120662. Epub 2013 Feb 11.


Endothelial expression of TGFβ type II receptor is required to maintain vascular integrity during postnatal development of the central nervous system.

Allinson KR, Lee HS, Fruttiger M, McCarty JH, Arthur HM.

PLoS One. 2012;7(6):e39336. doi: 10.1371/journal.pone.0039336. Epub 2012 Jun 26. Erratum in: PLoS One. 2012 Sep;7(9). doi: 10.1371/annotation/8d859757-284b-406d-9cb9-a8776ad32fb1. McCarty, Joseph [corrected to McCarty, Joseph H].


Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse.

Choi EJ, Walker EJ, Shen F, Oh SP, Arthur HM, Young WL, Su H.

Cerebrovasc Dis. 2012;33(6):540-7. doi: 10.1159/000337762. Epub 2012 May 9.


Nonischemic chest pain following successful percutaneous coronary intervention at a regional referral centre in southern Ontario.

McGillion M, Arthur HM, Natarajan M, Cook A, Gunn E, Watt-Watson J, Thorpe K, Cosman T.

Can J Cardiol. 2012 Mar-Apr;28(2 Suppl):S60-9. doi: 10.1016/j.cjca.2011.10.017.


Women, cardiac syndrome X, and microvascular heart disease.

Arthur HM, Campbell P, Harvey PJ, McGillion M, Oh P, Woodburn E, Hodgson C.

Can J Cardiol. 2012 Mar-Apr;28(2 Suppl):S42-9. doi: 10.1016/j.cjca.2011.09.006. Review.


Management of patients with refractory angina: Canadian Cardiovascular Society/Canadian Pain Society joint guidelines.

McGillion M, Arthur HM, Cook A, Carroll SL, Victor JC, L'allier PL, Jolicoeur EM, Svorkdal N, Niznick J, Teoh K, Cosman T, Sessle B, Watt-Watson J, Clark A, Taenzer P, Coyte P, Malysh L, Galte C, Stone J; Canadian Cardiovascular Society; Canadian Pain Society.

Can J Cardiol. 2012 Mar-Apr;28(2 Suppl):S20-41. doi: 10.1016/j.cjca.2011.07.007.


Age and mental health predict early device-specific quality of life in patients receiving prophylactic implantable defibrillators.

Carroll SL, Markle-Reid M, Ciliska D, Connolly SJ, Arthur HM.

Can J Cardiol. 2012 Jul-Aug;28(4):502-7. doi: 10.1016/j.cjca.2012.01.008. Epub 2012 Mar 15.


Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation.

Tan HL, Glen E, Töpf A, Hall D, O'Sullivan JJ, Sneddon L, Wren C, Avery P, Lewis RJ, ten Dijke P, Arthur HM, Goodship JA, Keavney BD.

Hum Mutat. 2012 Apr;33(4):720-7. doi: 10.1002/humu.22030. Epub 2012 Feb 14.

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