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Items: 1 to 50 of 160

1.

Structural Basis of the Differential Binding of Engineered Knottins to Integrins αVβ3 and α5β1.

Van Agthoven JF, Shams H, Cochran FV, Alonso JL, Kintzing JR, Garakani K, Adair BD, Xiong JP, Mofrad MRK, Cochran JR, Arnaout MA.

Structure. 2019 Jul 16. pii: S0969-2126(19)30232-1. doi: 10.1016/j.str.2019.06.011. [Epub ahead of print]

PMID:
31353240
2.

uPAR isoform 2 forms a dimer and induces severe kidney disease in mice.

Wei C, Li J, Adair BD, Zhu K, Cai J, Merchant M, Samelko B, Liao Z, Koh KH, Tardi NJ, Dande RR, Liu S, Ma J, Dibartolo S, Hägele S, Peev V, Hayek SS, Cimbaluk DJ, Tracy M, Klein J, Sever S, Shattil SJ, Arnaout MA, Reiser J.

J Clin Invest. 2019 Apr 2;129(5):1946-1959. doi: 10.1172/JCI124793. eCollection 2019 Apr 2.

3.

High-Affinity Bent β2-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis.

Fan Z, Kiosses WB, Sun H, Orecchioni M, Ghosheh Y, Zajonc DM, Arnaout MA, Gutierrez E, Groisman A, Ginsberg MH, Ley K.

Cell Rep. 2019 Jan 2;26(1):119-130.e5. doi: 10.1016/j.celrep.2018.12.038.

4.

A microfluidic renal proximal tubule with active reabsorptive function.

Vedula EM, Alonso JL, Arnaout MA, Charest JL.

PLoS One. 2017 Oct 11;12(10):e0184330. doi: 10.1371/journal.pone.0184330. eCollection 2017.

5.

Two-stage implant placement technique for the management of irradiated jaws: An animal study.

Aboushelib MN, Arnaout MA, Elsafi MH, Kassem YM.

J Prosthet Dent. 2017 Oct;118(4):546-550. doi: 10.1016/j.prosdent.2017.01.017. Epub 2017 Mar 23.

PMID:
28343674
6.

Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys.

Dehnadi A, Benedict Cosimi A, Neal Smith R, Li X, Alonso JL, Means TK, Arnaout MA.

Nat Commun. 2017 Jan 10;8:13899. doi: 10.1038/ncomms13899.

7.

Biology and structure of leukocyte β 2 integrins and their role in inflammation.

Arnaout MA.

F1000Res. 2016 Oct 4;5. pii: F1000 Faculty Rev-2433. eCollection 2016. Review.

8.

Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish.

Wu Q, Zhang J, Koh W, Yu Q, Zhu X, Amsterdam A, Davis GE, Arnaout MA, Xiong JW.

FASEB J. 2015 Dec;29(12):4989-5005. doi: 10.1096/fj.15-273409. Epub 2015 Aug 26.

9.

Negative Regulation of TGFβ Signaling by Stem Cell Antigen-1 Protects against Ischemic Acute Kidney Injury.

Camarata TD, Weaver GC, Vasilyev A, Arnaout MA.

PLoS One. 2015 Jun 8;10(6):e0129561. doi: 10.1371/journal.pone.0129561. eCollection 2015.

10.

Collective epithelial migration drives kidney repair after acute injury.

Palmyre A, Lee J, Ryklin G, Camarata T, Selig MK, Duchemin AL, Nowak P, Arnaout MA, Drummond IA, Vasilyev A.

PLoS One. 2014 Jul 10;9(7):e101304. doi: 10.1371/journal.pone.0101304. eCollection 2014.

11.

The α-subunit regulates stability of the metal ion at the ligand-associated metal ion-binding site in β3 integrins.

Rui X, Mehrbod M, Van Agthoven JF, Anand S, Xiong JP, Mofrad MR, Arnaout MA.

J Biol Chem. 2014 Aug 15;289(33):23256-63. doi: 10.1074/jbc.M114.581470. Epub 2014 Jun 28.

12.

Atomic basis for the species-specific inhibition of αV integrins by monoclonal antibody 17E6 is revealed by the crystal structure of αVβ3 ectodomain-17E6 Fab complex.

Mahalingam B, Van Agthoven JF, Xiong JP, Alonso JL, Adair BD, Rui X, Anand S, Mehrbod M, Mofrad MR, Burger C, Goodman SL, Arnaout MA.

J Biol Chem. 2014 May 16;289(20):13801-9. doi: 10.1074/jbc.M113.546929. Epub 2014 Apr 1.

13.

Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin.

Van Agthoven JF, Xiong JP, Alonso JL, Rui X, Adair BD, Goodman SL, Arnaout MA.

Nat Struct Mol Biol. 2014 Apr;21(4):383-8. doi: 10.1038/nsmb.2797. Epub 2014 Mar 23.

14.

Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89.

Li X, Romain RD, Park D, Scadden DT, Merchant JL, Arnaout MA.

Stem Cells. 2014 Mar;32(3):791-801. doi: 10.1002/stem.1598.

15.

Structure of the kidney slit diaphragm adapter protein CD2-associated protein as determined with electron microscopy.

Adair BD, Altintas MM, Möller CC, Arnaout MA, Reiser J.

J Am Soc Nephrol. 2014 Jul;25(7):1465-73. doi: 10.1681/ASN.2013090949. Epub 2014 Feb 7.

16.

Abatacept in B7-1-positive proteinuric kidney disease.

Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC, Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke GW 3rd, Mundel P.

N Engl J Med. 2013 Dec 19;369(25):2416-23. doi: 10.1056/NEJMoa1304572. Epub 2013 Nov 8.

17.

Topographically-patterned porous membranes in a microfluidic device as an in vitro model of renal reabsorptive barriers.

Frohlich EM, Alonso JL, Borenstein JT, Zhang X, Arnaout MA, Charest JL.

Lab Chip. 2013 Jun 21;13(12):2311-9. doi: 10.1039/c3lc50199j. Epub 2013 May 2.

18.

EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane.

Adair BD, Xiong JP, Alonso JL, Hyman BT, Arnaout MA.

PLoS One. 2013;8(2):e57951. doi: 10.1371/journal.pone.0057951. Epub 2013 Feb 28.

19.

Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design.

Mahalingam B, Ajroud K, Alonso JL, Anand S, Adair BD, Horenstein AL, Malavasi F, Xiong JP, Arnaout MA.

J Immunol. 2011 Dec 15;187(12):6393-401. doi: 10.4049/jimmunol.1102394. Epub 2011 Nov 16.

20.

Anti-PR3 immune responses induce segmental and necrotizing glomerulonephritis.

Primo VC, Marusic S, Franklin CC, Goldmann WH, Achaval CG, Smith RN, Arnaout MA, Nikolic B.

Clin Exp Immunol. 2010 Mar;159(3):327-37. doi: 10.1111/j.1365-2249.2009.04072.x. Epub 2009 Dec 14.

21.

Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment.

Xiong JP, Mahalingham B, Alonso JL, Borrelli LA, Rui X, Anand S, Hyman BT, Rysiok T, Müller-Pompalla D, Goodman SL, Arnaout MA.

J Cell Biol. 2009 Aug 24;186(4):589-600. doi: 10.1083/jcb.200905085.

22.

Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function.

Gupta V, Alonso JL, Sugimori T, Essafi M, Xiong JP, Arnaout MA.

J Immunol. 2008 Feb 1;180(3):1713-8. Erratum in: J Immunol. 2008 Mar 1;180(5):3613. Issafi, Makram [corrected to Essafi, Makram].

23.

Structure and mechanics of integrin-based cell adhesion.

Arnaout MA, Goodman SL, Xiong JP.

Curr Opin Cell Biol. 2007 Oct;19(5):495-507. Epub 2007 Oct 24. Review.

24.

Purification, analysis, and crystal structure of integrins.

Xiong JP, Goodman SL, Arnaout MA.

Methods Enzymol. 2007;426:307-36. Review.

PMID:
17697890
26.

A case management model to improve hemodialysis outpatient outcomes.

Steele DJ, Hamilton E, Arnaout MA.

Hemodial Int. 2007 Apr;11(2):247-51.

PMID:
17403178
27.

The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18.

Gupta V, Gylling A, Alonso JL, Sugimori T, Ianakiev P, Xiong JP, Arnaout MA.

Blood. 2007 Apr 15;109(8):3513-20. Epub 2006 Dec 14.

28.

Recombinant integrin CD11b A-domain blocks polymorphonuclear cells recruitment and protects against skeletal muscle inflammatory injury in the rat.

Zerria K, Jerbi E, Hammami S, Maaroufi A, Boubaker S, Xiong JP, Arnaout MA, Fathallah DM.

Immunology. 2006 Dec;119(4):431-40. Epub 2006 Oct 9.

29.

The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells.

Li X, Xiong JW, Shelley CS, Park H, Arnaout MA.

Development. 2006 Sep;133(18):3641-50. Epub 2006 Aug 16.

30.

Integrin structure, allostery, and bidirectional signaling.

Arnaout MA, Mahalingam B, Xiong JP.

Annu Rev Cell Dev Biol. 2005;21:381-410. Review.

PMID:
16212500
31.

Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin.

Adair BD, Xiong JP, Maddock C, Goodman SL, Arnaout MA, Yeager M.

J Cell Biol. 2005 Mar 28;168(7):1109-18.

32.

A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils.

Devchand PR, Schmidt BA, Primo VC, Zhang QY, Arnaout MA, Serhan CN, Nikolic B.

FASEB J. 2005 Feb;19(2):203-10.

PMID:
15677343
33.

A novel adaptation of the integrin PSI domain revealed from its crystal structure.

Xiong JP, Stehle T, Goodman SL, Arnaout MA.

J Biol Chem. 2004 Sep 24;279(39):40252-4. Epub 2004 Aug 6.

34.

The structural basis of elasticity in fibrillin-based microfibrils.

Arnaout MA.

Structure. 2004 May;12(5):734-6. No abstract available.

35.

Binding Affinity of Metal Ions to the CD11b A-domain Is Regulated by Integrin Activation and Ligands.

Ajroud K, Sugimori T, Goldmann WH, Fathallah DM, Xiong JP, Arnaout MA.

J Biol Chem. 2004 Jun 11;279(24):25483-8. Epub 2004 Apr 7.

36.

Integrins, cations and ligands: making the connection.

Xiong JP, Stehle T, Goodman SL, Arnaout MA.

J Thromb Haemost. 2003 Jul;1(7):1642-54. Review.

37.

New insights into the structural basis of integrin activation.

Xiong JP, Stehle T, Goodman SL, Arnaout MA.

Blood. 2003 Aug 15;102(4):1155-9. Epub 2003 Apr 24. Review.

38.

CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD.

Nicolaou F, Teodoridis JM, Park H, Georgakis A, Farokhzad OC, Böttinger EP, Da Silva N, Rousselot P, Chomienne C, Ferenczi K, Arnaout MA, Shelley CS.

Blood. 2003 May 15;101(10):4033-41. Epub 2003 Feb 6.

39.

Polycystin-1 activates and stabilizes the polycystin-2 channel.

Xu GM, González-Perrett S, Essafi M, Timpanaro GA, Montalbetti N, Arnaout MA, Cantiello HF.

J Biol Chem. 2003 Jan 17;278(3):1457-62. Epub 2002 Oct 28.

40.

The zinc finger transcription factor ZBP-89 is a repressor of the human beta 2-integrin CD11b gene.

Park H, Shelley CS, Arnaout MA.

Blood. 2003 Feb 1;101(3):894-902. Epub 2002 Sep 19.

41.

Integrin structure: new twists and turns in dynamic cell adhesion.

Arnaout MA.

Immunol Rev. 2002 Aug;186:125-40. Review. Erratum in: Immunol Rev. 2003 Jun;193:146.

PMID:
12234368
42.

Coming to grips with integrin binding to ligands.

Arnaout MA, Goodman SL, Xiong JP.

Curr Opin Cell Biol. 2002 Oct;14(5):641-51. Review.

PMID:
12231361
43.

Divalent cations and the relationship between alphaA and betaA domains in integrins.

Seow KT, Xiong JP, Arnaout MA, Welge J, Rippmann F, Goodman SL.

Biochem Pharmacol. 2002 Sep;64(5-6):805-12.

PMID:
12213573
44.

Does the integrin alphaA domain act as a ligand for its betaA domain?

Alonso JL, Essafi M, Xiong JP, Stehle T, Arnaout MA.

Curr Biol. 2002 May 14;12(10):R340-2. No abstract available.

45.

Voltage dependence and pH regulation of human polycystin-2-mediated cation channel activity.

Gonzalez-Perrett S, Batelli M, Kim K, Essafi M, Timpanaro G, Moltabetti N, Reisin IL, Arnaout MA, Cantiello HF.

J Biol Chem. 2002 Jul 12;277(28):24959-66. Epub 2002 May 3.

46.

During differentiation of the monocytic cell line U937, Pur alpha mediates induction of the CD11c beta 2 integrin gene promoter.

Shelley CS, Teodoridis JM, Park H, Farokhzad OC, Böttinger EP, Arnaout MA.

J Immunol. 2002 Apr 15;168(8):3887-93.

47.

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.

Xiong JP, Stehle T, Zhang R, Joachimiak A, Frech M, Goodman SL, Arnaout MA.

Science. 2002 Apr 5;296(5565):151-5. Epub 2002 Mar 7.

48.

Use of a bovine model to study the role of adhesion molecule CD11/CD18 in hemodialysis-induced neutropenia.

Rabb H, Chandran PK, Arnaout MA, Kehrli ME Jr.

Am J Kidney Dis. 2002 Mar;39(3):587-93.

PMID:
11877578
49.
50.

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