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Items: 38

1.

Ectonucleotidases in Blood Malignancies: A Tale of Surface Markers and Therapeutic Targets.

Vaisitti T, Arruga F, Guerra G, Deaglio S.

Front Immunol. 2019 Oct 4;10:2301. doi: 10.3389/fimmu.2019.02301. eCollection 2019. Review.

2.

HaTSPiL: A modular pipeline for high-throughput sequencing data analysis.

Morandi E, Cereda M, Incarnato D, Parlato C, Basile G, Anselmi F, Lauria A, Simon LM, Laurence Polignano I, Arruga F, Deaglio S, Tirtei E, Fagioli F, Oliviero S.

PLoS One. 2019 Oct 15;14(10):e0222512. doi: 10.1371/journal.pone.0222512. eCollection 2019.

3.

Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications.

Arruga F, Bracciamà V, Vitale N, Vaisitti T, Gizzi K, Yeomans A, Coscia M, D'Arena G, Gaidano G, Allan JN, Furman RR, Packham G, Forconi F, Deaglio S.

Leukemia. 2019 Aug 29. doi: 10.1038/s41375-019-0571-0. [Epub ahead of print]

PMID:
31467429
4.

Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia.

Diop F, Moia R, Favini C, Spaccarotella E, De Paoli L, Bruscaggin A, Spina V, Terzi-di-Bergamo L, Arruga F, Tarantelli C, Deambrogi C, Rasi S, Adhinaveni R, Patriarca A, Favini S, Sagiraju S, Jabangwe C, Kodipad AA, Peroni D, Mauro FR, Del Giudice I, Forconi F, Cortelezzi A, Zaja F, Bomben R, Rossi FM, Visco C, Chiarenza A, Rigolin GM, Marasca R, Coscia M, Perbellini O, Tedeschi A, Laurenti L, Motta M, Donaldson D, Weir P, Mills K, Thornton P, Lawless S, Bertoni F, Del Poeta G, Cuneo A, Follenzi A, Gattei V, Boldorini RL, Catherwood M, Deaglio S, Foá R, Gaidano G, Rossi D.

Haematologica. 2019 Aug 1. pii: haematol.2019.219550. doi: 10.3324/haematol.2019.219550. [Epub ahead of print]

5.

The NOTCH Pathway and Its Mutations in Mature B Cell Malignancies.

Arruga F, Vaisitti T, Deaglio S.

Front Oncol. 2018 Nov 26;8:550. doi: 10.3389/fonc.2018.00550. eCollection 2018. Review.

6.

Novel Richter Syndrome Xenograft Models to Study Genetic Architecture, Biology, and Therapy Responses.

Vaisitti T, Braggio E, Allan JN, Arruga F, Serra S, Zamò A, Tam W, Chadburn A, Furman RR, Deaglio S.

Cancer Res. 2018 Jul 1;78(13):3413-3420. doi: 10.1158/0008-5472.CAN-17-4004. Epub 2018 May 7.

7.

Targeting the Adenosinergic Axis in Chronic Lymphocytic Leukemia: A Way to Disrupt the Tumor Niche?

Vaisitti T, Arruga F, Deaglio S.

Int J Mol Sci. 2018 Apr 12;19(4). pii: E1167. doi: 10.3390/ijms19041167. Review.

8.

Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma.

Audrito V, Managò A, La Vecchia S, Zamporlini F, Vitale N, Baroni G, Cignetto S, Serra S, Bologna C, Stingi A, Arruga F, Vaisitti T, Massi D, Mandalà M, Raffaelli N, Deaglio S.

J Natl Cancer Inst. 2018 Mar 1;110(3). doi: 10.1093/jnci/djx198.

PMID:
29309612
9.

Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor.

Vaisitti T, Gaudino F, Ouk S, Moscvin M, Vitale N, Serra S, Arruga F, Zakrzewski JL, Liou HC, Allan JN, Furman RR, Deaglio S.

Haematologica. 2017 Nov;102(11):1878-1889. doi: 10.3324/haematol.2017.173419. Epub 2017 Aug 31.

10.

Mechanisms of Resistance to Targeted Therapies in Chronic Lymphocytic Leukemia.

Arruga F, Deaglio S.

Handb Exp Pharmacol. 2018;249:203-229. doi: 10.1007/164_2017_12. Review.

PMID:
28275912
11.

Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22.

Arruga F, Gizdic B, Bologna C, Cignetto S, Buonincontri R, Serra S, Vaisitti T, Gizzi K, Vitale N, Garaffo G, Mereu E, Diop F, Neri F, Incarnato D, Coscia M, Allan J, Piva R, Oliviero S, Furman RR, Rossi D, Gaidano G, Deaglio S.

Leukemia. 2017 Sep;31(9):1882-1893. doi: 10.1038/leu.2016.383. Epub 2016 Dec 26.

PMID:
28017968
12.

Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment.

Serra S, Vaisitti T, Audrito V, Bologna C, Buonincontri R, Chen SS, Arruga F, Brusa D, Coscia M, Jaksic O, Inghirami G, Rossi D, Furman RR, Robson SC, Gaidano G, Chiorazzi N, Deaglio S.

Blood Adv. 2016 Nov 22;1(1):47-61. doi: 10.1182/bloodadvances.2016000984. eCollection 2016 Nov 29.

13.

NOTCH1 mutations associate with low CD20 level in chronic lymphocytic leukemia: evidence for a NOTCH1 mutation-driven epigenetic dysregulation.

Pozzo F, Bittolo T, Arruga F, Bulian P, Macor P, Tissino E, Gizdic B, Rossi FM, Bomben R, Zucchetto A, Benedetti D, Degan M, D'Arena G, Chiarenza A, Zaja F, Pozzato G, Rossi D, Gaidano G, Del Poeta G, Deaglio S, Gattei V, Dal Bo M.

Leukemia. 2016 Jan;30(1):182-9. doi: 10.1038/leu.2015.182. Epub 2015 Jul 13.

PMID:
26165233
14.

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia.

Audrito V, Serra S, Brusa D, Mazzola F, Arruga F, Vaisitti T, Coscia M, Maffei R, Rossi D, Wang T, Inghirami G, Rizzi M, Gaidano G, Garcia JG, Wolberger C, Raffaelli N, Deaglio S.

Blood. 2015 Jan 1;125(1):111-23. doi: 10.1182/blood-2014-07-589069. Epub 2014 Nov 3.

15.

Multiple metamorphoses of CD38 from prognostic marker to disease modifier to therapeutic target in chronic lymphocytic leukemia.

Vaisitti T, Audrito V, Serra S, Bologna C, Arruga F, Brusa D, Buonincontri R, Gizdic B, Deaglio S.

Curr Top Med Chem. 2013;13(23):2955-64. Review.

PMID:
24171772
16.

Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia.

Arruga F, Gizdic B, Serra S, Vaisitti T, Ciardullo C, Coscia M, Laurenti L, D'Arena G, Jaksic O, Inghirami G, Rossi D, Gaidano G, Deaglio S.

Leukemia. 2014 May;28(5):1060-70. doi: 10.1038/leu.2013.319. Epub 2013 Oct 30.

PMID:
24170027
17.

The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development.

Rossi D, Trifonov V, Fangazio M, Bruscaggin A, Rasi S, Spina V, Monti S, Vaisitti T, Arruga F, Famà R, Ciardullo C, Greco M, Cresta S, Piranda D, Holmes A, Fabbri G, Messina M, Rinaldi A, Wang J, Agostinelli C, Piccaluga PP, Lucioni M, Tabbò F, Serra R, Franceschetti S, Deambrogi C, Daniele G, Gattei V, Marasca R, Facchetti F, Arcaini L, Inghirami G, Bertoni F, Pileri SA, Deaglio S, Foà R, Dalla-Favera R, Pasqualucci L, Rabadan R, Gaidano G.

J Exp Med. 2012 Aug 27;209(9):1537-51. doi: 10.1084/jem.20120904. Epub 2012 Aug 13.

18.

Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging.

Messa E, Carturan S, Maffè C, Pautasso M, Bracco E, Roetto A, Messa F, Arruga F, Defilippi I, Rosso V, Zanone C, Rotolo A, Greco E, Pellegrino RM, Alberti D, Saglio G, Cilloni D.

Haematologica. 2010 Aug;95(8):1308-16. doi: 10.3324/haematol.2009.016824. Epub 2010 Jun 9.

19.

WITHDRAWN: Proteinase 3 (PR3) gene is highly expressed in CBF leukemias and codes for a protein with abnormal nuclear localization that confers drug sensitivity.

Cilloni D, Carturan S, Maffè C, Messa F, Arruga F, Messa E, Pradotto M, Pautasso M, Zanone C, Fornaciari P, Defilippi I, Rotolo A, Greco E, Iacobucci I, Martinelli G, Lo-Coco F, Bracco E, Saglio G.

Leukemia. 2010 Jan 14. [Epub ahead of print]

PMID:
20072158
20.

FOXO transcription factor activity is partially retained in quiescent CML stem cells and induced by tyrosine kinase inhibitors in CML progenitor cells.

Pellicano F, Cilloni D, Helgason GV, Messa F, Panuzzo C, Arruga F, Bracco E, Allan E, Huntly BJ, Holyoake TL, Saglio G.

Blood. 2009 Dec 1. doi: 10.1182/blood-2009-06-226621. Epub 2009 Dec 1. Retraction in: Blood. 2010 Apr 8;115(14):2983.

PMID:
19965658
21.

Different isoforms of the B-cell mutator activation-induced cytidine deaminase are aberrantly expressed in BCR-ABL1-positive acute lymphoblastic leukemia patients.

Iacobucci I, Lonetti A, Messa F, Ferrari A, Cilloni D, Soverini S, Paoloni F, Arruga F, Ottaviani E, Chiaretti S, Messina M, Vignetti M, Papayannidis C, Vitale A, Pane F, Piccaluga PP, Paolini S, Berton G, Baruzzi A, Saglio G, Baccarani M, Foà R, Martinelli G.

Leukemia. 2010 Jan;24(1):66-73. doi: 10.1038/leu.2009.197. Epub 2009 Sep 17.

PMID:
19759560
22.

Identification of different Ikaros cDNA transcripts in Philadelphia-positive adult acute lymphoblastic leukemia by a high-throughput capillary electrophoresis sizing method.

Iacobucci I, Lonetti A, Cilloni D, Messa F, Ferrari A, Zuntini R, Ferrari S, Ottaviani E, Arruga F, Paolini S, Papayannidis C, Piccaluga PP, Soverini S, Saglio G, Pane F, Baruzzi A, Vignetti M, Berton G, Vitale A, Chiaretti S, Müschen M, Foà R, Baccarani M, Martinelli G.

Haematologica. 2008 Dec;93(12):1814-21. doi: 10.3324/haematol.13260. Epub 2008 Oct 6. Erratum in: Haematologica. 2010 Jun;95(6):1033.

23.

Deferasirox treatment improved the hemoglobin level and decreased transfusion requirements in four patients with the myelodysplastic syndrome and primary myelofibrosis.

Messa E, Cilloni D, Messa F, Arruga F, Roetto A, Saglio G.

Acta Haematol. 2008;120(2):70-4. doi: 10.1159/000158631. Epub 2008 Oct 1.

PMID:
18827475
24.

Detection of humoral immune responses against WT1 antigen in patients affected by different hematological malignancies.

Nicoli P, Defilippi I, Carturan S, Roetto A, Messa F, Arruga F, Messa E, Rotolo A, Iacobucci I, Bracco E, Saglio G, Cilloni D.

Acta Haematol. 2008;120(1):47-50. doi: 10.1159/000158576. Epub 2008 Sep 30. No abstract available.

PMID:
18824841
25.

Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance.

Iacobucci I, Lonetti A, Messa F, Cilloni D, Arruga F, Ottaviani E, Paolini S, Papayannidis C, Piccaluga PP, Giannoulia P, Soverini S, Amabile M, Poerio A, Saglio G, Pane F, Berton G, Baruzzi A, Vitale A, Chiaretti S, Perini G, Foà R, Baccarani M, Martinelli G.

Blood. 2008 Nov 1;112(9):3847-55. doi: 10.1182/blood-2007-09-112631. Epub 2008 Jul 23. Erratum in: Blood. 2010 Sep 23;116(12):2196.

PMID:
18650450
26.

Early prediction of treatment outcome in acute myeloid leukemia by measurement of WT1 transcript levels in peripheral blood samples collected after chemotherapy.

Cilloni D, Messa F, Arruga F, Defilippi I, Gottardi E, Fava M, Carturan S, Catalano R, Bracco E, Messa E, Nicoli P, Diverio D, Sanz MA, Martinelli G, Lo-Coco F, Saglio G.

Haematologica. 2008 Jun;93(6):921-4. doi: 10.3324/haematol.12165. Epub 2008 Apr 28.

27.

Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-kappaB in AML carrying NPM1 mutations.

Cilloni D, Messa F, Rosso V, Arruga F, Defilippi I, Carturan S, Catalano R, Pautasso M, Panuzzo C, Nicoli P, Messa E, Morotti A, Iacobucci I, Martinelli G, Bracco E, Saglio G.

Leukemia. 2008 Jun;22(6):1234-40. doi: 10.1038/leu.2008.68. Epub 2008 Apr 10. Retraction in: Leukemia. 2010 May;24(5):1103.

PMID:
18401421
28.

WT1 transcript amount discriminates secondary or reactive eosinophilia from idiopathic hypereosinophilic syndrome or chronic eosinophilic leukemia.

Cilloni D, Messa F, Martinelli G, Gottardi E, Arruga F, Defilippi I, Carturan S, Messa E, Fava M, Giugliano E, Rosso V, Catalano R, Merante S, Nicoli P, Rondoni M, Ottaviani E, Soverini S, Tiribelli M, Pane F, Baccarani M, Saglio G.

Leukemia. 2007 Jul;21(7):1442-50. Epub 2007 May 17.

PMID:
17508006
29.

CD7/CD56-positive acute myeloid leukemias are characterized by constitutive phosphorylation of the NF-kB subunit p65 at Ser536.

Morotti A, Parvis G, Cilloni D, Familiari U, Pautasso M, Bosa M, Messa F, Arruga F, Defilippi I, Catalano R, Rosso V, Carturan S, Bracco E, Guerrasio A, Saglio G.

Leukemia. 2007 Jun;21(6):1305-6. Epub 2007 Mar 22. No abstract available.

PMID:
17377595
30.

[Cardiology in the general hospital center, example of Blois].

Rodon C, Arruga F.

Soins. 2007 Jan-Feb;(712 Suppl):S19-21. French. No abstract available.

PMID:
17375598
31.

Genetic abnormalities as targets for molecular therapies in myelodysplastic syndromes.

Cilloni D, Messa E, Messa F, Carturan S, Defilippi I, Arruga F, Rosso V, Catalano R, Bracco E, Nicoli P, Saglio G.

Ann N Y Acad Sci. 2006 Nov;1089:411-23. Review.

PMID:
17261784
32.

NF-kB inhibition as a strategy to enhance etoposide-induced apoptosis in K562 cell line.

Morotti A, Cilloni D, Pautasso M, Messa F, Arruga F, Defilippi I, Carturan S, Catalano R, Rosso V, Chiarenza A, Taulli R, Bracco E, Rege-Cambrin G, Gottardi E, Saglio G.

Am J Hematol. 2006 Dec;81(12):938-45.

33.

Valproate enhances imatinib-induced growth arrest and apoptosis in chronic myeloid leukemia cells.

Morotti A, Cilloni D, Messa F, Arruga F, Defilippi I, Carturan S, Catalano R, Rosso V, Chiarenza A, Pilatrino C, Guerrasio A, Taulli R, Bracco E, Pautasso M, Baraban D, Gottardi E, Saglio G.

Cancer. 2006 Mar 1;106(5):1188-96.

34.

The NF-kappaB pathway blockade by the IKK inhibitor PS1145 can overcome imatinib resistance.

Cilloni D, Messa F, Arruga F, Defilippi I, Morotti A, Messa E, Carturan S, Giugliano E, Pautasso M, Bracco E, Rosso V, Sen A, Martinelli G, Baccarani M, Saglio G.

Leukemia. 2006 Jan;20(1):61-7.

PMID:
16270044
35.

WT1 overexpression: a clinically useful marker in acute and chronic myeloid leukemias.

Saglio G, Carturan S, Grillo S, Capella S, Arruga F, Defilippi I, Rosso V, Rauco M, Marina Liberati A, Cilloni D.

Hematology. 2005;10 Suppl 1:76-8. Review. No abstract available.

PMID:
16188642
36.

Myelodysplastic syndromes.

Cilloni D, Messa F, Carturan S, Arruga F, Defilippi I, Messa E, Gottardi E, Saglio G.

Ann N Y Acad Sci. 2004 Dec;1028:400-8. Review.

PMID:
15650265
37.

Sensitivity to imatinib therapy may be predicted by testing Wilms tumor gene expression and colony growth after a short in vitro incubation.

Cilloni D, Messa F, Gottardi E, Fava M, Arruga F, Defilippi I, Carturan S, Messa E, Morotti A, Giugliano E, Rege-Cambrin G, Alberti D, Baccarani M, Saglio G.

Cancer. 2004 Sep 1;101(5):979-88.

38.

Usefulness of the quantitative assessment of PRV-1 gene expression for the diagnosis of polycythemia vera and essential thrombocythemia patients.

Cilloni D, Carturan S, Gottardi E, Messa F, Fava M, Defilippi I, Arruga F, Saglio G.

Blood. 2004 Mar 15;103(6):2428; author reply 2429. No abstract available.

PMID:
14998918

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