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Items: 1 to 50 of 147

1.

Evolution in Neuromodulation-The Differential Roles of Acetylcholine in Higher Order Association vs. Primary Visual Cortices.

Galvin VC, Arnsten AFT, Wang M.

Front Neural Circuits. 2018 Aug 28;12:67. doi: 10.3389/fncir.2018.00067. eCollection 2018. Review.

2.

Persistent Spiking Activity Underlies Working Memory.

Constantinidis C, Funahashi S, Lee D, Murray JD, Qi XL, Wang M, Arnsten AFT.

J Neurosci. 2018 Aug 8;38(32):7020-7028. doi: 10.1523/JNEUROSCI.2486-17.2018.

PMID:
30089641
3.

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging.

Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH.

JAMA Neurol. 2018 Jul 16. doi: 10.1001/jamaneurol.2018.1836. [Epub ahead of print]

PMID:
30014145
4.

Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial.

Barcelos NM, Van Ness PH, Wagner AF, MacAvoy MG, Mecca AP, Anderson GM, Trentalange M, Hawkins KA, Sano M, Arnsten AFT, van Dyck CH.

Neurobiol Aging. 2018 Oct;70:117-124. doi: 10.1016/j.neurobiolaging.2018.05.033. Epub 2018 May 31.

5.

The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline.

Castonguay D, Dufort-Gervais J, Ménard C, Chatterjee M, Quirion R, Bontempi B, Schneider JS, Arnsten AFT, Nairn AC, Norris CM, Ferland G, Bézard E, Gaudreau P, Lombroso PJ, Brouillette J.

Curr Biol. 2018 Apr 2;28(7):1079-1089.e4. doi: 10.1016/j.cub.2018.02.047. Epub 2018 Mar 22.

PMID:
29576474
6.

Unique Molecular Regulation of Higher-Order Prefrontal Cortical Circuits: Insights into the Neurobiology of Schizophrenia.

Datta D, Arnsten AFT.

ACS Chem Neurosci. 2018 Sep 19;9(9):2127-2145. doi: 10.1021/acschemneuro.7b00505. Epub 2018 Mar 1.

7.

Core Differences in Synaptic Signaling Between Primary Visual and Dorsolateral Prefrontal Cortex.

Yang ST, Wang M, Paspalas CD, Crimins JL, Altman MT, Mazer JA, Arnsten AFT.

Cereb Cortex. 2018 Apr 1;28(4):1458-1471. doi: 10.1093/cercor/bhx357.

8.

The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology.

Paspalas CD, Carlyle BC, Leslie S, Preuss TM, Crimins JL, Huttner AJ, van Dyck CH, Rosene DL, Nairn AC, Arnsten AFT.

Alzheimers Dement. 2018 May;14(5):680-691. doi: 10.1016/j.jalz.2017.11.005. Epub 2017 Dec 11.

9.

Risky Business: The Circuits that Impact Stress-Induced Decision-Making.

Arnsten AFT, Lee D, Pittenger C.

Cell. 2017 Nov 16;171(5):992-993. doi: 10.1016/j.cell.2017.11.004.

PMID:
29149614
10.

mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions.

Jin LE, Wang M, Yang ST, Yang Y, Galvin VC, Lightbourne TC, Ottenheimer D, Zhong Q, Stein J, Raja A, Paspalas CD, Arnsten AFT.

Mol Psychiatry. 2017 Nov;22(11):1511. doi: 10.1038/mp.2017.206. No abstract available.

PMID:
29068001
11.

Nicotinic α4β2 Cholinergic Receptor Influences on Dorsolateral Prefrontal Cortical Neuronal Firing during a Working Memory Task.

Sun Y, Yang Y, Galvin VC, Yang S, Arnsten AF, Wang M.

J Neurosci. 2017 May 24;37(21):5366-5377. doi: 10.1523/JNEUROSCI.0364-17.2017. Epub 2017 Apr 27.

12.

mGluR2 versus mGluR3 Metabotropic Glutamate Receptors in Primate Dorsolateral Prefrontal Cortex: Postsynaptic mGluR3 Strengthen Working Memory Networks.

Jin LE, Wang M, Galvin VC, Lightbourne TC, Conn PJ, Arnsten AFT, Paspalas CD.

Cereb Cortex. 2018 Mar 1;28(3):974-987. doi: 10.1093/cercor/bhx005.

PMID:
28108498
13.

Ultrastructural evidence for impaired mitochondrial fission in the aged rhesus monkey dorsolateral prefrontal cortex.

Morozov YM, Datta D, Paspalas CD, Arnsten AFT.

Neurobiol Aging. 2017 Mar;51:9-18. doi: 10.1016/j.neurobiolaging.2016.12.001. Epub 2016 Dec 10.

14.

mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions.

Jin LE, Wang M, Yang ST, Yang Y, Galvin VC, Lightbourne TC, Ottenheimer D, Zhong Q, Stein J, Raja A, Paspalas CD, Arnsten AFT.

Mol Psychiatry. 2017 Nov;22(11):1615-1625. doi: 10.1038/mp.2016.129. Epub 2016 Aug 9.

15.

Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA Jr, Carter CS, Cook EH Jr, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA Jr, Zubieta JK.

Biol Psychiatry. 2016 Jul 15;80(2):84-86. doi: 10.1016/j.biopsych.2016.05.004. No abstract available.

PMID:
27346079
16.

Ketamine's Antidepressant Actions: Potential Mechanisms in the Primate Medial Prefrontal Circuits That Represent Aversive Experience.

Arnsten AF, Murray JD, Seo H, Lee D.

Biol Psychiatry. 2016 May 1;79(9):713-5. doi: 10.1016/j.biopsych.2016.02.014. No abstract available.

17.

Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia.

Arnsten AF, Girgis RR, Gray DL, Mailman RB.

Biol Psychiatry. 2017 Jan 1;81(1):67-77. doi: 10.1016/j.biopsych.2015.12.028. Epub 2016 Jan 18. Review.

18.

Targeting Prefrontal Cortical Systems for Drug Development: Potential Therapies for Cognitive Disorders.

Arnsten AF, Wang M.

Annu Rev Pharmacol Toxicol. 2016;56:339-60. doi: 10.1146/annurev-pharmtox-010715-103617. Review.

19.

Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology.

Abdallah CG, Averill LA, Krystal JH, Southwick SM, Arnsten AF.

Behav Brain Sci. 2016 Jan;39:e201. doi: 10.1017/S0140525X15001727.

21.

Stress weakens prefrontal networks: molecular insults to higher cognition.

Arnsten AF.

Nat Neurosci. 2015 Oct;18(10):1376-85. doi: 10.1038/nn.4087. Epub 2015 Sep 25. Review.

22.

Dopamine's Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders.

Arnsten AF, Wang M, Paspalas CD.

Pharmacol Rev. 2015 Jul;67(3):681-96. doi: 10.1124/pr.115.010512. Review.

23.

Contribution of NMDA receptors to dorsolateral prefrontal cortical networks in primates.

Wang M, Arnsten AF.

Neurosci Bull. 2015 Apr;31(2):191-7. doi: 10.1007/s12264-014-1504-6. Epub 2015 Mar 9. Review.

24.

Stress Impairs Prefrontal Cortical Function via D1 Dopamine Receptor Interactions With Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels.

Gamo NJ, Lur G, Higley MJ, Wang M, Paspalas CD, Vijayraghavan S, Yang Y, Ramos BP, Peng K, Kata A, Boven L, Lin F, Roman L, Lee D, Arnsten AF.

Biol Psychiatry. 2015 Dec 15;78(12):860-70. doi: 10.1016/j.biopsych.2015.01.009. Epub 2015 Feb 4.

26.

Ameliorating treatment-refractory depression with intranasal ketamine: potential NMDA receptor actions in the pain circuitry representing mental anguish.

Opler LA, Opler MG, Arnsten AF.

CNS Spectr. 2016 Feb;21(1):12-22. doi: 10.1017/S1092852914000686. Epub 2015 Jan 26. Review.

27.

A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation.

McKee SA, Potenza MN, Kober H, Sofuoglu M, Arnsten AF, Picciotto MR, Weinberger AH, Ashare R, Sinha R.

J Psychopharmacol. 2015 Mar;29(3):300-11. doi: 10.1177/0269881114562091. Epub 2014 Dec 16.

28.
29.

Guanfacine extended release for the treatment of attention-deficit/hyperactivity disorder in children and adolescents.

Connor DF, Arnsten AF, Pearson GS, Greco GF.

Expert Opin Pharmacother. 2014 Aug;15(11):1601-10. doi: 10.1517/14656566.2014.930437. Epub 2014 Jul 3. Review.

PMID:
24992513
30.

An Update on Posttraumatic Stress Disorder in Children and Adolescents.

Connor DF, Ford JD, Arnsten AF, Greene CA.

Clin Pediatr (Phila). 2015 Jun;54(6):517-28. doi: 10.1177/0009922814540793. Epub 2014 Jul 2. Review. No abstract available.

PMID:
24990362
31.

cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex.

Carlyle BC, Nairn AC, Wang M, Yang Y, Jin LE, Simen AA, Ramos BP, Bordner KA, Craft GE, Davies P, Pletikos M, Šestan N, Arnsten AF, Paspalas CD.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):5036-41. doi: 10.1073/pnas.1322360111. Epub 2014 Mar 18.

32.

Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels.

El-Hassar L, Simen AA, Duque A, Patel KD, Kaczmarek LK, Arnsten AF, Yeckel MF.

Biol Psychiatry. 2014 Sep 15;76(6):476-85. doi: 10.1016/j.biopsych.2013.12.019. Epub 2014 Jan 20.

33.

Molecular influences on working memory circuits in dorsolateral prefrontal cortex.

Arnsten AF, Jin LE.

Prog Mol Biol Transl Sci. 2014;122:211-31. doi: 10.1016/B978-0-12-420170-5.00008-8. Review.

PMID:
24484703
34.

Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction.

Gamo NJ, Duque A, Paspalas CD, Kata A, Fine R, Boven L, Bryan C, Lo T, Anighoro K, Bermudez L, Peng K, Annor A, Raja A, Mansson E, Taylor SR, Patel K, Simen AA, Arnsten AF.

Transl Psychiatry. 2013 Dec 3;3:e328. doi: 10.1038/tp.2013.104.

35.

The neurobiology of thought: the groundbreaking discoveries of Patricia Goldman-Rakic 1937-2003.

Arnsten AF.

Cereb Cortex. 2013 Oct;23(10):2269-81. doi: 10.1093/cercor/bht195. Epub 2013 Aug 7.

36.

Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex.

Yang Y, Paspalas CD, Jin LE, Picciotto MR, Arnsten AF, Wang M.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12078-83. doi: 10.1073/pnas.1307849110. Epub 2013 Jul 1.

37.

NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex.

Wang M, Yang Y, Wang CJ, Gamo NJ, Jin LE, Mazer JA, Morrison JH, Wang XJ, Arnsten AF.

Neuron. 2013 Feb 20;77(4):736-49. doi: 10.1016/j.neuron.2012.12.032.

38.

Noradrenergic control of error perseveration in medial prefrontal cortex.

Caetano MS, Jin LE, Harenberg L, Stachenfeld KL, Arnsten AF, Laubach M.

Front Integr Neurosci. 2013 Jan 2;6:125. doi: 10.3389/fnint.2012.00125. eCollection 2012. Erratum in: Front Integr Neurosci. 2013;7:48.

39.

Psychostimulants and motivated behavior: arousal and cognition.

Berridge CW, Arnsten AF.

Neurosci Biobehav Rev. 2013 Nov;37(9 Pt A):1976-84. doi: 10.1016/j.neubiorev.2012.11.005. Epub 2012 Nov 16. Review.

PMID:
23164814
40.

Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses.

Arnsten AF, Wang MJ, Paspalas CD.

Neuron. 2012 Oct 4;76(1):223-39. doi: 10.1016/j.neuron.2012.08.038. Review.

41.
42.

Guanfacine for the treatment of cognitive disorders: a century of discoveries at Yale.

Arnsten AF, Jin LE.

Yale J Biol Med. 2012 Mar;85(1):45-58. Epub 2012 Mar 29. Review.

43.

Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatric disorders.

Arnsten AF, Rubia K.

J Am Acad Child Adolesc Psychiatry. 2012 Apr;51(4):356-67. doi: 10.1016/j.jaac.2012.01.008. Epub 2012 Mar 3. Review.

PMID:
22449642
44.

Lost in transition: aging-related changes in executive control by the medial prefrontal cortex.

Caetano MS, Horst NK, Harenberg L, Liu B, Arnsten AF, Laubach M.

J Neurosci. 2012 Mar 14;32(11):3765-77. doi: 10.1523/JNEUROSCI.6011-11.2012.

45.

Effects of α-2A adrenergic receptor agonist on time and risk preference in primates.

Kim S, Bobeica I, Gamo NJ, Arnsten AF, Lee D.

Psychopharmacology (Berl). 2012 Jan;219(2):363-75. doi: 10.1007/s00213-011-2520-0. Epub 2011 Oct 7.

46.

Neuronal basis of age-related working memory decline.

Wang M, Gamo NJ, Yang Y, Jin LE, Wang XJ, Laubach M, Mazer JA, Lee D, Arnsten AF.

Nature. 2011 Jul 27;476(7359):210-3. doi: 10.1038/nature10243.

47.

Prefrontal cortical organization and function: implications for externalizing disorders.

Arnsten AF, Casey BJ.

Biol Psychiatry. 2011 Jun 15;69(12):1131-2. doi: 10.1016/j.biopsych.2011.03.010. No abstract available.

PMID:
21640860
48.

Catecholamine influences on dorsolateral prefrontal cortical networks.

Arnsten AF.

Biol Psychiatry. 2011 Jun 15;69(12):e89-99. doi: 10.1016/j.biopsych.2011.01.027. Epub 2011 Apr 13. Review.

49.

Molecular modulation of prefrontal cortex: rational development of treatments for psychiatric disorders.

Gamo NJ, Arnsten AF.

Behav Neurosci. 2011 Jun;125(3):282-96. doi: 10.1037/a0023165. Review.

50.

Prefrontal cortical network connections: key site of vulnerability in stress and schizophrenia.

Arnsten AF.

Int J Dev Neurosci. 2011 May;29(3):215-23. doi: 10.1016/j.ijdevneu.2011.02.006. Epub 2011 Feb 21. Review.

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