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Items: 1 to 50 of 62

1.

Bacillus thuringiensis Cry5B is Active against Strongyloides stercoralis in vitro.

Charuchaibovorn S, Sanprasert V, Sutthanont N, Hu Y, Abraham A, Ostroff GR, Aroian RV, Jaleta TG, Lok JB, Nuchprayoon S.

Am J Trop Med Hyg. 2019 Nov;101(5):1177-1182. doi: 10.4269/ajtmh.19-0083.

PMID:
31516117
2.

Drug Screening for Discovery of Broad-spectrum Agents for Soil-transmitted Nematodes.

Elfawal MA, Savinov SN, Aroian RV.

Sci Rep. 2019 Aug 26;9(1):12347. doi: 10.1038/s41598-019-48720-1.

3.

Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics.

Tyagi R, Elfawal MA, Wildman SA, Helander J, Bulman CA, Sakanari J, Rosa BA, Brindley PJ, Janetka JW, Aroian RV, Mitreva M.

Sci Rep. 2019 Jun 24;9(1):9085. doi: 10.1038/s41598-019-45548-7.

4.

Cognitive and Microbiome Impacts of Experimental Ancylostoma ceylanicum Hookworm Infections in Hamsters.

Pan SC, Ward DV, Yin Y, Hu Y, Elfawal MA, Clark RE, Aroian RV.

Sci Rep. 2019 May 27;9(1):7868. doi: 10.1038/s41598-019-44301-4.

5.

A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection.

Noon JB, Schwarz EM, Ostroff GR, Aroian RV.

PLoS Negl Trop Dis. 2019 Apr 22;13(4):e0007345. doi: 10.1371/journal.pntd.0007345. eCollection 2019 Apr.

6.

In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites.

Hu Y, Miller M, Zhang B, Nguyen TT, Nielsen MK, Aroian RV.

PLoS Negl Trop Dis. 2018 May 18;12(5):e0006506. doi: 10.1371/journal.pntd.0006506. eCollection 2018 May.

7.

Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure.

Hu Y, Nguyen TT, Lee ACY, Urban JF Jr, Miller MM, Zhan B, Koch DJ, Noon JB, Abraham A, Fujiwara RT, Bowman DD, Ostroff GR, Aroian RV.

Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):287-294. doi: 10.1016/j.ijpddr.2018.05.001. Epub 2018 May 4.

8.

Recombinant subunit vaccines for soil-transmitted helminths.

Noon JB, Aroian RV.

Parasitology. 2017 Dec;144(14):1845-1870. doi: 10.1017/S003118201700138X. Epub 2017 Aug 3. Review.

9.

HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.

Chen HD, Kao CY, Liu BY, Huang SW, Kuo CJ, Ruan JW, Lin YH, Huang CR, Chen YH, Wang HD, Aroian RV, Chen CS.

Autophagy. 2017 Feb;13(2):371-385. doi: 10.1080/15548627.2016.1256933. Epub 2016 Nov 22.

10.

The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins.

Dementiev A, Board J, Sitaram A, Hey T, Kelker MS, Xu X, Hu Y, Vidal-Quist C, Chikwana V, Griffin S, McCaskill D, Wang NX, Hung SC, Chan MK, Lee MM, Hughes J, Wegener A, Aroian RV, Narva KE, Berry C.

BMC Biol. 2016 Aug 30;14:71. doi: 10.1186/s12915-016-0295-9.

11.

Intracellular and Extracellular Expression of Bacillus thuringiensis Crystal Protein Cry5B in Lactococcus lactis for Use as an Anthelminthic.

Durmaz E, Hu Y, Aroian RV, Klaenhammer TR.

Appl Environ Microbiol. 2015 Dec 18;82(4):1286-94. doi: 10.1128/AEM.02365-15. Print 2016 Feb 15.

12.

eIF2α Confers Cellular Tolerance to S. aureus α-Toxin.

von Hoven G, Neukirch C, Meyenburg M, Füser S, Petrivna MB, Rivas AJ, Ryazanov A, Kaufman RJ, Aroian RV, Husmann M.

Front Immunol. 2015 Jul 27;6:383. doi: 10.3389/fimmu.2015.00383. eCollection 2015.

13.

Erratum: the genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families.

Schwarz EM, Hu Y, Antoshechkin I, Miller MM, Sternberg PW, Aroian RV.

Nat Genet. 2015 Jun;47(6):689. doi: 10.1038/ng0615-689a. No abstract available.

PMID:
26018900
14.

Protection and Delivery of Anthelmintic Protein Cry5B to Nematodes Using Mesoporous Silicon Particles.

Wu CC, Hu Y, Miller M, Aroian RV, Sailor MJ.

ACS Nano. 2015 Jun 23;9(6):6158-67. doi: 10.1021/acsnano.5b01426. Epub 2015 May 20.

15.

The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families.

Schwarz EM, Hu Y, Antoshechkin I, Miller MM, Sternberg PW, Aroian RV.

Nat Genet. 2015 Apr;47(4):416-22. doi: 10.1038/ng.3237. Epub 2015 Mar 2. Erratum in: Nat Genet. 2015 Jun;47(6):689.

16.

Nitazoxanide: nematicidal mode of action and drug combination studies.

Somvanshi VS, Ellis BL, Hu Y, Aroian RV.

Mol Biochem Parasitol. 2014 Jan;193(1):1-8. doi: 10.1016/j.molbiopara.2013.12.002. Epub 2014 Jan 8.

17.

Novel role for the yceGH tellurite resistance genes in the pathogenesis of Bacillus anthracis.

Franks SE, Ebrahimi C, Hollands A, Okumura CY, Aroian RV, Nizet V, McGillivray SM.

Infect Immun. 2014 Mar;82(3):1132-40. doi: 10.1128/IAI.01614-13. Epub 2013 Dec 23.

18.

An extensive comparison of the effect of anthelmintic classes on diverse nematodes.

Hu Y, Ellis BL, Yiu YY, Miller MM, Urban JF, Shi LZ, Aroian RV.

PLoS One. 2013 Jul 15;8(7):e70702. doi: 10.1371/journal.pone.0070702. Print 2013.

19.

Bacillus subtilis strain engineered for treatment of soil-transmitted helminth diseases.

Hu Y, Miller MM, Derman AI, Ellis BL, Monnerat RG, Pogliano J, Aroian RV.

Appl Environ Microbiol. 2013 Sep;79(18):5527-32. doi: 10.1128/AEM.01854-13. Epub 2013 Jul 8.

20.

Bacillus thuringiensis-derived Cry5B has potent anthelmintic activity against Ascaris suum.

Urban JF Jr, Hu Y, Miller MM, Scheib U, Yiu YY, Aroian RV.

PLoS Negl Trop Dis. 2013 Jun 20;7(6):e2263. doi: 10.1371/journal.pntd.0002263. Print 2013.

21.

Role of pore-forming toxins in bacterial infectious diseases.

Los FC, Randis TM, Aroian RV, Ratner AJ.

Microbiol Mol Biol Rev. 2013 Jun;77(2):173-207. doi: 10.1128/MMBR.00052-12. Review.

22.

Neuronal Goα and CAPS regulate behavioral and immune responses to bacterial pore-forming toxins.

Los FC, Ha C, Aroian RV.

PLoS One. 2013;8(1):e54528. doi: 10.1371/journal.pone.0054528. Epub 2013 Jan 17.

23.

Structure and glycolipid binding properties of the nematicidal protein Cry5B.

Hui F, Scheib U, Hu Y, Sommer RJ, Aroian RV, Ghosh P.

Biochemistry. 2012 Dec 11;51(49):9911-21. doi: 10.1021/bi301386q. Epub 2012 Nov 26.

24.

Mechanistic and single-dose in vivo therapeutic studies of Cry5B anthelmintic action against hookworms.

Hu Y, Zhan B, Keegan B, Yiu YY, Miller MM, Jones K, Aroian RV.

PLoS Negl Trop Dis. 2012;6(11):e1900. doi: 10.1371/journal.pntd.0001900. Epub 2012 Nov 8.

25.

Bacterial pore-forming proteins as anthelmintics.

Hu Y, Aroian RV.

Invert Neurosci. 2012 Jun;12(1):37-41. doi: 10.1007/s10158-012-0135-8. Epub 2012 May 5. Review.

26.

The pore-forming protein Cry5B elicits the pathogenicity of Bacillus sp. against Caenorhabditis elegans.

Kho MF, Bellier A, Balasubramani V, Hu Y, Hsu W, Nielsen-LeRoux C, McGillivray SM, Nizet V, Aroian RV.

PLoS One. 2011;6(12):e29122. doi: 10.1371/journal.pone.0029122. Epub 2011 Dec 22.

27.

Global functional analyses of cellular responses to pore-forming toxins.

Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV.

PLoS Pathog. 2011 Mar;7(3):e1001314. doi: 10.1371/journal.ppat.1001314. Epub 2011 Mar 3.

28.

RAB-5- and RAB-11-dependent vesicle-trafficking pathways are required for plasma membrane repair after attack by bacterial pore-forming toxin.

Los FC, Kao CY, Smitham J, McDonald KL, Ha C, Peixoto CA, Aroian RV.

Cell Host Microbe. 2011 Feb 17;9(2):147-57. doi: 10.1016/j.chom.2011.01.005.

29.

Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants.

Balla KM, Lugo-Villarino G, Spitsbergen JM, Stachura DL, Hu Y, Bañuelos K, Romo-Fewell O, Aroian RV, Traver D.

Blood. 2010 Nov 11;116(19):3944-54. doi: 10.1182/blood-2010-03-267419. Epub 2010 Aug 16.

30.

Discovery of a highly synergistic anthelmintic combination that shows mutual hypersusceptibility.

Hu Y, Platzer EG, Bellier A, Aroian RV.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5955-60. doi: 10.1073/pnas.0912327107. Epub 2010 Mar 15.

31.

WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.

Chen CS, Bellier A, Kao CY, Yang YL, Chen HD, Los FC, Aroian RV.

PLoS One. 2010 Mar 2;5(3):e9494. doi: 10.1371/journal.pone.0009494.

32.

Bacillus thuringiensis Cry5B protein is highly efficacious as a single-dose therapy against an intestinal roundworm infection in mice.

Hu Y, Georghiou SB, Kelleher AJ, Aroian RV.

PLoS Negl Trop Dis. 2010 Mar 2;4(3):e614. doi: 10.1371/journal.pntd.0000614.

33.

Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans.

Bellier A, Chen CS, Kao CY, Cinar HN, Aroian RV.

PLoS Pathog. 2009 Dec;5(12):e1000689. doi: 10.1371/journal.ppat.1000689. Epub 2009 Dec 11.

34.

The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist.

Hu Y, Xiao SH, Aroian RV.

PLoS Negl Trop Dis. 2009 Aug 11;3(8):e499. doi: 10.1371/journal.pntd.0000499.

35.

ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis.

McGillivray SM, Ebrahimi CM, Fisher N, Sabet M, Zhang DX, Chen Y, Haste NM, Aroian RV, Gallo RL, Guiney DG, Friedlander AM, Koehler TM, Nizet V.

J Innate Immun. 2009;1(5):494-506. doi: 10.1159/000225955. Epub 2009 Jun 18.

36.

Nervous about immunity: neuronal signals control innate immune system.

Kao CY, Los FC, Aroian RV.

Nat Immunol. 2008 Dec;9(12):1329-30. doi: 10.1038/ni1208-1329. No abstract available.

PMID:
19008931
37.

Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo.

Bischof LJ, Kao CY, Los FC, Gonzalez MR, Shen Z, Briggs SP, van der Goot FG, Aroian RV.

PLoS Pathog. 2008 Oct;4(10):e1000176. doi: 10.1371/journal.ppat.1000176. Epub 2008 Oct 10.

38.

Resistance is non-futile: resistance to Cry5B in the nematode Caenorhabditis elegans.

Barrows BD, Griffitts JS, Aroian RV.

J Invertebr Pathol. 2007 Jul;95(3):198-200. Epub 2007 Apr 6.

PMID:
17482642
39.

Resistance to root-knot nematode in tomato roots expressing a nematicidal Bacillus thuringiensis crystal protein.

Li XQ, Wei JZ, Tan A, Aroian RV.

Plant Biotechnol J. 2007 Jul;5(4):455-64. Epub 2007 Apr 19.

40.

Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose.

Barrows BD, Haslam SM, Bischof LJ, Morris HR, Dell A, Aroian RV.

J Biol Chem. 2007 Feb 2;282(5):3302-11. Epub 2006 Nov 29.

41.

Caenorhabditis elegans carbohydrates in bacterial toxin resistance.

Barrows BD, Griffitts JS, Aroian RV.

Methods Enzymol. 2006;417:340-58. Review.

PMID:
17132513
42.

A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum.

Cappello M, Bungiro RD, Harrison LM, Bischof LJ, Griffitts JS, Barrows BD, Aroian RV.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15154-9. Epub 2006 Sep 27.

43.

Assays for toxicity studies in C. elegans with Bt crystal proteins.

Bischof LJ, Huffman DL, Aroian RV.

Methods Mol Biol. 2006;351:139-54. Review.

PMID:
16988432
44.

Many roads to resistance: how invertebrates adapt to Bt toxins.

Griffitts JS, Aroian RV.

Bioessays. 2005 Jun;27(6):614-24. Review.

PMID:
15892110
45.

Glycolipids as receptors for Bacillus thuringiensis crystal toxin.

Griffitts JS, Haslam SM, Yang T, Garczynski SF, Mulloy B, Morris H, Cremer PS, Dell A, Adang MJ, Aroian RV.

Science. 2005 Feb 11;307(5711):922-5.

46.

Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins.

Huffman DL, Abrami L, Sasik R, Corbeil J, van der Goot FG, Aroian RV.

Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10995-1000. Epub 2004 Jul 15.

47.

Pore worms: using Caenorhabditis elegans to study how bacterial toxins interact with their target host.

Huffman DL, Bischof LJ, Griffitts JS, Aroian RV.

Int J Med Microbiol. 2004 Apr;293(7-8):599-607. Review.

PMID:
15149037
48.
49.

Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions.

Griffitts JS, Huffman DL, Whitacre JL, Barrows BD, Marroquin LD, Müller R, Brown JR, Hennet T, Esko JD, Aroian RV.

J Biol Chem. 2003 Nov 14;278(46):45594-602. Epub 2003 Aug 27.

50.

Bacillus thuringiensis crystal proteins that target nematodes.

Wei JZ, Hale K, Carta L, Platzer E, Wong C, Fang SC, Aroian RV.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2760-5. Epub 2003 Feb 21.

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