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Systematically Prioritizing Candidates in Genome-Based Drug Repurposing.

Challa AP, Lavieri RR, Lewis JT, Zaleski NM, Shirey-Rice JK, Harris PA, Aronoff DM, Pulley JM.

Assay Drug Dev Technol. 2019 Nov/Dec;17(8):352-363. doi: 10.1089/adt.2019.950. Epub 2019 Nov 26.


Modulation of Death and Inflammatory Signaling in Decidual Stromal Cells following Exposure to Group B Streptococcus.

Flaherty RA, Magel M, Aronoff DM, Gaddy JA, Petroff MG, Manning SD.

Infect Immun. 2019 Nov 18;87(12). pii: e00729-19. doi: 10.1128/IAI.00729-19. Print 2019 Dec.


Genetically distinct Group B Streptococcus strains induce varying macrophage cytokine responses.

Flaherty RA, Borges EC, Sutton JA, Aronoff DM, Gaddy JA, Petroff MG, Manning SD.

PLoS One. 2019 Sep 19;14(9):e0222910. doi: 10.1371/journal.pone.0222910. eCollection 2019.


A Unique Case of Burkholderia cepacia Prosthetic Mitral Valve Endocarditis and Literature Review.

Dellalana LE, Byrge KC, Gandelman JS, Lines T, Aronoff DM, Person AK.

Infect Dis Clin Pract (Baltim Md). 2019 May;27(3):123-125. doi: 10.1097/IPC.0000000000000708.


Using What We Already Have: Uncovering New Drug Repurposing Strategies in Existing Omics Data.

Pulley JM, Rhoads JP, Jerome RN, Challa AP, Erreger KB, Joly MM, Lavieri RR, Perry KE, Zaleski NM, Shirey-Rice JK, Aronoff DM.

Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:333-352. doi: 10.1146/annurev-pharmtox-010919-023537. Epub 2019 Jul 23.


Misoprostol protects mice against severe Clostridium difficile infection and promotes recovery of the gut microbiota after antibiotic perturbation.

Zackular JP, Kirk L, Trindade BC, Skaar EP, Aronoff DM.

Anaerobe. 2019 Aug;58:89-94. doi: 10.1016/j.anaerobe.2019.06.006. Epub 2019 Jun 17.


Raman microspectroscopy differentiates perinatal pathogens on ex vivo infected human fetal membrane tissues.

Ayala OD, Doster RS, Manning SD, O'Brien CM, Aronoff DM, Gaddy JA, Mahadevan-Jansen A.

J Biophotonics. 2019 Sep;12(9):e201800449. doi: 10.1002/jbio.201800449. Epub 2019 Jun 19.


High prevalence of Group B Streptococcus colonization among pregnant women in Amman, Jordan.

Clouse K, Shehabi A, Suleimat AM, Faouri S, Khuri-Bulos N, Al Jammal A, Chappell J, Fortner KB, Chamby AB, Randis TM, Ratner AJ, Aronoff DM, Halasa N.

BMC Pregnancy Childbirth. 2019 May 20;19(1):177. doi: 10.1186/s12884-019-2317-4.


A Clinical Review of Diabetic Foot Infections.

Chastain CA, Klopfenstein N, Serezani CH, Aronoff DM.

Clin Podiatr Med Surg. 2019 Jul;36(3):381-395. doi: 10.1016/j.cpm.2019.02.004. Epub 2019 Apr 6. Review.


Mildred Rebstock: Profile of the Medicinal Chemist Who Synthesized Chloramphenicol.

Aronoff DM.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00648-19. doi: 10.1128/AAC.00648-19. Print 2019 Jun.


Sex modifies placental gene expression in response to metabolic and inflammatory stress.

Barke TL, Money KM, Du L, Serezani A, Gannon M, Mirnics K, Aronoff DM.

Placenta. 2019 Mar;78:1-9. doi: 10.1016/j.placenta.2019.02.008. Epub 2019 Feb 22.


Fetal Membrane Organ-On-Chip: An Innovative Approach to Study Cellular Interactions.

Richardson L, Gnecco J, Ding T, Osteen K, Rogers LM, Aronoff DM, Menon R.

Reprod Sci. 2019 Feb 21:1933719119828084. doi: 10.1177/1933719119828084. [Epub ahead of print]


The PathLink Acquired Gestational Tissue Bank: Feasibility of Project PLACENTA.

Linder JE, Batey K, Johnston R, Cohen EM, Wang Y, Wang X, Zaleski NM, Rogers LM, McDonald WH, Reyzer ML, Judd A, Goldstein J, Correa H, Pulley J, Aronoff DM.

J Reprod Biotechnol Fertil. 2018;7:14-27.


Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate Clostridium difficile Colitis while Dysregulating the Inflammatory Response.

Maseda D, Zackular JP, Trindade B, Kirk L, Roxas JL, Rogers LM, Washington MK, Du L, Koyama T, Viswanathan VK, Vedantam G, Schloss PD, Crofford LJ, Skaar EP, Aronoff DM.

mBio. 2019 Jan 8;10(1). pii: e02282-18. doi: 10.1128/mBio.02282-18.


Protein kinase D mediates inflammatory responses of human placental macrophages to Group B Streptococcus.

Sutton JA, Rogers LM, Dixon BREA, Kirk L, Doster R, Algood HM, Gaddy JA, Flaherty R, Manning SD, Aronoff DM.

Am J Reprod Immunol. 2019 Mar;81(3):e13075. doi: 10.1111/aji.13075. Epub 2019 Jan 30.


Investigation of the Role That NADH Peroxidase Plays in Oxidative Stress Survival in Group B Streptococcus.

Korir ML, Flaherty RA, Rogers LM, Gaddy JA, Aronoff DM, Manning SD.

Front Microbiol. 2018 Nov 20;9:2786. doi: 10.3389/fmicb.2018.02786. eCollection 2018.


Honoring Sydney Finegold, founding president of the Anaerobe Society of the Americas (1921-2018).

Aronoff DM.

Anaerobe. 2018 Dec;54:iii-iv. doi: 10.1016/j.anaerobe.2018.11.007. Epub 2018 Nov 20. No abstract available.


Streptococcus agalactiae Induces Placental Macrophages To Release Extracellular Traps Loaded with Tissue Remodeling Enzymes via an Oxidative Burst-Dependent Mechanism.

Doster RS, Sutton JA, Rogers LM, Aronoff DM, Gaddy JA.

mBio. 2018 Nov 20;9(6). pii: e02084-18. doi: 10.1128/mBio.02084-18.


Indomethacin increases severity of Clostridium difficile infection in mouse model.

Muñoz-Miralles J, Trindade BC, Castro-Córdova P, Bergin IL, Kirk LA, Gil F, Aronoff DM, Paredes-Sabja D.

Future Microbiol. 2018 Sep;13:1271-1281. doi: 10.2217/fmb-2017-0311. Epub 2018 Sep 21.


COX-2-PGE2 Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis.

Li Y, Soendergaard C, Bergenheim FH, Aronoff DM, Milne G, Riis LB, Seidelin JB, Jensen KB, Nielsen OH.

EBioMedicine. 2018 Oct;36:497-507. doi: 10.1016/j.ebiom.2018.08.040. Epub 2018 Sep 3.


Decidual stromal cell-derived PGE2 regulates macrophage responses to microbial threat.

Rogers LM, Anders AP, Doster RS, Gill EA, Gnecco JS, Holley JM, Randis TM, Ratner AJ, Gaddy JA, Osteen K, Aronoff DM.

Am J Reprod Immunol. 2018 Oct;80(4):e13032. doi: 10.1111/aji.13032. Epub 2018 Aug 7.


"I will leave the baby with my mother": Long-distance travel and follow-up care among HIV-positive pregnant and postpartum women in South Africa.

Clouse K, Fox MP, Mongwenyana C, Motlhatlhedi M, Buthelezi S, Bokaba D, Norris SA, Bassett J, Lurie MN, Aronoff DM, Vermund SH.

J Int AIDS Soc. 2018 Jul;21 Suppl 4:e25121. doi: 10.1002/jia2.25121.


Gestational diabetes mellitus is associated with increased CD163 expression and iron storage in the placenta.

Barke TL, Goldstein JA, Sundermann AC, Reddy AP, Linder JE, Correa H, Velez-Edwards DR, Aronoff DM.

Am J Reprod Immunol. 2018 Oct;80(4):e13020. doi: 10.1111/aji.13020. Epub 2018 Jul 9.


Mesangial cells, specialized renal pericytes and cytomegalovirus infectivity: Implications for HCMV pathology in the glomerular vascular unit and post-transplant renal disease.

Popik W, Correa H, Khatua A, Aronoff DM, Alcendor DJ.

J Transl Sci. 2019 Feb;5(1). doi: 10.15761/JTS.1000248. Epub 2018 May 24.


"I just wish that everything is in one place": facilitators and barriers to continuity of care among HIV-positive, postpartum women with a non-communicable disease in South Africa.

Clouse K, Motlhatlhedi M, Bonnet K, Schlundt D, Aronoff DM, Chakkalakal R, Norris SA.

AIDS Care. 2018 Jun;30(sup2):5-10. doi: 10.1080/09540121.2018.1470308. Epub 2018 May 30.


Bacterial DNA is present in the fetal intestine and overlaps with that in the placenta in mice.

Martinez KA 2nd, Romano-Keeler J, Zackular JP, Moore DJ, Brucker RM, Hooper C, Meng S, Brown N, Mallal S, Reese J, Aronoff DM, Shin H, Dominguez-Bello MG, Weitkamp JH.

PLoS One. 2018 May 17;13(5):e0197439. doi: 10.1371/journal.pone.0197439. eCollection 2018.


PregOMICS-Leveraging systems biology and bioinformatics for drug repurposing in maternal-child health.

Goldstein JA, Bastarache LA, Denny JC, Pulley JM, Aronoff DM.

Am J Reprod Immunol. 2018 Aug;80(2):e12971. doi: 10.1111/aji.12971. Epub 2018 May 4.


Perinatal Case Fatality Rate Related to Congenital Zika Syndrome in Brazil: A Cross-Sectional Study.

Mendes Neto NN, da Silva Maia JT, Zacarkim MR, Queiroz I, Labeaud AD, Aronoff DM.

Pediatr Neurol. 2018 Apr;81:47-48. doi: 10.1016/j.pediatrneurol.2017.11.012. Epub 2017 Dec 12. No abstract available.


Historical and contemporary features of infections due to Clostridium novyi.

Aronoff DM, Kazanjian PH.

Anaerobe. 2018 Apr;50:80-84. doi: 10.1016/j.anaerobe.2017.12.012. Epub 2018 Feb 20. Review.


Examination of Signatures of Recent Positive Selection on Genes Involved in Human Sialic Acid Biology.

Moon JM, Aronoff DM, Capra JA, Abbot P, Rokas A.

G3 (Bethesda). 2018 Mar 28;8(4):1315-1325. doi: 10.1534/g3.118.200035.


Calcium channel blockers as drug repurposing candidates for gestational diabetes: Mining large scale genomic and electronic health records data to repurpose medications.

Goldstein JA, Bastarache LA, Denny JC, Roden DM, Pulley JM, Aronoff DM.

Pharmacol Res. 2018 Apr;130:44-51. doi: 10.1016/j.phrs.2018.02.013. Epub 2018 Feb 12.


Impact of the Levonorgestrel-Releasing Intrauterine System on the Progression of Chlamydia trachomatis Infection to Pelvic Inflammatory Disease in a Baboon Model.

Eastman AJ, Bergin IL, Chai D, Bassis CM, LeBar W, Oluoch GO, Liechty ER, Nyachieo A, Young VB, Aronoff DM, Patton DL, Bell JD.

J Infect Dis. 2018 Jan 30;217(4):656-666. doi: 10.1093/infdis/jix545.


A Nonhemolytic Group B Streptococcus Strain Exhibits Hypervirulence.

Gendrin C, Vornhagen J, Armistead B, Singh P, Whidbey C, Merillat S, Knupp D, Parker R, Rogers LM, Quach P, Iyer LM, Aravind L, Manning SD, Aronoff DM, Rajagopal L.

J Infect Dis. 2018 Mar 5;217(6):983-987. doi: 10.1093/infdis/jix646.


Prostaglandins D2 and E2 have opposite effects on alveolar macrophages infected with Histoplasma capsulatum.

Pereira PAT, Assis PA, Prado MKB, Ramos SG, Aronoff DM, de Paula-Silva FWG, Sorgi CA, Faccioli LH.

J Lipid Res. 2018 Feb;59(2):195-206. doi: 10.1194/jlr.M078162. Epub 2017 Dec 7.


Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii.

Ackerman DL, Craft KM, Doster RS, Weitkamp JH, Aronoff DM, Gaddy JA, Townsend SD.

ACS Infect Dis. 2018 Mar 9;4(3):315-324. doi: 10.1021/acsinfecdis.7b00183. Epub 2017 Dec 8.


When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data.

Pulley JM, Jerome RN, Zaleski NM, Shirey-Rice JK, Pruijssers AJ, Lavieri RR, Chettiar SN, Naylor HM, Aronoff DM, Edwards DA, Niswender CM, Dugan LL, Crofford LJ, Bernard GR, Holroyd KJ.

Assay Drug Dev Technol. 2017 Dec;15(8):354-361. doi: 10.1089/adt.2017.821. Epub 2017 Dec 1.


Sex-Dependent Influence of Developmental Toxicant Exposure on Group B Streptococcus-Mediated Preterm Birth in a Murine Model.

Ding T, Lambert LA, Aronoff DM, Osteen KG, Bruner-Tran KL.

Reprod Sci. 2018 May;25(5):662-673. doi: 10.1177/1933719117741378. Epub 2017 Nov 19.


Macrophage Extracellular Traps: A Scoping Review.

Doster RS, Rogers LM, Gaddy JA, Aronoff DM.

J Innate Immun. 2018;10(1):3-13. doi: 10.1159/000480373. Epub 2017 Oct 7. Review.


Gestational diabetes exacerbates maternal immune activation effects in the developing brain.

Money KM, Barke TL, Serezani A, Gannon M, Garbett KA, Aronoff DM, Mirnics K.

Mol Psychiatry. 2018 Sep;23(9):1920-1928. doi: 10.1038/mp.2017.191. Epub 2017 Sep 26.


A role for cellular senescence in birth timing.

Cha JM, Aronoff DM.

Cell Cycle. 2017;16(21):2023-2031. doi: 10.1080/15384101.2017.1371888. Epub 2017 Sep 25. Review.


Instrumenting a Fetal Membrane on a Chip as Emerging Technology for Preterm Birth Research.

Gnecco JS, Anders AP, Cliffel D, Pensabene V, Rogers LM, Osteen K, Aronoff DM.

Curr Pharm Des. 2017;23(40):6115-6124. doi: 10.2174/1381612823666170825142649. Review.


Placental pericytes and cytomegalovirus infectivity: Implications for HCMV placental pathology and congenital disease.

Aronoff DM, Correa H, Rogers LM, Arav-Boger R, Alcendor DJ.

Am J Reprod Immunol. 2017 Sep;78(3). doi: 10.1111/aji.12728. Epub 2017 Jul 25.


The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages.

Carson WF 4th, Cavassani KA, Soares EM, Hirai S, Kittan NA, Schaller MA, Scola MM, Joshi A, Matsukawa A, Aronoff DM, Johnson CN, Dou Y, Gallagher KA, Kunkel SL.

J Immunol. 2017 Sep 1;199(5):1865-1874. doi: 10.4049/jimmunol.1601272. Epub 2017 Jul 21.


Human Milk Oligosaccharides Exhibit Antimicrobial and Antibiofilm Properties against Group B Streptococcus.

Ackerman DL, Doster RS, Weitkamp JH, Aronoff DM, Gaddy JA, Townsend SD.

ACS Infect Dis. 2017 Aug 11;3(8):595-605. doi: 10.1021/acsinfecdis.7b00064. Epub 2017 Jun 13.


Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.

Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC.

Assay Drug Dev Technol. 2017 Apr;15(3):113-119. doi: 10.1089/adt.2016.772. Epub 2017 Apr 5.


Incidence and prevalence of type 2 diabetes mellitus with HIV infection in Africa: a systematic review and meta-analysis.

Prioreschi A, Munthali RJ, Soepnel L, Goldstein JA, Micklesfield LK, Aronoff DM, Norris SA.

BMJ Open. 2017 Mar 29;7(3):e013953. doi: 10.1136/bmjopen-2016-013953. Review.


Group B Streptococcus Induces Neutrophil Recruitment to Gestational Tissues and Elaboration of Extracellular Traps and Nutritional Immunity.

Kothary V, Doster RS, Rogers LM, Kirk LA, Boyd KL, Romano-Keeler J, Haley KP, Manning SD, Aronoff DM, Gaddy JA.

Front Cell Infect Microbiol. 2017 Feb 3;7:19. doi: 10.3389/fcimb.2017.00019. eCollection 2017.


DOHaD at the intersection of maternal immune activation and maternal metabolic stress: a scoping review.

Goldstein JA, Norris SA, Aronoff DM.

J Dev Orig Health Dis. 2017 Jun;8(3):273-283. doi: 10.1017/S2040174417000010. Epub 2017 Feb 15. Review.


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