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Microglial cell hyper-ramification and neuronal dendritic spine loss in the hippocampus and medial prefrontal cortex in a mouse model of PTSD.

Smith KL, Kassem MS, Clarke DJ, Kuligowski MP, Bedoya-Pérez MA, Todd SM, Lagopoulos J, Bennett MR, Arnold JC.

Brain Behav Immun. 2019 Aug;80:889-899. doi: 10.1016/j.bbi.2019.05.042. Epub 2019 May 31.


Functional genomics of epilepsy-associated mutations in the GABAA receptor subunits reveal that one mutation impairs function and two are catastrophic.

Absalom NL, Ahring PK, Liao VW, Balle T, Jiang T, Anderson LL, Arnold JC, McGregor IS, Bowen MT, Chebib M.

J Biol Chem. 2019 Apr 12;294(15):6157-6171. doi: 10.1074/jbc.RA118.005697. Epub 2019 Feb 6.


Dark Classics in Chemical Neuroscience: Δ9-Tetrahydrocannabinol.

Banister SD, Arnold JC, Connor M, Glass M, McGregor IS.

ACS Chem Neurosci. 2019 May 15;10(5):2160-2175. doi: 10.1021/acschemneuro.8b00651. Epub 2019 Feb 22.


Cannabidiol treatment reduces the motivation to self-administer methamphetamine and methamphetamine-primed relapse in rats.

Hay GL, Baracz SJ, Everett NA, Roberts J, Costa PA, Arnold JC, McGregor IS, Cornish JL.

J Psychopharmacol. 2018 Dec;32(12):1369-1378. doi: 10.1177/0269881118799954. Epub 2018 Sep 27.


Medicinal cannabis in Australia, 2016: the Cannabis as Medicine Survey (CAMS-16).

Lintzeris N, Driels J, Elias N, Arnold JC, McGregor IS, Allsop DJ.

Med J Aust. 2018 Aug 3;209(5):211-216. Epub 2018 Aug 13.


Author Correction: Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community.

Suraev A, Lintzeris N, Stuart J, Kevin RC, Blackburn R, Richards E, Arnold JC, Ireland C, Todd L, Allsop DJ, McGregor IS.

Sci Rep. 2018 Aug 2;8(1):11850. doi: 10.1038/s41598-018-30164-8.


Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community.

Suraev A, Lintzeris N, Stuart J, Kevin RC, Blackburn R, Richards E, Arnold JC, Ireland C, Todd L, Allsop DJ, McGregor IS.

Sci Rep. 2018 Jul 5;8(1):10154. doi: 10.1038/s41598-018-28127-0. Erratum in: Sci Rep. 2018 Aug 2;8(1):11850.


Nrg1 deficiency modulates the behavioural effects of prenatal stress in mice.

Clarke DJ, Sarkissian L, Todd SM, Suraev AS, Bahceci D, Brzozowska N, Arnold JC.

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jan 10;88:86-95. doi: 10.1016/j.pnpbp.2018.06.013. Epub 2018 Jun 30.


Neuregulin 1 Deficiency Modulates Adolescent Stress-Induced Dendritic Spine Loss in a Brain Region-Specific Manner and Increases Complement 4 Expression in the Hippocampus.

Clarke DJ, Chohan TW, Kassem MS, Smith KL, Chesworth R, Karl T, Kuligowski MP, Fok SY, Bennett MR, Arnold JC.

Schizophr Bull. 2019 Mar 7;45(2):339-349. doi: 10.1093/schbul/sby029.


Performance of the inFLUenza Patient-Reported Outcome (FLU-PRO) diary in patients with influenza-like illness (ILI).

Powers JH 3rd, Bacci ED, Leidy NK, Poon JL, Stringer S, Memoli MJ, Han A, Fairchok MP, Coles C, Owens J, Chen WJ, Arnold JC, Danaher PJ, Lalani T, Burgess TH, Millar EV, Ridore M, Hernández A, Rodríguez-Zulueta P, Ortega-Gallegos H, Galindo-Fraga A, Ruiz-Palacios GM, Pett S, Fischer W, Gillor D, Moreno Macias L, DuVal A, Rothman R, Dugas A, Guerrero ML.

PLoS One. 2018 Mar 22;13(3):e0194180. doi: 10.1371/journal.pone.0194180. eCollection 2018.


Reliability, Validity, and Responsiveness of InFLUenza Patient-Reported Outcome (FLU-PRO©) Scores in Influenza-Positive Patients.

Powers JH 3rd, Bacci ED, Guerrero ML, Leidy NK, Stringer S, Kim K, Memoli MJ, Han A, Fairchok MP, Chen WJ, Arnold JC, Danaher PJ, Lalani T, Ridoré M, Burgess TH, Millar EV, Hernández A, Rodríguez-Zulueta P, Smolskis MC, Ortega-Gallegos H, Pett S, Fischer W, Gillor D, Macias LM, DuVal A, Rothman R, Dugas A, Ruiz-Palacios GM.

Value Health. 2018 Feb;21(2):210-218. doi: 10.1016/j.jval.2017.04.014. Epub 2017 Jun 7.


Species-specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults.

Bouvier M, Chen WJ, Arnold JC, Fairchok MP, Danaher PJ, Lalani T, Malone L, Mor D, Ridoré M, Burgess TH, Millar EV.

Influenza Other Respir Viruses. 2018 Mar;12(2):299-303. doi: 10.1111/irv.12538. Epub 2018 Feb 2.


Aging-related limit of exercise efficacy on motor decline.

Arnold JC, Cantu MA, Kasanga EA, Nejtek VA, Papa EV, Bugnariu N, Salvatore MF.

PLoS One. 2017 Nov 27;12(11):e0188538. doi: 10.1371/journal.pone.0188538. eCollection 2017.


Posttraumatic Aneurysm of a Patent Umbilical Vein: Diagnosis and Specific Treatment.

Grade M, Krishnabhakdi S, Vestring T, Löbermann M, Arnold JC.

Surg J (N Y). 2017 Jul 19;3(3):e113-e116. doi: 10.1055/s-0037-1604075. eCollection 2017 Jul.


Genetic deletion of P-glycoprotein alters stress responsivity and increases depression-like behavior, social withdrawal and microglial activation in the hippocampus of female mice.

Brzozowska NI, Smith KL, Zhou C, Waters PM, Cavalcante LM, Abelev SV, Kuligowski M, Clarke DJ, Todd SM, Arnold JC.

Brain Behav Immun. 2017 Oct;65:251-261. doi: 10.1016/j.bbi.2017.05.008. Epub 2017 May 10.


The Differential Binding of Antipsychotic Drugs to the ABC Transporter P-Glycoprotein Predicts Cannabinoid-Antipsychotic Drug Interactions.

Brzozowska NI, de Tonnerre EJ, Li KM, Wang XS, Boucher AA, Callaghan PD, Kuligowski M, Wong A, Arnold JC.

Neuropsychopharmacology. 2017 Oct;42(11):2222-2231. doi: 10.1038/npp.2017.50. Epub 2017 Mar 8.


The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABAA receptors.

Bakas T, van Nieuwenhuijzen PS, Devenish SO, McGregor IS, Arnold JC, Chebib M.

Pharmacol Res. 2017 May;119:358-370. doi: 10.1016/j.phrs.2017.02.022. Epub 2017 Feb 27.


Interactions between cannabidiol and Δ9-THC following acute and repeated dosing: Rebound hyperactivity, sensorimotor gating and epigenetic and neuroadaptive changes in the mesolimbic pathway.

Todd SM, Zhou C, Clarke DJ, Chohan TW, Bahceci D, Arnold JC.

Eur Neuropsychopharmacol. 2017 Feb;27(2):132-145. doi: 10.1016/j.euroneuro.2016.12.004. Epub 2016 Dec 31.


Seeing through the smoke: Human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks.

Silveira MM, Arnold JC, Laviolette SR, Hillard CJ, Celorrio M, Aymerich MS, Adams WK.

Neurosci Biobehav Rev. 2017 May;76(Pt B):380-395. doi: 10.1016/j.neubiorev.2016.09.007. Epub 2016 Sep 14. Review.


Endocannabinoid dysregulation in cognitive and stress-related brain regions in the Nrg1 mouse model of schizophrenia.

Clarke DJ, Stuart J, McGregor IS, Arnold JC.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jan 4;72:9-15. doi: 10.1016/j.pnpbp.2016.08.006. Epub 2016 Aug 10.


ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice.

Brzozowska N, Li KM, Wang XS, Booth J, Stuart J, McGregor IS, Arnold JC.

PeerJ. 2016 May 26;4:e2081. doi: 10.7717/peerj.2081. eCollection 2016.


Type-specific clinical characteristics of adenovirus-associated influenza-like illness at five US military medical centers, 2009-2014.

Koren MA, Arnold JC, Fairchok MP, Lalani T, Danaher PJ, Schofield CM, Rajnik M, Hansen EA, Mor D, Chen WJ, Ridoré M, Burgess TH, Millar EV.

Influenza Other Respir Viruses. 2016 Sep;10(5):414-20. doi: 10.1111/irv.12392. Epub 2016 May 13.


Development of the Flu-PRO: a patient-reported outcome (PRO) instrument to evaluate symptoms of influenza.

Powers JH, Guerrero ML, Leidy NK, Fairchok MP, Rosenberg A, Hernández A, Stringer S, Schofield C, Rodríguez-Zulueta P, Kim K, Danaher PJ, Ortega-Gallegos H, Bacci ED, Stepp N, Galindo-Fraga A, St Clair K, Rajnik M, McDonough EA, Ridoré M, Arnold JC, Millar EV, Ruiz-Palacios GM.

BMC Infect Dis. 2016 Jan 5;16:1. doi: 10.1186/s12879-015-1330-0.


Exercise-Mediated Increase in Nigral Tyrosine Hydroxylase Is Accompanied by Increased Nigral GFR-α1 and EAAC1 Expression in Aging Rats.

Arnold JC, Salvatore MF.

ACS Chem Neurosci. 2016 Feb 17;7(2):227-39. doi: 10.1021/acschemneuro.5b00282. Epub 2015 Dec 8.


Vaccine-associated reduction in symptom severity among patients with influenza A/H3N2 disease.

Deiss RG, Arnold JC, Chen WJ, Echols S, Fairchok MP, Schofield C, Danaher PJ, McDonough E, Ridoré M, Mor D, Burgess TH, Millar EV.

Vaccine. 2015 Dec 16;33(51):7160-7167. doi: 10.1016/j.vaccine.2015.11.004. Epub 2015 Nov 10.


Neural correlates of interactions between cannabidiol and Δ(9) -tetrahydrocannabinol in mice: implications for medical cannabis.

Todd SM, Arnold JC.

Br J Pharmacol. 2016 Jan;173(1):53-65. doi: 10.1111/bph.13333. Epub 2015 Nov 18.


Osteoarticular Infections in Children.

Arnold JC, Bradley JS.

Infect Dis Clin North Am. 2015 Sep;29(3):557-74. doi: 10.1016/j.idc.2015.05.012. Review.


Neuraminidase inhibitor therapy in a military population.

Fairchok MP, Chen WJ, Arnold JC, Schofield C, Danaher PJ, McDonough EA, Ottolini M, Mor D, Ridore M, Burgess TH, Millar EV.

J Clin Virol. 2015 Jun;67:17-22. doi: 10.1016/j.jcv.2015.03.018. Epub 2015 Mar 24.


Epidemiologic, clinical, and virologic characteristics of human rhinovirus infection among otherwise healthy children and adults: rhinovirus among adults and children.

Chen WJ, Arnold JC, Fairchok MP, Danaher PJ, McDonough EA, Blair PJ, Garcia J, Halsey ES, Schofield C, Ottolini M, Mor D, Ridoré M, Burgess TH, Millar EV.

J Clin Virol. 2015 Mar;64:74-82. doi: 10.1016/j.jcv.2015.01.007. Epub 2015 Jan 13.


Schizophrenia: a consequence of gene-environment interactions?

Karl T, Arnold JC.

Front Behav Neurosci. 2014 Dec 23;8:435. doi: 10.3389/fnbeh.2014.00435. eCollection 2014. No abstract available.


Partial genetic deletion of neuregulin 1 and adolescent stress interact to alter NMDA receptor binding in the medial prefrontal cortex.

Chohan TW, Nguyen A, Todd SM, Bennett MR, Callaghan P, Arnold JC.

Front Behav Neurosci. 2014 Sep 29;8:298. doi: 10.3389/fnbeh.2014.00298. eCollection 2014.


Why sigma-1 receptor dysfunction might confer vulnerability to cannabis-induced psychosis.

Arnold JC.

Int J Neuropsychopharmacol. 2014 Dec;17(12):1911-3. doi: 10.1017/S1461145714000960. Epub 2014 Aug 13. No abstract available.


Fasting and exercise increase plasma cannabinoid levels in THC pre-treated rats: an examination of behavioural consequences.

Wong A, Keats K, Rooney K, Hicks C, Allsop DJ, Arnold JC, McGregor IS.

Psychopharmacology (Berl). 2014 Oct;231(20):3987-96. doi: 10.1007/s00213-014-3532-3. Epub 2014 Apr 3.


The effects of mGluR2/3 activation on acute and repeated amphetamine-induced locomotor activity in differentially reared male rats.

Arndt DL, Arnold JC, Cain ME.

Exp Clin Psychopharmacol. 2014 Jun;22(3):257-65. doi: 10.1037/a0035273. Epub 2014 Jan 27.


Partial genetic deletion of neuregulin 1 modulates the effects of stress on sensorimotor gating, dendritic morphology, and HPA axis activity in adolescent mice.

Chohan TW, Boucher AA, Spencer JR, Kassem MS, Hamdi AA, Karl T, Fok SY, Bennett MR, Arnold JC.

Schizophr Bull. 2014 Nov;40(6):1272-84. doi: 10.1093/schbul/sbt193. Epub 2014 Jan 17.


Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson's model.

Chotibut T, Davis RW, Arnold JC, Frenchek Z, Gurwara S, Bondada V, Geddes JW, Salvatore MF.

Mol Neurobiol. 2014 Jun;49(3):1282-92. doi: 10.1007/s12035-013-8598-0. Epub 2013 Dec 3.


Female neuregulin 1 heterozygous mice require repeated exposure to Δ⁹-tetrahydrocannabinol to alter sensorimotor gating function.

Spencer JR, Chohan TW, Karl T, Arnold JC.

Pharmacopsychiatry. 2013 Nov;46(7):286-91. doi: 10.1055/s-0033-1355390. Epub 2013 Oct 8.


Exercise increases plasma THC concentrations in regular cannabis users.

Wong A, Montebello ME, Norberg MM, Rooney K, Lintzeris N, Bruno R, Booth J, Arnold JC, McGregor IS.

Drug Alcohol Depend. 2013 Dec 1;133(2):763-7. doi: 10.1016/j.drugalcdep.2013.07.031. Epub 2013 Aug 11.


Analysis of cannabis seizures in NSW, Australia: cannabis potency and cannabinoid profile.

Swift W, Wong A, Li KM, Arnold JC, McGregor IS.

PLoS One. 2013 Jul 24;8(7):e70052. doi: 10.1371/journal.pone.0070052. Print 2013.


Novel molecular changes induced by Nrg1 hypomorphism and Nrg1-cannabinoid interaction in adolescence: a hippocampal proteomic study in mice.

Spencer JR, Darbyshire KM, Boucher AA, Kashem MA, Long LE, McGregor IS, Karl T, Arnold JC.

Front Cell Neurosci. 2013 Feb 26;7:15. doi: 10.3389/fncel.2013.00015. eCollection 2013.


What does a mouse tell us about neuregulin 1-cannabis interactions?

Karl T, Arnold JC.

Front Cell Neurosci. 2013 Feb 26;7:18. doi: 10.3389/fncel.2013.00018. eCollection 2013.


Comparative analysis of hemagglutination inhibition titers generated using temporally matched serum and plasma samples.

Defang GN, Martin NJ, Burgess TH, Millar EV, Pecenka LA, Danko JR, Arnold JC, Kochel TJ, Luke TC.

PLoS One. 2012;7(12):e48229. doi: 10.1371/journal.pone.0048229. Epub 2012 Dec 20.


Stress-induced grey matter loss determined by MRI is primarily due to loss of dendrites and their synapses.

Kassem MS, Lagopoulos J, Stait-Gardner T, Price WS, Chohan TW, Arnold JC, Hatton SN, Bennett MR.

Mol Neurobiol. 2013 Apr;47(2):645-61. doi: 10.1007/s12035-012-8365-7. Epub 2012 Nov 9.


Acute bacterial osteoarticular infections: eight-year analysis of C-reactive protein for oral step-down therapy.

Arnold JC, Cannavino CR, Ross MK, Westley B, Miller TC, Riffenburgh RH, Bradley J.

Pediatrics. 2012 Oct;130(4):e821-8. doi: 10.1542/peds.2012-0220. Epub 2012 Sep 10.


Adolescent neuregulin 1 heterozygous mice display enhanced behavioural sensitivity to methamphetamine.

Spencer JR, Darbyshire KM, Boucher AA, Arnold JC.

Prog Neuropsychopharmacol Biol Psychiatry. 2012 Dec 3;39(2):376-81. doi: 10.1016/j.pnpbp.2012.07.014. Epub 2012 Jul 29.


CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells.

Arnold JC, Hone P, Holland ML, Allen JD.

Pharmacol Rep. 2012;64(3):751-7.


Enhanced brain disposition and effects of Δ9-tetrahydrocannabinol in P-glycoprotein and breast cancer resistance protein knockout mice.

Spiro AS, Wong A, Boucher AA, Arnold JC.

PLoS One. 2012;7(4):e35937. doi: 10.1371/journal.pone.0035937. Epub 2012 Apr 20.


Distinct neurobehavioural effects of cannabidiol in transmembrane domain neuregulin 1 mutant mice.

Long LE, Chesworth R, Huang XF, Wong A, Spiro A, McGregor IS, Arnold JC, Karl T.

PLoS One. 2012;7(4):e34129. doi: 10.1371/journal.pone.0034129. Epub 2012 Apr 3.

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