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Items: 1 to 50 of 613

1.

Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Ligands.

Goldberg NW, Knight AM, Zhang RK, Arnold FH.

J Am Chem Soc. 2019 Dec 6. doi: 10.1021/jacs.9b11608. [Epub ahead of print]

PMID:
31790588
2.

Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation.

Dick M, Sarai NS, Martynowycz MW, Gonen T, Arnold FH.

J Am Chem Soc. 2019 Dec 6. doi: 10.1021/jacs.9b09864. [Epub ahead of print]

PMID:
31747522
3.

Molecular Mechanisms and Therapeutics for SBMA/Kennedy's Disease.

Arnold FJ, Merry DE.

Neurotherapeutics. 2019 Nov 4. doi: 10.1007/s13311-019-00790-9. [Epub ahead of print] Review.

PMID:
31686397
4.

Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics.

Bedbrook CN, Yang KK, Robinson JE, Mackey ED, Gradinaru V, Arnold FH.

Nat Methods. 2019 Nov;16(11):1176-1184. doi: 10.1038/s41592-019-0583-8. Epub 2019 Oct 14.

PMID:
31611694
5.

An enzymatic platform for the asymmetric amination of primary, secondary and tertiary C(sp3)-H bonds.

Yang Y, Cho I, Qi X, Liu P, Arnold FH.

Nat Chem. 2019 Nov;11(11):987-993. doi: 10.1038/s41557-019-0343-5. Epub 2019 Oct 14.

PMID:
31611634
6.

Incidence and Mortality of Adults Hospitalized With Community-Acquired Pneumonia According to Clinical Course.

Peyrani P, Arnold FW, Bordon J, Furmanek S, Luna CM, Cavallazzi R, Ramirez J.

Chest. 2019 Oct 11. pii: S0012-3692(19)34004-8. doi: 10.1016/j.chest.2019.09.022. [Epub ahead of print]

PMID:
31610158
7.

Spatial control of heavy-fermion superconductivity in CeIrIn5.

Bachmann MD, Ferguson GM, Theuss F, Meng T, Putzke C, Helm T, Shirer KR, Li YS, Modic KA, Nicklas M, König M, Low D, Ghosh S, Mackenzie AP, Arnold F, Hassinger E, McDonald RD, Winter LE, Bauer ED, Ronning F, Ramshaw BJ, Nowack KC, Moll PJW.

Science. 2019 Oct 11;366(6462):221-226. doi: 10.1126/science.aao6640.

PMID:
31601766
8.

The transient expression of CHIKV VLP in large stirred tank bioreactors.

Chen P, Demirji J, Ivleva VB, Horwitz J, Schwartz R, Arnold F.

Cytotechnology. 2019 Dec;71(6):1079-1093. doi: 10.1007/s10616-019-00346-x. Epub 2019 Sep 27.

PMID:
31560090
9.

Direct Enzymatic Synthesis of a Deep-Blue Fluorescent Noncanonical Amino Acid from Azulene and Serine.

Watkins EJ, Almhjell PJ, Arnold FH.

Chembiochem. 2019 Sep 12. doi: 10.1002/cbic.201900497. [Epub ahead of print]

PMID:
31513332
10.

Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial.

Gaudinski MR, Houser KV, Doria-Rose NA, Chen GL, Rothwell RSS, Berkowitz N, Costner P, Holman LA, Gordon IJ, Hendel CS, Kaltovich F, Conan-Cibotti M, Gomez Lorenzo M, Carter C, Sitar S, Carlton K, Gall J, Laurencot C, Lin BC, Bailer RT, McDermott AB, Ko SY, Pegu A, Kwon YD, Kwong PD, Namboodiri AM, Pandey JP, Schwartz R, Arnold F, Hu Z, Zhang L, Huang Y, Koup RA, Capparelli EV, Graham BS, Mascola JR, Ledgerwood JE; VRC 605 study team.

Lancet HIV. 2019 Oct;6(10):e667-e679. doi: 10.1016/S2352-3018(19)30181-X. Epub 2019 Aug 28.

PMID:
31473167
11.

Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture).

Arnold FH.

Angew Chem Int Ed Engl. 2019 Oct 7;58(41):14420-14426. doi: 10.1002/anie.201907729. Epub 2019 Aug 21. Review.

PMID:
31433107
12.

Root cause analysis of epidural spinal cord stimulator implant infections with resolution after implementation of an improved protocol for surgical placement.

Arnold FW, Bishop S, Johnson D, Scott L, Heishman C, Oppy L, Ball T, Sharma M, Angeli C, Ferreira C, Chen Y, Harkema S, Boakye M.

J Infect Prev. 2019 Jul;20(4):185-190. doi: 10.1177/1757177419844323. Epub 2019 May 2.

PMID:
31428199
13.

Characterization of AEBSF-antibody modifications for a protease inhibitor supplementation strategy.

Cai CX, Schneck NA, Zhao W, Blackstock D, Cai J, Harris D, Ivleva VB, Gollapudi D, Horwitz J, Arnold FJ, Cooper JW, Lei QP.

Anal Bioanal Chem. 2019 Sep;411(23):6111-6118. doi: 10.1007/s00216-019-01995-9. Epub 2019 Aug 1.

PMID:
31367804
14.

High frequency of inactivating tetraspanin C D37 mutations in diffuse large B-cell lymphoma at immune-privileged sites.

Elfrink S, de Winde CM, van den Brand M, Berendsen M, Roemer MGM, Arnold F, Janssen L, van der Schaaf A, Jansen E, Groenen PJTA, Eijkelenboom A, Stevens W, Hess CJ, van Krieken JH, Vermaat JSP, Cleven AHG, de Groen RAL, Neviani V, de Jong D, van Deventer S, Scheijen B, van Spriel AB.

Blood. 2019 Sep 19;134(12):946-950. doi: 10.1182/blood.2019001185. Epub 2019 Jul 31.

PMID:
31366619
15.

Machine-learning-guided directed evolution for protein engineering.

Yang KK, Wu Z, Arnold FH.

Nat Methods. 2019 Aug;16(8):687-694. doi: 10.1038/s41592-019-0496-6. Epub 2019 Jul 15. Review.

PMID:
31308553
16.

Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks.

Perkhofer L, Engler M, Gout J, Arnold F, Morawe M, Breunig M, Seufferlein T, Kleger A, Frappart PO.

Stem Cells Int. 2019 May 19;2019:2079742. doi: 10.1155/2019/2079742. eCollection 2019.

17.

Enantiodivergent α-Amino C-H Fluoroalkylation Catalyzed by Engineered Cytochrome P450s.

Zhang J, Huang X, Zhang RK, Arnold FH.

J Am Chem Soc. 2019 Jun 26;141(25):9798-9802. doi: 10.1021/jacs.9b04344. Epub 2019 Jun 12.

PMID:
31187993
18.

Overcoming Challenges in Structural Characterization of HIV-1 Envelope Glycoprotein by LC-MS/MS.

Ivleva VB, Cooper JW, Arnold FJ, Lei QP.

J Am Soc Mass Spectrom. 2019 Sep;30(9):1663-1678. doi: 10.1007/s13361-019-02225-3. Epub 2019 May 20.

PMID:
31111416
19.

Site-selective enzymatic C‒H amidation for synthesis of diverse lactams.

Cho I, Jia ZJ, Arnold FH.

Science. 2019 May 10;364(6440):575-578. doi: 10.1126/science.aaw9068. Epub 2019 May 9.

PMID:
31073063
20.

Directed Evolution of a Cytochrome P450 Carbene Transferase for Selective Functionalization of Cyclic Compounds.

Brandenberg OF, Chen K, Arnold FH.

J Am Chem Soc. 2019 Jun 5;141(22):8989-8995. doi: 10.1021/jacs.9b02931. Epub 2019 May 22.

PMID:
31070908
21.

Titer measurement of HIV-1 envelope trimeric glycoprotein in cell culture media by a new tandem ion exchange and size exclusion chromatography (IEC-SEC) method.

Yang G, Schneck NA, Barefoot N, Yang Y, Gollapudi D, Arnold FJ, Cooper JW, Lei QP.

Vaccine. 2019 May 27;37(24):3142-3145. doi: 10.1016/j.vaccine.2019.04.089. Epub 2019 May 3.

PMID:
31060952
22.

Development of an alternating tangential flow (ATF) perfusion-based transient gene expression (TGE) bioprocess for universal influenza vaccine.

Hong J, Demirji J, Blackstock D, Lee J, Dinh T, Goh A, Arnold F, Horwitz J.

Biotechnol Prog. 2019 Sep;35(5):e2831. doi: 10.1002/btpr.2831. Epub 2019 May 29.

PMID:
31050215
23.

Development of a New Tandem Ion Exchange and Size Exclusion Chromatography Method To Monitor Vaccine Particle Titer in Cell Culture Media.

Shaddeau AW, Schneck NA, Li Y, Ivleva VB, Arnold FJ, Cooper JW, Lei QP.

Anal Chem. 2019 May 21;91(10):6430-6434. doi: 10.1021/acs.analchem.9b00095. Epub 2019 Apr 29.

PMID:
31034206
24.

Engineered peptide barcodes for in-depth analyses of binding protein libraries.

Egloff P, Zimmermann I, Arnold FM, Hutter CAJ, Morger D, Opitz L, Poveda L, Keserue HA, Panse C, Roschitzki B, Seeger MA.

Nat Methods. 2019 May;16(5):421-428. doi: 10.1038/s41592-019-0389-8. Epub 2019 Apr 22.

PMID:
31011184
25.

Machine learning-assisted directed protein evolution with combinatorial libraries.

Wu Z, Kan SBJ, Lewis RD, Wittmann BJ, Arnold FH.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8852-8858. doi: 10.1073/pnas.1901979116. Epub 2019 Apr 12.

26.

Quantification of residual AEBSF-related impurities by reversed-phase liquid chromatography.

Cai CX, Schneck NA, Harris D, Blackstock D, Ivleva VB, Cheng KC, Charlton A, Arnold FJ, Cooper JW, Lei QP.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 May 15;1116:19-23. doi: 10.1016/j.jchromb.2019.03.022. Epub 2019 Mar 20.

PMID:
30953918
27.

Engineered Cytochrome c-Catalyzed Lactone-Carbene B-H Insertion.

Chen K, Huang X, Zhang SQ, Zhou AZ, Kan SBJ, Hong X, Arnold FH.

Synlett. 2019 Mar;30(4):378-382. doi: 10.1055/s-0037-1611662. Epub 2019 Jan 14.

28.

A Biocatalytic Platform for Synthesis of Chiral α-Trifluoromethylated Organoborons.

Huang X, Garcia-Borràs M, Miao K, Kan SBJ, Zutshi A, Houk KN, Arnold FH.

ACS Cent Sci. 2019 Feb 27;5(2):270-276. doi: 10.1021/acscentsci.8b00679. Epub 2019 Feb 1.

29.

"Every Newborn-INDEPTH" (EN-INDEPTH) study protocol for a randomised comparison of household survey modules for measuring stillbirths and neonatal deaths in five Health and Demographic Surveillance sites.

Baschieri A, Gordeev VS, Akuze J, Kwesiga D, Blencowe H, Cousens S, Waiswa P, Fisker AB, Thysen SM, Rodrigues A, Biks GA, Abebe SM, Gelaye KA, Mengistu MY, Geremew BM, Delele TG, Tesega AK, Yitayew TA, Kasasa S, Galiwango E, Natukwatsa D, Kajungu D, Enuameh YA, Nettey OE, Dzabeng F, Amenga-Etego S, Newton SK, Manu AA, Tawiah C, Asante KP, Owusu-Agyei S, Alam N, Haider MM, Alam SS, Arnold F, Byass P, Croft TN, Herbst K, Kishor S, Serbanescu F, Lawn JE.

J Glob Health. 2019 Jun;9(1):010901. doi: 10.7189/jogh.09.010901.

30.

Increased drug permeability of a stiffened mycobacterial outer membrane in cells lacking MFS transporter Rv1410 and lipoprotein LprG.

Hohl M, Remm S, Eskandarian HA, Dal Molin M, Arnold FM, Hürlimann LM, Krügel A, Fantner GE, Sander P, Seeger MA.

Mol Microbiol. 2019 May;111(5):1263-1282. doi: 10.1111/mmi.14220. Epub 2019 Mar 18.

31.

Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study.

Gaudinski MR, Coates EE, Novik L, Widge A, Houser KV, Burch E, Holman LA, Gordon IJ, Chen GL, Carter C, Nason M, Sitar S, Yamshchikov G, Berkowitz N, Andrews C, Vazquez S, Laurencot C, Misasi J, Arnold F, Carlton K, Lawlor H, Gall J, Bailer RT, McDermott A, Capparelli E, Koup RA, Mascola JR, Graham BS, Sullivan NJ, Ledgerwood JE; VRC 608 Study team.

Lancet. 2019 Mar 2;393(10174):889-898. doi: 10.1016/S0140-6736(19)30036-4. Epub 2019 Jan 24.

PMID:
30686586
32.

Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy.

Arnold FJ, Pluciennik A, Merry DE.

Sci Rep. 2019 Jan 15;9(1):119. doi: 10.1038/s41598-018-36784-4.

33.

Measuring malaria diagnosis and treatment coverage in population-based surveys: a recall validation study in Mali among caregivers of febrile children under 5 years.

Ashton RA, Doumbia B, Diallo D, Druetz T, Florey L, Taylor C, Arnold F, Mihigo J, Koné D, Fomba S, Eckert E, Eisele TP.

Malar J. 2019 Jan 3;18(1):3. doi: 10.1186/s12936-018-2636-3.

34.

Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein.

Cho I, Prier CK, Jia ZJ, Zhang RK, Görbe T, Arnold FH.

Angew Chem Int Ed Engl. 2019 Mar 4;58(10):3138-3142. doi: 10.1002/anie.201812968. Epub 2019 Jan 25.

PMID:
30600873
35.

Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp3 C-H functionalization.

Zhang RK, Chen K, Huang X, Wohlschlager L, Renata H, Arnold FH.

Nature. 2019 Jan;565(7737):67-72. doi: 10.1038/s41586-018-0808-5. Epub 2018 Dec 19.

36.

Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions.

Chen K, Zhang SQ, Brandenberg OF, Hong X, Arnold FH.

J Am Chem Soc. 2018 Dec 5;140(48):16402-16407. doi: 10.1021/jacs.8b09613. Epub 2018 Nov 1.

PMID:
30372623
37.

VEGF-A Inhibition as a Potential Therapeutic Approach in Merkel Cell Carcinoma.

Kervarrec T, Gaboriaud P, Tallet A, Leblond V, Arnold F, Berthon P, Schweinitzer S, Larcher T, Guyétant S, Schrama D, Houben R, Samimi M, Touzé A.

J Invest Dermatol. 2019 Mar;139(3):736-739. doi: 10.1016/j.jid.2018.08.029. Epub 2018 Oct 22. No abstract available.

PMID:
30359576
38.

Overcoming the Multiple-Monomeric-Peak Profile of Broadly Neutralizing HIV-1 Antibody 10E8 with a Unique Size-Exclusion-Chromatography Method.

Li Y, Wang XE, Bender MF, Yang R, Cozine TJ, Atallah KM, Arnold F, Cooper JW, Lei QP.

Anal Chem. 2018 Nov 6;90(21):12390-12394. doi: 10.1021/acs.analchem.8b03594. Epub 2018 Oct 22.

PMID:
30346697
39.

Selective CH bond functionalization with engineered heme proteins: new tools to generate complexity.

Zhang RK, Huang X, Arnold FH.

Curr Opin Chem Biol. 2019 Apr;49:67-75. doi: 10.1016/j.cbpa.2018.10.004. Epub 2018 Oct 18. Review.

PMID:
30343008
40.

Assessing whether universal coverage with insecticide-treated nets has been achieved: is the right indicator being used?

Koenker H, Arnold F, Ba F, Cisse M, Diouf L, Eckert E, Erskine M, Florey L, Fotheringham M, Gerberg L, Lengeler C, Lynch M, Mnzava A, Nasr S, Ndiop M, Poyer S, Renshaw M, Shargie E, Taylor C, Thwing J, Van Hulle S, Ye Y, Yukich J, Kilian A.

Malar J. 2018 Oct 11;17(1):355. doi: 10.1186/s12936-018-2505-0.

41.

Engineering enzymes for noncanonical amino acid synthesis.

Almhjell PJ, Boville CE, Arnold FH.

Chem Soc Rev. 2018 Dec 21;47(24):8980-8997. doi: 10.1039/c8cs00665b. Epub 2018 Oct 3. Review.

PMID:
30280154
42.

Resonant torsion magnetometry in anisotropic quantum materials.

Modic KA, Bachmann MD, Ramshaw BJ, Arnold F, Shirer KR, Estry A, Betts JB, Ghimire NJ, Bauer ED, Schmidt M, Baenitz M, Svanidze E, McDonald RD, Shekhter A, Moll PJW.

Nat Commun. 2018 Sep 28;9(1):3975. doi: 10.1038/s41467-018-06412-w.

43.

Engineered Biosynthesis of β-Alkyl Tryptophan Analogues.

Boville CE, Scheele RA, Koch P, Brinkmann-Chen S, Buller AR, Arnold FH.

Angew Chem Int Ed Engl. 2018 Nov 5;57(45):14764-14768. doi: 10.1002/anie.201807998. Epub 2018 Oct 12.

PMID:
30215880
44.

Chemistry Takes a Bath: Reactions in Aqueous Media.

Romney DK, Arnold FH, Lipshutz BH, Li CJ.

J Org Chem. 2018 Jul 20;83(14):7319-7322. doi: 10.1021/acs.joc.8b01412. No abstract available.

PMID:
30025465
45.

Tracking aluminium impurities in single crystals of the heavy-fermion superconductor UBe13.

Amon A, Zelenina I, Simon P, Bobnar M, Naumann M, Svanidze E, Arnold F, Borrmann H, Burkhardt U, Schnelle W, Hassinger E, Leithe-Jasper A, Grin Y.

Sci Rep. 2018 Jul 13;8(1):10654. doi: 10.1038/s41598-018-28991-w.

46.
47.

Macrolide therapy is associated with lower mortality in community-acquired bacteraemic pneumonia.

Arnold FW, Lopardo G, Wiemken TL, Kelley R, Peyrani P, Mattingly WA, Feldman C, Gnoni M, Maurici R, Ramirez JA; Community-Acquired Pneumonia Organization (CAPO).

Respir Med. 2018 Jul;140:115-121. doi: 10.1016/j.rmed.2018.05.020. Epub 2018 Jun 5.

PMID:
29957272
48.

Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase.

Lewis RD, Garcia-Borràs M, Chalkley MJ, Buller AR, Houk KN, Kan SBJ, Arnold FH.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7308-7313. doi: 10.1073/pnas.1807027115. Epub 2018 Jun 26.

49.

A uniform cloning platform for mycobacterial genetics and protein production.

Arnold FM, Hohl M, Remm S, Koliwer-Brandl H, Adenau S, Chusri S, Sander P, Hilbi H, Seeger MA.

Sci Rep. 2018 Jun 22;8(1):9539. doi: 10.1038/s41598-018-27687-5.

50.

Learned protein embeddings for machine learning.

Yang KK, Wu Z, Bedbrook CN, Arnold FH.

Bioinformatics. 2018 Dec 1;34(23):4138. doi: 10.1093/bioinformatics/bty455. No abstract available.

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