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Items: 1 to 50 of 93

1.

Neuromuscular junction transmission failure is a late phenotype in aging mice.

Chugh D, Iyer CC, Wang X, Bobbili P, Rich MM, Arnold WD.

Neurobiol Aging. 2020 Feb;86:182-190. doi: 10.1016/j.neurobiolaging.2019.10.022. Epub 2019 Nov 5.

PMID:
31866157
2.

Sex differences in body composition but not neuromuscular function following long-term, doxycycline-induced reduction in circulating levels of myostatin in mice.

Tavoian D, Arnold WD, Mort SC, de Lacalle S.

PLoS One. 2019 Nov 21;14(11):e0225283. doi: 10.1371/journal.pone.0225283. eCollection 2019.

3.

CSF Protein Level and Short-Term Prognosis in Guillain-Barré Syndrome.

Saba K, Hossieny ZS, Arnold WD, Elsheikh B, Palettas M, Kline D, Stino AM.

J Clin Neuromuscul Dis. 2019 Dec;21(2):118-119. doi: 10.1097/CND.0000000000000259. No abstract available.

PMID:
31743257
4.

Outcome measures in a cohort of ambulatory adults with spinal muscular atrophy.

Elsheikh B, King W, Peng J, Swoboda KJ, Reyna SP, LaSalle B, Prior TW, Arnold WD, Kissel JT, Kolb SJ.

Muscle Nerve. 2020 Feb;61(2):187-191. doi: 10.1002/mus.26756. Epub 2019 Dec 11.

PMID:
31725909
5.

Assessing Rat Forelimb and Hindlimb Motor Unit Connectivity as Objective and Robust Biomarkers of Spinal Motor Neuron Function.

Harrigan ME, Filous AR, Tosolini AP, Morris R, Schwab JM, Arnold WD.

Sci Rep. 2019 Nov 13;9(1):16699. doi: 10.1038/s41598-019-53235-w.

6.

Faster, higher, farther: outpacing age-related motor neuron losses.

Arnold WD, Clark BC.

J Physiol. 2019 Oct;597(19):4867-4868. doi: 10.1113/JP278735. Epub 2019 Sep 17. No abstract available.

PMID:
31482576
7.

AVXS-101 (Onasemnogene Abeparvovec) for SMA1: Comparative Study with a Prospective Natural History Cohort.

Al-Zaidy SA, Kolb SJ, Lowes L, Alfano LN, Shell R, Church KR, Nagendran S, Sproule DM, Feltner DE, Wells C, Ogrinc F, Menier M, L'Italien J, Arnold WD, Kissel JT, Kaspar BK, Mendell JR.

J Neuromuscul Dis. 2019;6(3):307-317. doi: 10.3233/JND-190403.

PMID:
31381526
8.

Hyperexcitability precedes motoneuron loss in the Smn2B/- mouse model of spinal muscular atrophy.

Quinlan KA, Reedich EJ, Arnold WD, Puritz AC, Cavarsan CF, Heckman CJ, DiDonato CJ.

J Neurophysiol. 2019 Oct 1;122(4):1297-1311. doi: 10.1152/jn.00652.2018. Epub 2019 Jul 31.

PMID:
31365319
9.

Early-onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1).

Nagarajan P, Agudelo Garcia PA, Iyer CC, Popova LV, Arnold WD, Parthun MR.

Aging Cell. 2019 Oct;18(5):e12992. doi: 10.1111/acel.12992. Epub 2019 Jul 10.

10.

Impact of Age and Motor Function in a Phase 1/2A Study of Infants With SMA Type 1 Receiving Single-Dose Gene Replacement Therapy.

Lowes LP, Alfano LN, Arnold WD, Shell R, Prior TW, McColly M, Lehman KJ, Church K, Sproule DM, Nagendran S, Menier M, Feltner DE, Wells C, Kissel JT, Al-Zaidy S, Mendell J.

Pediatr Neurol. 2019 Sep;98:39-45. doi: 10.1016/j.pediatrneurol.2019.05.005. Epub 2019 May 13.

11.
12.

Accuracy and Precision of a Point-of-Care HbA1c Test.

Arnold WD, Kupfer K, Little RR, Amar M, Horowitz B, Godbole N, Hvidsten Swensen M, Li Y, San George RC.

J Diabetes Sci Technol. 2019 Mar 10:1932296819831292. doi: 10.1177/1932296819831292. [Epub ahead of print]

PMID:
30854894
13.

Fingerstick Precision and Total Error of a Point-of-Care HbA1c Test.

Arnold WD, Kupfer K, Hvidsten Swensen M, Fortner KS, Bays HE, Davis M, Klaff LJ, San George RC.

J Diabetes Sci Technol. 2019 Mar 6:1932296819831273. doi: 10.1177/1932296819831273. [Epub ahead of print]

PMID:
30841743
14.

Health outcomes in spinal muscular atrophy type 1 following AVXS-101 gene replacement therapy.

Al-Zaidy S, Pickard AS, Kotha K, Alfano LN, Lowes L, Paul G, Church K, Lehman K, Sproule DM, Dabbous O, Maru B, Berry K, Arnold WD, Kissel JT, Mendell JR, Shell R.

Pediatr Pulmonol. 2019 Feb;54(2):179-185. doi: 10.1002/ppul.24203. Epub 2018 Dec 12.

15.

Muscle contractility dysfunction precedes loss of motor unit connectivity in SOD1(G93A) mice.

Wier CG, Crum AE, Reynolds AB, Iyer CC, Chugh D, Palettas MS, Heilman PL, Kline DM, Arnold WD, Kolb SJ.

Muscle Nerve. 2019 Feb;59(2):254-262. doi: 10.1002/mus.26365. Epub 2018 Dec 21.

16.

Myotonic Dystrophies: Targeting Therapies for Multisystem Disease.

LoRusso S, Weiner B, Arnold WD.

Neurotherapeutics. 2018 Oct;15(4):872-884. doi: 10.1007/s13311-018-00679-z. Review.

17.

Efficacy of exogenous pyruvate in TremblerJ mouse model of Charcot-Marie-Tooth neuropathy.

Sahenk Z, Yalvac ME, Amornvit J, Arnold WD, Chen L, Shontz KM, Lewis S.

Brain Behav. 2018 Oct;8(10):e01118. doi: 10.1002/brb3.1118. Epub 2018 Sep 21.

18.

Recruitment & retention program for the NeuroNEXT SMA Biomarker Study: Super Babies for SMA!

Bartlett A, Kolb SJ, Kingsley A, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Iannaccone ST, Parsons J, Connolly AM, Chiriboga CA, McDonald C, Burnette WB, Werner K, Thangarajh M, Shieh PB, Finanger E, Coffey CS, Yankey JW, Cudkowicz ME, McGovern MM, McNeil DE, Arnold WD, Kissel JT; NeuroNEXT Clinical Trial Network and on behalf of the NN101 SMA Biomarker Investigators.

Contemp Clin Trials Commun. 2018 Jul 20;11:113-119. doi: 10.1016/j.conctc.2018.07.002. eCollection 2018 Sep.

19.

Mild SMN missense alleles are only functional in the presence of SMN2 in mammals.

Iyer CC, Corlett KM, Massoni-Laporte A, Duque SI, Madabusi N, Tisdale S, McGovern VL, Le TT, Zaworski PG, Arnold WD, Pellizzoni L, Burghes AHM.

Hum Mol Genet. 2018 Oct 1;27(19):3404-3416. doi: 10.1093/hmg/ddy251.

20.

Muscle strength and size are associated with motor unit connectivity in aged mice.

Sheth KA, Iyer CC, Wier CG, Crum AE, Bratasz A, Kolb SJ, Clark BC, Burghes AHM, Arnold WD.

Neurobiol Aging. 2018 Jul;67:128-136. doi: 10.1016/j.neurobiolaging.2018.03.016. Epub 2018 Mar 23.

21.

OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity.

Leblanc AF, Sprowl JA, Alberti P, Chiorazzi A, Arnold WD, Gibson AA, Hong KW, Pioso MS, Chen M, Huang KM, Chodisetty V, Costa O, Florea T, de Bruijn P, Mathijssen RH, Reinbolt RE, Lustberg MB, Sucheston-Campbell LE, Cavaletti G, Sparreboom A, Hu S.

J Clin Invest. 2018 Feb 1;128(2):816-825. doi: 10.1172/JCI96160. Epub 2018 Jan 16.

22.

Infections and the relationship to treatment in neuromuscular autoimmunity.

Prior DE, Nurre E, Roller SL, Kline D, Panara R, Stino AM, Davis JA, Freimer ML, Arnold WD.

Muscle Nerve. 2018 Jun;57(6):927-931. doi: 10.1002/mus.26032. Epub 2017 Dec 20.

23.

Reply.

Aubuchon A, Arnold WD, Hoyle JC.

Muscle Nerve. 2018 Mar;57(3):E114. doi: 10.1002/mus.26019. Epub 2017 Dec 22. No abstract available.

PMID:
29178449
24.

Natural history of infantile-onset spinal muscular atrophy.

Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Parsons J, Connolly AM, Chiriboga CA, McDonald C, Burnette WB, Werner K, Thangarajh M, Shieh PB, Finanger E, Cudkowicz ME, McGovern MM, McNeil DE, Finkel R, Iannaccone ST, Kaye E, Kingsley A, Renusch SR, McGovern VL, Wang X, Zaworski PG, Prior TW, Burghes AHM, Bartlett A, Kissel JT; NeuroNEXT Clinical Trial Network on behalf of the NN101 SMA Biomarker Investigators.

Ann Neurol. 2017 Dec;82(6):883-891. doi: 10.1002/ana.25101. Epub 2017 Dec 8.

25.

Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy.

Mendell JR, Al-Zaidy S, Shell R, Arnold WD, Rodino-Klapac LR, Prior TW, Lowes L, Alfano L, Berry K, Church K, Kissel JT, Nagendran S, L'Italien J, Sproule DM, Wells C, Cardenas JA, Heitzer MD, Kaspar A, Corcoran S, Braun L, Likhite S, Miranda C, Meyer K, Foust KD, Burghes AHM, Kaspar BK.

N Engl J Med. 2017 Nov 2;377(18):1713-1722. doi: 10.1056/NEJMoa1706198.

26.

Electrical impedance myography detects age-related muscle change in mice.

Arnold WD, Taylor RS, Li J, Nagy JA, Sanchez B, Rutkove SB.

PLoS One. 2017 Oct 19;12(10):e0185614. doi: 10.1371/journal.pone.0185614. eCollection 2017.

27.

Open-label trial of ranolazine for the treatment of myotonia congenita.

Arnold WD, Kline D, Sanderson A, Hawash AA, Bartlett A, Novak KR, Rich MM, Kissel JT.

Neurology. 2017 Aug 15;89(7):710-713. doi: 10.1212/WNL.0000000000004229. Epub 2017 Jul 14.

28.

Is sarcopenia driven by motor neuron/unit loss? An unresolved question.

Arnold WD, Clark BC.

Muscle Nerve. 2017 Jun;55(6):930. doi: 10.1002/mus.25649. Epub 2017 Apr 12. No abstract available.

PMID:
28329915
29.

SMN Blood Levels in a Porcine Model of Spinal Muscular Atrophy.

Iyer CC, Wang X, Renusch SR, Duque SI, Wehr AM, Mo XM, McGovern VL, Arnold WD, Burghes AH, Kolb SJ.

J Neuromuscul Dis. 2017;4(1):59-66. doi: 10.3233/JND-170209.

30.

Sciatic neuropathy due to popliteal fossa nerve block.

Aubuchon A, Arnold WD, Bracewell A, Hoyle JC.

Muscle Nerve. 2017 Oct;56(4):822-824. doi: 10.1002/mus.25622. Epub 2017 Jun 6.

PMID:
28214338
31.

Missed myocardial infarctions in ED patients prospectively categorized as low risk by established risk scores.

Singer AJ, Than MP, Smith S, McCullough P, Barrett TW, Birkhahn R, Reed M, Thode HC, Arnold WD, Daniels LB, de Filippi C, Headden G, Peacock WF.

Am J Emerg Med. 2017 May;35(5):704-709. doi: 10.1016/j.ajem.2017.01.003. Epub 2017 Jan 5.

PMID:
28108220
32.

Normalization of Patient-Identified Plasma Biomarkers in SMNΔ7 Mice following Postnatal SMN Restoration.

Arnold WD, Duque S, Iyer CC, Zaworski P, McGovern VL, Taylor SJ, von Herrmann KM, Kobayashi DT, Chen KS, Kolb SJ, Paushkin SV, Burghes AH.

PLoS One. 2016 Dec 1;11(12):e0167077. doi: 10.1371/journal.pone.0167077. eCollection 2016.

33.

Neurodegeneration: Etiologies and New Therapies 2016.

Tan EK, Srivastava AK, Arnold WD, Singh MP, Zhang Y.

Biomed Res Int. 2016;2016:8363179. Epub 2016 Nov 3. No abstract available.

34.

Variable phenotypic expression and onset in MYH14 distal hereditary motor neuropathy phenotype in a large, multigenerational North American family.

Iyadurai S, Arnold WD, Kissel JT, Ruhno C, Mcgovern VL, Snyder PJ, Prior TW, Roggenbuck J, Burghes AH, Kolb SJ.

Muscle Nerve. 2017 Aug;56(2):341-345. doi: 10.1002/mus.25491. Epub 2017 Feb 20.

35.

Comment: Genotype-phenotype correlation with CRISPR-Cas9-: Bedside to bench.

Arnold WD.

Neurology. 2016 Sep 13;87(11):1138. doi: 10.1212/WNL.0000000000003108. Epub 2016 Aug 24. No abstract available.

36.

Defective membrane fusion and repair in Anoctamin5-deficient muscular dystrophy.

Griffin DA, Johnson RW, Whitlock JM, Pozsgai ER, Heller KN, Grose WE, Arnold WD, Sahenk Z, Hartzell HC, Rodino-Klapac LR.

Hum Mol Genet. 2016 May 15;25(10):1900-1911. Epub 2016 Feb 23.

37.

Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study.

Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Iannaccone ST, Parsons J, Connolly AM, Chiriboga CA, McDonald C, Burnette WB, Werner K, Thangarajh M, Shieh PB, Finanger E, Cudkowicz ME, McGovern MM, McNeil DE, Finkel R, Kaye E, Kingsley A, Renusch SR, McGovern VL, Wang X, Zaworski PG, Prior TW, Burghes AH, Bartlett A, Kissel JT; NeuroNEXT Clinical Trial Network and on behalf of the NN101 SMA Biomarker Investigators.

Ann Clin Transl Neurol. 2016 Jan 21;3(2):132-45. doi: 10.1002/acn3.283. eCollection 2016 Feb.

38.

Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine.

Burns TM, Smith GA, Allen JA, Amato AA, Arnold WD, Barohn R, Benatar M, Bird SJ, Bromberg M, Chahin N, Ciafaloni E, Cohen JA, Corse A, Crum BA, David WS, Dimberg E, Sousa EA, Donofrio PD, Dyck PJ, Engel AG, Ensrud ER, Ferrante M, Freimer M, Gable KL, Gibson S, Gilchrist JM, Goldstein JM, Gooch CL, Goodman BP, Gorelov D, Gospe SM Jr, Goyal NA, Guidon AC, Guptill JT, Gutmann L, Gutmann L, Gwathmey K, Harati Y, Harper CM Jr, Hehir MK, Hobson-Webb LD, Howard JF Jr, Jackson CE, Johnson N, Jones SM, Juel VC, Kaminski HJ, Karam C, Kennelly KD, Khella S, Khoury J, Kincaid JC, Kissel JT, Kolb N, Lacomis D, Ladha S, Larriviere D, Lewis RA, Li Y, Litchy WJ, Logigian E, Lou JS, MacGowen DJ, Maselli R, Massey JM, Mauermann ML, Mathews KD, Meriggioli MN, Miller RG, Moon JS, Mozaffar T, Nations SP, Nowak RJ, Ostrow LW, Pascuzzi RM, Peltier A, Ruzhansky K, Richman DP, Ross MA, Rubin DI, Russell JA, Sachs GM, Salajegheh MK, Saperstein DS, Scelsa S, Selcen D, Shaibani A, Shieh PB, Silvestri NJ, Singleton JR, Smith BE, So YT, Solorzano G, Sorenson EJ, Srinivasen J, Tavee J, Tawil R, Thaisetthawatkul P, Thornton C, Trivedi J, Vernino S, Wang AK, Webb TA, Weiss MD, Windebank AJ, Wolfe GI.

Muscle Nerve. 2016 Feb;53(2):165-8. doi: 10.1002/mus.25009. Epub 2015 Dec 21. No abstract available.

PMID:
26662952
39.

The genetics of Charcot-Marie-Tooth disease: current trends and future implications for diagnosis and management.

Hoyle JC, Isfort MC, Roggenbuck J, Arnold WD.

Appl Clin Genet. 2015 Oct 19;8:235-43. doi: 10.2147/TACG.S69969. eCollection 2015. Review.

40.

Correlation of single-breath count test and neck flexor muscle strength with spirometry in myasthenia gravis.

Elsheikh B, Arnold WD, Gharibshahi S, Reynolds J, Freimer M, Kissel JT.

Muscle Nerve. 2016 Jan;53(1):134-6. doi: 10.1002/mus.24929.

41.

Electrophysiological Motor Unit Number Estimation (MUNE) Measuring Compound Muscle Action Potential (CMAP) in Mouse Hindlimb Muscles.

Arnold WD, Sheth KA, Wier CG, Kissel JT, Burghes AH, Kolb SJ.

J Vis Exp. 2015 Sep 25;(103). doi: 10.3791/52899.

42.

SMN expression is required in motor neurons to rescue electrophysiological deficits in the SMNΔ7 mouse model of SMA.

McGovern VL, Iyer CC, Arnold WD, Gombash SE, Zaworski PG, Blatnik AJ 3rd, Foust KD, Burghes AH.

Hum Mol Genet. 2015 Oct 1;24(19):5524-41. doi: 10.1093/hmg/ddv283. Epub 2015 Jul 23.

43.

AAV1.NT-3 gene therapy attenuates spontaneous autoimmune peripheral polyneuropathy.

Yalvac ME, Arnold WD, Braganza C, Chen L, Mendell JR, Sahenk Z.

Gene Ther. 2016 Jan;23(1):95-102. doi: 10.1038/gt.2015.67. Epub 2015 Jun 30.

44.

Disease course and therapeutic approach in dermatomyositis: A four-center retrospective study of 100 patients.

Johnson NE, Arnold WD, Hebert D, Gwathmey K, Dimachkie MM, Barohn RJ, McVey AL, Pasnoor M, Amato AA, McDermott MP, Kissel J, Heatwole CR.

Neuromuscul Disord. 2015 Aug;25(8):625-31. doi: 10.1016/j.nmd.2015.04.013. Epub 2015 May 7.

45.

Defective fast inactivation recovery of Nav 1.4 in congenital myasthenic syndrome.

Arnold WD, Feldman DH, Ramirez S, He L, Kassar D, Quick A, Klassen TL, Lara M, Nguyen J, Kissel JT, Lossin C, Maselli RA.

Ann Neurol. 2015 May;77(5):840-50. doi: 10.1002/ana.24389. Epub 2015 Mar 27.

46.

Neurodegeneration: etiologies and new therapies.

Tan EK, Srivastava AK, Arnold WD, Singh MP, Zhang Y.

Biomed Res Int. 2015;2015:272630. doi: 10.1155/2015/272630. Epub 2015 Feb 3. No abstract available.

47.

A large animal model of spinal muscular atrophy and correction of phenotype.

Duque SI, Arnold WD, Odermatt P, Li X, Porensky PN, Schmelzer L, Meyer K, Kolb SJ, Schümperli D, Kaspar BK, Burghes AH.

Ann Neurol. 2015 Mar;77(3):399-414. doi: 10.1002/ana.24332. Epub 2015 Feb 9.

48.

A comparison of three electrophysiological methods for the assessment of disease status in a mild spinal muscular atrophy mouse model.

Li J, Geisbush TR, Arnold WD, Rosen GD, Zaworski PG, Rutkove SB.

PLoS One. 2014 Oct 27;9(10):e111428. doi: 10.1371/journal.pone.0111428. eCollection 2014.

49.

Spinal muscular atrophy: diagnosis and management in a new therapeutic era.

Arnold WD, Kassar D, Kissel JT.

Muscle Nerve. 2015 Feb;51(2):157-67. doi: 10.1002/mus.24497. Epub 2014 Dec 16. Review.

50.

The clinical spectrum of isolated peripheral motor dysfunction.

Sanderson AB, Arnold WD, Elsheikh B, Kissel JT.

Muscle Nerve. 2015 Mar;51(3):358-62. doi: 10.1002/mus.24326. Epub 2015 Jan 9.

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