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Best matches for Arnér ES[au]:

Selenoprotein Gene Nomenclature. Gladyshev VN et al. J Biol Chem. (2016)

Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications. Lei XG et al. Physiol Rev. (2016)

Physiological functions of thioredoxin and thioredoxin reductase. Arnér ES et al. Eur J Biochem. (2000)

Search results

Items: 1 to 50 of 140

1.

Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system.

Selvaraju K, Mofers A, Pellegrini P, Salomonsson J, Ahlner A, Morad V, Hillert EK, Espinosa B, Arnér ESJ, Jensen L, Malmström J, Turkina MV, D'Arcy P, Walters MA, Sunnerhagen M, Linder S.

Sci Rep. 2019 Jul 8;9(1):9841. doi: 10.1038/s41598-019-46168-x.

2.

Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades.

Dagnell M, Cheng Q, Rizvi SHM, Pace PE, Boivin B, Winterbourn CC, Arnér ESJ.

J Biol Chem. 2019 Aug 16;294(33):12330-12338. doi: 10.1074/jbc.RA119.009001. Epub 2019 Jun 13.

3.

ProPerDP: A Protein Persulfide Detection Protocol.

Dóka É, Arnér ESJ, Schmidt EE, Nagy P.

Methods Mol Biol. 2019;2007:51-77. doi: 10.1007/978-1-4939-9528-8_5.

PMID:
31148106
4.

TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.

McLoughlin MR, Orlicky DJ, Prigge JR, Krishna P, Talago EA, Cavigli IR, Eriksson S, Miller CG, Kundert JA, Sayin VI, Sabol RA, Heinemann J, Brandenberger LO, Iverson SV, Bothner B, Papagiannakopoulos T, Shearn CT, Arnér ESJ, Schmidt EE.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11408-11417. doi: 10.1073/pnas.1903244116. Epub 2019 May 16.

PMID:
31097586
5.

Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug.

Zhang X, Selvaraju K, Saei AA, D'Arcy P, Zubarev RA, Arnér ES, Linder S.

Biochimie. 2019 Jul;162:46-54. doi: 10.1016/j.biochi.2019.03.015. Epub 2019 Apr 1.

PMID:
30946948
6.

Which Antioxidant System Shapes Intracellular H2O2 Gradients?

Mishina NM, Bogdanova YA, Ermakova YG, Panova AS, Kotova DA, Bilan DS, Steinhorn B, Arnér ESJ, Michel T, Belousov VV.

Antioxid Redox Signal. 2019 Sep 20;31(9):664-670. doi: 10.1089/ars.2018.7697. Epub 2019 Apr 24.

PMID:
30864831
7.

Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate.

Katsu-Jiménez Y, Vázquez-Calvo C, Maffezzini C, Halldin M, Peng X, Freyer C, Wredenberg A, Giménez-Cassina A, Wedell A, Arnér ESJ.

Diabetes. 2019 Apr;68(4):709-723. doi: 10.2337/db18-0557. Epub 2019 Feb 12.

PMID:
30755400
8.

Selenium and selenoproteins in (redox) signaling, diseases, and animal models - 200 year anniversary issue.

Brigelius-Flohé R, Arnér ESJ.

Free Radic Biol Med. 2018 Nov 1;127:1-2. doi: 10.1016/j.freeradbiomed.2018.09.026. No abstract available.

PMID:
30274914
9.

Thioredoxin-related protein of 14 kDa as a modulator of redox signalling pathways.

Espinosa B, Arnér ESJ.

Br J Pharmacol. 2019 Feb;176(4):544-553. doi: 10.1111/bph.14479. Epub 2018 Oct 6. Review.

PMID:
30129655
10.

Selenium research in biochemistry and biophysics - 200 year anniversary issue.

Arnér ESJ, Brigelius-Flohé R.

Biochim Biophys Acta Gen Subj. 2018 Jul 24. pii: S0304-4165(18)30220-4. doi: 10.1016/j.bbagen.2018.07.026. [Epub ahead of print] No abstract available.

PMID:
30053537
11.

Efficient selenocysteine-dependent reduction of toxoflavin by mammalian thioredoxin reductase.

Gencheva R, Cheng Q, Arnér ESJ.

Biochim Biophys Acta Gen Subj. 2018 May 25. pii: S0304-4165(18)30146-6. doi: 10.1016/j.bbagen.2018.05.014. [Epub ahead of print]

PMID:
29807072
12.

Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry.

Silvestri I, Lyu H, Fata F, Boumis G, Miele AE, Ardini M, Ippoliti R, Bellelli A, Jadhav A, Lea WA, Simeonov A, Cheng Q, Arnér ESJ, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F.

ACS Chem Biol. 2018 Aug 17;13(8):2190-2202. doi: 10.1021/acschembio.8b00349. Epub 2018 Jun 11.

PMID:
29800515
13.

NADPH-dependent and -independent disulfide reductase systems.

Miller CG, Holmgren A, Arnér ESJ, Schmidt EE.

Free Radic Biol Med. 2018 Nov 1;127:248-261. doi: 10.1016/j.freeradbiomed.2018.03.051. Epub 2018 Mar 30. Review.

PMID:
29609022
14.

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.

Stafford WC, Peng X, Olofsson MH, Zhang X, Luci DK, Lu L, Cheng Q, Trésaugues L, Dexheimer TS, Coussens NP, Augsten M, Ahlzén HM, Orwar O, Östman A, Stone-Elander S, Maloney DJ, Jadhav A, Simeonov A, Linder S, Arnér ESJ.

Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444. doi: 10.1126/scitranslmed.aaf7444.

PMID:
29444979
15.

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.

Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T, Mehr L, Aichler M, Walch A, Lamp D, Jastroch M, Miyamoto S, Wurst W, Ursini F, Arnér ESJ, Fradejas-Villar N, Schweizer U, Zischka H, Friedmann Angeli JP, Conrad M.

Cell. 2018 Jan 25;172(3):409-422.e21. doi: 10.1016/j.cell.2017.11.048. Epub 2017 Dec 28.

16.

The A to Z of modulated cell patterning by mammalian thioredoxin reductases.

Dagnell M, Schmidt EE, Arnér ESJ.

Free Radic Biol Med. 2018 Feb 1;115:484-496. doi: 10.1016/j.freeradbiomed.2017.12.029. Epub 2017 Dec 24. Review.

17.

Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy.

Arnér ESJ.

Adv Cancer Res. 2017;136:139-151. doi: 10.1016/bs.acr.2017.07.005. Epub 2017 Aug 23. Review.

PMID:
29054416
18.

Selective Evaluation of Thioredoxin Reductase Enzymatic Activities.

Arnér ESJ.

Methods Mol Biol. 2018;1661:301-309. doi: 10.1007/978-1-4939-7258-6_21.

PMID:
28917053
19.

Overexpression of Recombinant Selenoproteins in E. coli.

Cheng Q, Arnér ESJ.

Methods Mol Biol. 2018;1661:231-240. doi: 10.1007/978-1-4939-7258-6_17.

PMID:
28917049
20.

Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure.

Dagnell M, Pace PE, Cheng Q, Frijhoff J, Östman A, Arnér ESJ, Hampton MB, Winterbourn CC.

J Biol Chem. 2017 Sep 1;292(35):14371-14380. doi: 10.1074/jbc.M117.793745. Epub 2017 Jul 6.

21.

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase.

Prigge JR, Coppo L, Martin SS, Ogata F, Miller CG, Bruschwein MD, Orlicky DJ, Shearn CT, Kundert JA, Lytchier J, Herr AE, Mattsson Å, Taylor MP, Gustafsson TN, Arnér ESJ, Holmgren A, Schmidt EE.

Cell Rep. 2017 Jun 27;19(13):2771-2781. doi: 10.1016/j.celrep.2017.06.019.

22.

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase.

Peng X, Zhang MQ, Conserva F, Hosny G, Selivanova G, Bykov VJ, Arnér ES, Wiman KG.

Cell Death Dis. 2017 Apr 13;8(4):e2751. doi: 10.1038/cddis.2016.137. No abstract available.

23.

Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells.

Kipp AP, Deubel S, Arnér ESJ, Johansson K.

Redox Biol. 2017 Aug;12:403-409. doi: 10.1016/j.redox.2017.03.013. Epub 2017 Mar 10.

24.

Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress.

Sthijns MMJPE, Schiffers PM, Janssen GM, Lemmens KJA, Ides B, Vangrieken P, Bouwman FG, Mariman EC, Pader I, Arnér ESJ, Johansson K, Bast A, Haenen GRMM.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):1177-1189. doi: 10.1016/j.bbagen.2017.03.004. Epub 2017 Mar 7.

PMID:
28286015
25.

Homozygous mutation in TXNRD1 is associated with genetic generalized epilepsy.

Kudin AP, Baron G, Zsurka G, Hampel KG, Elger CE, Grote A, Weber Y, Lerche H, Thiele H, Nürnberg P, Schulz H, Ruppert AK, Sander T, Cheng Q, Arnér ES, Schomburg L, Seeher S, Fradejas-Villar N, Schweizer U, Kunz WS.

Free Radic Biol Med. 2017 May;106:270-277. doi: 10.1016/j.freeradbiomed.2017.02.040. Epub 2017 Feb 21.

PMID:
28232204
26.
27.

Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER.

Poet GJ, Oka OB, van Lith M, Cao Z, Robinson PJ, Pringle MA, Arnér ES, Bulleid NJ.

EMBO J. 2017 Mar 1;36(5):693-702. doi: 10.15252/embj.201695336. Epub 2017 Jan 16.

28.

Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads.

Kaminska KK, Bertrand HC, Tajima H, Stafford WC, Cheng Q, Chen W, Wells G, Arner ES, Chew EH.

Oncotarget. 2016 Jun 28;7(26):40233-40251. doi: 10.18632/oncotarget.9579.

29.

Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.

Zhang L, Cheng Q, Zhang L, Wang Y, Merrill GF, Ilani T, Fass D, Arnér ESJ, Zhang J.

Free Radic Biol Med. 2016 Oct;99:426-435. doi: 10.1016/j.freeradbiomed.2016.08.028. Epub 2016 Aug 28.

PMID:
27581528
30.

Selenoprotein Gene Nomenclature.

Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Köhrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonović M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y.

J Biol Chem. 2016 Nov 11;291(46):24036-24040. Epub 2016 Sep 19.

31.

Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake.

Cheng Q, Wållberg H, Grafström J, Lu L, Thorell JO, Hägg Olofsson M, Linder S, Johansson K, Tegnebratt T, Arnér ES, Stone-Elander S, Ahlzén HS, Ståhl S; Sel-tag imaging project.

EJNMMI Res. 2016 Dec;6(1):58. doi: 10.1186/s13550-016-0213-8. Epub 2016 Jul 7.

32.

Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance.

Engelman R, Ziv T, Arnér ESJ, Benhar M.

Free Radic Biol Med. 2016 Aug;97:375-385. doi: 10.1016/j.freeradbiomed.2016.06.032. Epub 2016 Jul 1.

PMID:
27377780
33.

Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness.

Peng X, Giménez-Cassina A, Petrus P, Conrad M, Rydén M, Arnér ES.

Sci Rep. 2016 Jun 27;6:28080. doi: 10.1038/srep28080.

34.

Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells.

van Gisbergen MW, Cebula M, Zhang J, Ottosson-Wadlund A, Dubois L, Lambin P, Tew KD, Townsend DM, Haenen GR, Drittij-Reijnders MJ, Saneyoshi H, Araki M, Shishido Y, Ito Y, Arnér ES, Abe H, Morgenstern R, Johansson K.

Mol Pharm. 2016 Jun 6;13(6):2010-25. doi: 10.1021/acs.molpharmaceut.6b00140. Epub 2016 Apr 28.

35.

Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities.

Xu J, Cheng Q, Arnér ES.

Free Radic Biol Med. 2016 May;94:110-20. doi: 10.1016/j.freeradbiomed.2016.02.013. Epub 2016 Feb 17.

PMID:
26898501
36.

A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems.

Dóka É, Pader I, Bíró A, Johansson K, Cheng Q, Ballagó K, Prigge JR, Pastor-Flores D, Dick TP, Schmidt EE, Arnér ES, Nagy P.

Sci Adv. 2016 Jan 22;2(1):e1500968. doi: 10.1126/sciadv.1500968. eCollection 2016 Jan.

37.

Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.

Lei XG, Zhu JH, Cheng WH, Bao Y, Ho YS, Reddi AR, Holmgren A, Arnér ES.

Physiol Rev. 2016 Jan;96(1):307-64. doi: 10.1152/physrev.00010.2014. Review.

38.

Cross Talk in HEK293 Cells Between Nrf2, HIF, and NF-κB Activities upon Challenges with Redox Therapeutics Characterized with Single-Cell Resolution.

Johansson K, Cebula M, Rengby O, Dreij K, Carlström KE, Sigmundsson K, Piehl F, Arnér ES.

Antioxid Redox Signal. 2017 Feb 20;26(6):229-246. doi: 10.1089/ars.2015.6419. Epub 2015 Nov 11.

39.

TrxR1 as a potent regulator of the Nrf2-Keap1 response system.

Cebula M, Schmidt EE, Arnér ES.

Antioxid Redox Signal. 2015 Oct 1;23(10):823-53. doi: 10.1089/ars.2015.6378. Epub 2015 Jun 24. Review.

40.

Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.

Sachweh MC, Stafford WC, Drummond CJ, McCarthy AR, Higgins M, Campbell J, Brodin B, Arnér ES, Laín S.

Oncotarget. 2015 Jun 30;6(18):16488-506.

41.

Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver.

Eriksson S, Prigge JR, Talago EA, Arnér ES, Schmidt EE.

Nat Commun. 2015 Mar 20;6:6479. doi: 10.1038/ncomms7479.

42.

The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death.

Xu J, Eriksson SE, Cebula M, Sandalova T, Hedström E, Pader I, Cheng Q, Myers CR, Antholine WE, Nagy P, Hellman U, Selivanova G, Lindqvist Y, Arnér ES.

Cell Death Dis. 2015 Jan 22;6:e1616. doi: 10.1038/cddis.2014.574.

43.

Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2.

Peng X, Mandal PK, Kaminskyy VO, Lindqvist A, Conrad M, Arnér ES.

Cell Death Dis. 2014 May 22;5:e1235. doi: 10.1038/cddis.2014.209.

44.

Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.

Pader I, Sengupta R, Cebula M, Xu J, Lundberg JO, Holmgren A, Johansson K, Arnér ES.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):6964-9. doi: 10.1073/pnas.1317320111. Epub 2014 Apr 28.

45.

Redox active motifs in selenoproteins.

Li F, Lutz PB, Pepelyayeva Y, Arnér ES, Bayse CA, Rozovsky S.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):6976-81. doi: 10.1073/pnas.1319022111. Epub 2014 Apr 25.

46.

The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.

Wang X, Stafford W, Mazurkiewicz M, Fryknäs M, Brjnic S, Zhang X, Gullbo J, Larsson R, Arnér ES, D'Arcy P, Linder S.

Mol Pharmacol. 2014 Jun;85(6):932-45. doi: 10.1124/mol.113.091322. Epub 2014 Apr 8.

PMID:
24714215
47.

Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures.

Dammeyer P, Hellberg V, Wallin I, Laurell G, Shoshan M, Ehrsson H, Arnér ES, Kirkegaard M.

Acta Otolaryngol. 2014 May;134(5):448-54. doi: 10.3109/00016489.2013.879740.

48.

Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury.

Sun K, Eriksson SE, Tan Y, Zhang L, Arnér ES, Zhang J.

Biochim Biophys Acta. 2014 Jul;1840(7):2105-11. doi: 10.1016/j.bbagen.2014.02.028. Epub 2014 Mar 6.

PMID:
24608031
49.

Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1.

Kurokawa S, Eriksson S, Rose KL, Wu S, Motley AK, Hill S, Winfrey VP, McDonald WH, Capecchi MR, Atkins JF, Arnér ES, Hill KE, Burk RF.

Free Radic Biol Med. 2014 Apr;69:67-76. doi: 10.1016/j.freeradbiomed.2014.01.010. Epub 2014 Jan 14.

50.

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.

Shi Y, Nikulenkov F, Zawacka-Pankau J, Li H, Gabdoulline R, Xu J, Eriksson S, Hedström E, Issaeva N, Kel A, Arnér ES, Selivanova G.

Cell Death Differ. 2014 Apr;21(4):612-23. doi: 10.1038/cdd.2013.186. Epub 2014 Jan 10.

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