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Items: 1 to 50 of 96

1.

Targeted disruption of glycogen synthase kinase-3β in cardiomyocytes attenuates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice.

Zhang Y, Welzig CM, Haburcak M, Wang B, Aronovitz M, Blanton RM, Park HJ, Force T, Noujaim S, Galper JB.

PLoS One. 2019 Apr 12;14(4):e0215213. doi: 10.1371/journal.pone.0215213. eCollection 2019.

2.

Distinct Phenotypes Induced by Three Degrees of Transverse Aortic Constriction in Mice.

Richards DA, Aronovitz MJ, Calamaras TD, Tam K, Martin GL, Liu P, Bowditch HK, Zhang P, Huggins GS, Blanton RM.

Sci Rep. 2019 Apr 10;9(1):5844. doi: 10.1038/s41598-019-42209-7.

3.

CXCR3 regulates CD4+ T cell cardiotropism in pressure overload-induced cardiac dysfunction.

Ngwenyama N, Salvador AM, Velázquez F, Nevers T, Levy A, Aronovitz M, Luster AD, Huggins GS, Alcaide P.

JCI Insight. 2019 Apr 4;4(7). pii: 125527. doi: 10.1172/jci.insight.125527. eCollection 2019 Apr 4.

4.

Mixed lineage kinase-3 prevents cardiac dysfunction and structural remodeling with pressure overload.

Calamaras TD, Baumgartner RA, Aronovitz MJ, McLaughlin AL, Tam K, Richards DA, Cooper CW, Li N, Baur WE, Qiao X, Wang GR, Davis RJ, Kapur NK, Karas RH, Blanton RM.

Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H145-H159. doi: 10.1152/ajpheart.00029.2018. Epub 2018 Oct 26.

PMID:
30362822
5.

Membrane-Initiated Estrogen Receptor Signaling Mediates Metabolic Homeostasis via Central Activation of Protein Phosphatase 2A.

Ueda K, Takimoto E, Lu Q, Liu P, Fukuma N, Adachi Y, Suzuki R, Chou S, Baur W, Aronovitz MJ, Greenberg AS, Komuro I, Karas RH.

Diabetes. 2018 Aug;67(8):1524-1537. doi: 10.2337/db17-1342. Epub 2018 May 15.

6.

Bone Morphogenetic Protein 9 Reduces Cardiac Fibrosis and Improves Cardiac Function in Heart Failure.

Morine KJ, Qiao X, York S, Natov PS, Paruchuri V, Zhang Y, Aronovitz MJ, Karas RH, Kapur NK.

Circulation. 2018 Jul 31;138(5):513-526. doi: 10.1161/CIRCULATIONAHA.117.031635.

7.

Smooth Muscle Cell-Mineralocorticoid Receptor as a Mediator of Cardiovascular Stiffness With Aging.

Kim SK, McCurley AT, DuPont JJ, Aronovitz M, Moss ME, Stillman IE, Karumanchi SA, Christou DD, Jaffe IZ.

Hypertension. 2018 Apr;71(4):609-621. doi: 10.1161/HYPERTENSIONAHA.117.10437. Epub 2018 Feb 20.

8.

Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure.

Nevers T, Salvador AM, Velazquez F, Ngwenyama N, Carrillo-Salinas FJ, Aronovitz M, Blanton RM, Alcaide P.

J Exp Med. 2017 Nov 6;214(11):3311-3329. doi: 10.1084/jem.20161791. Epub 2017 Oct 2.

9.

Reduced activin receptor-like kinase 1 activity promotes cardiac fibrosis in heart failure.

Morine KJ, Qiao X, Paruchuri V, Aronovitz MJ, Mackey EE, Buiten L, Levine J, Ughreja K, Nepali P, Blanton RM, Oh SP, Karas RH, Kapur NK.

Cardiovasc Pathol. 2017 Nov - Dec;31:26-33. doi: 10.1016/j.carpath.2017.07.004. Epub 2017 Jul 18.

10.

Short-Term Administration of Serelaxin Produces Predominantly Vascular Benefits in the Angiotensin II/L-NAME Chronic Heart Failure Model.

McCarthy JC, Aronovitz M, DuPont JJ, Calamaras TD, Jaffe IZ, Blanton RM.

JACC Basic Transl Sci. 2017 Jun 26;2(3):285-296. doi: 10.1016/j.jacbts.2017.03.011. eCollection 2017 Jun.

11.

Endothelial mineralocorticoid receptor contributes to systolic dysfunction induced by pressure overload without modulating cardiac hypertrophy or inflammation.

Salvador AM, Moss ME, Aronovitz M, Mueller KB, Blanton RM, Jaffe IZ, Alcaide P.

Physiol Rep. 2017 Jun;5(12). pii: e13313. doi: 10.14814/phy2.13313.

12.

QRS/T-wave and calcium alternans in a type I diabetic mouse model for spontaneous postmyocardial infarction ventricular tachycardia: A mechanism for the antiarrhythmic effect of statins.

Jin H, Welzig CM, Aronovitz M, Noubary F, Blanton R, Wang B, Rajab M, Albano A, Link MS, Noujaim SF, Park HJ, Galper JB.

Heart Rhythm. 2017 Sep;14(9):1406-1416. doi: 10.1016/j.hrthm.2017.05.026. Epub 2017 May 15.

13.

Conditional knockout of activin like kinase-1 (ALK-1) leads to heart failure without maladaptive remodeling.

Morine KJ, Qiao X, Paruchuri V, Aronovitz MJ, Mackey EE, Buiten L, Levine J, Ughreja K, Nepali P, Blanton RM, Karas RH, Oh SP, Kapur NK.

Heart Vessels. 2017 May;32(5):628-636. doi: 10.1007/s00380-017-0955-x. Epub 2017 Feb 17.

14.

Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging.

DuPont JJ, McCurley A, Davel AP, McCarthy J, Bender SB, Hong K, Yang Y, Yoo JK, Aronovitz M, Baur WE, Christou DD, Hill MA, Jaffe IZ.

JCI Insight. 2016 Sep 8;1(14):e88942. doi: 10.1172/jci.insight.88942.

15.

Endoglin selectively modulates transient receptor potential channel expression in left and right heart failure.

Morine KJ, Paruchuri V, Qiao X, Aronovitz M, Huggins GS, DeNofrio D, Kiernan MS, Karas RH, Kapur NK.

Cardiovasc Pathol. 2016 Nov - Dec;25(6):478-482. doi: 10.1016/j.carpath.2016.08.004. Epub 2016 Aug 21.

16.

MicroRNA-Offset RNA Alters Gene Expression and Cell Proliferation.

Zhao J, Schnitzler GR, Iyer LK, Aronovitz MJ, Baur WE, Karas RH.

PLoS One. 2016 Jun 8;11(6):e0156772. doi: 10.1371/journal.pone.0156772. eCollection 2016.

17.

Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload-Induced Heart Failure.

Salvador AM, Nevers T, Velázquez F, Aronovitz M, Wang B, Abadía Molina A, Jaffe IZ, Karas RH, Blanton RM, Alcaide P.

J Am Heart Assoc. 2016 Mar 15;5(3):e003126. doi: 10.1161/JAHA.115.003126.

18.

Endothelial Mineralocorticoid Receptors Differentially Contribute to Coronary and Mesenteric Vascular Function Without Modulating Blood Pressure.

Mueller KB, Bender SB, Hong K, Yang Y, Aronovitz M, Jaisser F, Hill MA, Jaffe IZ.

Hypertension. 2015 Nov;66(5):988-97. doi: 10.1161/HYPERTENSIONAHA.115.06172. Epub 2015 Sep 8.

19.

Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart Failure.

Nevers T, Salvador AM, Grodecki-Pena A, Knapp A, Velázquez F, Aronovitz M, Kapur NK, Karas RH, Blanton RM, Alcaide P.

Circ Heart Fail. 2015 Jul;8(4):776-87. doi: 10.1161/CIRCHEARTFAILURE.115.002225. Epub 2015 May 28.

20.

Exposure to experimental preeclampsia in mice enhances the vascular response to future injury.

Pruthi D, Khankin EV, Blanton RM, Aronovitz M, Burke SD, McCurley A, Karumanchi SA, Jaffe IZ.

Hypertension. 2015 Apr;65(4):863-70. doi: 10.1161/HYPERTENSIONAHA.114.04971. Epub 2015 Feb 23.

21.

Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload.

Kapur NK, Qiao X, Paruchuri V, Mackey EE, Daly GH, Ughreja K, Morine KJ, Levine J, Aronovitz MJ, Hill NS, Jaffe IZ, Letarte M, Karas RH.

J Am Heart Assoc. 2014 Jul 11;3(4). pii: e000965. doi: 10.1161/JAHA.114.000965. Erratum in: J Am Heart Assoc. 2014 Aug;3(4):e000419. Ughreja, Kesahn [Corrected to Ughreja, Kishan].

22.

Glycogen synthase kinase-3β inhibition ameliorates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice.

Zhang Y, Welzig CM, Picard KL, Du C, Wang B, Pan JQ, Kyriakis JM, Aronovitz MJ, Claycomb WC, Blanton RM, Park HJ, Galper JB.

Diabetes. 2014 Jun;63(6):2097-113. doi: 10.2337/db12-1459. Epub 2014 Jan 23.

23.

The time-to-integrate-to-nest test as an indicator of wellbeing in laboratory mice.

Rock ML, Karas AZ, Rodriguez KB, Gallo MS, Pritchett-Corning K, Karas RH, Aronovitz M, Gaskill BN.

J Am Assoc Lab Anim Sci. 2014 Jan;53(1):24-8.

24.

Aldosterone promotes vascular remodeling by direct effects on smooth muscle cell mineralocorticoid receptors.

Pruthi D, McCurley A, Aronovitz M, Galayda C, Karumanchi SA, Jaffe IZ.

Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):355-64. doi: 10.1161/ATVBAHA.113.302854. Epub 2013 Dec 5.

25.

Increased inducibility of ventricular tachycardia and decreased heart rate variability in a mouse model for type 1 diabetes: effect of pravastatin.

Rajab M, Jin H, Welzig CM, Albano A, Aronovitz M, Zhang Y, Park HJ, Link MS, Noujaim SF, Galper JB.

Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1807-16. doi: 10.1152/ajpheart.00979.2012. Epub 2013 Oct 25.

26.

Biventricular remodeling in murine models of right ventricular pressure overload.

Kapur NK, Paruchuri V, Aronovitz MJ, Qiao X, Mackey EE, Daly GH, Ughreja K, Levine J, Blanton R, Hill NS, Karas RH.

PLoS One. 2013 Jul 30;8(7):e70802. doi: 10.1371/journal.pone.0070802. Print 2013.

27.

Rapid estrogen receptor signaling mediates estrogen-induced inhibition of vascular smooth muscle cell proliferation.

Ueda K, Lu Q, Baur W, Aronovitz MJ, Karas RH.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1837-43. doi: 10.1161/ATVBAHA.112.300752. Epub 2013 Jun 6.

28.

Mutation of the protein kinase I alpha leucine zipper domain produces hypertension and progressive left ventricular hypertrophy: a novel mouse model of age-dependent hypertensive heart disease.

Blanton RM, Takimoto E, Aronovitz M, Thoonen R, Kass DA, Karas RH, Mendelsohn ME.

J Gerontol A Biol Sci Med Sci. 2013 Nov;68(11):1351-5. doi: 10.1093/gerona/glt042. Epub 2013 May 8.

29.

Protein kinase g iα inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo.

Blanton RM, Takimoto E, Lane AM, Aronovitz M, Piotrowski R, Karas RH, Kass DA, Mendelsohn ME.

J Am Heart Assoc. 2012 Oct;1(5):e003731. doi: 10.1161/JAHA.112.003731. Epub 2012 Oct 25.

30.

Estrogen receptor-mediated regulation of microRNA inhibits proliferation of vascular smooth muscle cells.

Zhao J, Imbrie GA, Baur WE, Iyer LK, Aronovitz MJ, Kershaw TB, Haselmann GM, Lu Q, Karas RH.

Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):257-65. doi: 10.1161/ATVBAHA.112.300200. Epub 2012 Nov 21.

31.

Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury.

Bernelot Moens SJ, Schnitzler GR, Nickerson M, Guo H, Ueda K, Lu Q, Aronovitz MJ, Nickerson H, Baur WE, Hansen U, Iyer LK, Karas RH.

Circulation. 2012 Oct 16;126(16):1993-2004. doi: 10.1161/CIRCULATIONAHA.112.124529. Epub 2012 Sep 20.

32.

Mineralocorticoid receptor antagonism inhibits vein graft remodeling in mice.

Ehsan A, McGraw AP, Aronovitz MJ, Galayda C, Conte MS, Karas RH, Jaffe IZ.

J Thorac Cardiovasc Surg. 2013 Jun;145(6):1642-9, 1649.e1. doi: 10.1016/j.jtcvs.2012.08.007. Epub 2012 Sep 13.

33.

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors.

McCurley A, Pires PW, Bender SB, Aronovitz M, Zhao MJ, Metzger D, Chambon P, Hill MA, Dorrance AM, Mendelsohn ME, Jaffe IZ.

Nat Med. 2012 Sep;18(9):1429-33.

34.

Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure.

Kapur NK, Wilson S, Yunis AA, Qiao X, Mackey E, Paruchuri V, Baker C, Aronovitz MJ, Karumanchi SA, Letarte M, Kass DA, Mendelsohn ME, Karas RH.

Circulation. 2012 Jun 5;125(22):2728-38. doi: 10.1161/CIRCULATIONAHA.111.080002. Epub 2012 May 16.

35.

Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8.

Georgescu SP, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S.

Am J Physiol Cell Physiol. 2011 Nov;301(5):C1046-56. doi: 10.1152/ajpcell.00211.2011. Epub 2011 Jul 20.

36.

Elevated soluble fms-like tyrosine kinase-1 levels in acute coronary occlusion.

Kapur NK, Heffernan KS, Yunis AA, Nguyen TA, Aronovitz MJ, Parpos P, Wilson S, Baker CK, Esposito ML, Shah A, Kimmelstiel CD, Weintraub A, Karas RH, Mendelsohn ME.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):443-50. doi: 10.1161/ATVBAHA.110.215897. Epub 2010 Nov 11.

PMID:
21071694
37.

Placental growth factor mediates aldosterone-dependent vascular injury in mice.

Jaffe IZ, Newfell BG, Aronovitz M, Mohammad NN, McGraw AP, Perreault RE, Carmeliet P, Ehsan A, Mendelsohn ME.

J Clin Invest. 2010 Nov;120(11):3891-900. doi: 10.1172/JCI40205.

38.

Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.

Kong DK, Georgescu SP, Cano C, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S.

Mol Biol Cell. 2010 Apr 15;21(8):1335-49. doi: 10.1091/mbc.E09-09-0818. Epub 2010 Feb 24.

39.

Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita mice.

Park HJ, Zhang Y, Du C, Welzig CM, Madias C, Aronovitz MJ, Georgescu SP, Naggar I, Wang B, Kim YB, Blaustein RO, Karas RH, Liao R, Mathews CE, Galper JB.

Circ Res. 2009 Jul 31;105(3):287-94. doi: 10.1161/CIRCRESAHA.109.193995. Epub 2009 May 7.

40.

Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation.

Donaldson C, Eder S, Baker C, Aronovitz MJ, Weiss AD, Hall-Porter M, Wang F, Ackerman A, Karas RH, Molkentin JD, Patten RD.

Circ Res. 2009 Jan 30;104(2):265-75, 11p following 275. doi: 10.1161/CIRCRESAHA.108.190397. Epub 2008 Dec 12.

41.

Rapid recruitment of temporally distinct vascular gene sets by estrogen.

Schnoes KK, Jaffe IZ, Iyer L, Dabreo A, Aronovitz M, Newfell B, Hansen U, Rosano G, Mendelsohn ME.

Mol Endocrinol. 2008 Nov;22(11):2544-56. doi: 10.1210/me.2008-0044. Epub 2008 Sep 11.

42.

High blood pressure arising from a defect in vascular function.

Michael SK, Surks HK, Wang Y, Zhu Y, Blanton R, Jamnongjit M, Aronovitz M, Baur W, Ohtani K, Wilkerson MK, Bonev AD, Nelson MT, Karas RH, Mendelsohn ME.

Proc Natl Acad Sci U S A. 2008 May 6;105(18):6702-7. doi: 10.1073/pnas.0802128105. Epub 2008 Apr 30.

43.

17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload.

Patten RD, Pourati I, Aronovitz MJ, Alsheikh-Ali A, Eder S, Force T, Mendelsohn ME, Karas RH.

J Card Fail. 2008 Apr;14(3):245-53. doi: 10.1016/j.cardfail.2007.10.024.

44.

Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.

Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, Liao R, Link MS, Galper JB.

J Clin Invest. 2008 Jan;118(1):259-71.

45.

The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failure.

Huggins GS, Lepore JJ, Greytak S, Patten R, McNamee R, Aronovitz M, Wang PJ, Reed GL.

Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1877-82. Epub 2007 Jul 6.

46.

The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy.

Chen X, Shevtsov SP, Hsich E, Cui L, Haq S, Aronovitz M, Kerkelä R, Molkentin JD, Liao R, Salomon RN, Patten R, Force T.

Mol Cell Biol. 2006 Jun;26(12):4462-73.

47.

c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo.

Shao Z, Bhattacharya K, Hsich E, Park L, Walters B, Germann U, Wang YM, Kyriakis J, Mohanlal R, Kuida K, Namchuk M, Salituro F, Yao YM, Hou WM, Chen X, Aronovitz M, Tsichlis PN, Bhattacharya S, Force T, Kilter H.

Circ Res. 2006 Jan 6;98(1):111-8. Epub 2005 Nov 23.

PMID:
16306447
48.

Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways.

D'Eon TM, Souza SC, Aronovitz M, Obin MS, Fried SK, Greenberg AS.

J Biol Chem. 2005 Oct 28;280(43):35983-91. Epub 2005 Aug 17.

49.

Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor.

Bridgman P, Aronovitz MA, Kakkar R, Oliverio MI, Coffman TM, Rand WM, Konstam MA, Mendelsohn ME, Patten RD.

Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H586-92. Epub 2005 Mar 11.

50.

17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling.

Patten RD, Pourati I, Aronovitz MJ, Baur J, Celestin F, Chen X, Michael A, Haq S, Nuedling S, Grohe C, Force T, Mendelsohn ME, Karas RH.

Circ Res. 2004 Oct 1;95(7):692-9. Epub 2004 Sep 2.

PMID:
15345655

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