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Items: 1 to 50 of 57

1.

Short telomere syndromes cause a primary T cell immunodeficiency.

Wagner CL, Hanumanthu VS, Talbot CC Jr, Abraham RS, Hamm D, Gable DL, Kanakry CG, Applegate CD, Siliciano J, Jackson JB, Desiderio S, Alder JK, Luznik L, Armanios M.

J Clin Invest. 2018 Oct 22. pii: 120216. doi: 10.1172/JCI120216. [Epub ahead of print]

2.

Understanding the evolving phenotype of vascular complications in telomere biology disorders.

Higgs C, Crow YJ, Adams DM, Chang E, Hayes D Jr, Herbig U, Huang JN, Himes R, Jajoo K, Johnson FB, Reynolds SD, Yonekawa Y, Armanios M, Boulad F, DiNardo CD, Dufour C, Goldman FD, Khan S, Kratz C, Myers KC, Raghu G, Alter BP, Aubert G, Bhala S, Cowen EW, Dror Y, El-Youssef M, Friedman B, Giri N, Helms Guba L, Khincha PP, Lin TF, Longhurst H, McReynolds LJ, Nelson A, Olson T, Pariser A, Perona R, Sasa G, Schratz K, Simonetto DA, Townsley D, Walsh M, Stevens K, Agarwal S, Bertuch AA, Savage SA; Clinical Care Consortium for Telomere-associated Ailments (CCCTAA).

Angiogenesis. 2018 Aug 25. doi: 10.1007/s10456-018-9640-7. [Epub ahead of print]

PMID:
30168024
3.

Impaired CMV Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres.

Popescu I, Mannem H, Winters SA, Hoji A, Silveira F, McNally E, Pipeling MR, Lendermon EA, Morrell MR, Pilewski JM, Hanumanthu VS, Zhang Y, Gulati S, Shah PD, Iasella CJ, Ensor CR, Armanios M, McDyer JF.

Am J Respir Crit Care Med. 2018 Aug 8. doi: 10.1164/rccm.201805-0825OC. [Epub ahead of print]

PMID:
30088779
4.

Telomeres in the Clinic, Not on TV.

Armanios M.

Mayo Clin Proc. 2018 Jul;93(7):815-817. doi: 10.1016/j.mayocp.2018.05.024. No abstract available.

PMID:
29976370
5.

Diagnostic utility of telomere length testing in a hospital-based setting.

Alder JK, Hanumanthu VS, Strong MA, DeZern AE, Stanley SE, Takemoto CM, Danilova L, Applegate CD, Bolton SG, Mohr DW, Brodsky RA, Casella JF, Greider CW, Jackson JB, Armanios M.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2358-E2365. doi: 10.1073/pnas.1720427115. Epub 2018 Feb 20. Erratum in: Proc Natl Acad Sci U S A. 2018 Apr 23;:.

6.

IPF lung fibroblasts have a senescent phenotype.

Álvarez D, Cárdenes N, Sellarés J, Bueno M, Corey C, Hanumanthu VS, Peng Y, D'Cunha H, Sembrat J, Nouraie M, Shanker S, Caufield C, Shiva S, Armanios M, Mora AL, Rojas M.

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1164-L1173. doi: 10.1152/ajplung.00220.2017. Epub 2017 Aug 31.

PMID:
28860144
7.

Germline Mutations in DNA Repair Genes in Lung Adenocarcinoma.

Parry EM, Gable DL, Stanley SE, Khalil SE, Antonescu V, Florea L, Armanios M.

J Thorac Oncol. 2017 Nov;12(11):1673-1678. doi: 10.1016/j.jtho.2017.08.011. Epub 2017 Aug 24.

8.

The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.

Budinger GRS, Kohanski RA, Gan W, Kobor MS, Amaral LA, Armanios M, Kelsey KT, Pardo A, Tuder R, Macian F, Chandel N, Vaughan D, Rojas M, Mora AL, Kovacs E, Duncan SR, Finkel T, Choi A, Eickelberg O, Chen D, Agusti A, Selman M, Balch WE, Busse P, Lin A, Morimoto R, Sznajder JI, Thannickal VJ.

J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1492-1500. doi: 10.1093/gerona/glx090. Review.

9.

Systematic Computational Identification of Variants That Activate Exonic and Intronic Cryptic Splice Sites.

Lee M, Roos P, Sharma N, Atalar M, Evans TA, Pellicore MJ, Davis E, Lam AN, Stanley SE, Khalil SE, Solomon GM, Walker D, Raraigh KS, Vecchio-Pagan B, Armanios M, Cutting GR.

Am J Hum Genet. 2017 May 4;100(5):751-765. doi: 10.1016/j.ajhg.2017.04.001.

10.

Telomerase and the Genetics of Emphysema Susceptibility. Implications for Pathogenesis Paradigms and Patient Care.

Stanley SE, Merck SJ, Armanios M.

Ann Am Thorac Soc. 2016 Dec;13 Suppl 5:S447-S451. doi: 10.1513/AnnalsATS.201609-718AW. Review.

11.

Shall we call them "telomere-mediated"? Renaming the idiopathic after the cause is found.

Merck SJ, Armanios M.

Eur Respir J. 2016 Dec;48(6):1556-1558. doi: 10.1183/13993003.02115-2016. No abstract available.

12.

Integration-free erythroblast-derived human induced pluripotent stem cells (iPSCs) from an individual with Ataxia-Telangiectasia (A-T).

Bhatt N, Ghosh R, Roy S, Gao Y, Armanios M, Cheng L, Franco S.

Stem Cell Res. 2016 Sep;17(2):205-207. doi: 10.1016/j.scr.2016.08.003. Epub 2016 Aug 5.

13.

Robust reprogramming of Ataxia-Telangiectasia patient and carrier erythroid cells to induced pluripotent stem cells.

Bhatt N, Ghosh R, Roy S, Gao Y, Armanios M, Cheng L, Franco S.

Stem Cell Res. 2016 Sep;17(2):296-305. doi: 10.1016/j.scr.2016.08.006. Epub 2016 Aug 12.

14.

Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema.

Stanley SE, Gable DL, Wagner CL, Carlile TM, Hanumanthu VS, Podlevsky JD, Khalil SE, DeZern AE, Rojas-Duran MF, Applegate CD, Alder JK, Parry EM, Gilbert WV, Armanios M.

Sci Transl Med. 2016 Aug 10;8(351):351ra107. doi: 10.1126/scitranslmed.aaf7837.

15.

Case 41-2015: A Boy with Immune and Liver Abnormalities.

Walter JE, Armanios M.

N Engl J Med. 2016 Jun 2;374(22):2193. doi: 10.1056/NEJMc1601156. No abstract available.

16.

Evaluation of Patients and Families With Concern for Predispositions to Hematologic Malignancies Within the Hereditary Hematologic Malignancy Clinic (HHMC).

DiNardo CD, Bannon SA, Routbort M, Franklin A, Mork M, Armanios M, Mace EM, Orange JS, Jeff-Eke M, Churpek JE, Takahashi K, Jorgensen JL, Garcia-Manero G, Kornblau S, Bertuch A, Cheung H, Bhalla K, Futreal A, Godley LA, Patel KP.

Clin Lymphoma Myeloma Leuk. 2016 Jul;16(7):417-428.e2. doi: 10.1016/j.clml.2016.04.001. Epub 2016 Apr 27.

17.

A Syndromic Intellectual Disability Disorder Caused by Variants in TELO2, a Gene Encoding a Component of the TTT Complex.

You J, Sobreira NL, Gable DL, Jurgens J, Grange DK, Belnap N, Siniard A, Szelinger S, Schrauwen I, Richholt RF, Vallee SE, Dinulos MBP, Valle D, Armanios M, Hoover-Fong J.

Am J Hum Genet. 2016 May 5;98(5):909-918. doi: 10.1016/j.ajhg.2016.03.014. Epub 2016 Apr 28.

18.

Ligase-4 Deficiency Causes Distinctive Immune Abnormalities in Asymptomatic Individuals.

Felgentreff K, Baxi SN, Lee YN, Dobbs K, Henderson LA, Csomos K, Tsitsikov EN, Armanios M, Walter JE, Notarangelo LD.

J Clin Immunol. 2016 May;36(4):341-53. doi: 10.1007/s10875-016-0266-5. Epub 2016 Apr 11.

19.

CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 41-2015. A 14-Year-Old Boy with Immune and Liver Abnormalities.

Walter JE, Armanios M, Shah U, Friedmann AM, Spitzer T, Sharatz SM, Hagen C.

N Engl J Med. 2015 Dec 31;373(27):2664-76. doi: 10.1056/NEJMcpc1408595. No abstract available.

PMID:
26716919
20.

Translational strategies in aging and age-related disease.

Armanios M, de Cabo R, Mannick J, Partridge L, van Deursen J, Villeda S.

Nat Med. 2015 Dec;21(12):1395-9. doi: 10.1038/nm.4004.

PMID:
26646495
21.

Radiation Sensitivity and Radiation Necrosis in the Short Telomere Syndromes.

Stanley SE, Rao AD, Gable DL, McGrath-Morrow S, Armanios M.

Int J Radiat Oncol Biol Phys. 2015 Dec 1;93(5):1115-7. doi: 10.1016/j.ijrobp.2015.08.048. Epub 2015 Sep 4. No abstract available. Erratum in: Int J Radiat Oncol Biol Phys. 2016 Feb 1;94(2):423.

22.

Treating Myeloproliferation--On Target or Off?

Armanios M, Greider CW.

N Engl J Med. 2015 Sep 3;373(10):965-6. doi: 10.1056/NEJMe1508740. No abstract available.

PMID:
26332552
23.

The short and long telomere syndromes: paired paradigms for molecular medicine.

Stanley SE, Armanios M.

Curr Opin Genet Dev. 2015 Aug;33:1-9. doi: 10.1016/j.gde.2015.06.004. Epub 2015 Jul 29. Review.

24.

Hepatopulmonary syndrome is a frequent cause of dyspnea in the short telomere disorders.

Gorgy AI, Jonassaint NL, Stanley SE, Koteish A, DeZern AE, Walter JE, Sopha SC, Hamilton JP, Hoover-Fong J, Chen AR, Anders RA, Kamel IR, Armanios M.

Chest. 2015 Oct;148(4):1019-1026. doi: 10.1378/chest.15-0825.

25.

Telomere dysfunction causes alveolar stem cell failure.

Alder JK, Barkauskas CE, Limjunyawong N, Stanley SE, Kembou F, Tuder RM, Hogan BL, Mitzner W, Armanios M.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5099-104. doi: 10.1073/pnas.1504780112. Epub 2015 Apr 3.

26.

What the genetics "RTEL"ing us about telomeres and pulmonary fibrosis.

Stanley SE, Noth I, Armanios M.

Am J Respir Crit Care Med. 2015 Mar 15;191(6):608-10. doi: 10.1164/rccm.201501-0119ED. No abstract available.

27.

Telomerase mutations in smokers with severe emphysema.

Stanley SE, Chen JJ, Podlevsky JD, Alder JK, Hansel NN, Mathias RA, Qi X, Rafaels NM, Wise RA, Silverman EK, Barnes KC, Armanios M.

J Clin Invest. 2015 Feb;125(2):563-70. doi: 10.1172/JCI78554. Epub 2014 Dec 22.

28.

Exome sequencing identifies mutant TINF2 in a family with pulmonary fibrosis.

Alder JK, Stanley SE, Wagner CL, Hamilton M, Hanumanthu VS, Armanios M.

Chest. 2015 May;147(5):1361-1368. doi: 10.1378/chest.14-1947.

29.

Short telomeres: a repeat offender in IPF.

Stanley SE, Armanios M.

Lancet Respir Med. 2014 Jul;2(7):513-4. doi: 10.1016/S2213-2600(14)70140-7. Epub 2014 Jun 24. No abstract available.

PMID:
24973280
30.

Lung transplantation in telomerase mutation carriers with pulmonary fibrosis.

Silhan LL, Shah PD, Chambers DC, Snyder LD, Riise GC, Wagner CL, Hellström-Lindberg E, Orens JB, Mewton JF, Danoff SK, Arcasoy MO, Armanios M.

Eur Respir J. 2014 Jul;44(1):178-87. doi: 10.1183/09031936.00060014. Epub 2014 May 15.

31.

Reply: telomerase makes connections between pulmonary fibrosis and emphysema.

Armanios M.

Am J Respir Crit Care Med. 2014 Mar 15;189(6):754-5. doi: 10.1164/rccm.201401-0019LE. No abstract available.

32.

Detection of paroxysmal nocturnal hemoglobinuria clones to exclude inherited bone marrow failure syndromes.

DeZern AE, Symons HJ, Resar LS, Borowitz MJ, Armanios MY, Brodsky RA.

Eur J Haematol. 2014 Jun;92(6):467-70. doi: 10.1111/ejh.12299. Epub 2014 Mar 18.

33.

Telomere phenotypes in females with heterozygous mutations in the dyskeratosis congenita 1 (DKC1) gene.

Alder JK, Parry EM, Yegnasubramanian S, Wagner CL, Lieblich LM, Auerbach R, Auerbach AD, Wheelan SJ, Armanios M.

Hum Mutat. 2013 Nov;34(11):1481-5. doi: 10.1002/humu.22397. Epub 2013 Sep 11.

34.

Telomeres and age-related disease: how telomere biology informs clinical paradigms.

Armanios M.

J Clin Invest. 2013 Mar;123(3):996-1002. doi: 10.1172/JCI66370. Epub 2013 Mar 1. Review.

35.

The gastrointestinal manifestations of telomere-mediated disease.

Jonassaint NL, Guo N, Califano JA, Montgomery EA, Armanios M.

Aging Cell. 2013 Apr;12(2):319-23. doi: 10.1111/acel.12041. Epub 2013 Jan 4.

36.

The telomere syndromes.

Armanios M, Blackburn EH.

Nat Rev Genet. 2012 Oct;13(10):693-704. doi: 10.1038/nrg3246. Epub 2012 Sep 11. Review. Erratum in: Nat Rev Genet. 2013 Mar;14(3):235.

37.

Telomerase mutations and the pulmonary fibrosis-bone marrow failure syndrome complex.

Armanios M.

N Engl J Med. 2012 Jul 26;367(4):384; author reply 384. doi: 10.1056/NEJMc1206730. No abstract available.

38.

An emerging role for the conserved telomere component 1 (CTC1) in human genetic disease.

Armanios M.

Pediatr Blood Cancer. 2012 Aug;59(2):209-10. doi: 10.1002/pbc.24200. Epub 2012 May 3. No abstract available.

PMID:
22556055
39.

Telomeres and disease: an overview.

Armanios M, Price C.

Mutat Res. 2012 Feb 1;730(1-2):1-2. doi: 10.1016/j.mrfmmm.2011.11.005. Epub 2011 Nov 11. No abstract available.

PMID:
22100639
40.

Telomerase and idiopathic pulmonary fibrosis.

Armanios M.

Mutat Res. 2012 Feb 1;730(1-2):52-8. doi: 10.1016/j.mrfmmm.2011.10.013. Epub 2011 Nov 4. Review.

41.

Telomere length is a determinant of emphysema susceptibility.

Alder JK, Guo N, Kembou F, Parry EM, Anderson CJ, Gorgy AI, Walsh MF, Sussan T, Biswal S, Mitzner W, Tuder RM, Armanios M.

Am J Respir Crit Care Med. 2011 Oct 15;184(8):904-12. doi: 10.1164/rccm.201103-0520OC. Epub 2011 Jul 14.

42.

Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis.

Alder JK, Cogan JD, Brown AF, Anderson CJ, Lawson WE, Lansdorp PM, Phillips JA 3rd, Loyd JE, Chen JJ, Armanios M.

PLoS Genet. 2011 Mar;7(3):e1001352. doi: 10.1371/journal.pgen.1001352. Epub 2011 Mar 31.

43.

Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase.

Parry EM, Alder JK, Qi X, Chen JJ, Armanios M.

Blood. 2011 May 26;117(21):5607-11. doi: 10.1182/blood-2010-11-322149. Epub 2011 Mar 24. Erratum in: Blood. 2016 Apr 7;127(14):1837.

44.

Short telomeres compromise β-cell signaling and survival.

Guo N, Parry EM, Li LS, Kembou F, Lauder N, Hussain MA, Berggren PO, Armanios M.

PLoS One. 2011 Mar 10;6(3):e17858. doi: 10.1371/journal.pone.0017858.

45.

Decreased dyskerin levels as a mechanism of telomere shortening in X-linked dyskeratosis congenita.

Parry EM, Alder JK, Lee SS, Phillips JA 3rd, Loyd JE, Duggal P, Armanios M.

J Med Genet. 2011 May;48(5):327-33. doi: 10.1136/jmg.2010.085100. Epub 2011 Mar 17.

46.

Short telomeres are sufficient to cause the degenerative defects associated with aging.

Armanios M, Alder JK, Parry EM, Karim B, Strong MA, Greider CW.

Am J Hum Genet. 2009 Dec;85(6):823-32. doi: 10.1016/j.ajhg.2009.10.028.

47.

Dyskeratosis congenita: the first NIH clinical research workshop.

Savage SA, Dokal I, Armanios M, Aubert G, Cowen EW, Domingo DL, Giri N, Greene MH, Orchard PJ, Tolar J, Tsilou E, Van Waes C, Wong JM, Young NS, Alter BP.

Pediatr Blood Cancer. 2009 Sep;53(3):520-3. doi: 10.1002/pbc.22061.

48.

Syndromes of telomere shortening.

Armanios M.

Annu Rev Genomics Hum Genet. 2009;10:45-61. doi: 10.1146/annurev-genom-082908-150046. Review.

49.

Short telomeres are a risk factor for idiopathic pulmonary fibrosis.

Alder JK, Chen JJ, Lancaster L, Danoff S, Su SC, Cogan JD, Vulto I, Xie M, Qi X, Tuder RM, Phillips JA 3rd, Lansdorp PM, Loyd JE, Armanios MY.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13051-6. doi: 10.1073/pnas.0804280105. Epub 2008 Aug 27.

50.

Telomerase mutations in families with idiopathic pulmonary fibrosis.

Armanios MY, Chen JJ, Cogan JD, Alder JK, Ingersoll RG, Markin C, Lawson WE, Xie M, Vulto I, Phillips JA 3rd, Lansdorp PM, Greider CW, Loyd JE.

N Engl J Med. 2007 Mar 29;356(13):1317-26.

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