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Items: 1 to 50 of 103

1.

Blocking α4β7 integrin binding to SIV does not improve virologic control.

Iwamoto N, Mason RD, Song K, Gorman J, Welles HC, Arthos J, Cicala C, Min S, King HAD, Belli AJ, Reimann KA, Foulds KE, Kwong PD, Lifson JD, Keele BF, Roederer M.

Science. 2019 Sep 6;365(6457):1033-1036. doi: 10.1126/science.aaw7765.

PMID:
31488690
2.

Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques.

Calenda G, Frank I, Arrode-Brusés G, Pegu A, Wang K, Arthos J, Cicala C, Rogers KA, Shirreff L, Grasperge B, Blanchard JL, Maldonado S, Roberts K, Gettie A, Villinger F, Fauci AS, Mascola JR, Martinelli E.

PLoS Pathog. 2019 May 13;15(5):e1007776. doi: 10.1371/journal.ppat.1007776. eCollection 2019 May.

3.

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

Lu M, Ma X, Castillo-Menendez LR, Gorman J, Alsahafi N, Ermel U, Terry DS, Chambers M, Peng D, Zhang B, Zhou T, Reichard N, Wang K, Grover JR, Carman BP, Gardner MR, Nikić-Spiegel I, Sugawara A, Arthos J, Lemke EA, Smith AB 3rd, Farzan M, Abrams C, Munro JB, McDermott AB, Finzi A, Kwong PD, Blanchard SC, Sodroski JG, Mothes W.

Nature. 2019 Apr;568(7752):415-419. doi: 10.1038/s41586-019-1101-y. Epub 2019 Apr 10.

4.

Role of T-cell trafficking in the pathogenesis of HIV disease.

Cicala C, Arthos J, Fauci AS.

Curr Opin HIV AIDS. 2019 Mar;14(2):115-120. doi: 10.1097/COH.0000000000000529.

PMID:
30601238
5.

Common helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virions.

Wibmer CK, Richardson SI, Yolitz J, Cicala C, Arthos J, Moore PL, Morris L.

Nat Commun. 2018 Oct 26;9(1):4489. doi: 10.1038/s41467-018-06794-x.

6.

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7.

Lertjuthaporn S, Cicala C, Van Ryk D, Liu M, Yolitz J, Wei D, Nawaz F, Doyle A, Horowitch B, Park C, Lu S, Lou Y, Wang S, Pan R, Jiang X, Villinger F, Byrareddy SN, Santangelo PJ, Morris L, Wibmer CK, Biris K, Mason RD, Gorman J, Hiatt J, Martinelli E, Roederer M, Fujikawa D, Gorini G, Franchini G, Arakelyan A, Ansari AA, Pattanapanyasat K, Kong XP, Fauci AS, Arthos J.

PLoS Pathog. 2018 Aug 28;14(8):e1007278. doi: 10.1371/journal.ppat.1007278. eCollection 2018 Aug.

7.

HIV-1 targets L-selectin for adhesion and induces its shedding for viral release.

Kononchik J, Ireland J, Zou Z, Segura J, Holzapfel G, Chastain A, Wang R, Spencer M, He B, Stutzman N, Kano D, Arthos J, Fischer E, Chun TW, Moir S, Sun P.

Nat Commun. 2018 Jul 19;9(1):2825. doi: 10.1038/s41467-018-05197-2.

8.

MAdCAM costimulation through Integrin-α4β7 promotes HIV replication.

Nawaz F, Goes LR, Ray JC, Olowojesiku R, Sajani A, Ansari AA, Perrone I, Hiatt J, Van Ryk D, Wei D, Waliszewski M, Soares MA, Jelicic K, Connors M, Migueles SA, Martinelli E, Villinger F, Cicala C, Fauci AS, Arthos J.

Mucosal Immunol. 2018 Sep;11(5):1342-1351. doi: 10.1038/s41385-018-0044-1. Epub 2018 Jun 6.

9.

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations.

Ma X, Lu M, Gorman J, Terry DS, Hong X, Zhou Z, Zhao H, Altman RB, Arthos J, Blanchard SC, Kwong PD, Munro JB, Mothes W.

Elife. 2018 Mar 21;7. pii: e34271. doi: 10.7554/eLife.34271.

10.

The Role of Integrin α4β7 in HIV Pathogenesis and Treatment.

Arthos J, Cicala C, Nawaz F, Byrareddy SN, Villinger F, Santangelo PJ, Ansari AA, Fauci AS.

Curr HIV/AIDS Rep. 2018 Apr;15(2):127-135. doi: 10.1007/s11904-018-0382-3. Review.

11.

Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120.

Yolitz J, Schwing C, Chang J, Van Ryk D, Nawaz F, Wei D, Cicala C, Arthos J, Fauci AS.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2443-2448. doi: 10.1073/pnas.1722627115. Epub 2018 Feb 20.

12.

Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes.

Sivro A, Schuetz A, Sheward D, Joag V, Yegorov S, Liebenberg LJ, Yende-Zuma N, Stalker A, Mwatelah RS, Selhorst P, Garrett N, Samsunder N, Balgobin A, Nawaz F, Cicala C, Arthos J, Fauci AS, Anzala AO, Kimani J, Bagaya BS, Kiwanuka N, Williamson C, Kaul R, Passmore JS, Phanuphak N, Ananworanich J, Ansari A, Abdool Karim Q, Abdool Karim SS, McKinnon LR; CAPRISA004 and RV254 study groups.

Sci Transl Med. 2018 Jan 24;10(425). pii: eaam6354. doi: 10.1126/scitranslmed.aam6354.

PMID:
29367348
13.

Early treatment of SIV+ macaques with an α4β7 mAb alters virus distribution and preserves CD4+ T cells in later stages of infection.

Santangelo PJ, Cicala C, Byrareddy SN, Ortiz KT, Little D, Lindsay KE, Gumber S, Hong JJ, Jelicic K, Rogers KA, Zurla C, Villinger F, Ansari AA, Fauci AS, Arthos J.

Mucosal Immunol. 2018 May;11(3):932-946. doi: 10.1038/mi.2017.112. Epub 2017 Dec 20.

14.

Integrin α4β7 Blockade Preferentially Impacts CCR6+ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques.

Calenda G, Keawvichit R, Arrode-Brusés G, Pattanapanyasat K, Frank I, Byrareddy SN, Arthos J, Cicala C, Grasperge B, Blanchard JL, Gettie A, Reimann KA, Ansari AA, Martinelli E.

J Immunol. 2018 Jan 15;200(2):810-820. doi: 10.4049/jimmunol.1701150. Epub 2017 Dec 1.

15.

Screening of primary gp120 immunogens to formulate the next generation polyvalent DNA prime-protein boost HIV-1 vaccines.

Wang S, Chou TH, Hackett A, Efros V, Wang Y, Han D, Wallace A, Chen Y, Hu G, Liu S, Clapham P, Arthos J, Montefiori D, Lu S.

Hum Vaccin Immunother. 2017 Dec 2;13(12):2996-3009. doi: 10.1080/21645515.2017.1380137. Epub 2017 Sep 21.

16.

Correction: Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection.

Kijak GH, Sanders-Buell E, Chenine AL, Eller MA, Goonetilleke N, Thomas R, Leviyang S, Harbolick EA, Bose M, Pham P, Oropeza C, Poltavee K, O'Sullivan AM, Billings E, Merbah M, Costanzo MC, Warren JA, Slike B, Li H, Peachman KK, Fischer W, Gao F, Cicala C, Arthos J, Eller LA, O'Connell RJ, Sinei S, Maganga L, Kibuuka H, Nitayaphan S, Rao M, Marovich MA, Krebs SJ, Rolland M, Korber BT, Shaw GM, Michael NL, Robb ML, Tovanabutra S, Kim JH.

PLoS Pathog. 2017 Sep 14;13(9):e1006620. doi: 10.1371/journal.ppat.1006620. eCollection 2017 Sep.

17.

Extracellular Matrix Proteins Mediate HIV-1 gp120 Interactions with α4β7.

Plotnik D, Guo W, Cleveland B, von Haller P, Eng JK, Guttman M, Lee KK, Arthos J, Hu SL.

J Virol. 2017 Oct 13;91(21). pii: e01005-17. doi: 10.1128/JVI.01005-17. Print 2017 Nov 1.

18.

Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing.

Guzzo C, Ichikawa D, Park C, Phillips D, Liu Q, Zhang P, Kwon A, Miao H, Lu J, Rehm C, Arthos J, Cicala C, Cohen MS, Fauci AS, Kehrl JH, Lusso P.

Sci Immunol. 2017 May 12;2(11). pii: eaam7341. doi: 10.1126/sciimmunol.aam7341.

19.

Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection.

Kijak GH, Sanders-Buell E, Chenine AL, Eller MA, Goonetilleke N, Thomas R, Leviyang S, Harbolick EA, Bose M, Pham P, Oropeza C, Poltavee K, O'Sullivan AM, Billings E, Merbah M, Costanzo MC, Warren JA, Slike B, Li H, Peachman KK, Fischer W, Gao F, Cicala C, Arthos J, Eller LA, O'Connell RJ, Sinei S, Maganga L, Kibuuka H, Nitayaphan S, Rao M, Marovich MA, Krebs SJ, Rolland M, Korber BT, Shaw GM, Michael NL, Robb ML, Tovanabutra S, Kim JH.

PLoS Pathog. 2017 Jul 31;13(7):e1006510. doi: 10.1371/journal.ppat.1006510. eCollection 2017 Jul. Erratum in: PLoS Pathog. 2017 Sep 14;13(9):e1006620.

20.

Neutralizing and Targeting Properties of a New Set of α4β7-Specific Antibodies Are Influenced by Their Isotype.

Girard A, Jelicic K, Van Ryk D, Rochereau N, Cicala C, Arthos J, Noailly B, Genin C, Verrier B, Laurant S, Razanajaoana-Doll D, Pin JJ, Paul S.

J Acquir Immune Defic Syndr. 2017 May 1;75(1):118-127. doi: 10.1097/QAI.0000000000001307.

PMID:
28177967
21.

Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy.

Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LR, Arnold KB, Woody CE, Walter L, Roos C, Noll A, Van Ryk D, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AS, Ansari AA.

Science. 2016 Oct 14;354(6309):197-202.

22.

HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell Activation.

Deng J, Mitsuki YY, Shen G, Ray JC, Cicala C, Arthos J, Dustin ML, Hioe CE.

J Virol. 2016 Nov 14;90(23):10513-10526. doi: 10.1128/JVI.01532-16. Print 2016 Dec 1.

23.

Correction: A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3.

Arrode-Brusés G, Goode D, Kleinbeck K, Wilk J, Frank I, Byrareddy S, Arthos J, Grasperge B, Blanchard J, Zydowsky T, Gettie A, Martinelli E.

PLoS Pathog. 2016 Jul 14;12(7):e1005781. doi: 10.1371/journal.ppat.1005781. eCollection 2016 Jul.

24.

A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3.

Arrode-Brusés G, Goode D, Kleinbeck K, Wilk J, Frank I, Byrareddy S, Arthos J, Grasperge B, Blanchard J, Zydowsky T, Gettie A, Martinelli E.

PLoS Pathog. 2016 Jun 27;12(6):e1005720. doi: 10.1371/journal.ppat.1005720. eCollection 2016 Jun. Erratum in: PLoS Pathog. 2016 Jul;12(7):e1005781.

25.

Worldwide Genetic Features of HIV-1 Env α4β7 Binding Motif: The Local Dissemination Impact of the LDI Tripeptide.

Hait SH, Soares EA, Sprinz E, Arthos J, Machado ES, Soares MA.

J Acquir Immune Defic Syndr. 2015 Dec 15;70(5):463-71. doi: 10.1097/QAI.0000000000000802.

26.

HIV-1 gp120: A Target for Therapeutics and Vaccine Design.

Cicala C, Nawaz F, Jelicic K, Arthos J, Fauci AS.

Curr Drug Targets. 2016;17(1):122-35. Review.

PMID:
26302793
27.
28.

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.

Kwon YD, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O'Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GB, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Schön A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD.

Nat Struct Mol Biol. 2015 Jul;22(7):522-31. doi: 10.1038/nsmb.3051. Epub 2015 Jun 22.

29.

Species-specific differences in the expression and regulation of α4β7 integrin in various nonhuman primates.

Byrareddy SN, Sidell N, Arthos J, Cicala C, Zhao C, Little DM, Dunbar P, Yang GX, Pierzchalski K, Kane MA, Mayne AE, Song B, Soares MA, Villinger F, Fauci AS, Ansari AA.

J Immunol. 2015 Jun 15;194(12):5968-79. doi: 10.4049/jimmunol.1402866. Epub 2015 May 6.

30.

Identification of preferential CD4+ T-cell targets for HIV infection in the cervix.

Joag VR, McKinnon LR, Liu J, Kidane ST, Yudin MH, Nyanga B, Kimwaki S, Besel KE, Obila JO, Huibner S, Oyugi JO, Arthos J, Anzala O, Kimani J, Ostrowski MA; Toronto HIV Research Group, Kaul R.

Mucosal Immunol. 2016 Jan;9(1):1-12. doi: 10.1038/mi.2015.28. Epub 2015 Apr 15.

PMID:
25872482
31.

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.

Byrareddy SN, Kallam B, Arthos J, Cicala C, Nawaz F, Hiatt J, Kersh EN, McNicholl JM, Hanson D, Reimann KA, Brameier M, Walter L, Rogers K, Mayne AE, Dunbar P, Villinger T, Little D, Parslow TG, Santangelo PJ, Villinger F, Fauci AS, Ansari AA.

Nat Med. 2014 Dec;20(12):1397-400. doi: 10.1038/nm.3715. Epub 2014 Nov 24.

32.

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.

Munro JB, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Courter JR, Smith AB 3rd, Kwong PD, Blanchard SC, Mothes W.

Science. 2014 Nov 7;346(6210):759-63. doi: 10.1126/science.1254426. Epub 2014 Oct 8.

33.

Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity.

Cimbro R, Gallant TR, Dolan MA, Guzzo C, Zhang P, Lin Y, Miao H, Van Ryk D, Arthos J, Gorshkova I, Brown PH, Hurt DE, Lusso P.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3152-7. doi: 10.1073/pnas.1314718111. Epub 2014 Feb 3.

34.

The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.

Jelicic K, Cimbro R, Nawaz F, Huang da W, Zheng X, Yang J, Lempicki RA, Pascuccio M, Van Ryk D, Schwing C, Hiatt J, Okwara N, Wei D, Roby G, David A, Hwang IY, Kehrl JH, Arthos J, Cicala C, Fauci AS.

Nat Immunol. 2013 Dec;14(12):1256-65. doi: 10.1038/ni.2746. Epub 2013 Oct 27.

35.

Virion attachment and entry: HIV gp120 Env biotinylation, gp120 Env, or integrin ligand-binding assay.

Cicala C, Arthos J.

Methods Mol Biol. 2014;1087:3-12. doi: 10.1007/978-1-62703-670-2_1.

PMID:
24158809
36.

Preferential HIV infection of CCR6+ Th17 cells is associated with higher levels of virus receptor expression and lack of CCR5 ligands.

Alvarez Y, Tuen M, Shen G, Nawaz F, Arthos J, Wolff MJ, Poles MA, Hioe CE.

J Virol. 2013 Oct;87(19):10843-54. doi: 10.1128/JVI.01838-13. Epub 2013 Jul 31.

37.

The frequency of α₄β₇(high) memory CD4⁺ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection.

Martinelli E, Veglia F, Goode D, Guerra-Perez N, Aravantinou M, Arthos J, Piatak M Jr, Lifson JD, Blanchard J, Gettie A, Robbiani M.

J Acquir Immune Defic Syndr. 2013 Dec 1;64(4):325-31. doi: 10.1097/QAI.0b013e31829f6e1a.

38.

IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa.

Cimbro R, Vassena L, Arthos J, Cicala C, Kehrl JH, Park C, Sereti I, Lederman MM, Fauci AS, Lusso P.

Blood. 2012 Sep 27;120(13):2610-9. Epub 2012 Aug 14.

39.

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.

McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O'Dell S, Patel N, Shahzad-ul-Hussan S, Yang Y, Zhang B, Zhou T, Zhu J, Boyington JC, Chuang GY, Diwanji D, Georgiev I, Kwon YD, Lee D, Louder MK, Moquin S, Schmidt SD, Yang ZY, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Burton DR, Koff WC, Walker LM, Phogat S, Wyatt R, Orwenyo J, Wang LX, Arthos J, Bewley CA, Mascola JR, Nabel GJ, Schief WR, Ward AB, Wilson IA, Kwong PD.

Nature. 2011 Nov 23;480(7377):336-43. doi: 10.1038/nature10696.

40.

A Novel High-Throughput Screening Assay to Identify Inhibitors of HIV-1 gp120 Protein Interaction with DC-SIGN.

Tran TH, El Baz R, Cuconati A, Arthos J, Jain P, Khan ZK.

J Antivir Antiretrovir. 2011 Oct 17;3:49-54.

41.

Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility.

McKinnon LR, Nyanga B, Chege D, Izulla P, Kimani M, Huibner S, Gelmon L, Block KE, Cicala C, Anzala AO, Arthos J, Kimani J, Kaul R.

J Immunol. 2011 Dec 1;187(11):6032-42. doi: 10.4049/jimmunol.1101836. Epub 2011 Nov 2.

42.

Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids.

Zou Z, Chastain A, Moir S, Ford J, Trandem K, Martinelli E, Cicala C, Crocker P, Arthos J, Sun PD.

PLoS One. 2011;6(9):e24559. doi: 10.1371/journal.pone.0024559. Epub 2011 Sep 8.

43.

Polymorphisms in the α4 integrin of neotropical primates: insights for binding of natural ligands and HIV-1 gp120 to the human α4β7.

Darc M, Hait SH, Soares EA, Cicala C, Seuanez HN, Machado ES, Arthos JA, Soares MA.

PLoS One. 2011;6(9):e24461. doi: 10.1371/journal.pone.0024461. Epub 2011 Sep 2.

44.

HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target.

Martinelli E, Tharinger H, Frank I, Arthos J, Piatak M Jr, Lifson JD, Blanchard J, Gettie A, Robbiani M.

PLoS Pathog. 2011 Jun;7(6):e1002109. doi: 10.1371/journal.ppat.1002109. Epub 2011 Jun 30.

45.

Two closely related Env antigens from the same patient elicited different spectra of neutralizing antibodies against heterologous HIV-1 isolates.

Vaine M, Duenas-Decamp M, Peters P, Liu Q, Arthos J, Wang S, Clapham P, Lu S.

J Virol. 2011 May;85(10):4927-36. doi: 10.1128/JVI.00081-11. Epub 2011 Mar 16.

46.

The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) +/CD4+ T cells as key targets in mucosal transmission.

Nawaz F, Cicala C, Van Ryk D, Block KE, Jelicic K, McNally JP, Ogundare O, Pascuccio M, Patel N, Wei D, Fauci AS, Arthos J.

PLoS Pathog. 2011 Feb;7(2):e1001301. doi: 10.1371/journal.ppat.1001301. Epub 2011 Feb 24.

47.

HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV.

Cicala C, Arthos J, Fauci AS.

J Transl Med. 2011 Jan 27;9 Suppl 1:S2. doi: 10.1186/1479-5876-9-S1-S2. Review.

48.

Profiles of human serum antibody responses elicited by three leading HIV vaccines focusing on the induction of Env-specific antibodies.

Vaine M, Wang S, Liu Q, Arthos J, Montefiori D, Goepfert P, McElrath MJ, Lu S.

PLoS One. 2010 Nov 9;5(11):e13916. doi: 10.1371/journal.pone.0013916.

49.

Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity.

Vaine M, Wang S, Hackett A, Arthos J, Lu S.

Vaccine. 2010 Apr 9;28(17):2999-3007. doi: 10.1016/j.vaccine.2010.02.006. Epub 2010 Feb 17.

50.

Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.

Chen L, Kwon YD, Zhou T, Wu X, O'Dell S, Cavacini L, Hessell AJ, Pancera M, Tang M, Xu L, Yang ZY, Zhang MY, Arthos J, Burton DR, Dimitrov DS, Nabel GJ, Posner MR, Sodroski J, Wyatt R, Mascola JR, Kwong PD.

Science. 2009 Nov 20;326(5956):1123-7. doi: 10.1126/science.1175868.

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