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Photoreceptors in a mouse model of Leigh syndrome are capable of normal light-evoked signaling.

Gospe SM 3rd, Travis AM, Kolesnikov AV, Klingeborn M, Wang L, Kefalov VJ, Arshavsky VY.

J Biol Chem. 2019 Aug 16;294(33):12432-12443. doi: 10.1074/jbc.RA119.007945. Epub 2019 Jun 27.


PRCD is essential for high-fidelity photoreceptor disc formation.

Spencer WJ, Ding JD, Lewis TR, Yu C, Phan S, Pearring JN, Kim KY, Thor A, Mathew R, Kalnitsky J, Hao Y, Travis AM, Biswas SK, Lo WK, Besharse JC, Ellisman MH, Saban DR, Burns ME, Arshavsky VY.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13087-13096. doi: 10.1073/pnas.1906421116. Epub 2019 Jun 12.


Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration.

O'Koren EG, Yu C, Klingeborn M, Wong AYW, Prigge CL, Mathew R, Kalnitsky J, Msallam RA, Silvin A, Kay JN, Bowes Rickman C, Arshavsky VY, Ginhoux F, Merad M, Saban DR.

Immunity. 2019 Mar 19;50(3):723-737.e7. doi: 10.1016/j.immuni.2019.02.007. Epub 2019 Mar 5.


Transducin β-Subunit Can Interact with Multiple G-Protein γ-Subunits to Enable Light Detection by Rod Photoreceptors.

Dexter PM, Lobanova ES, Finkelstein S, Spencer WJ, Skiba NP, Arshavsky VY.

eNeuro. 2018 Jun 11;5(3). pii: ENEURO.0144-18.2018. doi: 10.1523/ENEURO.0144-18.2018. eCollection 2018 May-Jun.


Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration.

Lobanova ES, Finkelstein S, Li J, Travis AM, Hao Y, Klingeborn M, Skiba NP, Deshaies RJ, Arshavsky VY.

Nat Commun. 2018 Apr 30;9(1):1738. doi: 10.1038/s41467-018-04117-8.


C8ORF37 Is Required for Photoreceptor Outer Segment Disc Morphogenesis by Maintaining Outer Segment Membrane Protein Homeostasis.

Sharif AS, Yu D, Loertscher S, Austin R, Nguyen K, Mathur PD, Clark AM, Zou J, Lobanova ES, Arshavsky VY, Yang J.

J Neurosci. 2018 Mar 28;38(13):3160-3176. doi: 10.1523/JNEUROSCI.2964-17.2018. Epub 2018 Feb 13.


Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is Conveyed through Wide-Field Amacrine Cells.

Travis AM, Heflin SJ, Hirano AA, Brecha NC, Arshavsky VY.

J Neurosci. 2018 Jan 17;38(3):723-732. doi: 10.1523/JNEUROSCI.1994-17.2017. Epub 2017 Dec 7.


Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration.

Pearring JN, San Agustin JT, Lobanova ES, Gabriel CJ, Lieu EC, Monis WJ, Stuck MW, Strittmatter L, Jaber SM, Arshavsky VY, Pazour GJ.

PLoS Genet. 2017 Apr 14;13(4):e1006740. doi: 10.1371/journal.pgen.1006740. eCollection 2017 Apr.


Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release.

Salinas RY, Pearring JN, Ding JD, Spencer WJ, Hao Y, Arshavsky VY.

J Cell Biol. 2017 May 1;216(5):1489-1499. doi: 10.1083/jcb.201608081. Epub 2017 Apr 5.


Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.

Ploier B, Caro LN, Morizumi T, Pandey K, Pearring JN, Goren MA, Finnemann SC, Graumann J, Arshavsky VY, Dittman JS, Ernst OP, Menon AK.

Nat Commun. 2016 Oct 3;7:12832. doi: 10.1038/ncomms12832.


Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor Outer Segment Localization and Maintaining Intracellular Stability.

Spencer WJ, Pearring JN, Salinas RY, Loiselle DR, Skiba NP, Arshavsky VY.

Biochemistry. 2016 Sep 13;55(36):5028-37. doi: 10.1021/acs.biochem.6b00489. Epub 2016 Aug 30.


Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking.

Pearring JN, Spencer WJ, Lieu EC, Arshavsky VY.

Elife. 2015 Nov 21;4. pii: e12058. doi: 10.7554/eLife.12058.


Discs of mammalian rod photoreceptors form through the membrane evagination mechanism.

Ding JD, Salinas RY, Arshavsky VY.

J Cell Biol. 2015 Nov 9;211(3):495-502. doi: 10.1083/jcb.201508093. Epub 2015 Nov 2.


Introducing Kirill A. Martemyanov, the 2014 recipient of the Cogan Award.

Arshavsky VY.

Invest Ophthalmol Vis Sci. 2014 Dec 15;55(12):8200. doi: 10.1167/iovs.14-14819. No abstract available.


Current understanding of signal amplification in phototransduction.

Arshavsky VY, Burns ME.

Cell Logist. 2014 Jun 4;4:e29390. eCollection 2014.


R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain.

Pearring JN, Lieu EC, Winter JR, Baker SA, Arshavsky VY.

Mol Biol Cell. 2014 Sep 1;25(17):2644-9. doi: 10.1091/mbc.E14-02-0747. Epub 2014 Jul 9.


FASEB Science Research Conference on Biology and Chemistry of Vision.

Kefalov VJ, Arshavsky VY.

FASEB J. 2014 Jun;28(6):2395-7. doi: 10.1096/fj.14-0602ufm. No abstract available.


Automatic segmentation of up to ten layer boundaries in SD-OCT images of the mouse retina with and without missing layers due to pathology.

Srinivasan PP, Heflin SJ, Izatt JA, Arshavsky VY, Farsiu S.

Biomed Opt Express. 2014 Jan 7;5(2):348-65. doi: 10.1364/BOE.5.000348. eCollection 2014 Feb 1.


Absence of synaptic regulation by phosducin in retinal slices.

Long JH, Arshavsky VY, Burns ME.

PLoS One. 2013 Dec 20;8(12):e83970. doi: 10.1371/journal.pone.0083970. eCollection 2013.


Timing is everything: GTPase regulation in phototransduction.

Arshavsky VY, Wensel TG.

Invest Ophthalmol Vis Sci. 2013 Nov 21;54(12):7725-33. doi: 10.1167/iovs.13-13281. Review.


Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration.

Lobanova ES, Finkelstein S, Skiba NP, Arshavsky VY.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9986-91. doi: 10.1073/pnas.1305521110. Epub 2013 May 28.


Proteomic identification of unique photoreceptor disc components reveals the presence of PRCD, a protein linked to retinal degeneration.

Skiba NP, Spencer WJ, Salinas RY, Lieu EC, Thompson JW, Arshavsky VY.

J Proteome Res. 2013 Jun 7;12(6):3010-8. doi: 10.1021/pr4003678. Epub 2013 May 24.


Protein sorting, targeting and trafficking in photoreceptor cells.

Pearring JN, Salinas RY, Baker SA, Arshavsky VY.

Prog Retin Eye Res. 2013 Sep;36:24-51. doi: 10.1016/j.preteyeres.2013.03.002. Epub 2013 Apr 3. Review.


A single valine residue plays an essential role in peripherin/rds targeting to photoreceptor outer segments.

Salinas RY, Baker SA, Gospe SM 3rd, Arshavsky VY.

PLoS One. 2013;8(1):e54292. doi: 10.1371/journal.pone.0054292. Epub 2013 Jan 14.


Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.

Cohen SP, Buckley BK, Kosloff M, Garland AL, Bosch DE, Cheng G Jr, Radhakrishna H, Brown MD, Willard FS, Arshavsky VY, Tarran R, Siderovski DP, Kimple AJ.

J Biol Chem. 2012 Dec 7;287(50):41706-19. doi: 10.1074/jbc.M112.423806. Epub 2012 Oct 24.


The relationship between slow photoresponse recovery rate and temporal resolution of vision.

Umino Y, Herrmann R, Chen CK, Barlow RB, Arshavsky VY, Solessio E.

J Neurosci. 2012 Oct 10;32(41):14364-73. doi: 10.1523/JNEUROSCI.1296-12.2012.


CNG-modulin: a novel Ca-dependent modulator of ligand sensitivity in cone photoreceptor cGMP-gated ion channels.

Rebrik TI, Botchkina I, Arshavsky VY, Craft CM, Korenbrot JI.

J Neurosci. 2012 Feb 29;32(9):3142-53. doi: 10.1523/JNEUROSCI.5518-11.2012.


RGS9 knockout causes a short delay in light responses of ON-bipolar cells.

Herrmann R, Lee B, Arshavsky VY.

PLoS One. 2011;6(11):e27573. doi: 10.1371/journal.pone.0027573. Epub 2011 Nov 11.


Photoreceptor signaling: supporting vision across a wide range of light intensities.

Arshavsky VY, Burns ME.

J Biol Chem. 2012 Jan 13;287(3):1620-6. doi: 10.1074/jbc.R111.305243. Epub 2011 Nov 10. Review.


Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptors.

Gospe SM 3rd, Baker SA, Kessler C, Brucato MF, Winter JR, Burns ME, Arshavsky VY.

J Neurosci. 2011 Oct 12;31(41):14660-8. doi: 10.1523/JNEUROSCI.3516-11.2011.


Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA.

Herrmann R, Heflin SJ, Hammond T, Lee B, Wang J, Gainetdinov RR, Caron MG, Eggers ED, Frishman LJ, McCall MA, Arshavsky VY.

Neuron. 2011 Oct 6;72(1):101-10. doi: 10.1016/j.neuron.2011.07.030.


Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions.

Kosloff M, Travis AM, Bosch DE, Siderovski DP, Arshavsky VY.

Nat Struct Mol Biol. 2011 Jun 19;18(7):846-53. doi: 10.1038/nsmb.2068.


Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors.

Osawa S, Jo R, Xiong Y, Reidel B, Tserentsoodol N, Arshavsky VY, Iuvone PM, Weiss ER.

J Biol Chem. 2011 Jun 10;286(23):20923-9. doi: 10.1074/jbc.M111.230904. Epub 2011 Apr 19.


Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells.

Reidel B, Thompson JW, Farsiu S, Moseley MA, Skiba NP, Arshavsky VY.

Mol Cell Proteomics. 2011 Mar;10(3):M110.002469. doi: 10.1074/mcp.M110.002469. Epub 2010 Dec 20.


Facilitative glucose transporter Glut1 is actively excluded from rod outer segments.

Gospe SM 3rd, Baker SA, Arshavsky VY.

J Cell Sci. 2010 Nov 1;123(Pt 21):3639-44. doi: 10.1242/jcs.072389. Epub 2010 Oct 5.


Heparan sulfate, including that in Bruch's membrane, inhibits the complement alternative pathway: implications for age-related macular degeneration.

Kelly U, Yu L, Kumar P, Ding JD, Jiang H, Hageman GS, Arshavsky VY, Frank MM, Hauser MA, Rickman CB.

J Immunol. 2010 Nov 1;185(9):5486-94. doi: 10.4049/jimmunol.0903596. Epub 2010 Sep 27.


Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light.

Lobanova ES, Herrmann R, Finkelstein S, Reidel B, Skiba NP, Deng WT, Jo R, Weiss ER, Hauswirth WW, Arshavsky VY.

J Neurosci. 2010 May 19;30(20):6815-24. doi: 10.1523/JNEUROSCI.0613-10.2010.


Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse.

Herrmann R, Lobanova ES, Hammond T, Kessler C, Burns ME, Frishman LJ, Arshavsky VY.

J Neurosci. 2010 Mar 3;30(9):3239-53. doi: 10.1523/JNEUROSCI.4775-09.2010.


Vision: the retinoid cycle in Drosophila.

Arshavsky VY.

Curr Biol. 2010 Feb 9;20(3):R96-8. doi: 10.1016/j.cub.2009.12.039.


Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation.

Rajala A, Daly RJ, Tanito M, Allen DT, Holt LJ, Lobanova ES, Arshavsky VY, Rajala RV.

Biochemistry. 2009 Jun 23;48(24):5563-72. doi: 10.1021/bi9000062.


Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia.

Kizhatil K, Baker SA, Arshavsky VY, Bennett V.

Science. 2009 Mar 20;323(5921):1614-7. doi: 10.1126/science.1169789.


Biology and functions of the RGS9 isoforms.

Martemyanov KA, Arshavsky VY.

Prog Mol Biol Transl Sci. 2009;86:205-27. doi: 10.1016/S1877-1173(09)86007-9. Epub 2009 Oct 7. Review.


Functional comparison of RGS9 splice isoforms in a living cell.

Martemyanov KA, Krispel CM, Lishko PV, Burns ME, Arshavsky VY.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20988-93. doi: 10.1073/pnas.0808941106. Epub 2008 Dec 19.


Rapid and sensitive method for detection of Y402, H402, I62, and V62 variants of complement factor H in human plasma samples using mass spectrometry.

Kelly U, Rickman CB, Postel EA, Hauser MA, Hageman GS, Arshavsky VY, Skiba NP.

Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1540-5. doi: 10.1167/iovs.08-2782. Epub 2008 Nov 21.


The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors.

Baker SA, Haeri M, Yoo P, Gospe SM 3rd, Skiba NP, Knox BE, Arshavsky VY.

J Cell Biol. 2008 Nov 3;183(3):485-98. doi: 10.1083/jcb.200806009.


Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation.

Kosloff M, Alexov E, Arshavsky VY, Honig B.

J Biol Chem. 2008 Nov 7;283(45):31197-207. doi: 10.1074/jbc.M803799200. Epub 2008 Sep 9.


Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.

Zhang XJ, Cahill KB, Elfenbein A, Arshavsky VY, Cote RH.

J Biol Chem. 2008 Oct 31;283(44):29699-705. doi: 10.1074/jbc.M803948200. Epub 2008 Sep 8.


Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability.

Lobanova ES, Finkelstein S, Herrmann R, Chen YM, Kessler C, Michaud NA, Trieu LH, Strissel KJ, Burns ME, Arshavsky VY.

J Neurosci. 2008 Mar 26;28(13):3510-20. doi: 10.1523/JNEUROSCI.0338-08.2008.


Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation.

Krispel CM, Sokolov M, Chen YM, Song H, Herrmann R, Arshavsky VY, Burns ME.

J Gen Physiol. 2007 Sep;130(3):303-12.


Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina.

Yu L, Kelly U, Ebright JN, Malek G, Saloupis P, Rickman DW, McKay BS, Arshavsky VY, Bowes Rickman C.

Biochim Biophys Acta. 2007 Sep;1773(9):1473-82. Epub 2007 Jun 26.

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