Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 31

1.

Synthesis of a 6-Aza-Isoindolinone-Based Inhibitor of Phosphoinositide 3-Kinase γ via Ruthenium-Catalyzed [2 + 2 + 2] Cyclotrimerization.

Collier PN, Panchagnula A, O'Dowd H, Le Tiran A, Aronov AM.

ACS Med Chem Lett. 2018 Nov 29;10(1):117-120. doi: 10.1021/acsmedchemlett.8b00530. eCollection 2019 Jan 10.

PMID:
30655957
2.

Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS).

Come JH, Collier PN, Henderson JA, Pierce AC, Davies RJ, Le Tiran A, O'Dowd H, Bandarage UK, Cao J, Deininger D, Grey R, Krueger EB, Lowe DB, Liang J, Liao Y, Messersmith D, Nanthakumar S, Sizensky E, Wang J, Xu J, Chin EY, Damagnez V, Doran JD, Dworakowski W, Griffith JP, Jacobs MD, Khare-Pandit S, Mahajan S, Moody CS, Aronov AM.

J Med Chem. 2018 Jun 28;61(12):5245-5256. doi: 10.1021/acs.jmedchem.8b00085. Epub 2018 Jun 14.

PMID:
29847724
3.

Drug discovery effectiveness from the standpoint of therapeutic mechanisms and indications.

Shih HP, Zhang X, Aronov AM.

Nat Rev Drug Discov. 2018 Jan;17(1):78. doi: 10.1038/nrd.2017.255. Epub 2017 Dec 15.

PMID:
29242612
4.

Drug discovery effectiveness from the standpoint of therapeutic mechanisms and indications.

Shih HP, Zhang X, Aronov AM.

Nat Rev Drug Discov. 2018 Jan;17(1):19-33. doi: 10.1038/nrd.2017.194. Epub 2017 Oct 27. Review. Erratum in: Nat Rev Drug Discov. 2017 Dec 15;:.

PMID:
29075002
5.

Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib).

Germann UA, Furey BF, Markland W, Hoover RR, Aronov AM, Roix JJ, Hale M, Boucher DM, Sorrell DA, Martinez-Botella G, Fitzgibbon M, Shapiro P, Wick MJ, Samadani R, Meshaw K, Groover A, DeCrescenzo G, Namchuk M, Emery CM, Saha S, Welsch DJ.

Mol Cancer Ther. 2017 Nov;16(11):2351-2363. doi: 10.1158/1535-7163.MCT-17-0456. Epub 2017 Sep 22.

6.

Prediction of Protein Pairs Sharing Common Active Ligands Using Protein Sequence, Structure, and Ligand Similarity.

Chen YC, Tolbert R, Aronov AM, McGaughey G, Walters WP, Meireles L.

J Chem Inf Model. 2016 Sep 26;56(9):1734-45. doi: 10.1021/acs.jcim.6b00118. Epub 2016 Sep 2.

7.

Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors.

Bonafoux D, Nanthakumar S, Bandarage UK, Memmott C, Lowe D, Aronov AM, Bhisetti GR, Bonanno KC, Coll J, Leeman J, Lepre CA, Lu F, Perola E, Rijnbrand R, Taylor WP, Wilson D, Zhou Y, Zwahlen J, Ter Haar E.

J Med Chem. 2016 Aug 11;59(15):7138-51. doi: 10.1021/acs.jmedchem.6b00486. Epub 2016 Jul 20.

PMID:
27385654
8.

Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3-Kinase γ.

Collier PN, Messersmith D, Le Tiran A, Bandarage UK, Boucher C, Come J, Cottrell KM, Damagnez V, Doran JD, Griffith JP, Khare-Pandit S, Krueger EB, Ledeboer MW, Ledford B, Liao Y, Mahajan S, Moody CS, Roday S, Wang T, Xu J, Aronov AM.

J Med Chem. 2015 Jul 23;58(14):5684-8. doi: 10.1021/acs.jmedchem.5b00498. Epub 2015 Jul 6.

PMID:
26121481
9.

Structural basis for isoform selectivity in a class of benzothiazole inhibitors of phosphoinositide 3-kinase γ.

Collier PN, Martinez-Botella G, Cornebise M, Cottrell KM, Doran JD, Griffith JP, Mahajan S, Maltais F, Moody CS, Huck EP, Wang T, Aronov AM.

J Med Chem. 2015 Jan 8;58(1):517-21. doi: 10.1021/jm500362j. Epub 2014 May 2.

PMID:
24754609
10.

Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.

Aronov AM, Tang Q, Martinez-Botella G, Bemis GW, Cao J, Chen G, Ewing NP, Ford PJ, Germann UA, Green J, Hale MR, Jacobs M, Janetka JW, Maltais F, Markland W, Namchuk MN, Nanthakumar S, Poondru S, Straub J, ter Haar E, Xie X.

J Med Chem. 2009 Oct 22;52(20):6362-8. doi: 10.1021/jm900630q.

PMID:
19827834
11.

Ligand structural aspects of hERG channel blockade.

Aronov AM.

Curr Top Med Chem. 2008;8(13):1113-27. Review.

PMID:
18782007
12.

[Thin calcium-phosphate coatings produced by high frequency magnetron sputtering and prospects for their use in biomedical engineering].

Aronov AM, Pichugin VF, Eshenko EV, Riabtseva MA, Surmenev RA, Tverdokhlebov SI, Shesterikov EV.

Med Tekh. 2008 May-Jun;(3):18-22. Russian.

PMID:
18683576
13.

Kinase-likeness and kinase-privileged fragments: toward virtual polypharmacology.

Aronov AM, McClain B, Moody CS, Murcko MA.

J Med Chem. 2008 Mar 13;51(5):1214-22. doi: 10.1021/jm701021b. Epub 2008 Feb 21.

PMID:
18288794
14.

Tuning out of hERG.

Aronov AM.

Curr Opin Drug Discov Devel. 2008 Jan;11(1):128-40. Review.

PMID:
18175275
15.

[Experience in development of an infusion syringe pump].

Aronov AM, Mel'nichenko ZN, Stepkin AV.

Med Tekh. 2007 Jul-Aug;(4):54-5. Russian.

PMID:
17879624
16.
17.

Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors.

Aronov AM, Baker C, Bemis GW, Cao J, Chen G, Ford PJ, Germann UA, Green J, Hale MR, Jacobs M, Janetka JW, Maltais F, Martinez-Botella G, Namchuk MN, Straub J, Tang Q, Xie X.

J Med Chem. 2007 Mar 22;50(6):1280-7. Epub 2007 Feb 15.

PMID:
17300186
18.
19.

Predictive in silico modeling for hERG channel blockers.

Aronov AM.

Drug Discov Today. 2005 Jan 15;10(2):149-55. Review.

PMID:
15718164
20.

Toward a pharmacophore for kinase frequent hitters.

Aronov AM, Murcko MA.

J Med Chem. 2004 Nov 4;47(23):5616-9.

PMID:
15509160
21.
22.

A model for identifying HERG K+ channel blockers.

Aronov AM, Goldman BB.

Bioorg Med Chem. 2004 May 1;12(9):2307-15.

PMID:
15080928
23.

Design of virtual combinatorial libraries.

Aronov AM.

Methods Mol Biol. 2002;201:267-76. No abstract available.

PMID:
12357932
24.
25.

Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.

Bressi JC, Verlinde CL, Aronov AM, Shaw ML, Shin SS, Nguyen LN, Suresh S, Buckner FS, Van Voorhis WC, Kuntz ID, Hol WG, Gelb MH.

J Med Chem. 2001 Jun 21;44(13):2080-93.

26.

Rational design of selective submicromolar inhibitors of Tritrichomonas foetus hypoxanthine-guanine-xanthine phosphoribosyltransferase.

Aronov AM, Munagala NR, Ortiz De Montellano PR, Kuntz ID, Wang CC.

Biochemistry. 2000 Apr 25;39(16):4684-91.

PMID:
10769124
27.

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.

Aronov AM, Suresh S, Buckner FS, Van Voorhis WC, Verlinde CL, Opperdoes FR, Hol WG, Gelb MH.

Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4273-8.

29.
30.

[Diagnostic unit EKS-K1200].

Aronov AM, Eliseev DV, Kostrichko IA, Filonov SV, Fikhman MI.

Med Tekh. 1998 Jan-Feb;(1):37-40. Russian.

PMID:
9560818
31.

[Device for removing concrements from tubular organs].

Aronov AM, Kirichenko VI.

Med Tekh. 1997 Nov-Dec;(6):42. Russian.

PMID:
9460668

Supplemental Content

Loading ...
Support Center