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Regulation of Tumor-Associated Myeloid Cell Activity by CBP/EP300 Bromodomain Modulation of H3K27 Acetylation.

de Almeida Nagata DE, Chiang EY, Jhunjhunwala S, Caplazi P, Arumugam V, Modrusan Z, Chan E, Merchant M, Jin L, Arnott D, Romero FA, Magnuson S, Gascoigne KE, Grogan JL.

Cell Rep. 2019 Apr 2;27(1):269-281.e4. doi: 10.1016/j.celrep.2019.03.008.


Stop Smoking Practitioners' understanding of e-cigarettes' use and efficacy with particular reference to vapers' socioeconomic status.

Hiscock R, Arnott D, Dockrell M, Ross L, McEwen A.

J Smok Cessat. 2019 Mar;14(1):21-31. doi: 10.1017/jsc.2018.9.


Open letter to Simon Stevens to ensure that tobacco dependence treatment is provided for every smoker cared for by the NHS, as part of the long term plan.

Goddard A, Burn W, Regan L, Viner R, Stokes-Lampard H, Mahajan R, Anagnostara E, Hollins S, Wessely S, Arnott D, Cramer S, Watson M, Black C, Ashcroft R, Hopkinson N; 800 doctors, health professionals, and academics.

BMJ. 2018 Nov 15;363:k4827. doi: 10.1136/bmj.k4827. No abstract available.


Harm perceptions of electronic cigarettes and nicotine: A nationally representative cross-sectional survey of young people in Great Britain.

East K, Brose LS, McNeill A, Cheeseman H, Arnott D, Hitchman SC.

Drug Alcohol Depend. 2018 Nov 1;192:257-263. doi: 10.1016/j.drugalcdep.2018.08.016. Epub 2018 Oct 2.


Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.

Raisner R, Kharbanda S, Jin L, Jeng E, Chan E, Merchant M, Haverty PM, Bainer R, Cheung T, Arnott D, Flynn EM, Romero FA, Magnuson S, Gascoigne KE.

Cell Rep. 2018 Aug 14;24(7):1722-1729. doi: 10.1016/j.celrep.2018.07.041.


The Authors reply.

East K, Hitchman SC, Bakolis I, Williams S, Cheeseman H, Arnott D, McNeill A.

J Adolesc Health. 2018 Jul;63(1):118-119. doi: 10.1016/j.jadohealth.2018.04.006. No abstract available.


Why tobacco product regulation is no magic bullet.

Arnott D.

Tob Control. 2019 May;28(3):249. doi: 10.1136/tobaccocontrol-2018-054452. Epub 2018 Jul 21. No abstract available.


Should we recommend e-cigarettes to help smokers quit?

Aveyard P, Arnott D, Johnson KC.

BMJ. 2018 Apr 25;361:k1759. doi: 10.1136/bmj.k1759. No abstract available.


Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes.

Arenzana TL, Lianoglou S, Seki A, Eidenschenk C, Cheung T, Seshasayee D, Hagenbeek T, Sambandam A, Noubade R, Peng I, Lesch J, DeVoss J, Wu X, Lee WP, Caplazi P, Webster J, Liu J, Pham VC, Arnott D, Lill JR, Modrusan Z, Dey A, Rutz S.

Sci Immunol. 2018 Apr 20;3(22). pii: eaal1953. doi: 10.1126/sciimmunol.aal1953.


The Association Between Smoking and Electronic Cigarette Use in a Cohort of Young People.

East K, Hitchman SC, Bakolis I, Williams S, Cheeseman H, Arnott D, McNeill A.

J Adolesc Health. 2018 May;62(5):539-547. doi: 10.1016/j.jadohealth.2017.11.301. Epub 2018 Mar 2.


Smoking: Developing the evidence base.

Holliday R, Arnott D, Preshaw PM, Bauld L.

Br Dent J. 2018 Jan 12;224(1):3-4. doi: 10.1038/sj.bdj.2018.11. No abstract available.


A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine.

Leadem BR, Kagiampakis I, Wilson C, Cheung TK, Arnott D, Trojer P, Classon M, Easwaran H, Baylin SB.

Cancer Res. 2018 Mar 1;78(5):1127-1139. doi: 10.1158/0008-5472.CAN-17-1453. Epub 2017 Dec 27.


SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.

Viotti M, Wilson C, McCleland M, Koeppen H, Haley B, Jhunjhunwala S, Klijn C, Modrusan Z, Arnott D, Classon M, Stephan JP, Mellman I.

J Cell Biol. 2018 Feb 5;217(2):763-777. doi: 10.1083/jcb.201705031. Epub 2017 Dec 11.


The impact diverging public opinion on cannabis and tobacco regulation has on constructive engagement between advocates.

Arnott D.

Addiction. 2018 Apr;113(4):605-606. doi: 10.1111/add.14024. Epub 2017 Oct 16. No abstract available.


Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia.

Cuellar TL, Herzner AM, Zhang X, Goyal Y, Watanabe C, Friedman BA, Janakiraman V, Durinck S, Stinson J, Arnott D, Cheung TK, Chaudhuri S, Modrusan Z, Doerr JM, Classon M, Haley B.

J Cell Biol. 2017 Nov 6;216(11):3535-3549. doi: 10.1083/jcb.201612160. Epub 2017 Sep 8.


Young People's Use of E-Cigarettes across the United Kingdom: Findings from Five Surveys 2015-2017.

Bauld L, MacKintosh AM, Eastwood B, Ford A, Moore G, Dockrell M, Arnott D, Cheeseman H, McNeill A.

Int J Environ Res Public Health. 2017 Aug 29;14(9). pii: E973. doi: 10.3390/ijerph14090973.


Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure.

Guler GD, Tindell CA, Pitti R, Wilson C, Nichols K, KaiWai Cheung T, Kim HJ, Wongchenko M, Yan Y, Haley B, Cuellar T, Webster J, Alag N, Hegde G, Jackson E, Nance TL, Giresi PG, Chen KB, Liu J, Jhunjhunwala S, Settleman J, Stephan JP, Arnott D, Classon M.

Cancer Cell. 2017 Aug 14;32(2):221-237.e13. doi: 10.1016/j.ccell.2017.07.002. Epub 2017 Aug 3.


Electronic cigarette use in young people in Great Britain 2015-2016.

Eastwood B, East K, Brose LS, Dockrell MJ, Arnott D, Cheeseman H, McNeill A.

Public Health. 2017 Aug;149:45-48. doi: 10.1016/j.puhe.2017.03.019. Epub 2017 May 19. No abstract available.


Restrictions on the use of e-cigarettes in public and private places-current practice and support among adults in Great Britain.

Brose LS, McNeill A, Arnott D, Cheeseman H.

Eur J Public Health. 2017 Aug 1;27(4):729-736. doi: 10.1093/eurpub/ckw268.


A global database of nitrogen and phosphorus excretion rates of aquatic animals.

Vanni MJ, McIntyre PB, Allen D, Arnott DL, Benstead JP, Berg DJ, Brabrand Å, Brosse S, Bukaveckas PA, Caliman A, Capps KA, Carneiro LS, Chadwick NE, Christian AD, Clarke A, Conroy JD, Cross WF, Culver DA, Dalton CM, Devine JA, Domine LM, Evans-White MA, Faafeng BA, Flecker AS, Gido KB, Godinot C, Guariento RD, Haertel-Borer S, Hall RO, Henry R, Herwig BR, Hicks BJ, Higgins KA, Hood JM, Hopton ME, Ikeda T, James WF, Jansen HM, Johnson CR, Koch BJ, Lamberti GA, Lessard-Pilon S, Maerz JC, Mather ME, McManamay RA, Milanovich JR, Morgan DKJ, Moslemi JM, Naddafi R, Nilssen JP, Pagano M, Pilati A, Post DM, Roopin M, Rugenski AT, Schaus MH, Shostell J, Small GE, Solomon CT, Sterrett SC, Strand Ø, Tarvainen M, Taylor JM, Torres-Gerald LE, Turner CB, Urabe J, Uye SI, Ventelä AM, Villeger S, Whiles MR, Wilhelm FM, Wilson HF, Xenopoulos MA, Zimmer KD.

Ecology. 2017 May;98(5):1475. doi: 10.1002/ecy.1792. Epub 2017 Apr 18.


What factors are associated with current smokers using or stopping e-cigarette use?

Simonavicius E, McNeill A, Arnott D, Brose LS.

Drug Alcohol Depend. 2017 Apr 1;173:139-143. doi: 10.1016/j.drugalcdep.2017.01.002. Epub 2017 Feb 14.


An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition.

Egan B, Yuan CC, Craske ML, Labhart P, Guler GD, Arnott D, Maile TM, Busby J, Henry C, Kelly TK, Tindell CA, Jhunjhunwala S, Zhao F, Hatton C, Bryant BM, Classon M, Trojer P.

PLoS One. 2016 Nov 22;11(11):e0166438. doi: 10.1371/journal.pone.0166438. eCollection 2016.


Quantitative Proteomics Reveals Fundamental Regulatory Differences in Oncogenic HRAS and Isocitrate Dehydrogenase (IDH1) Driven Astrocytoma.

Doll S, Urisman A, Oses-Prieto JA, Arnott D, Burlingame AL.

Mol Cell Proteomics. 2017 Jan;16(1):39-56. doi: 10.1074/mcp.M116.063883. Epub 2016 Nov 10.


A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase.

Morisaki JH, Smith PA, Date SV, Kajihara KK, Truong CL, Modrusan Z, Yan D, Kang J, Xu M, Shah IM, Mintzer R, Kofoed EM, Cheung TK, Arnott D, Koehler MF, Heise CE, Brown EJ, Tan MW, Hazenbos WL.

MBio. 2016 Sep 6;7(5). pii: e00412-16. doi: 10.1128/mBio.00412-16.


UK government should fund stop smoking media campaigns not give tax breaks to films with smoking imagery.

Hopkinson NS, Millett C, Glantz S, Arnott D, McNeill A.

Addiction. 2016 Nov;111(11):2066-2067. doi: 10.1111/add.13511. Epub 2016 Aug 1. No abstract available.


Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network.

Gnad F, Wallin J, Edgar K, Doll S, Arnott D, Robillard L, Kirkpatrick DS, Stokes MP, Vijapurkar U, Hatzivassiliou G, Friedman LS, Belvin M.

Proteomics. 2016 Jul;16(14):1992-7. doi: 10.1002/pmic.201600118. Epub 2016 Jul 8.


Phosphoproteome analysis of the MAPK pathway reveals previously undetected feedback mechanisms.

Gnad F, Doll S, Song K, Stokes MP, Moffat J, Liu B, Arnott D, Wallin J, Friedman LS, Hatzivassiliou G, Belvin M.

Proteomics. 2016 Jul;16(14):1998-2004. doi: 10.1002/pmic.201600119.


An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.

Vinogradova M, Gehling VS, Gustafson A, Arora S, Tindell CA, Wilson C, Williamson KE, Guler GD, Gangurde P, Manieri W, Busby J, Flynn EM, Lan F, Kim HJ, Odate S, Cochran AG, Liu Y, Wongchenko M, Yang Y, Cheung TK, Maile TM, Lau T, Costa M, Hegde GV, Jackson E, Pitti R, Arnott D, Bailey C, Bellon S, Cummings RT, Albrecht BK, Harmange JC, Kiefer JR, Trojer P, Classon M.

Nat Chem Biol. 2016 Jul;12(7):531-8. doi: 10.1038/nchembio.2085. Epub 2016 May 23.


NLRP3 recruitment by NLRC4 during Salmonella infection.

Qu Y, Misaghi S, Newton K, Maltzman A, Izrael-Tomasevic A, Arnott D, Dixit VM.

J Exp Med. 2016 May 30;213(6):877-85. doi: 10.1084/jem.20132234. Epub 2016 May 2.


Nicotine without smoke-putting electronic cigarettes in context.

Britton J, Arnott D, McNeill A, Hopkinson N; Tobacco Advisory Group of the Royal College of Physicians.

BMJ. 2016 Apr 27;353:i1745. doi: 10.1136/bmj.i1745. No abstract available.


Views from the Coalface: What Do English Stop Smoking Service Personnel Think about E-Cigarettes?

Hiscock R, Bauld L, Arnott D, Dockrell M, Ross L, McEwen A.

Int J Environ Res Public Health. 2015 Dec 21;12(12):16157-67. doi: 10.3390/ijerph121215048.


Should psychiatric hospitals completely ban smoking?

Arnott D, Wessely S, Fitzpatrick M.

BMJ. 2015 Nov 4;351:h5654. doi: 10.1136/bmj.h5654. No abstract available.


Proteomic Profiling of Cranial (Superior) Cervical Ganglia Reveals Beta-Amyloid and Ubiquitin Proteasome System Perturbations in an Equine Multiple System Neuropathy.

McGorum BC, Pirie RS, Eaton SL, Keen JA, Cumyn EM, Arnott DM, Chen W, Lamont DJ, Graham LC, Llavero Hurtado M, Pemberton A, Wishart TM.

Mol Cell Proteomics. 2015 Nov;14(11):3072-86. doi: 10.1074/mcp.M115.054635. Epub 2015 Sep 13.


Electronic cigarette use in young people in Great Britain 2013-2014.

Eastwood B, Dockrell MJ, Arnott D, Britton J, Cheeseman H, Jarvis MJ, McNeill A.

Public Health. 2015 Sep;129(9):1150-6. doi: 10.1016/j.puhe.2015.07.009. Epub 2015 Aug 17.


Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer.

Gnad F, Doll S, Manning G, Arnott D, Zhang Z.

BMC Genomics. 2015;16 Suppl 8:S5. doi: 10.1186/1471-2164-16-S8-S5. Epub 2015 Jun 18.


Mass spectrometric quantification of histone post-translational modifications by a hybrid chemical labeling method.

Maile TM, Izrael-Tomasevic A, Cheung T, Guler GD, Tindell C, Masselot A, Liang J, Zhao F, Trojer P, Classon M, Arnott D.

Mol Cell Proteomics. 2015 Apr;14(4):1148-58. doi: 10.1074/mcp.O114.046573. Epub 2015 Feb 13.


Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells.

Sun Y, Daemen A, Hatzivassiliou G, Arnott D, Wilson C, Zhuang G, Gao M, Liu P, Boudreau A, Johnson L, Settleman J.

Cancer Metab. 2014 Nov 3;2(1):20. doi: 10.1186/2049-3002-2-20. eCollection 2014.


E-cigarettes: online survey of UK smoking cessation practitioners.

Hiscock R, Goniewicz ML, McEwen A, Murray S, Arnott D, Dockrell M, Bauld L.

Tob Induc Dis. 2014 Aug 21;12(1):13. doi: 10.1186/1617-9625-12-13. eCollection 2014.


Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains.

Bainbridge TW, DeAlmeida VI, Izrael-Tomasevic A, Chalouni C, Pan B, Goldsmith J, Schoen AP, Quiñones GA, Kelly R, Lill JR, Sandoval W, Costa M, Polakis P, Arnott D, Rubinfeld B, Ernst JA.

PLoS One. 2014 Jul 16;9(7):e102695. doi: 10.1371/journal.pone.0102695. eCollection 2014.


Stable-isotope-labeled histone peptide library for histone post-translational modification and variant quantification by mass spectrometry.

Lin S, Wein S, Gonzales-Cope M, Otte GL, Yuan ZF, Afjehi-Sadat L, Maile T, Berger SL, Rush J, Lill JR, Arnott D, Garcia BA.

Mol Cell Proteomics. 2014 Sep;13(9):2450-66. doi: 10.1074/mcp.O113.036459. Epub 2014 Jul 7.


Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomics.

Wildsmith KR, Schauer SP, Smith AM, Arnott D, Zhu Y, Haznedar J, Kaur S, Mathews WR, Honigberg LA.

Mol Neurodegener. 2014 Jun 6;9:22. doi: 10.1186/1750-1326-9-22.


Standardised packaging and tobacco-industry-funded research.

Laverty AA, Watt HC, Arnott D, Hopkinson NS.

Lancet. 2014 Apr 19;383(9926):1384. doi: 10.1016/S0140-6736(14)60499-2. Epub 2014 Apr 9. No abstract available.


Child uptake of smoking by area across the UK.

Hopkinson NS, Lester-George A, Ormiston-Smith N, Cox A, Arnott D.

Thorax. 2014 Sep;69(9):873-5. doi: 10.1136/thoraxjnl-2013-204379. Epub 2013 Dec 4.


Identifying potential therapeutic targets of methicillin-resistant Staphylococcus aureus through in vivo proteomic analysis.

Diep BA, Phung Q, Date S, Arnott D, Bakalarski C, Xu M, Nakamura G, Swem DL, Alexander MK, Le HN, Mai TT, Tan MW, Brown EJ, Nishiyama M.

J Infect Dis. 2014 May 15;209(10):1533-41. doi: 10.1093/infdis/jit662. Epub 2013 Nov 26.


The perceptions of UK youth of branded and standardized, 'plain' cigarette packaging.

Hammond D, White C, Anderson W, Arnott D, Dockrell M.

Eur J Public Health. 2014 Aug;24(4):537-43. doi: 10.1093/eurpub/ckt142. Epub 2013 Oct 8.


There's no single endgame.

Arnott D.

Tob Control. 2013 May;22 Suppl 1:i38-9. doi: 10.1136/tobaccocontrol-2012-050823.


OTUB1 modulates c-IAP1 stability to regulate signalling pathways.

Goncharov T, Niessen K, de Almagro MC, Izrael-Tomasevic A, Fedorova AV, Varfolomeev E, Arnott D, Deshayes K, Kirkpatrick DS, Vucic D.

EMBO J. 2013 Apr 17;32(8):1103-14. doi: 10.1038/emboj.2013.62. Epub 2013 Mar 22.


Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.

Lee DY, Arnott D, Brown EJ.

EMBO Rep. 2013 Apr;14(4):373-81. doi: 10.1038/embor.2013.22. Epub 2013 Mar 5.


Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.

Pantua H, Diao J, Ultsch M, Hazen M, Mathieu M, McCutcheon K, Takeda K, Date S, Cheung TK, Phung Q, Hass P, Arnott D, Hongo JA, Matthews DJ, Brown A, Patel AH, Kelley RF, Eigenbrot C, Kapadia SB.

J Mol Biol. 2013 Jun 12;425(11):1899-1914. doi: 10.1016/j.jmb.2013.02.025. Epub 2013 Feb 28.


Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels.

Lipari MT, Li W, Moran P, Kong-Beltran M, Sai T, Lai J, Lin SJ, Kolumam G, Zavala-Solorio J, Izrael-Tomasevic A, Arnott D, Wang J, Peterson AS, Kirchhofer D.

J Biol Chem. 2012 Dec 21;287(52):43482-91. doi: 10.1074/jbc.M112.380618. Epub 2012 Nov 7.

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