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Rational Design of an Organocatalyst for Peptide Bond Formation.

Handoko, Satishkumar S, Panigrahi NR, Arora PS.

J Am Chem Soc. 2019 Oct 9;141(40):15977-15985. doi: 10.1021/jacs.9b07742. Epub 2019 Sep 26.


Synthetic Control of Tertiary Helical Structures in Short Peptides.

Wuo MG, Hong SH, Singh A, Arora PS.

J Am Chem Soc. 2018 Nov 28;140(47):16284-16290. doi: 10.1021/jacs.8b10082. Epub 2018 Nov 14.


Hydrogen Bond Surrogate Stabilization of β-Hairpins.

Sawyer N, Arora PS.

ACS Chem Biol. 2018 Aug 17;13(8):2027-2032. doi: 10.1021/acschembio.8b00641. Epub 2018 Jul 18.


Engineered protein scaffolds as leads for synthetic inhibitors of protein-protein interactions.

Wuo MG, Arora PS.

Curr Opin Chem Biol. 2018 Jun;44:16-22. doi: 10.1016/j.cbpa.2018.05.013. Epub 2018 May 24. Review.


Rotamer Libraries for the High-Resolution Design of β-Amino Acid Foldamers.

Watkins AM, Craven TW, Renfrew PD, Arora PS, Bonneau R.

Structure. 2017 Nov 7;25(11):1771-1780.e3. doi: 10.1016/j.str.2017.09.005. Epub 2017 Oct 12.


Iterative Design of a Biomimetic Catalyst for Amino Acid Thioester Condensation.

Wu H, Handoko, Raj M, Arora PS.

Org Lett. 2017 Oct 6;19(19):5122-5125. doi: 10.1021/acs.orglett.7b02412. Epub 2017 Sep 11.


Targeting Unoccupied Surfaces on Protein-Protein Interfaces.

Rooklin D, Modell AE, Li H, Berdan V, Arora PS, Zhang Y.

J Am Chem Soc. 2017 Nov 8;139(44):15560-15563. doi: 10.1021/jacs.7b05960. Epub 2017 Aug 4.


Protein Domain Mimics as Modulators of Protein-Protein Interactions.

Sawyer N, Watkins AM, Arora PS.

Acc Chem Res. 2017 Jun 20;50(6):1313-1322. doi: 10.1021/acs.accounts.7b00130. Epub 2017 May 31. Review.


Modeling and Design of Peptidomimetics to Modulate Protein-Protein Interactions.

Watkins AM, Bonneau R, Arora PS.

Methods Mol Biol. 2017;1561:291-307. doi: 10.1007/978-1-4939-6798-8_17.


Dynamic Phenylalanine Clamp Interactions Define Single-Channel Polypeptide Translocation through the Anthrax Toxin Protective Antigen Channel.

Ghosal K, Colby JM, Das D, Joy ST, Arora PS, Krantz BA.

J Mol Biol. 2017 Mar 24;429(6):900-910. doi: 10.1016/j.jmb.2017.02.005. Epub 2017 Feb 10.


Side-Chain Conformational Preferences Govern Protein-Protein Interactions.

Watkins AM, Bonneau R, Arora PS.

J Am Chem Soc. 2016 Aug 24;138(33):10386-9. doi: 10.1021/jacs.6b04892. Epub 2016 Aug 9.


Systematic Targeting of Protein-Protein Interactions.

Modell AE, Blosser SL, Arora PS.

Trends Pharmacol Sci. 2016 Aug;37(8):702-713. doi: 10.1016/ Epub 2016 Jun 4. Review.


An optimal hydrogen-bond surrogate for α-helices.

Joy ST, Arora PS.

Chem Commun (Camb). 2016 Apr 28;52(33):5738-41. doi: 10.1039/c6cc01104g.


An Effective Strategy for Stabilizing Minimal Coiled Coil Mimetics.

Wuo MG, Mahon AB, Arora PS.

J Am Chem Soc. 2015 Sep 16;137(36):11618-21. doi: 10.1021/jacs.5b05525. Epub 2015 Sep 4.


Protein-Protein Interactions Mediated by Helical Tertiary Structure Motifs.

Watkins AM, Wuo MG, Arora PS.

J Am Chem Soc. 2015 Sep 16;137(36):11622-30. doi: 10.1021/jacs.5b05527. Epub 2015 Sep 4.


AlphaSpace: Fragment-Centric Topographical Mapping To Target Protein-Protein Interaction Interfaces.

Rooklin D, Wang C, Katigbak J, Arora PS, Zhang Y.

J Chem Inf Model. 2015 Aug 24;55(8):1585-99. doi: 10.1021/acs.jcim.5b00103. Epub 2015 Aug 7.


Aldehyde capture ligation for synthesis of native peptide bonds.

Raj M, Wu H, Blosser SL, Vittoria MA, Arora PS.

J Am Chem Soc. 2015 Jun 3;137(21):6932-40. doi: 10.1021/jacs.5b03538. Epub 2015 May 22.


Posterior auricular approach for decompression and drainage of superficial temporal space infections of odontogenic origin.

Thakur G, Bhargava D, Thomas S, Arora PS.

J Maxillofac Oral Surg. 2015 Mar;14(1):119-20. doi: 10.1007/s12663-013-0579-3. Epub 2013 Sep 4.


Structure-based inhibition of protein-protein interactions.

Watkins AM, Arora PS.

Eur J Med Chem. 2015 Apr 13;94:480-8. doi: 10.1016/j.ejmech.2014.09.047. Epub 2014 Sep 16. Review.


Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions.

Lao BB, Drew K, Guarracino DA, Brewer TF, Heindel DW, Bonneau R, Arora PS.

J Am Chem Soc. 2014 Jun 4;136(22):7877-88. doi: 10.1021/ja502310r. Epub 2014 May 23.


Synthesis of hydrogen-bond surrogate α-helices as inhibitors of protein-protein interactions.

Miller SE, Thomson PF, Arora PS.

Curr Protoc Chem Biol. 2014 Jun 3;6(2):101-16. doi: 10.1002/9780470559277.ch130202.


Amyloid fibrils nucleated and organized by DNA origami constructions.

Udomprasert A, Bongiovanni MN, Sha R, Sherman WB, Wang T, Arora PS, Canary JW, Gras SL, Seeman NC.

Nat Nanotechnol. 2014 Jul;9(7):537-41. doi: 10.1038/nnano.2014.102. Epub 2014 Jun 1.


Anatomy of β-strands at protein-protein interfaces.

Watkins AM, Arora PS.

ACS Chem Biol. 2014 Aug 15;9(8):1747-54. doi: 10.1021/cb500241y. Epub 2014 Jun 9.


In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics.

Lao BB, Grishagin I, Mesallati H, Brewer TF, Olenyuk BZ, Arora PS.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7531-6. doi: 10.1073/pnas.1402393111. Epub 2014 May 12.


Effects of side chains in helix nucleation differ from helix propagation.

Miller SE, Watkins AM, Kallenbach NR, Arora PS.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6636-41. doi: 10.1073/pnas.1322833111. Epub 2014 Apr 21.


Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling.

Kushal S, Lao BB, Henchey LK, Dubey R, Mesallati H, Traaseth NJ, Olenyuk BZ, Arora PS.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15602-7. doi: 10.1073/pnas.1312473110. Epub 2013 Sep 9.


HippDB: a database of readily targeted helical protein-protein interactions.

Bergey CM, Watkins AM, Arora PS.

Bioinformatics. 2013 Nov 1;29(21):2806-7. doi: 10.1093/bioinformatics/btt483. Epub 2013 Aug 19.


Adding diverse noncanonical backbones to rosetta: enabling peptidomimetic design.

Drew K, Renfrew PD, Craven TW, Butterfoss GL, Chou FC, Lyskov S, Bullock BN, Watkins A, Labonte JW, Pacella M, Kilambi KP, Leaver-Fay A, Kuhlman B, Gray JJ, Bradley P, Kirshenbaum K, Arora PS, Das R, Bonneau R.

PLoS One. 2013 Jul 15;8(7):e67051. doi: 10.1371/journal.pone.0067051. Print 2013.


Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma.

Xie X, Piao L, Bullock BN, Smith A, Su T, Zhang M, Teknos TN, Arora PS, Pan Q.

Oncogene. 2014 Feb 20;33(8):1037-46. doi: 10.1038/onc.2013.25. Epub 2013 Mar 11.


An orthosteric inhibitor of the RAS-SOS interaction.

Nickerson S, Joy ST, Arora PS, Bar-Sagi D.

Enzymes. 2013;34 Pt. B:25-39. doi: 10.1016/B978-0-12-420146-0.00002-0. Epub 2013 Nov 7. Review.


Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions.

Raj M, Bullock BN, Arora PS.

Bioorg Med Chem. 2013 Jul 15;21(14):4051-7. doi: 10.1016/j.bmc.2012.11.023. Epub 2012 Dec 4.


Reversible α-helix formation controlled by a hydrogen bond surrogate.

Miller SE, Kallenbach NR, Arora PS.

Tetrahedron. 2012 Jun 10;68(23):4434-4437. Epub 2011 Dec 29.


Reversible redox reconfiguration of secondary structures in a designed peptide.

Wang X, Bergenfeld I, Arora PS, Canary JW.

Angew Chem Int Ed Engl. 2012 Nov 26;51(48):12099-101. doi: 10.1002/anie.201206009. Epub 2012 Oct 25. No abstract available.


Nucleation effects in peptide foldamers.

Patgiri A, Joy ST, Arora PS.

J Am Chem Soc. 2012 Jul 18;134(28):11495-502. doi: 10.1021/ja301953j. Epub 2012 Jul 5.


End-Capped α-Helices as Modulators of Protein Function.

Mahon AB, Arora PS.

Drug Discov Today Technol. 2012 Spring;9(1):e57-e62.


Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells.

Jespersen C, Soragni E, James Chou C, Arora PS, Dervan PB, Gottesfeld JM.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):4068-71. doi: 10.1016/j.bmcl.2012.04.090. Epub 2012 Apr 25.


Serum sclerostin and risk of hip fracture in older Caucasian women.

Arasu A, Cawthon PM, Lui LY, Do TP, Arora PS, Cauley JA, Ensrud KE, Cummings SR; Study of Osteoporotic Fractures Research Group.

J Clin Endocrinol Metab. 2012 Jun;97(6):2027-32. doi: 10.1210/jc.2011-3419. Epub 2012 Mar 30.


Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices.

Mahon AB, Arora PS.

Chem Commun (Camb). 2012 Feb 1;48(10):1416-8. doi: 10.1039/c1cc14730g. Epub 2011 Sep 28.


Assessing helical protein interfaces for inhibitor design.

Bullock BN, Jochim AL, Arora PS.

J Am Chem Soc. 2011 Sep 14;133(36):14220-3. doi: 10.1021/ja206074j. Epub 2011 Aug 22.


An orthosteric inhibitor of the Ras-Sos interaction.

Patgiri A, Yadav KK, Arora PS, Bar-Sagi D.

Nat Chem Biol. 2011 Jul 17;7(9):585-7. doi: 10.1038/nchembio.612.


Solid-phase synthesis of short α-helices stabilized by the hydrogen bond surrogate approach.

Patgiri A, Menzenski MZ, Mahon AB, Arora PS.

Nat Protoc. 2010 Nov;5(11):1857-65. doi: 10.1038/nprot.2010.146. Epub 2010 Oct 28.


Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics.

Guarracino DA, Bullock BN, Arora PS.

Biopolymers. 2011 Jan;95(1):1-7. doi: 10.1002/bip.21546. Review.


Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2.

Porter JR, Helmers MR, Wang P, Furman JL, Joy ST, Arora PS, Ghosh I.

Chem Commun (Camb). 2010 Nov 14;46(42):8020-2. doi: 10.1039/c0cc02969f. Epub 2010 Sep 20.


High specificity in protein recognition by hydrogen-bond-surrogate α-helices: selective inhibition of the p53/MDM2 complex.

Henchey LK, Porter JR, Ghosh I, Arora PS.

Chembiochem. 2010 Oct 18;11(15):2104-7. doi: 10.1002/cbic.201000378. No abstract available.


Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors.

Jochim AL, Arora PS.

ACS Chem Biol. 2010 Oct 15;5(10):919-23. doi: 10.1021/cb1001747.


Solid phase synthesis of hydrogen bond surrogate derived alpha-helices: resolving the case of a difficult amide coupling.

Patgiri A, Witten MR, Arora PS.

Org Biomol Chem. 2010 Apr 21;8(8):1773-6. doi: 10.1039/c000905a.


Oligooxopiperazines as nonpeptidic alpha-helix mimetics.

Tosovská P, Arora PS.

Org Lett. 2010 Apr 2;12(7):1588-91. doi: 10.1021/ol1003143.


Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix.

Henchey LK, Kushal S, Dubey R, Chapman RN, Olenyuk BZ, Arora PS.

J Am Chem Soc. 2010 Jan 27;132(3):941-3. doi: 10.1021/ja9082864. Erratum in: J Am Chem Soc. 2012 May 9;134(18):8000.


Chemical biology: A Notch above other inhibitors.

Arora PS, Ansari AZ.

Nature. 2009 Nov 12;462(7270):171-3. doi: 10.1038/462171a. No abstract available.


Evaluation of triazolamers as active site inhibitors of HIV-1 protease.

Jochim AL, Miller SE, Angelo NG, Arora PS.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6023-6. doi: 10.1016/j.bmcl.2009.09.049. Epub 2009 Sep 17.


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