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Items: 29


Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer.

Wardell SE, Ellis MJ, Alley HM, Eisele K, VanArsdale T, Dann SG, Arndt KT, Primeau T, Griffin E, Shao J, Crowder R, Lai JP, Norris JD, McDonnell DP, Li S.

Clin Cancer Res. 2015 Nov 15;21(22):5121-5130. doi: 10.1158/1078-0432.CCR-15-0360. Epub 2015 May 19.


Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment.

VanArsdale T, Boshoff C, Arndt KT, Abraham RT.

Clin Cancer Res. 2015 Jul 1;21(13):2905-10. doi: 10.1158/1078-0432.CCR-14-0816. Epub 2015 May 4. Review.


Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments.

Loganzo F, Tan X, Sung M, Jin G, Myers JS, Melamud E, Wang F, Diesl V, Follettie MT, Musto S, Lam MH, Hu W, Charati MB, Khandke K, Kim KS, Cinque M, Lucas J, Graziani E, Maderna A, O'Donnell CJ, Arndt KT, Gerber HP.

Mol Cancer Ther. 2015 Apr;14(4):952-63. doi: 10.1158/1535-7163.MCT-14-0862. Epub 2015 Feb 2.


Control of mammary tumor differentiation by SKI-606 (bosutinib).

Hebbard L, Cecena G, Golas J, Sawada J, Ellies LG, Charbono A, Williams R, Jimenez RE, Wankell M, Arndt KT, DeJoy SQ, Rollins RA, Diesl V, Follettie M, Chen L, Rosfjord E, Cardiff RD, Komatsu M, Boschelli F, Oshima RG.

Oncogene. 2011 Jan 20;30(3):301-12. doi: 10.1038/onc.2010.412. Epub 2010 Sep 6.


A cell-based screen for inhibitors of protein folding and degradation.

Boschelli F, Golas JM, Petersen R, Lau V, Chen L, Tkach D, Zhao Q, Fruhling DS, Liu H, Nam C, Arndt KT.

Cell Stress Chaperones. 2010 Nov;15(6):913-27. doi: 10.1007/s12192-010-0200-3. Epub 2010 Aug 19.


2,4-Diamino-quinazolines as inhibitors of beta-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer.

Chen Z, Venkatesan AM, Dehnhardt CM, Dos Santos O, Delos Santos E, Ayral-Kaloustian S, Chen L, Geng Y, Arndt KT, Lucas J, Chaudhary I, Mansour TS.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):4980-3. doi: 10.1016/j.bmcl.2009.07.070. Epub 2009 Jul 17.


Physiological effects of unassembled chaperonin Cct subunits in the yeast Saccharomyces cerevisiae.

Kabir MA, Kaminska J, Segel GB, Bethlendy G, Lin P, Della Seta F, Blegen C, Swiderek KM, ZoƂadek T, Arndt KT, Sherman F.

Yeast. 2005 Feb;22(3):219-39.


Identification of a conserved sequence motif that promotes Cdc37 and cyclin D1 binding to Cdk4.

Zhao Q, Boschelli F, Caplan AJ, Arndt KT.

J Biol Chem. 2004 Mar 26;279(13):12560-4. Epub 2003 Dec 30.


TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.

Jacinto E, Guo B, Arndt KT, Schmelzle T, Hall MN.

Mol Cell. 2001 Nov;8(5):1017-26.


Stimulation of transcription by mutations affecting conserved regions of RNA polymerase II.

Archambault J, Jansma DB, Kawasoe JH, Arndt KT, Greenblatt J, Friesen JD.

J Bacteriol. 1998 May;180(10):2590-8.


The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase.

Luke MM, Della Seta F, Di Como CJ, Sugimoto H, Kobayashi R, Arndt KT.

Mol Cell Biol. 1996 Jun;16(6):2744-55.


Transcriptional regulation of the yeast DnaJ homologue SIS1.

Zhong T, Luke MM, Arndt KT.

J Biol Chem. 1996 Jan 19;271(3):1349-56.


Activation of CLN1 and CLN2 G1 cyclin gene expression by BCK2.

Di Como CJ, Chang H, Arndt KT.

Mol Cell Biol. 1995 Apr;15(4):1835-46.


SIT4 protein phosphatase is required for the normal accumulation of SWI4, CLN1, CLN2, and HCS26 RNAs during late G1.

Fernandez-Sarabia MJ, Sutton A, Zhong T, Arndt KT.

Genes Dev. 1992 Dec;6(12A):2417-28.


RAP1 is required for BAS1/BAS2- and GCN4-dependent transcription of the yeast HIS4 gene.

Devlin C, Tice-Baldwin K, Shore D, Arndt KT.

Mol Cell Biol. 1991 Jul;11(7):3642-51.


The SIT4 protein phosphatase functions in late G1 for progression into S phase.

Sutton A, Immanuel D, Arndt KT.

Mol Cell Biol. 1991 Apr;11(4):2133-48.


The SIT4 protein phosphatase is required in late G1 for progression into S phase.

Sutton A, Lin F, Arndt KT.

Cold Spring Harb Symp Quant Biol. 1991;56:75-81. No abstract available.


BAS1 has a Myb motif and activates HIS4 transcription only in combination with BAS2.

Tice-Baldwin K, Fink GR, Arndt KT.

Science. 1989 Nov 17;246(4932):931-5.


Multiple global regulators control HIS4 transcription in yeast.

Arndt KT, Styles C, Fink GR.

Science. 1987 Aug 21;237(4817):874-80.


lambda Phage cro repressor interaction with DNA.

Arndt KT, Boschelli F, Cook J, Takeda Y, Tecza E, Lu P.

J Biol Chem. 1983 Apr 10;258(7):4177-83.


lac Repressor: a proton magnetic resonance look at the deoxyribonucleic acid binding fragment.

Arndt KT, Boschelli F, Lu P, Miller JH.

Biochemistry. 1981 Oct 13;20(21):6109-18.


Genetic insertion of nuclear spin labels in the lac repressor.

Jarema MA, Arndt KT, Savage M, Lu P, Miller JH.

J Biol Chem. 1981 Jul 10;256(13):6544-7.

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