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Items: 40

1.

Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD.

Rios X, Gómez-Vallejo V, Martín A, Cossío U, Morcillo MÁ, Alemi M, Cardoso I, Quintana J, Jiménez-Barbero J, Cotrina EY, Valencia G, Arsequell G, Llop J.

Sci Rep. 2019 Sep 20;9(1):13672. doi: 10.1038/s41598-019-50071-w.

2.

Benzyl-2-Acetamido-2-Deoxy-α-d-Galactopyranoside Increases Human Immunodeficiency Virus Replication and Viral Outgrowth Efficacy In Vitro.

Olvera A, Martinez JP, Casadellà M, Llano A, Rosás M, Mothe B, Ruiz-Riol M, Arsequell G, Valencia G, Noguera-Julian M, Paredes R, Meyerhans A, Brander C.

Front Immunol. 2018 Jan 26;8:2010. doi: 10.3389/fimmu.2017.02010. eCollection 2017.

3.

Insights on the Interaction between Transthyretin and Aβ in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal.

Gimeno A, Santos LM, Alemi M, Rivas J, Blasi D, Cotrina EY, Llop J, Valencia G, Cardoso I, Quintana J, Arsequell G, Jiménez-Barbero J.

J Med Chem. 2017 Jul 13;60(13):5749-5758. doi: 10.1021/acs.jmedchem.7b00428. Epub 2017 Jun 16.

PMID:
28587455
4.

Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides.

Rosa M, Gonzalez-Nunez V, Barreto-Valer K, Marcelo F, Sánchez-Sánchez J, Calle LP, Arévalo JC, Rodríguez RE, Jiménez-Barbero J, Arsequell G, Valencia G.

Bioorg Med Chem. 2017 Apr 1;25(7):2260-2265. doi: 10.1016/j.bmc.2017.02.052. Epub 2017 Feb 27.

PMID:
28284867
5.

Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptide.

Rosa M, Marcelo F, Calle LP, Rougeot C, Jiménez-Barbero J, Arsequell G, Valencia G.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5190-3. doi: 10.1016/j.bmcl.2015.09.071. Epub 2015 Oct 14.

PMID:
26463133
6.

Modulation of the Interaction between a Peptide Ligand and a G Protein-Coupled Receptor by Halogen Atoms.

Rosa M, Caltabiano G, Barreto-Valer K, Gonzalez-Nunez V, Gómez-Tamayo JC, Ardá A, Jiménez-Barbero J, Pardo L, Rodríguez RE, Arsequell G, Valencia G.

ACS Med Chem Lett. 2015 Jul 16;6(8):872-6. doi: 10.1021/acsmedchemlett.5b00126. eCollection 2015 Aug 13.

7.

Optimized Proteomic Mass Spectrometry Characterization of Recombinant Human μ-Opioid Receptor Functionally Expressed in Pichia pastoris Cell Lines.

Rosa M, Bech-Serra JJ, Canals F, Zajac JM, Talmont F, Arsequell G, Valencia G.

J Proteome Res. 2015 Aug 7;14(8):3162-73. doi: 10.1021/acs.jproteome.5b00104. Epub 2015 Jul 7.

PMID:
26090583
8.

Tuning transthyretin amyloidosis inhibition properties of iododiflunisal by combinatorial engineering of the nonsalicylic ring substitutions.

Vilaró M, Nieto J, La Parra JR, Almeida MR, Ballesteros A, Planas A, Arsequell G, Valencia G.

ACS Comb Sci. 2015 Jan 12;17(1):32-8. doi: 10.1021/co5001234. Epub 2014 Nov 25.

PMID:
25394203
9.

Transthyretin stabilization by iododiflunisal promotes amyloid-β peptide clearance, decreases its deposition, and ameliorates cognitive deficits in an Alzheimer's disease mouse model.

Ribeiro CA, Oliveira SM, Guido LF, Magalhães A, Valencia G, Arsequell G, Saraiva MJ, Cardoso I.

J Alzheimers Dis. 2014;39(2):357-70. doi: 10.3233/JAD-131355.

PMID:
24169237
10.

Modulation of the fibrillogenesis inhibition properties of two transthyretin ligands by halogenation.

Cotrina EY, Pinto M, Bosch L, Vilà M, Blasi D, Quintana J, Centeno NB, Arsequell G, Planas A, Valencia G.

J Med Chem. 2013 Nov 27;56(22):9110-21. doi: 10.1021/jm401061w. Epub 2013 Nov 7.

PMID:
24147937
11.

Methods to evaluate the inhibition of TTR fibrillogenesis induced by small ligands.

Arsequell G, Planas A.

Curr Med Chem. 2012;19(15):2343-55. Review.

PMID:
22471983
12.

Proposed Bioactive Conformations of Opiorphin, an Endogenous Dual APN/NEP Inhibitor.

Pinto M, Rougeot C, Gracia L, Rosa M, García A, Arsequell G, Valencia G, Centeno NB.

ACS Med Chem Lett. 2011 Nov 17;3(1):20-4. doi: 10.1021/ml200182v. eCollection 2012 Jan 12.

13.

Structure-activity relationship study of opiorphin, a human dual ectopeptidase inhibitor with antinociceptive properties.

Rosa M, Arsequell G, Rougeot C, Calle LP, Marcelo F, Pinto M, Centeno NB, Jiménez-Barbero J, Valencia G.

J Med Chem. 2012 Feb 9;55(3):1181-8. doi: 10.1021/jm2012112. Epub 2012 Jan 25.

PMID:
22224710
14.

Drug discovery targeted at transthyretin cardiac amyloidosis: rational design, synthesis, and biological activity of new transthyretin amyloid inhibitors.

Blasi D, Pinto M, Nieto J, Arsequell G, Valencia G, Planas A, Centeno NB, Quintana J.

Amyloid. 2011 Jun;18 Suppl 1:55-7. doi: 10.3109/13506129.2011.574354019. No abstract available. Erratum in: Amyloid. 2011 Jun;18 Suppl 1:57.

PMID:
21838431
15.

Ligand-binding properties of human transthyretin.

Pinto M, Blasi D, Nieto J, Arsequell G, Valencia G, Planas A, Quintana J, Centeno NB.

Amyloid. 2011 Jun;18 Suppl 1:51-4. doi: 10.3109/13506129.2011.574354018. No abstract available. Erratum in: Amyloid. 2011 Jun;18 Suppl 1:54.

PMID:
21838430
16.

Synthesis, biological evaluation and structural characterization of novel glycopeptide analogues of nociceptin N/OFQ.

Arsequell G, Rosa M, Mayato C, Dorta RL, Gonzalez-Nunez V, Barreto-Valer K, Marcelo F, Calle LP, Vázquez JT, Rodríguez RE, Jiménez-Barbero J, Valencia G.

Org Biomol Chem. 2011 Sep 7;9(17):6133-42. doi: 10.1039/c1ob05197k. Epub 2011 Jul 19.

PMID:
21773621
17.

Retrospective Mapping of SAR Data for TTR Protein in Chemico-Biological Space Using Ligand Efficiency Indices as a Guide to Drug Discovery Strategies.

Blasi D, Arsequell G, Valencia G, Nieto J, Planas A, Pinto M, Centeno NB, Abad-Zapatero C, Quintana J.

Mol Inform. 2011 Mar 14;30(2-3):161-7. doi: 10.1002/minf.201000157. Epub 2011 Mar 18.

PMID:
27466770
18.

Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.

González A, Quirante J, Nieto J, Almeida MR, Saraiva MJ, Planas A, Arsequell G, Valencia G.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5270-3. doi: 10.1016/j.bmcl.2009.03.004. Epub 2009 Mar 6.

PMID:
19651509
19.

Synthesis, conformation, and biological characterization of a sugar derivative of morphine that is a potent, long-lasting, and nontolerant antinociceptive.

Arsequell G, Salvatella M, Valencia G, Fernández-Mayoralas A, Fontanella M, Venturi C, Jiménez-Barbero J, Marrón E, Rodríguez RE.

J Med Chem. 2009 May 14;52(9):2656-66. doi: 10.1021/jm8011245.

PMID:
19351163
20.

Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.

Mairal T, Nieto J, Pinto M, Almeida MR, Gales L, Ballesteros A, Barluenga J, Pérez JJ, Vázquez JT, Centeno NB, Saraiva MJ, Damas AM, Planas A, Arsequell G, Valencia G.

PLoS One. 2009;4(1):e4124. doi: 10.1371/journal.pone.0004124. Epub 2009 Jan 6.

21.

Arylation of Phe and Tyr side chains of unprotected peptides by a Suzuki-Miyaura reaction in water.

Vilaró M, Arsequell G, Valencia G, Ballesteros A, Barluenga J.

Org Lett. 2008 Aug 7;10(15):3243-5. doi: 10.1021/ol801009z. Epub 2008 Jul 4.

PMID:
18598051
22.

Iodination of salicylic acid improves its binding to transthyretin.

Gales L, Almeida MR, Arsequell G, Valencia G, Saraiva MJ, Damas AM.

Biochim Biophys Acta. 2008 Mar;1784(3):512-7. Epub 2007 Dec 3.

PMID:
18155178
23.

Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design.

Cardoso I, Almeida MR, Ferreira N, Arsequell G, Valencia G, Saraiva MJ.

Biochem J. 2007 Nov 15;408(1):131-8.

24.

Identification of dynorphin a from zebrafish: a comparative study with mammalian dynorphin A.

Gonzalez-Nuñez V, Marrón Fernández de Velasco E, Arsequell G, Valencia G, Rodríguez RE.

Neuroscience. 2007 Jan 19;144(2):675-84. Epub 2006 Oct 25.

PMID:
17069980
25.

Iodination of proteins by IPy2BF4, a new tool in protein chemistry.

Espuña G, Andreu D, Barluenga J, Pérez X, Planas A, Arsequell G, Valencia G.

Biochemistry. 2006 May 16;45(19):5957-63.

PMID:
16681367
26.

Binding profile of the endogenous novel heptapeptide Met-enkephalin-Gly-tyr in zebrafish and rat brain.

González-Nuñez V, Arsequell G, Szemenyei E, Toth G, Valencia G, Rodriguez RE.

J Pharmacol Exp Ther. 2005 Aug;314(2):862-7. Epub 2005 May 18.

PMID:
15901806
27.

Kinetic assay for high-throughput screening of in vitro transthyretin amyloid fibrillogenesis inhibitors.

Dolado I, Nieto J, Saraiva MJ, Arsequell G, Valencia G, Planas A.

J Comb Chem. 2005 Mar-Apr;7(2):246-52.

PMID:
15762752
28.

Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor.

Gales L, Macedo-Ribeiro S, Arsequell G, Valencia G, Saraiva MJ, Damas AM.

Biochem J. 2005 Jun 1;388(Pt 2):615-21.

29.

Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative.

Almeida MR, Macedo B, Cardoso I, Alves I, Valencia G, Arsequell G, Planas A, Saraiva MJ.

Biochem J. 2004 Jul 15;381(Pt 2):351-6.

30.

A highly toxic morphine-3-glucuronide derivative.

Salvatella M, Arsequell G, Valencia G, Rodríguez RE.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):905-8.

PMID:
15012991
31.

Regioselective postsynthetic modification of phenylalanine side chains of peptides leading to uncommon ortho-iodinated analogues.

Espuña G, Arsequell G, Valencia G, Barluenga J, Alvarez-Gutiérrez JM, Ballesteros A, González JM.

Angew Chem Int Ed Engl. 2004 Jan 3;43(3):325-9. No abstract available.

PMID:
14705088
32.

Lectin purified human class I MHC-derived peptides: evidence for presentation of glycopeptides in vivo.

Kastrup IB, Stevanovic S, Arsequell G, Valencia G, Zeuthen J, Rammensee HG, Elliott T, Haurum JS.

Tissue Antigens. 2000 Aug;56(2):129-35.

PMID:
11019912
33.

Phosphorylated peptides can be transported by TAP molecules, presented by class I MHC molecules, and recognized by phosphopeptide-specific CTL.

Andersen MH, Bonfill JE, Neisig A, Arsequell G, Sondergaard I, Valencia G, Neefjes J, Zeuthen J, Elliott T, Haurum JS.

J Immunol. 1999 Oct 1;163(7):3812-8. Erratum in: J Immunol 2000 May 15;164(10):5531.

34.

Presentation of cytosolic glycosylated peptides by human class I major histocompatibility complex molecules in vivo.

Haurum JS, Høier IB, Arsequell G, Neisig A, Valencia G, Zeuthen J, Neefjes J, Elliott T.

J Exp Med. 1999 Jul 5;190(1):145-50.

35.

Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity.

Glithero A, Tormo J, Haurum JS, Arsequell G, Valencia G, Edwards J, Springer S, Townsend A, Pao YL, Wormald M, Dwek RA, Jones EY, Elliott T.

Immunity. 1999 Jan;10(1):63-74.

36.

Peptide anchor residue glycosylation: effect on class I major histocompatibility complex binding and cytotoxic T lymphocyte recognition.

Haurum JS, Tan L, Arsequell G, Frodsham P, Lellouch AC, Moss PA, Dwek RA, McMichael AJ, Elliott T.

Eur J Immunol. 1995 Dec;25(12):3270-6.

PMID:
8566011
37.

Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes.

Haurum JS, Arsequell G, Lellouch AC, Wong SY, Dwek RA, McMichael AJ, Elliott T.

J Exp Med. 1994 Aug 1;180(2):739-44.

40.

Sex pheromone biosynthesis in the processionary moth Thaumetopoea pityocampa by delta-13 desaturation.

Arsequell G, Fabriàs G, Camps F.

Arch Insect Biochem Physiol. 1990;14(1):47-56.

PMID:
2134170

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