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Ibrutinib blocks Btk-dependent NF-ĸB and NFAT responses in human macrophages during Aspergillus fumigatus phagocytosis.

Bercusson A, Colley T, Shah A, Warris A, Armstrong-James D.

Blood. 2018 Jul 18. pii: blood-2017-12-823393. doi: 10.1182/blood-2017-12-823393. [Epub ahead of print] No abstract available.


Impact of an antifungal stewardship programme in a tertiary respiratory medicine setting: A prospective real-world study.

Nwankwo L, Periselneris J, Cheong J, Thompson K, Darby P, Leaver N, Schelenz S, Armstrong-James D.

Antimicrob Agents Chemother. 2018 Jul 16. pii: AAC.00402-18. doi: 10.1128/AAC.00402-18. [Epub ahead of print]


Author Correction: Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris.

Rhodes J, Abdolrasouli A, Farrer RA, Cuomo CA, Aanensen DM, Armstrong-James D, Fisher MC, Schelenz S.

Emerg Microbes Infect. 2018 May 31;7(1):104. doi: 10.1038/s41426-018-0098-x.


Airway persistence by the emerging multi-azole-resistant Rasamsonia argillacea complex in cystic fibrosis.

Abdolrasouli A, Bercusson AC, Rhodes JL, Hagen F, Buil JB, Tang AYY, de Boer LL, Shah A, Milburn AJ, Elborn JS, Jones AL, Meis JF, Fisher MC, Schelenz S, Simmonds NJ, Armstrong-James D.

Mycoses. 2018 Apr 27. doi: 10.1111/myc.12789. [Epub ahead of print]


Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris.

Rhodes J, Abdolrasouli A, Farrer RA, Cuomo CA, Aanensen DM, Armstrong-James D, Fisher MC, Schelenz S.

Emerg Microbes Infect. 2018 Mar 29;7(1):43. doi: 10.1038/s41426-018-0045-x. Erratum in: Emerg Microbes Infect. 2018 May 31;7(1):104.


Improvement in Exophiala dermatitidis airway persistence and respiratory decline in response to interferon-gamma therapy in a patient with cystic fibrosis.

Eades CP, Armstrong-James DPH, Periselneris J, Jones A, Simmonds N, Kelleher P, Shah A.

J Cyst Fibros. 2018 May;17(3):e32-e34. doi: 10.1016/j.jcf.2018.02.002. Epub 2018 Feb 15. No abstract available.


In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.

Colley T, Sehra G, Chowdhary A, Alanio A, Kelly SL, Kizawa Y, Armstrong-James D, Fisher MC, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Nishimoto Y, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, McConville M, King-Underwood J, Naylor A, Bretagne S, Murray J, Ito K, Strong P, Rapeport G.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01941-17. doi: 10.1128/AAC.01941-17. Print 2018 May.


Reduced Clearance of Fungal Spores by Chronic Obstructive Pulmonary Disease GM-CSF- and M-CSF-derived Macrophages.

Wrench C, Belchamber KBR, Bercusson A, Shah A, Barnes PJ, Armstrong-James D, Donnelly LE.

Am J Respir Cell Mol Biol. 2018 Feb;58(2):271-273. doi: 10.1165/rcmb.2017-0351LE. No abstract available.


From phagocytosis to metaforosis: Calcineurin's deadly role in innate processing of fungi.

Armstrong-James D, de Boer L, Bercusson A, Shah A.

PLoS Pathog. 2018 Jan 4;14(1):e1006627. doi: 10.1371/journal.ppat.1006627. eCollection 2018 Jan. No abstract available.


Mutual independence of alkaline- and calcium-mediated signalling in Aspergillus fumigatus refutes the existence of a conserved druggable signalling nexus.

Loss O, Bertuzzi M, Yan Y, Fedorova N, McCann BL, Armstrong-James D, Espeso EA, Read ND, Nierman WC, Bignell EM.

Mol Microbiol. 2017 Dec;106(6):861-875. doi: 10.1111/mmi.13840. Epub 2017 Nov 14.


In vitro efficacy of disinfectants utilised for skin decolonisation and environmental decontamination during a hospital outbreak with Candida auris.

Abdolrasouli A, Armstrong-James D, Ryan L, Schelenz S.

Mycoses. 2017 Nov;60(11):758-763. doi: 10.1111/myc.12699. Epub 2017 Sep 15.


Immunotherapeutic approaches to treatment of fungal diseases.

Armstrong-James D, Brown GD, Netea MG, Zelante T, Gresnigt MS, van de Veerdonk FL, Levitz SM.

Lancet Infect Dis. 2017 Dec;17(12):e393-e402. doi: 10.1016/S1473-3099(17)30442-5. Epub 2017 Jul 31. Review.


Caspofungin Increases Fungal Chitin and Eosinophil and γδ T Cell-Dependent Pathology in Invasive Aspergillosis.

Amarsaikhan N, Sands EM, Shah A, Abdolrasouli A, Reed A, Slaven JE, Armstrong-James D, Templeton SP.

J Immunol. 2017 Jul 15;199(2):624-632. doi: 10.4049/jimmunol.1700078. Epub 2017 May 31.


AIDS-Related Mycoses: Current Progress in the Field and Future Priorities.

Armstrong-James D, Bicanic T, Brown GD, Hoving JC, Meintjes G, Nielsen K; Working Group from the EMBO Workshop on AIDS-Related Mycoses.

Trends Microbiol. 2017 Jun;25(6):428-430. doi: 10.1016/j.tim.2017.02.013. Epub 2017 Apr 25.


Immunotherapy for infectious diseases in haematological immunocompromise.

Cutino-Moguel MT, Eades C, Rezvani K, Armstrong-James D.

Br J Haematol. 2017 May;177(3):348-356. doi: 10.1111/bjh.14595. Epub 2017 Mar 29. Review.


A subset of virus-specific CD161+ T cells selectively express the multidrug transporter MDR1 and are resistant to chemotherapy in AML.

Alsuliman A, Muftuoglu M, Khoder A, Ahn YO, Basar R, Verneris MR, Muranski P, Barrett AJ, Liu E, Li L, Stringaris K, Armstrong-James D, Shaim H, Kondo K, Imahashi N, Andersson B, Marin D, Champlin RE, Shpall EJ, Rezvani K.

Blood. 2017 Feb 9;129(6):740-758. doi: 10.1182/blood-2016-05-713347. Epub 2016 Nov 7.


Calcineurin Orchestrates Lateral Transfer of Aspergillus fumigatus during Macrophage Cell Death.

Shah A, Kannambath S, Herbst S, Rogers A, Soresi S, Carby M, Reed A, Mostowy S, Fisher MC, Shaunak S, Armstrong-James DP.

Am J Respir Crit Care Med. 2016 Nov 1;194(9):1127-1139.


First hospital outbreak of the globally emerging Candida auris in a European hospital.

Schelenz S, Hagen F, Rhodes JL, Abdolrasouli A, Chowdhary A, Hall A, Ryan L, Shackleton J, Trimlett R, Meis JF, Armstrong-James D, Fisher MC.

Antimicrob Resist Infect Control. 2016 Oct 19;5:35. eCollection 2016.


Opportunist Turns Allergen: Double Life of Pneumocystis jirovecii in Asthma.

Shah A, Armstrong-James D.

Am J Respir Crit Care Med. 2016 Oct 1;194(7):779-780. No abstract available.


Endosomal sensing of fungi: current understanding and emerging concepts.

Bercusson A, de Boer L, Armstrong-James D.

Med Mycol. 2017 Jan 1;55(1):10-15. Epub 2016 Sep 5. Review.


Specific combinations of donor and recipient KIR-HLA genotypes predict for large differences in outcome after cord blood transplantation.

Sekine T, Marin D, Cao K, Li L, Mehta P, Shaim H, Sobieski C, Jones R, Oran B, Hosing C, Rondon G, Alsuliman A, Paust S, Andersson B, Popat U, Kebriaei P, Muftuoglu M, Basar R, Kondo K, Nieto Y, Shah N, Olson A, Alousi A, Liu E, Sarvaria A, Parmar S, Armstrong-James D, Imahashi N, Molldrem J, Champlin R, Shpall EJ, Rezvani K.

Blood. 2016 Jul 14;128(2):297-312. doi: 10.1182/blood-2016-03-706317. Epub 2016 May 31.


Burden of serious fungal infections in Mexico.

Corzo-León DE, Armstrong-James D, Denning DW.

Mycoses. 2015 Oct;58 Suppl 5:34-44. doi: 10.1111/myc.12395.


In silico modeling of spore inhalation reveals fungal persistence following low dose exposure.

Tanaka RJ, Boon NJ, Vrcelj K, Nguyen A, Vinci C, Armstrong-James D, Bignell E.

Sci Rep. 2015 Sep 14;5:13958. doi: 10.1038/srep13958.


Erratum for Abdolrasouli et al., Genomic Context of Azole Resistance Mutations in Aspergillus fumigatus Determined Using Whole-Genome Sequencing.

Abdolrasouli A, Rhodes J, Beale MA, Hagen F, Rogers TR, Chowdhary A, Meis JF, Armstrong-James D, Fisher MC.

MBio. 2015 Jul 14;6(4):e00939. doi: 10.1128/mBio.00939-15. No abstract available.


H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses.

Bidula S, Sexton DW, Yates M, Abdolrasouli A, Shah A, Wallis R, Reed A, Armstrong-James D, Schelenz S.

Immunology. 2015 Oct;146(2):281-91. doi: 10.1111/imm.12501. Epub 2015 Aug 24.


Correction: The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis.

Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM.

PLoS Pathog. 2015 Jun 18;11(6):e1004943. doi: 10.1371/journal.ppat.1004943. eCollection 2015 Jun. No abstract available.


Genomic Context of Azole Resistance Mutations in Aspergillus fumigatus Determined Using Whole-Genome Sequencing.

Abdolrasouli A, Rhodes J, Beale MA, Hagen F, Rogers TR, Chowdhary A, Meis JF, Armstrong-James D, Fisher MC.

MBio. 2015 Jun 2;6(3):e00536. doi: 10.1128/mBio.00536-15. Erratum in: MBio. 2015;6(4):e00939.


Nebulised amphotericin B-polymethacrylic acid nanoparticle prophylaxis prevents invasive aspergillosis.

Shirkhani K, Teo I, Armstrong-James D, Shaunak S.

Nanomedicine. 2015 Jul;11(5):1217-26. doi: 10.1016/j.nano.2015.02.012. Epub 2015 Mar 16.


Staphylococcus aureus adapts to oxidative stress by producing H2O2-resistant small-colony variants via the SOS response.

Painter KL, Strange E, Parkhill J, Bamford KB, Armstrong-James D, Edwards AM.

Infect Immun. 2015 May;83(5):1830-44. doi: 10.1128/IAI.03016-14. Epub 2015 Feb 17.


Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.

Herbst S, Shah A, Mazon Moya M, Marzola V, Jensen B, Reed A, Birrell MA, Saijo S, Mostowy S, Shaunak S, Armstrong-James D.

EMBO Mol Med. 2015 Mar;7(3):240-58. doi: 10.15252/emmm.201404556.


The serum opsonin L-ficolin is detected in lungs of human transplant recipients following fungal infections and modulates inflammation and killing of Aspergillus fumigatus.

Bidula S, Sexton DW, Abdolrasouli A, Shah A, Reed A, Armstrong-James D, Schelenz S.

J Infect Dis. 2015 Jul 15;212(2):234-46. doi: 10.1093/infdis/jiv027. Epub 2015 Jan 22.


The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis.

Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM.

PLoS Pathog. 2014 Oct 16;10(10):e1004413. doi: 10.1371/journal.ppat.1004413. eCollection 2014 Oct. Erratum in: PLoS Pathog. 2015 Apr;11(4):e1004802. PLoS Pathog. 2015 Jun 18;11(6):e1004943.


AIDS-related mycoses: the way forward.

Brown GD, Meintjes G, Kolls JK, Gray C, Horsnell W; Working Group from the EMBO-AIDS Related Mycoses Workshop, Achan B, Alber G, Aloisi M, Armstrong-James D, Beale M, Bicanic T, Black J, Bohjanen P, Botes A, Boulware DR, Brown G, Bunjun R, Carr W, Casadevall A, Chang C, Chivero E, Corcoran C, Cross A, Dawood H, Day J, De Bernardis F, De Jager V, De Repentigny L, Denning D, Eschke M, Finkelman M, Govender N, Gow N, Graham L, Gryschek R, Hammond-Aryee K, Harrison T, Heard N, Hill M, Hoving JC, Janoff E, Jarvis J, Kayuni S, King K, Kolls J, Kullberg BJ, Lalloo DG, Letang E, Levitz S, Limper A, Longley N, Machiridza TR, Mahabeer Y, Martinsons N, Meiring S, Meya D, Miller R, Molloy S, Morris L, Mukaremera L, Musubire AK, Muzoora C, Nair A, Nakiwala Kimbowa J, Netea M, Nielsen K, O'hern J, Okurut S, Parker A, Patterson T, Pennap G, Perfect J, Prinsloo C, Rhein J, Rolfes MA, Samuel C, Schutz C, Scriven J, Sebolai OM, Sojane K, Sriruttan C, Stead D, Steyn A, Thawer NK, Thienemann F, Von Hohenberg M, Vreulink JM, Wessels J, Wood K, Yang YL.

Trends Microbiol. 2014 Mar;22(3):107-9. doi: 10.1016/j.tim.2013.12.008.


A neglected epidemic: fungal infections in HIV/AIDS.

Armstrong-James D, Meintjes G, Brown GD.

Trends Microbiol. 2014 Mar;22(3):120-7. doi: 10.1016/j.tim.2014.01.001. Epub 2014 Feb 13. Review.


A new and clinically relevant murine model of solid-organ transplant aspergillosis.

Herbst S, Shah A, Carby M, Chusney G, Kikkeri N, Dorling A, Bignell E, Shaunak S, Armstrong-James D.

Dis Model Mech. 2013 May;6(3):643-51. doi: 10.1242/dmm.010330. Epub 2012 Dec 20.


Renal allograft recipients fail to increase interferon-γ during invasive fungal diseases.

Armstrong-James D, Teo I, Herbst S, Petrou M, Shiu KY, McLean A, Taube D, Dorling A, Shaunak S.

Am J Transplant. 2012 Dec;12(12):3437-40. doi: 10.1111/j.1600-6143.2012.04254.x. Epub 2012 Sep 13.


Immunotherapy for fungal infections.

Armstrong-James D, Harrison TS.

Curr Opin Microbiol. 2012 Aug;15(4):434-9. doi: 10.1016/j.mib.2012.06.001. Epub 2012 Aug 10. Review.


Transcript profiling of the murine immune response to invasive aspergillosis.

Dhesi Z, Herbst S, Armstrong-James D.

Methods Mol Biol. 2012;845:435-44. doi: 10.1007/978-1-61779-539-8_30.


A prognostic scoring tool for identification of patients at high and low risk of death from HIV-associated Pneumocystis jirovecii pneumonia.

Armstrong-James D, Copas AJ, Walzer PD, Edwards SG, Miller RF.

Int J STD AIDS. 2011 Nov;22(11):628-34. doi: 10.1258/ijsa.2011.011040.


Management of quinolone-resistant typhoid osteomyelitis.

McGregor A, Wing JL, Pollock E, Armstrong-James D, Morris-Jones S, Brown M.

Br J Hosp Med (Lond). 2011 Aug;72(8):468-9. No abstract available.


Blind, breathless, and paralysed from benign malaria.

Flower B, Armstrong-James D, Dance C, Bremner F, Doherty T.

Lancet. 2011 Jan 29;377(9763):438. doi: 10.1016/S0140-6736(10)61382-7. No abstract available.


Missed opportunities for HIV testing--a costly oversight.

Read P, Armstrong-James D, Tong CY, Fox J.

QJM. 2011 May;104(5):421-4. doi: 10.1093/qjmed/hcq236. Epub 2010 Dec 5.


A trial of caspofungin salvage treatment in PCP pneumonia.

Armstrong-James D, Stebbing J, John L, Murungi A, Bower M, Gazzard B, Nelson M.

Thorax. 2011 Jun;66(6):537-8. doi: 10.1136/thx.2010.135350. Epub 2010 Sep 29. No abstract available.


Novel H1N1 influenza and Panton-Valentine leukocidin Staphylococcus aureus necrotizing pneumonia.

Barrett NA, Armstrong-James D, Edgeworth J, Wyncoll D.

Br J Hosp Med (Lond). 2010 Jun;71(6):350-1.


Exogenous interferon-gamma immunotherapy for invasive fungal infections in kidney transplant patients.

Armstrong-James D, Teo IA, Shrivastava S, Petrou MA, Taube D, Dorling A, Shaunak S.

Am J Transplant. 2010 Aug;10(8):1796-803. doi: 10.1111/j.1600-6143.2010.03094.x. Epub 2010 Mar 26.


Clinical outcome in resistant HIV-2 infection treated with raltegravir and maraviroc.

Armstrong-James D, Stebbing J, Scourfield A, Smit E, Ferns B, Pillay D, Nelson M.

Antiviral Res. 2010 May;86(2):224-6. doi: 10.1016/j.antiviral.2010.02.324. Epub 2010 Mar 6.


Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis.

Armstrong-James DP, Turnbull SA, Teo I, Stark J, Rogers NJ, Rogers TR, Bignell E, Haynes K.

J Infect Dis. 2009 Oct 15;200(8):1341-51. doi: 10.1086/605931.


The utility of nucleos(t)ide-only regimens in the treatment of Mycobacterium tuberculosis-HIV-1 coinfection.

Armstrong-James D, Menon-Johansson A, Pozniak A.

AIDS. 2009 Apr 27;23(7):865-7. doi: 10.1097/QAD.0b013e3283294a04.


Sub-telomere directed gene expression during initiation of invasive aspergillosis.

McDonagh A, Fedorova ND, Crabtree J, Yu Y, Kim S, Chen D, Loss O, Cairns T, Goldman G, Armstrong-James D, Haynes K, Haas H, Schrettl M, May G, Nierman WC, Bignell E.

PLoS Pathog. 2008 Sep 12;4(9):e1000154. doi: 10.1371/journal.ppat.1000154.


Invasive Candida species infection: the importance of adequate empirical antifungal therapy.

Armstrong-James D.

J Antimicrob Chemother. 2007 Sep;60(3):459-60. Epub 2007 Jul 23.


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