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Multiplicity of asymptomatic Plasmodium falciparum infections and risk of clinical malaria: A systematic review and pooled analysis of individual participant data.

Eldh M, Hammar U, Arnot D, Beck HP, Garcia A, Liljander A, Mercereau-Puijalon O, Migot-Nabias F, Mueller I, Ntoumi F, Ross A, Smith T, Sondén K, Homann MV, Yman V, Felger I, Färnert A.

J Infect Dis. 2019 Oct 4. pii: jiz510. doi: 10.1093/infdis/jiz510. [Epub ahead of print]


Tying up Loose Ends in the Malaria Antigenic Variation Story.

Arnot DE.

Trends Parasitol. 2019 Aug;35(8):588-590. doi: 10.1016/ Epub 2019 Jun 29.


A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds.

Hong Y, Zhou F, Hua Y, Zhang X, Ni C, Pan D, Zhang Y, Jiang D, Yang L, Lin Q, Zou Y, Yu D, Arnot DE, Zou X, Zhu L, Zhang S, Ouyang H.

Nat Commun. 2019 May 14;10(1):2060. doi: 10.1038/s41467-019-10004-7.


South-west Scotland to West Bengal: where does patient expectation fall?

Hallam S, Arnot D.

Br J Gen Pract. 2016 Jan;66(642):35. doi: 10.3399/bjgp16X683209. Review. No abstract available.


A healthy patient with bilateral frozen hips preceding bilateral frozen shoulders: a cautionary tale.

Miller AR, Arnot D, Wake M.

BMJ Case Rep. 2015 Nov 12;2015. pii: bcr2015210523. doi: 10.1136/bcr-2015-210523.


How malaria parasites avoid running out of ammo.

Arnot DE.

PLoS Genet. 2014 Dec 18;10(12):e1004878. doi: 10.1371/journal.pgen.1004878. eCollection 2014 Dec. No abstract available.


Antibody responses to a novel Plasmodium falciparum merozoite surface protein vaccine correlate with protection against experimental malaria infection in Aotus monkeys.

Cavanagh DR, Kocken CH, White JH, Cowan GJ, Samuel K, Dubbeld MA, Voorberg-van der Wel A, Thomas AW, McBride JS, Arnot DE.

PLoS One. 2014 Jan 8;9(1):e83704. doi: 10.1371/journal.pone.0083704. eCollection 2014.


DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families.

Sander AF, Lavstsen T, Rask TS, Lisby M, Salanti A, Fordyce SL, Jespersen JS, Carter R, Deitsch KW, Theander TG, Pedersen AG, Arnot DE.

Nucleic Acids Res. 2014 Feb;42(4):2270-81. doi: 10.1093/nar/gkt1174. Epub 2013 Nov 18.


Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametes.

Mwakalinga SB, Wang CW, Bengtsson DC, Turner L, Dinko B, Lusingu JP, Arnot DE, Sutherland CJ, Theander TG, Lavstsen T.

Malar J. 2012 Dec 21;11:429. doi: 10.1186/1475-2875-11-429.


Analysis of single-cell gene transcription by RNA fluorescent in situ hybridization (FISH).

Ronander E, Bengtsson DC, Joergensen L, Jensen AT, Arnot DE.

J Vis Exp. 2012 Oct 7;(68). pii: 4073. doi: 10.3791/4073.


A malaria serological map indicating the intersection between parasite antigenic diversity and host antibody repertoires.

Giha HA, Nasr AA, Iriemenam NC, Berzins K, Troye-Blomberg M, Arnot DE, Elghazali G.

Eur J Clin Microbiol Infect Dis. 2012 Nov;31(11):3117-25. doi: 10.1007/s10096-012-1673-z. Epub 2012 Jun 29.


Plasmodium falciparum 19-kilodalton merozoite surface protein 1 (MSP1)-specific antibodies that interfere with parasite growth in vitro can inhibit MSP1 processing, merozoite invasion, and intracellular parasite development.

Moss DK, Remarque EJ, Faber BW, Cavanagh DR, Arnot DE, Thomas AW, Holder AA.

Infect Immun. 2012 Mar;80(3):1280-7. doi: 10.1128/IAI.05887-11. Epub 2011 Dec 27.


The effect of adjuvants on the immune response induced by a DBL4ɛ-ID4 VAR2CSA based Plasmodium falciparum vaccine against placental malaria.

Pinto VV, Salanti A, Joergensen LM, Dahlbäck M, Resende M, Ditlev SB, Agger EM, Arnot DE, Theander TG, Nielsen MA.

Vaccine. 2012 Jan 11;30(3):572-9. doi: 10.1016/j.vaccine.2011.11.068. Epub 2011 Nov 26.


Comparative decline in funding of European Commission malaria vaccine projects: what next for the European scientists working in this field?

Thøgersen RL, Holder AA, Hill AV, Arnot DE, Imoukhuede EB, Leroy O.

Malar J. 2011 Sep 1;10:255. doi: 10.1186/1475-2875-10-255.


Pattern of pre-existing IgG subclass responses to a panel of asexual stage malaria antigens reported during the lengthy dry season in Daraweesh, Sudan.

Nasr A, Iriemenam NC, Troye-Blomberg M, Arnot D, Theander TG, Berzins K, Giha HA, Elghazali G.

Scand J Immunol. 2011 Oct;74(4):390-6. doi: 10.1111/j.1365-3083.2011.02585.x.


Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women.

Sander AF, Salanti A, Lavstsen T, Nielsen MA, Theander TG, Leke RG, Lo YY, Bobbili N, Arnot DE, Taylor DW.

J Infect Dis. 2011 Jun 1;203(11):1679-85. doi: 10.1093/infdis/jir168.


Antigenic Variation and the Genetics and Epigenetics of the PfEMP1 Erythrocyte Surface Antigens in Plasmodium falciparum Malaria.

Arnot DE, Jensen AT.

Adv Appl Microbiol. 2011;74:77-96. doi: 10.1016/B978-0-12-387022-3.00007-0.


The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains.

Dahlbäck M, Jørgensen LM, Nielsen MA, Clausen TM, Ditlev SB, Resende M, Pinto VV, Arnot DE, Theander TG, Salanti A.

J Biol Chem. 2011 May 6;286(18):15908-17. doi: 10.1074/jbc.M110.191510. Epub 2011 Mar 11.


Insect cells are superior to Escherichia coli in producing malaria proteins inducing IgG targeting PfEMP1 on infected erythrocytes.

Victor ME, Bengtsson A, Andersen G, Bengtsson D, Lusingu JP, Vestergaard LS, Arnot DE, Theander TG, Joergensen L, Jensen AT.

Malar J. 2010 Nov 15;9:325. doi: 10.1186/1475-2875-9-325.


Surface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1.

Joergensen L, Bengtsson DC, Bengtsson A, Ronander E, Berger SS, Turner L, Dalgaard MB, Cham GK, Victor ME, Lavstsen T, Theander TG, Arnot DE, Jensen AT.

PLoS Pathog. 2010 Sep 2;6(9):e1001083. doi: 10.1371/journal.ppat.1001083.


The progression of the intra-erythrocytic cell cycle of Plasmodium falciparum and the role of the centriolar plaques in asynchronous mitotic division during schizogony.

Arnot DE, Ronander E, Bengtsson DC.

Int J Parasitol. 2011 Jan;41(1):71-80. doi: 10.1016/j.ijpara.2010.07.012. Epub 2010 Sep 17.


The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs.

Joergensen LM, Salanti A, Dobrilovic T, Barfod L, Hassenkam T, Theander TG, Hviid L, Arnot DE.

Malar J. 2010 Apr 19;9:100. doi: 10.1186/1475-2875-9-100.


Clustering of malaria treatment failure (TF) in Daraweesh: hints for host genetic susceptibility to TF with emphasis on immune-modulating SNPs.

Giha HA, ElGhazali G, Nasr A, Iriemenam NC, Berzins K, Troye-Blomberg M, Theander TG, Arnot D.

Infect Genet Evol. 2010 May;10(4):481-6. doi: 10.1016/j.meegid.2010.02.013. Epub 2010 Mar 7.


Age-dependent association between IgG2 and IgG3 subclasses to Pf332-C231 antigen and protection from malaria, and induction of protective antibodies by sub-patent malaria infections, in Daraweesh.

Giha HA, Nasr A, Iriemenam NC, Balogun HA, Arnot D, Theander TG, Troye-Blomberg M, Berzins K, ElGhazali G.

Vaccine. 2010 Feb 17;28(7):1732-9. doi: 10.1016/j.vaccine.2009.12.018. Epub 2009 Dec 28.


Antigen-specific influence of GM/KM allotypes on IgG isotypes and association of GM allotypes with susceptibility to Plasmodium falciparum malaria.

Giha HA, Nasr A, Iriemenam NC, Arnot D, Troye-Blomberg M, Theander TG, Berzins K, ElGhazali G, Pandey JP.

Malar J. 2009 Dec 22;8:306. doi: 10.1186/1475-2875-8-306.


Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria.

Giha HA, Nasr A, Ekström M, Israelsson E, Arambepola G, Arnot D, Theander TG, Troye-Blomberg M, Berzins K, Tornvall P, ElGhazali G.

Mol Med. 2010 Jan-Feb;16(1-2):27-33. doi: 10.2119/molmed.2009.00136. Epub 2009 Nov 17.


Multiple var2csa-type PfEMP1 genes located at different chromosomal loci occur in many Plasmodium falciparum isolates.

Sander AF, Salanti A, Lavstsen T, Nielsen MA, Magistrado P, Lusingu J, Ndam NT, Arnot DE.

PLoS One. 2009 Aug 19;4(8):e6667. doi: 10.1371/journal.pone.0006667.


The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer.

Wang CW, Hermsen CC, Sauerwein RW, Arnot DE, Theander TG, Lavstsen T.

Parasitol Int. 2009 Dec;58(4):478-80. doi: 10.1016/j.parint.2009.07.004. Epub 2009 Jul 16.


Dual fluorescence labeling of surface-exposed and internal proteins in erythrocytes infected with the malaria parasite Plasmodium falciparum.

Bengtsson DC, Sowa KM, Arnot DE.

Nat Protoc. 2008;3(12):1990-6. doi: 10.1038/nprot.2008.196.


Comparative testing of six antigen-based malaria vaccine candidates directed toward merozoite-stage Plasmodium falciparum.

Arnot DE, Cavanagh DR, Remarque EJ, Creasey AM, Sowa MP, Morgan WD, Holder AA, Longacre S, Thomas AW.

Clin Vaccine Immunol. 2008 Sep;15(9):1345-55. doi: 10.1128/CVI.00172-08. Epub 2008 Jun 11.


A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in Plasmodium falciparum infected erythrocytes.

Bengtsson D, Sowa KM, Salanti A, Jensen AT, Joergensen L, Turner L, Theander TG, Arnot DE.

Malar J. 2008 Jun 5;7:101. doi: 10.1186/1475-2875-7-101.


Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites.

Dahlbäck M, Lavstsen T, Salanti A, Hviid L, Arnot DE, Theander TG, Nielsen MA.

Malar J. 2007 Jun 12;6:78.


The dog that did not bark: malaria vaccines without antibodies.

Heppner DG, Schwenk RJ, Arnot D, Sauerwein RW, Luty AJ.

Trends Parasitol. 2007 Jul;23(7):293-6. Epub 2007 May 18.


Generation of cross-protective antibodies against Plasmodium falciparum sequestration by immunization with an erythrocyte membrane protein 1-duffy binding-like 1 alpha domain.

Moll K, Pettersson F, Vogt AM, Jonsson C, Rasti N, Ahuja S, Spångberg M, Mercereau-Puijalon O, Arnot DE, Wahlgren M, Chen Q.

Infect Immun. 2007 Jan;75(1):211-9. Epub 2006 Oct 30.


Malaria vaccine research and testing in Africa.

Arnot DE, Koram K, Kilama W.

Parasitol Today. 1998 Jul;14(7):254-6. No abstract available.


Atlas of Human Parasitology, 4th edn.

Arnot D.

Parasitol Today. 1998 Apr;14(4):168.


Characteristics of younger and older men with urethral chlamydial infection.

Arnot DJ, Manavi K, McMillan A.

Int J STD AIDS. 2006 Aug;17(8):535-8.


Further definition of PfEMP-1 DBL-1alpha domains mediating rosetting adhesion of Plasmodium falciparum.

Russell C, Mercereau-Puijalon O, Le Scanf C, Steward M, Arnot DE.

Mol Biochem Parasitol. 2005 Nov;144(1):109-13. No abstract available.


Eleven years of malaria surveillance in a Sudanese village highlights unexpected variation in individual disease susceptibility and outbreak severity.

Creasey A, Giha H, Hamad AA, El Hassan IM, Theander TG, Arnot DE.

Parasitology. 2004 Sep;129(Pt 3):263-71.


High throughput immuno-screening of cDNA expression libraries produced by in vitro recombination; exploring the Plasmodium falciparum proteome.

Sowa MP, Sharling L, Humphreys G, Cavanagh DR, Gregory WF, Fenn K, Creasey AM, Arnot DE.

Mol Biochem Parasitol. 2004 Feb;133(2):267-74.


Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions.

Lavstsen T, Salanti A, Jensen AT, Arnot DE, Theander TG.

Malar J. 2003 Sep 10;2:27. Epub 2003 Sep 10.


Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria.

Salanti A, Staalsoe T, Lavstsen T, Jensen AT, Sowa MP, Arnot DE, Hviid L, Theander TG.

Mol Microbiol. 2003 Jul;49(1):179-91.


In vivo switching between variant surface antigens in human Plasmodium falciparum infection.

Staalsoe T, Hamad AA, Hviid L, Elhassan IM, Arnot DE, Theander TG.

J Infect Dis. 2002 Sep 1;186(5):719-22. Epub 2002 Aug 5.


A sub-family of common and highly conserved Plasmodium falciparum var genes.

Salanti A, Jensen AT, Zornig HD, Staalsoe T, Joergensen L, Nielsen MA, Khattab A, Arnot DE, Klinkert MQ, Hviid L, Theander TG.

Mol Biochem Parasitol. 2002 Jun;122(1):111-5. No abstract available.


A marked seasonality of malaria transmission in two rural sites in eastern Sudan.

Hamad AA, Nugud Ael H, Arnot DE, Giha HA, Abdel-Muhsin AM, Satti GM, Theander TG, Creasey AM, Babiker HA, Elnaiem DE.

Acta Trop. 2002 Jul;83(1):71-82.


The influence of the genetic complexity of Plasmodium falciparum infections on the epidemiology of malaria.

Arnot DE.

Trans R Soc Trop Med Hyg. 2002 Apr;96 Suppl 1:S131-6. Review.


Novel Plasmodium falciparum clones and rising clone multiplicities are associated with the increase in malaria morbidity in Ghanaian children during the transition into the high transmission season.

Ofosu-Okyere A, Mackinnon MJ, Sowa MP, Koram KA, Nkrumah F, Osei YD, Hill WG, Wilson MD, Arnot DE.

Parasitology. 2001 Aug;123(Pt 2):113-23.


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