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Utility of obesity and metabolic dyslipidemia (a non-insulin based determinate of the metabolic syndrome and insulin resistance) in predicting arterial stiffness.

Aroor AR, Whaley-Connell A, Sowers JR.

J Clin Hypertens (Greenwich). 2019 Aug;21(8):1071-1074. doi: 10.1111/jch.13615. Epub 2019 Jul 18.


Epithelial sodium channels in endothelial cells mediate diet-induced endothelium stiffness and impaired vascular relaxation in obese female mice.

Sowers JR, Habibi J, Aroor AR, Yang Y, Lastra G, Hill MA, Whaley-Connell A, Jaisser F, Jia G.

Metabolism. 2019 Jul 11;99:57-66. doi: 10.1016/j.metabol.2019.153946. [Epub ahead of print]


Binge Alcohol Is More Injurious to Liver in Female than in Male Rats: Histopathological, Pharmacologic, and Epigenetic Profiles.

Shukla SD, Restrepo R, Aroor AR, Liu X, Lim RW, Franke JD, Ford DA, Korthuis RJ.

J Pharmacol Exp Ther. 2019 Sep;370(3):390-398. doi: 10.1124/jpet.119.258871. Epub 2019 Jul 1.


Endothelial cell senescence in aging-related vascular dysfunction.

Jia G, Aroor AR, Jia C, Sowers JR.

Biochim Biophys Acta Mol Basis Dis. 2019 Jul 1;1865(7):1802-1809. doi: 10.1016/j.bbadis.2018.08.008. Epub 2018 Aug 18. Review.


The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat.

Habibi J, Aroor AR, Das NA, Manrique-Acevedo CM, Johnson MS, Hayden MR, Nistala R, Wiedmeyer C, Chandrasekar B, DeMarco VG.

Cardiovasc Diabetol. 2019 Mar 25;18(1):40. doi: 10.1186/s12933-019-0847-8.


Empagliflozin Ameliorates Type 2 Diabetes-Induced Ultrastructural Remodeling of the Neurovascular Unit and Neuroglia in the Female db/db Mouse.

Hayden MR, Grant DG, Aroor AR, DeMarco VG.

Brain Sci. 2019 Mar 7;9(3). pii: E57. doi: 10.3390/brainsci9030057.


Diet-Induced Obesity Promotes Kidney Endothelial Stiffening and Fibrosis Dependent on the Endothelial Mineralocorticoid Receptor.

Aroor AR, Habibi J, Nistala R, Ramirez-Perez FI, Martinez-Lemus LA, Jaffe IZ, Sowers JR, Jia G, Whaley-Connell A.

Hypertension. 2019 Apr;73(4):849-858. doi: 10.1161/HYPERTENSIONAHA.118.12198.


Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm.

Sharma N, Dev R, Belenchia AM, Aroor AR, Whaley-Connell A, Pulakat L, Hans CP.

Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):212-223. doi: 10.1161/ATVBAHA.118.311969.


Glycemic control by the SGLT2 inhibitor empagliflozin decreases aortic stiffness, renal resistivity index and kidney injury.

Aroor AR, Das NA, Carpenter AJ, Habibi J, Jia G, Ramirez-Perez FI, Martinez-Lemus L, Manrique-Acevedo CM, Hayden MR, Duta C, Nistala R, Mayoux E, Padilla J, Chandrasekar B, DeMarco VG.

Cardiovasc Diabetol. 2018 Jul 30;17(1):108. doi: 10.1186/s12933-018-0750-8.


Role of Renin-Angiotensin-Aldosterone System Activation in Promoting Cardiovascular Fibrosis and Stiffness.

Jia G, Aroor AR, Hill MA, Sowers JR.

Hypertension. 2018 Sep;72(3):537-548. doi: 10.1161/HYPERTENSIONAHA.118.11065. Review. No abstract available.


Epithelial Sodium Channel in Aldosterone-Induced Endothelium Stiffness and Aortic Dysfunction.

Jia G, Habibi J, Aroor AR, Hill MA, Yang Y, Whaley-Connell A, Jaisser F, Sowers JR.

Hypertension. 2018 Sep;72(3):731-738. doi: 10.1161/HYPERTENSIONAHA.118.11339.


Potential Role of Antihypertensive Medications in Preventing Excessive Arterial Stiffening.

Jia G, Aroor AR, Martinez-Lemus LA, Sowers JR.

Curr Hypertens Rep. 2018 Jul 6;20(9):76. doi: 10.1007/s11906-018-0876-9. Review.


The role of dipeptidylpeptidase-4 inhibitors in management of cardiovascular disease in diabetes; focus on linagliptin.

Aroor AR, Manrique-Acevedo C, DeMarco VG.

Cardiovasc Diabetol. 2018 Apr 18;17(1):59. doi: 10.1186/s12933-018-0704-1. Review.


Cellular mechanisms underlying obesity-induced arterial stiffness.

Aroor AR, Jia G, Sowers JR.

Am J Physiol Regul Integr Comp Physiol. 2018 Mar 1;314(3):R387-R398. doi: 10.1152/ajpregu.00235.2016. Epub 2017 Nov 22. Review.


Dipeptidyl Peptidase-4 Inhibition With Saxagliptin Ameliorates Angiotensin II-Induced Cardiac Diastolic Dysfunction in Male Mice.

Brown SM, Smith CE, Meuth AI, Khan M, Aroor AR, Cleeton HM, Meininger GA, Sowers JR, DeMarco VG, Chandrasekar B, Nistala R, Bender SB.

Endocrinology. 2017 Oct 1;158(10):3592-3604. doi: 10.1210/en.2017-00416.


Enhanced endothelium epithelial sodium channel signaling prompts left ventricular diastolic dysfunction in obese female mice.

Jia G, Habibi J, Aroor AR, Hill MA, DeMarco VG, Lee LE, Ma L, Barron BJ, Whaley-Connell A, Sowers JR.

Metabolism. 2018 Jan;78:69-79. doi: 10.1016/j.metabol.2017.08.008. Epub 2017 Sep 8.


The role of mineralocorticoid receptor signaling in the cross-talk between adipose tissue and the vascular wall.

Jia G, Aroor AR, Sowers JR.

Cardiovasc Res. 2017 Jul 1;113(9):1055-1063. doi: 10.1093/cvr/cvx097. Review.


Uric acid promotes vascular stiffness, maladaptive inflammatory responses and proteinuria in western diet fed mice.

Aroor AR, Jia G, Habibi J, Sun Z, Ramirez-Perez FI, Brady B, Chen D, Martinez-Lemus LA, Manrique C, Nistala R, Whaley-Connell AT, Demarco VG, Meininger GA, Sowers JR.

Metabolism. 2017 Sep;74:32-40. doi: 10.1016/j.metabol.2017.06.006. Epub 2017 Jun 21.


Amiloride Improves Endothelial Function and Reduces Vascular Stiffness in Female Mice Fed a Western Diet.

Martinez-Lemus LA, Aroor AR, Ramirez-Perez FI, Jia G, Habibi J, DeMarco VG, Barron B, Whaley-Connell A, Nistala R, Sowers JR.

Front Physiol. 2017 Jun 30;8:456. doi: 10.3389/fphys.2017.00456. eCollection 2017.


Xanthine oxidase inhibition protects against Western diet-induced aortic stiffness and impaired vasorelaxation in female mice.

Lastra G, Manrique C, Jia G, Aroor AR, Hayden MR, Barron BJ, Niles B, Padilla J, Sowers JR.

Am J Physiol Regul Integr Comp Physiol. 2017 Aug 1;313(2):R67-R77. doi: 10.1152/ajpregu.00483.2016. Epub 2017 May 24.


Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice.

Aroor AR, Habibi J, Kandikattu HK, Garro-Kacher M, Barron B, Chen D, Hayden MR, Whaley-Connell A, Bender SB, Klein T, Padilla J, Sowers JR, Chandrasekar B, DeMarco VG.

Cardiovasc Diabetol. 2017 May 5;16(1):61. doi: 10.1186/s12933-017-0544-4.


Absence of Endothelial ERα Results in Arterial Remodeling and Decreased Stiffness in Western Diet-Fed Male Mice.

Manrique-Acevedo C, Ramirez-Perez FI, Padilla J, Vieira-Potter VJ, Aroor AR, Barron BJ, Chen D, Haertling D, Declue C, Sowers JR, Martinez-Lemus LA.

Endocrinology. 2017 Jun 1;158(6):1875-1885. doi: 10.1210/en.2016-1831.


Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function in a female rodent model of diabetes.

Habibi J, Aroor AR, Sowers JR, Jia G, Hayden MR, Garro M, Barron B, Mayoux E, Rector RS, Whaley-Connell A, DeMarco VG.

Cardiovasc Diabetol. 2017 Jan 13;16(1):9. doi: 10.1186/s12933-016-0489-z.


Daily exercise prevents diastolic dysfunction and oxidative stress in a female mouse model of western diet induced obesity by maintaining cardiac heme oxygenase-1 levels.

Bostick B, Aroor AR, Habibi J, Durante W, Ma L, DeMarco VG, Garro M, Hayden MR, Booth FW, Sowers JR.

Metabolism. 2017 Jan;66:14-22. doi: 10.1016/j.metabol.2016.09.005. Epub 2016 Sep 22.


Regular Exercise Reduces Endothelial Cortical Stiffness in Western Diet-Fed Female Mice.

Padilla J, Ramirez-Perez FI, Habibi J, Bostick B, Aroor AR, Hayden MR, Jia G, Garro M, DeMarco VG, Manrique C, Booth FW, Martinez-Lemus LA, Sowers JR.

Hypertension. 2016 Nov;68(5):1236-1244. Epub 2016 Aug 29.


Dipeptidyl peptidase-4 inhibition with linagliptin prevents western diet-induced vascular abnormalities in female mice.

Manrique C, Habibi J, Aroor AR, Sowers JR, Jia G, Hayden MR, Garro M, Martinez-Lemus LA, Ramirez-Perez FI, Klein T, Meininger GA, DeMarco VG.

Cardiovasc Diabetol. 2016 Jul 8;15:94. doi: 10.1186/s12933-016-0414-5.


Glucagon-Like Peptide 1 Receptor Activation and Platelet Function: Beyond Glycemic Control.

Jia G, Aroor AR, Sowers JR.

Diabetes. 2016 Jun;65(6):1487-9. doi: 10.2337/dbi16-0014. No abstract available.


Clinical Manifestations and Predictors of Thrombocytopenia in Hospitalized Adults with Dengue Fever.

Aroor AR, Saya RP, Sharma A, Venkatesh A, Alva R.

N Am J Med Sci. 2015 Dec;7(12):547-52. doi: 10.4103/1947-2714.172841.


Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in Females.

Jia G, Habibi J, Aroor AR, Martinez-Lemus LA, DeMarco VG, Ramirez-Perez FI, Sun Z, Hayden MR, Meininger GA, Mueller KB, Jaffe IZ, Sowers JR.

Circ Res. 2016 Mar 18;118(6):935-943. doi: 10.1161/CIRCRESAHA.115.308269. Epub 2016 Feb 15.


Endothelial Estrogen Receptor-α Does Not Protect Against Vascular Stiffness Induced by Western Diet in Female Mice.

Manrique C, Lastra G, Ramirez-Perez FI, Haertling D, DeMarco VG, Aroor AR, Jia G, Chen D, Barron BJ, Garro M, Padilla J, Martinez-Lemus LA, Sowers JR.

Endocrinology. 2016 Apr;157(4):1590-600. doi: 10.1210/en.2015-1681. Epub 2016 Feb 12.


In Vivo Acute on Chronic Ethanol Effects in Liver: A Mouse Model Exhibiting Exacerbated Injury, Altered Metabolic and Epigenetic Responses.

Shukla SD, Aroor AR, Restrepo R, Kharbanda KK, Ibdah JA.

Biomolecules. 2015 Nov 20;5(4):3280-94. doi: 10.3390/biom5043280.


Endothelial Mineralocorticoid Receptor Deletion Prevents Diet-Induced Cardiac Diastolic Dysfunction in Females.

Jia G, Habibi J, DeMarco VG, Martinez-Lemus LA, Ma L, Whaley-Connell AT, Aroor AR, Domeier TL, Zhu Y, Meininger GA, Mueller KB, Jaffe IZ, Sowers JR.

Hypertension. 2015 Dec;66(6):1159-1167. doi: 10.1161/HYPERTENSIONAHA.115.06015. Epub 2015 Oct 5.


Vascular stiffness in insulin resistance and obesity.

Jia G, Aroor AR, DeMarco VG, Martinez-Lemus LA, Meininger GA, Sowers JR.

Front Physiol. 2015 Aug 14;6:231. doi: 10.3389/fphys.2015.00231. eCollection 2015. Review.


Erratum to: Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury.

Aroor AR, Restrepo RJ, Kharbanda KK, Shukla SD.

Hepatol Int. 2014 Sep;8 Suppl 2:431. doi: 10.1007/s12072-014-9564-2. No abstract available.


Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury.

Aroor AR, Restrepo RJ, Kharbanda KK, Shukla SD.

Hepatol Int. 2014 Sep;8 Suppl 2:421-30. doi: 10.1007/s12072-014-9546-4. Epub 2014 Jun 18. Erratum in: Hepatol Int. 2014 Sep;8 Suppl 2:431.


Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet-Induced Arterial Stiffening in Female Mice.

DeMarco VG, Habibi J, Jia G, Aroor AR, Ramirez-Perez FI, Martinez-Lemus LA, Bender SB, Garro M, Hayden MR, Sun Z, Meininger GA, Manrique C, Whaley-Connell A, Sowers JR.

Hypertension. 2015 Jul;66(1):99-107. doi: 10.1161/HYPERTENSIONAHA.115.05674. Epub 2015 May 26.


Mineralocorticoid receptor blockade prevents Western diet-induced diastolic dysfunction in female mice.

Bostick B, Habibi J, DeMarco VG, Jia G, Domeier TL, Lambert MD, Aroor AR, Nistala R, Bender SB, Garro M, Hayden MR, Ma L, Manrique C, Sowers JR.

Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1126-35. doi: 10.1152/ajpheart.00898.2014. Epub 2015 Mar 6.


Mineralocorticoid receptor antagonism treats obesity-associated cardiac diastolic dysfunction.

Bender SB, DeMarco VG, Padilla J, Jenkins NT, Habibi J, Garro M, Pulakat L, Aroor AR, Jaffe IZ, Sowers JR.

Hypertension. 2015 May;65(5):1082-8. doi: 10.1161/HYPERTENSIONAHA.114.04912. Epub 2015 Feb 23.


Anthropometry and Prevalence of Common Health Problems among School Going Children in Surathkal, Karnataka.

Aroor AR, Airody SK, Mahale R, Sr R, Shetty S, Rao AR.

J Clin Diagn Res. 2014 Dec;8(12):PC01-5. doi: 10.7860/JCDR/2014/8769.5233. Epub 2014 Dec 5.


Dipeptidyl peptidase-4 inhibition ameliorates Western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function.

Aroor AR, Habibi J, Ford DA, Nistala R, Lastra G, Manrique C, Dunham MM, Ford KD, Thyfault JP, Parks EJ, Sowers JR, Rector RS.

Diabetes. 2015 Jun;64(6):1988-2001. doi: 10.2337/db14-0804. Epub 2015 Jan 20.


Mitochondrial functional impairment in response to environmental toxins in the cardiorenal metabolic syndrome.

Jia G, Aroor AR, Martinez-Lemus LA, Sowers JR.

Arch Toxicol. 2015 Feb;89(2):147-53. doi: 10.1007/s00204-014-1431-3. Epub 2015 Jan 6. Review.


Uric acid promotes left ventricular diastolic dysfunction in mice fed a Western diet.

Jia G, Habibi J, Bostick BP, Ma L, DeMarco VG, Aroor AR, Hayden MR, Whaley-Connell AT, Sowers JR.

Hypertension. 2015 Mar;65(3):531-9. doi: 10.1161/HYPERTENSIONAHA.114.04737. Epub 2014 Dec 8.


Multiple splenic artery aneurysms: a rare cause of extrahepatic portal hypertension and massive splenomegaly.

Aroor AR, Prakasha S R, U R, Attar NR.

J Clin Diagn Res. 2014 Sep;8(9):MD01-2. doi: 10.7860/JCDR/2014/8498.4821. Epub 2014 Sep 20.


Overnutrition, mTOR signaling, and cardiovascular diseases.

Jia G, Aroor AR, Martinez-Lemus LA, Sowers JR.

Am J Physiol Regul Integr Comp Physiol. 2014 Nov 15;307(10):R1198-206. doi: 10.1152/ajpregu.00262.2014. Epub 2014 Sep 24. Review.


Estrogen and mitochondria function in cardiorenal metabolic syndrome.

Jia G, Aroor AR, Sowers JR.

Prog Mol Biol Transl Sci. 2014;127:229-49. doi: 10.1016/B978-0-12-394625-6.00009-X. Review.


Awareness about basic life support and emergency medical services and its associated factors among students in a tertiary care hospital in South India.

Aroor AR, Saya RP, Attar NR, Saya GK, Ravinanthanan M.

J Emerg Trauma Shock. 2014 Jul;7(3):166-9. doi: 10.4103/0974-2700.136857.


Oxidative stress and obesity: the chicken or the egg?

Aroor AR, DeMarco VG.

Diabetes. 2014 Jul;63(7):2216-8. doi: 10.2337/db14-0424. No abstract available.


Pleiotropic effects of the dipeptidylpeptidase-4 inhibitors on the cardiovascular system.

Aroor AR, Sowers JR, Jia G, DeMarco VG.

Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H477-92. Review.


Arterial Stiffness: A Nexus between Cardiac and Renal Disease.

Jia G, Aroor AR, Sowers JR.

Cardiorenal Med. 2014 Apr;4(1):60-71. doi: 10.1159/000360867. Epub 2014 Mar 14. Review.


Fructose and uric acid: is there a role in endothelial function?

Jia G, Aroor AR, Whaley-Connell AT, Sowers JR.

Curr Hypertens Rep. 2014 Jun;16(6):434. doi: 10.1007/s11906-014-0434-z. Review.

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