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Items: 31

1.

Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies.

Sánchez-Fernández EM, García-Moreno MI, Arroba AI, Aguilar-Diosdado M, Padrón JM, García-Hernández R, Gamarro F, Fustero S, Sánchez-Aparicio JE, Masgrau L, García Fernández JM, Ortiz Mellet C.

Eur J Med Chem. 2019 Aug 8;182:111604. doi: 10.1016/j.ejmech.2019.111604. [Epub ahead of print]

PMID:
31425910
2.

Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury.

Villar-Lorenzo A, Rada P, Rey E, Marañón P, Arroba AI, Santamaría B, Sáiz J, Rupérez FJ, Barbas C, García-Monzón C, Valverde ÁM, González-Rodríguez Á.

Dis Model Mech. 2019 Jul 16;12(7). pii: dmm038810. doi: 10.1242/dmm.038810.

3.

IGF-1, Inflammation and Retinal Degeneration: A Close Network.

Arroba AI, Campos-Caro A, Aguilar-Diosdado M, Valverde ÁM.

Front Aging Neurosci. 2018 Jul 5;10:203. doi: 10.3389/fnagi.2018.00203. eCollection 2018. Review.

4.

The sp2-iminosugar glycolipid 1-dodecylsulfonyl-5N,6O-oxomethylidenenojirimycin (DSO2-ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants.

Alcalde-Estévez E, Arroba AI, Sánchez-Fernández EM, Mellet CO, García Fernández JM, Masgrau L, Valverde ÁM.

Food Chem Toxicol. 2018 Jan;111:454-466. doi: 10.1016/j.fct.2017.11.050. Epub 2017 Nov 27.

PMID:
29191728
5.

Somatostatin protects human retinal pericytes from inflammation mediated by microglia.

Mazzeo A, Arroba AI, Beltramo E, Valverde AM, Porta M.

Exp Eye Res. 2017 Nov;164:46-54. doi: 10.1016/j.exer.2017.07.011. Epub 2017 Jul 20.

PMID:
28734673
6.

Modulation of microglia in the retina: new insights into diabetic retinopathy.

Arroba AI, Valverde ÁM.

Acta Diabetol. 2017 Jun;54(6):527-533. doi: 10.1007/s00592-017-0984-z. Epub 2017 Mar 27. Review.

PMID:
28349217
7.

Imbalance between pro-apoptotic and pro-survival factors in human retinal pericytes in diabetic-like conditions.

Beltramo E, Arroba AI, Mazzeo A, Valverde AM, Porta M.

Acta Ophthalmol. 2018 Feb;96(1):e19-e26. doi: 10.1111/aos.13377. Epub 2017 Jan 27.

8.

Somatostatin protects photoreceptor cells against high glucose-induced apoptosis.

Arroba AI, Mazzeo A, Cazzoni D, Beltramo E, Hernández C, Porta M, Simó R, Valverde ÁM.

Mol Vis. 2016 Dec 30;22:1522-1531. eCollection 2016.

9.

A novel glucagon-like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice.

Valdecantos MP, Pardo V, Ruiz L, Castro-Sánchez L, Lanzón B, Fernández-Millán E, García-Monzón C, Arroba AI, González-Rodríguez Á, Escrivá F, Álvarez C, Rupérez FJ, Barbas C, Konkar A, Naylor J, Hornigold D, Santos AD, Bednarek M, Grimsby J, Rondinone CM, Valverde ÁM.

Hepatology. 2017 Mar;65(3):950-968. doi: 10.1002/hep.28962. Epub 2017 Jan 30.

PMID:
27880981
10.

Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.

García-Casarrubios E, de Moura C, Arroba AI, Pescador N, Calderon-Dominguez M, Garcia L, Herrero L, Serra D, Cadenas S, Reis F, Carvalho E, Obregon MJ, Valverde ÁM.

Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):1929-1941. doi: 10.1016/j.bbalip.2016.09.016. Epub 2016 Sep 26.

PMID:
27686967
11.

Friedelane-type triterpenoids as selective anti-inflammatory agents by regulation of differential signaling pathways in LPS-stimulated macrophages.

Villar-Lorenzo A, Ardiles AE, Arroba AI, Hernández-Jiménez E, Pardo V, López-Collazo E, Jiménez IA, Bazzocchi IL, González-Rodríguez Á, Valverde ÁM.

Toxicol Appl Pharmacol. 2016 Dec 15;313:57-67. doi: 10.1016/j.taap.2016.10.004. Epub 2016 Oct 15.

PMID:
27751938
12.

Effects of the neuroprotective drugs somatostatin and brimonidine on retinal cell models of diabetic retinopathy.

Beltramo E, Lopatina T, Mazzeo A, Arroba AI, Valverde AM, Hernández C, Simó R, Porta M.

Acta Diabetol. 2016 Dec;53(6):957-964. doi: 10.1007/s00592-016-0895-4. Epub 2016 Aug 23.

PMID:
27552833
13.

Autophagy resolves early retinal inflammation in Igf1-deficient mice.

Arroba AI, Rodríguez-de la Rosa L, Murillo-Cuesta S, Vaquero-Villanueva L, Hurlé JM, Varela-Nieto I, Valverde ÁM.

Dis Model Mech. 2016 Sep 1;9(9):965-74. doi: 10.1242/dmm.026344. Epub 2016 Jul 21.

14.

Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice.

Arroba AI, Alcalde-Estevez E, García-Ramírez M, Cazzoni D, de la Villa P, Sánchez-Fernández EM, Mellet CO, García Fernández JM, Hernández C, Simó R, Valverde ÁM.

Biochim Biophys Acta. 2016 Sep;1862(9):1663-74. doi: 10.1016/j.bbadis.2016.05.024. Epub 2016 Jun 4. No abstract available.

15.

Inhibition of Protein Tyrosine Phosphatase 1B Improves IGF-I Receptor Signaling and Protects Against Inflammation-Induced Gliosis in the Retina.

Arroba AI, Valverde ÁM.

Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8031-44. doi: 10.1167/iovs.15-17234.

16.

Topical Administration of GLP-1 Receptor Agonists Prevents Retinal Neurodegeneration in Experimental Diabetes.

Hernández C, Bogdanov P, Corraliza L, García-Ramírez M, Solà-Adell C, Arranz JA, Arroba AI, Valverde AM, Simó R.

Diabetes. 2016 Jan;65(1):172-87. doi: 10.2337/db15-0443. Epub 2015 Sep 17.

17.

Microglia-Müller glia crosstalk in the rd10 mouse model of retinitis pigmentosa.

Arroba AI, Alvarez-Lindo N, van Rooijen N, de la Rosa EJ.

Adv Exp Med Biol. 2014;801:373-9. doi: 10.1007/978-1-4614-3209-8_47.

PMID:
24664720
18.

Spontaneous generation of infectious prion disease in transgenic mice.

Torres JM, Castilla J, Pintado B, Gutiérrez-Adan A, Andréoletti O, Aguilar-Calvo P, Arroba AI, Parra-Arrondo B, Ferrer I, Manzanares J, Espinosa JC.

Emerg Infect Dis. 2013 Dec;19(12):1938-47. doi: 10.3201/eid1912.130106.

19.

Loss of protein tyrosine phosphatase 1B increases IGF-I receptor tyrosine phosphorylation but does not rescue retinal defects in IRS2-deficient mice.

Arroba AI, Revuelta-Cervantes J, Menes L, González-Rodríguez Á, Pardo V, de la Villa P, Burks DJ, Valverde ÁM.

Invest Ophthalmol Vis Sci. 2013 Jun 19;54(6):4215-25. doi: 10.1167/iovs.12-11438.

PMID:
23702782
20.

Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells.

Vázquez P, Arroba AI, Cecconi F, de la Rosa EJ, Boya P, de Pablo F.

Autophagy. 2012 Feb 1;8(2):187-99. doi: 10.4161/auto.8.2.18535. Epub 2012 Feb 1.

PMID:
22240590
21.

Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pigmentosa.

Arroba AI, Alvarez-Lindo N, van Rooijen N, de la Rosa EJ.

Invest Ophthalmol Vis Sci. 2011 Nov 25;52(12):9124-30. doi: 10.1167/iovs.11-7736.

PMID:
22039242
22.

IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death.

Arroba AI, Wallace D, Mackey A, de la Rosa EJ, Cotter TG.

Eur J Neurosci. 2009 Sep;30(6):975-86. doi: 10.1111/j.1460-9568.2009.06902.x. Epub 2009 Sep 1.

PMID:
19723289
23.

Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa.

Corrochano S, Barhoum R, Boya P, Arroba AI, Rodríguez-Muela N, Gómez-Vicente V, Bosch F, de Pablo F, de la Villa P, de la Rosa EJ.

Invest Ophthalmol Vis Sci. 2008 Sep;49(9):4188-94. doi: 10.1167/iovs.08-2182. Epub 2008 May 30.

24.

Cell-specific expression of X-linked inhibitor of apoptosis in the anterior pituitary of streptozotocin-induced diabetic rats.

Arroba AI, Lechuga-Sancho AM, Frago LM, Argente J, Chowen JA.

J Endocrinol. 2007 Jan;192(1):215-27.

PMID:
17210759
25.

Increased apoptosis of lactotrophs in streptozotocin-induced diabetic rats is followed by increased proliferation.

Arroba AI, Lechuga-Sancho AM, Frago LM, Argente J, Chowen JA.

J Endocrinol. 2006 Oct;191(1):55-63.

PMID:
17065389
26.

Reduction in the number of astrocytes and their projections is associated with increased synaptic protein density in the hypothalamus of poorly controlled diabetic rats.

Lechuga-Sancho AM, Arroba AI, Frago LM, García-Cáceres C, de Célix AD, Argente J, Chowen JA.

Endocrinology. 2006 Nov;147(11):5314-24. Epub 2006 Jul 27.

PMID:
16873533
27.

Activation of the intrinsic cell death pathway, increased apoptosis and modulation of astrocytes in the cerebellum of diabetic rats.

Lechuga-Sancho AM, Arroba AI, Frago LM, Pañeda C, García-Cáceres C, Delgado Rubín de Célix A, Argente J, Chowen JA.

Neurobiol Dis. 2006 Aug;23(2):290-9. Epub 2006 Jun 6.

PMID:
16753303
28.

Activation of caspase 8 in the pituitaries of streptozotocin-induced diabetic rats: implication in increased apoptosis of lactotrophs.

Arroba AI, Frago LM, Argente J, Chowen JA.

Endocrinology. 2005 Oct;146(10):4417-24. Epub 2005 Jun 23.

PMID:
15976052
29.
30.

Growth hormone-releasing peptide-6 inhibits cerebellar cell death in aged rats.

Pañeda C, Arroba AI, Frago LM, Holm AM, Rømer J, Argente J, Chowen JA.

Neuroreport. 2003 Aug 26;14(12):1633-5.

PMID:
14502090
31.

The number of lactotrophs is reduced in the anterior pituitary of streptozotocin-induced diabetic rats.

Arroba AI, Frago LM, Pañeda C, Argente J, Chowen JA.

Diabetologia. 2003 May;46(5):634-8. Epub 2003 May 13.

PMID:
12743699

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