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Items: 13


Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.

Koundinya M, Sudhalter J, Courjaud A, Lionne B, Touyer G, Bonnet L, Menguy I, Schreiber I, Perrault C, Vougier S, Benhamou B, Zhang B, He T, Gao Q, Gee P, Simard D, Castaldi MP, Tomlinson R, Reiling S, Barrague M, Newcombe R, Cao H, Wang Y, Sun F, Murtie J, Munson M, Yang E, Harper D, Bouaboula M, Pollard J, Grepin C, Garcia-Echeverria C, Cheng H, Adrian F, Winter C, Licht S, Cornella-Taracido I, Arrebola R, Morris A.

Cell Chem Biol. 2018 Jun 21;25(6):705-717.e11. doi: 10.1016/j.chembiol.2018.03.005. Epub 2018 Apr 5.


A Robust Multiplex Mass Spectrometric Assay for Screening Small-Molecule Inhibitors of CD73 with Diverse Inhibition Modalities.

McManus J, He T, Gavigan JA, Marchand G, Vougier S, Bedel O, Ferrari P, Arrebola R, Gillespy T, Gregory RC, Licht S, Cheng H, Zhang B, Deng G.

SLAS Discov. 2018 Mar;23(3):264-273. doi: 10.1177/2472555217750386. Epub 2018 Jan 16.


Tricyclic series of heat shock protein 90 (Hsp90) inhibitors part I: discovery of tricyclic imidazo[4,5-c]pyridines as potent inhibitors of the Hsp90 molecular chaperone.

Vallée F, Carrez C, Pilorge F, Dupuy A, Parent A, Bertin L, Thompson F, Ferrari P, Fassy F, Lamberton A, Thomas A, Arrebola R, Guerif S, Rohaut A, Certal V, Ruxer JM, Gouyon T, Delorme C, Jouanen A, Dumas J, Grépin C, Combeau C, Goulaouic H, Dereu N, Mikol V, Mailliet P, Minoux H.

J Med Chem. 2011 Oct 27;54(20):7206-19. doi: 10.1021/jm200784m. Epub 2011 Oct 5. Erratum in: J Med Chem. 2012 Jan 12;55(1):564. Gouyon, Thierry [added].


Multiple roles of the tau131 subunit of yeast transcription factor IIIC (TFIIIC) in TFIIIB assembly.

Dumay-Odelot H, Acker J, Arrebola R, Sentenac A, Marck C.

Mol Cell Biol. 2002 Jan;22(1):298-308.


A subunit of yeast TFIIIC participates in the recruitment of TATA-binding protein.

Deprez E, Arrebola R, Conesa C, Sentenac A.

Mol Cell Biol. 1999 Dec;19(12):8042-51.


A chimeric subunit of yeast transcription factor IIIC forms a subcomplex with tau95.

Manaud N, Arrebola R, Buffin-Meyer B, Lefebvre O, Voss H, Riva M, Conesa C, Sentenac A.

Mol Cell Biol. 1998 Jun;18(6):3191-200.


Tau91, an essential subunit of yeast transcription factor IIIC, cooperates with tau138 in DNA binding.

Arrebola R, Manaud N, Rozenfeld S, Marsolier MC, Lefebvre O, Carles C, Thuriaux P, Conesa C, Sentenac A.

Mol Cell Biol. 1998 Jan;18(1):1-9.


Description of a novel eukaryotic deoxyuridine 5'-triphosphate nucleotidohydrolase in Leishmania major.

Camacho A, Arrebola R, Peña-Diaz J, Ruiz-Pérez LM, González-Pacanowska D.

Biochem J. 1997 Jul 15;325 ( Pt 2):441-7.


A mutant dihydrofolate reductase-thymidylate synthase from Leishmania major as a selectable marker in transfection experiments.

Arrebola R, Olmo A, Camacho A, Ruiz-Pérez LM, González-Pacanowska D.

Mol Biochem Parasitol. 1996 Jul;79(1):129-33. No abstract available.


Expression and characterization of the Trypanosoma cruzi dihydrofolate reductase domain.

Reche P, Arrebola R, Santi DV, Gonzalez-Pacanowska D, Ruiz-Perez LM.

Mol Biochem Parasitol. 1996 Feb-Mar;76(1-2):175-85.


Co-existence of circular and multiple linear amplicons in methotrexate-resistant Leishmania.

Olmo A, Arrebola R, Bernier V, González-Pacanowska D, Ruiz-Pérez LM.

Nucleic Acids Res. 1995 Aug 11;23(15):2856-64.


Cloning and expression of the dihydrofolate reductase-thymidylate synthase gene from Trypanosoma cruzi.

Reche P, Arrebola R, Olmo A, Santi DV, Gonzalez-Pacanowska D, Ruiz-Perez LM.

Mol Biochem Parasitol. 1994 Jun;65(2):247-58.


Isolation and characterization of a mutant dihydrofolate reductase-thymidylate synthase from methotrexate-resistant Leishmania cells.

Arrebola R, Olmo A, Reche P, Garvey EP, Santi DV, Ruiz-Perez LM, Gonzalez-Pacanowska D.

J Biol Chem. 1994 Apr 8;269(14):10590-6.

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