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Items: 26


Cytotoxic Chemotherapy as an Immune Stimulus: A Molecular Perspective on Turning Up the Immunological Heat on Cancer.

Opzoomer JW, Sosnowska D, Anstee JE, Spicer JF, Arnold JN.

Front Immunol. 2019 Jul 17;10:1654. doi: 10.3389/fimmu.2019.01654. eCollection 2019. Review.


Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis.

Muliaditan T, Caron J, Okesola M, Opzoomer JW, Kosti P, Georgouli M, Gordon P, Lall S, Kuzeva DM, Pedro L, Shields JD, Gillett CE, Diebold SS, Sanz-Moreno V, Ng T, Hoste E, Arnold JN.

Nat Commun. 2018 Jul 27;9(1):2951. doi: 10.1038/s41467-018-05346-7.


Perspectives on Chimeric Antigen Receptor T-Cell Immunotherapy for Solid Tumors.

Kosti P, Maher J, Arnold JN.

Front Immunol. 2018 May 22;9:1104. doi: 10.3389/fimmu.2018.01104. eCollection 2018. Review.


Repurposing Tin Mesoporphyrin as an Immune Checkpoint Inhibitor Shows Therapeutic Efficacy in Preclinical Models of Cancer.

Muliaditan T, Opzoomer JW, Caron J, Okesola M, Kosti P, Lall S, Van Hemelrijck M, Dazzi F, Tutt A, Grigoriadis A, Gillett CE, Madden SF, Burchell JM, Kordasti S, Diebold SS, Spicer JF, Arnold JN.

Clin Cancer Res. 2018 Apr 1;24(7):1617-1628. doi: 10.1158/1078-0432.CCR-17-2587. Epub 2018 Jan 16.


Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor.

Weitsman G, Mitchell NJ, Evans R, Cheung A, Kalber TL, Bofinger R, Fruhwirth GO, Keppler M, Wright ZVF, Barber PR, Gordon P, de Koning T, Wulaningsih W, Sander K, Vojnovic B, Ameer-Beg S, Lythgoe M, Arnold JN, Årstad E, Festy F, Hailes HC, Tabor AB, Ng T.

Oncogene. 2017 Jun 22;36(25):3618-3628. doi: 10.1038/onc.2016.522. Epub 2017 Feb 6.


Tumoral immune suppression by macrophages expressing fibroblast activation protein-α and heme oxygenase-1.

Arnold JN, Magiera L, Kraman M, Fearon DT.

Cancer Immunol Res. 2014 Feb;2(2):121-6. doi: 10.1158/2326-6066.CIR-13-0150. Epub 2013 Nov 18.


Purification, quantification, and functional analysis of Complement Factor H.

Yu BB, Moffatt BE, Fedorova M, Villiers CG, Arnold JN, Du E, Swinkels A, Li MC, Ryan A, Sim RB.

Methods Mol Biol. 2014;1100:207-23. doi: 10.1007/978-1-62703-724-2_17.


Novel glycan biomarkers for the detection of lung cancer.

Arnold JN, Saldova R, Galligan MC, Murphy TB, Mimura-Kimura Y, Telford JE, Godwin AK, Rudd PM.

J Proteome Res. 2011 Apr 1;10(4):1755-64. doi: 10.1021/pr101034t. Epub 2011 Mar 16.


Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry.

Brown KS, Keogh MJ, Owsianka AM, Adair R, Patel AH, Arnold JN, Ball JK, Sim RB, Tarr AW, Hickling TP.

Protein Cell. 2010 Jul;1(7):664-74. doi: 10.1007/s13238-010-0088-9. Epub 2010 Jul 29.


Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha.

Kraman M, Bambrough PJ, Arnold JN, Roberts EW, Magiera L, Jones JO, Gopinathan A, Tuveson DA, Fearon DT.

Science. 2010 Nov 5;330(6005):827-30. doi: 10.1126/science.1195300.


A chemical approach to immunoprotein engineering: chemoselective functionalization of thioester proteins in their native state.

Cole MA, Tully SE, Dodds AW, Arnold JN, Boldt GE, Sim RB, Offer J, Wentworth P Jr.

Chembiochem. 2009 May 25;10(8):1340-3. doi: 10.1002/cbic.200900168.


Evaluation of the serum N-linked glycome for the diagnosis of cancer and chronic inflammation.

Arnold JN, Saldova R, Hamid UM, Rudd PM.

Proteomics. 2008 Aug;8(16):3284-93. doi: 10.1002/pmic.200800163. Review.


Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG.

Saldova R, Royle L, Radcliffe CM, Abd Hamid UM, Evans R, Arnold JN, Banks RE, Hutson R, Harvey DJ, Antrobus R, Petrescu SM, Dwek RA, Rudd PM.

Glycobiology. 2007 Dec;17(12):1344-56. Epub 2007 Sep 20.


Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.

Radcliffe CM, Arnold JN, Suter DM, Wormald MR, Harvey DJ, Royle L, Mimura Y, Kimura Y, Sim RB, Inogès S, Rodriguez-Calvillo M, Zabalegui N, de Cerio AL, Potter KN, Mockridge CI, Dwek RA, Bendandi M, Rudd PM, Stevenson FK.

J Biol Chem. 2007 Mar 9;282(10):7405-15. Epub 2006 Dec 29.


Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides.

Tsiftsoglou SA, Arnold JN, Roversi P, Crispin MD, Radcliffe C, Lea SM, Dwek RA, Rudd PM, Sim RB.

Biochim Biophys Acta. 2006 Nov;1764(11):1757-66. Epub 2006 Sep 16.


The impact of glycosylation on the biological function and structure of human immunoglobulins.

Arnold JN, Wormald MR, Sim RB, Rudd PM, Dwek RA.

Annu Rev Immunol. 2007;25:21-50. Review.


Discrete MBL-MASP complexes show wide inter-individual variability in concentration: data from UK vs Armenian populations.

Mayilyan KR, Presanis JS, Arnold JN, Sim RB.

Int J Immunopathol Pharmacol. 2006 Jul-Sep;19(3):567-80.


Increased complement classical and mannan-binding lectin pathway activities in schizophrenia.

Mayilyan KR, Arnold JN, Presanis JS, Soghoyan AF, Sim RB.

Neurosci Lett. 2006 Sep 1;404(3):336-41. Epub 2006 Jul 24.


Mannan binding lectin and its interaction with immunoglobulins in health and in disease.

Arnold JN, Dwek RA, Rudd PM, Sim RB.

Immunol Lett. 2006 Aug 15;106(2):103-10. Epub 2006 Jun 12. Review.


Carbohydrate-independent recognition of collagens by the macrophage mannose receptor.

Martinez-Pomares L, Wienke D, Stillion R, McKenzie EJ, Arnold JN, Harris J, McGreal E, Sim RB, Isacke CM, Gordon S.

Eur J Immunol. 2006 May;36(5):1074-82.


Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor.

Boskovic J, Arnold JN, Stilion R, Gordon S, Sim RB, Rivera-Calzada A, Wienke D, Isacke CM, Martinez-Pomares L, Llorca O.

J Biol Chem. 2006 Mar 31;281(13):8780-7. Epub 2006 Feb 1.


Interaction of mannan binding lectin with alpha2 macroglobulin via exposed oligomannose glycans: a conserved feature of the thiol ester protein family?

Arnold JN, Wallis R, Willis AC, Harvey DJ, Royle L, Dwek RA, Rudd PM, Sim RB.

J Biol Chem. 2006 Mar 17;281(11):6955-63. Epub 2006 Jan 5.


Human immunoglobulin glycosylation and the lectin pathway of complement activation.

Arnold JN, Royle L, Dwek RA, Rudd PM, Sim RB.

Adv Exp Med Biol. 2005;564:27-43. No abstract available.


Heterogeneity of MBL-MASP complexes.

Mayilyan KR, Presanis JS, Arnold JN, Hajela K, Sim RB.

Mol Immunol. 2006 Mar;43(8):1286-92. Epub 2005 Aug 15.


Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin.

Arnold JN, Wormald MR, Suter DM, Radcliffe CM, Harvey DJ, Dwek RA, Rudd PM, Sim RB.

J Biol Chem. 2005 Aug 12;280(32):29080-7. Epub 2005 Jun 14.


The glycosylation of human serum IgD and IgE and the accessibility of identified oligomannose structures for interaction with mannan-binding lectin.

Arnold JN, Radcliffe CM, Wormald MR, Royle L, Harvey DJ, Crispin M, Dwek RA, Sim RB, Rudd PM.

J Immunol. 2004 Dec 1;173(11):6831-40.

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