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Items: 1 to 50 of 93

1.

Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses.

Gauvreau GM, Arm JP, Boulet LP, Leigh R, Cockcroft DW, Davis BE, Mayers I, FitzGerald JM, Dahlen B, Killian KJ, Laviolette M, Carlsten C, Lazarinis N, Watson RM, Milot J, Swystun V, Bowen M, Hui L, Lantz AS, Meiser K, Maahs S, Lowe PJ, Skerjanec A, Drollmann A, O'Byrne PM.

J Allergy Clin Immunol. 2016 Oct;138(4):1051-1059. doi: 10.1016/j.jaci.2016.02.027. Epub 2016 Apr 7.

PMID:
27185571
2.

Short-term subcutaneous grass pollen immunotherapy under the umbrella of anti-IL-4: A randomized controlled trial.

Chaker AM, Shamji MH, Dumitru FA, Calderon MA, Scadding GW, Makatsori M, Jones I, He QA, Subramanian KK, Arm JP, Durham SR, Schmidt-Weber CB.

J Allergy Clin Immunol. 2016 Feb;137(2):452-461.e9. doi: 10.1016/j.jaci.2015.08.046. Epub 2015 Oct 31.

PMID:
26531865
3.

LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma.

Kazani S, Arm JP, Boyce J, Chhay H, Dutile S, Wechsler ME, Govindarajulu U, Ivester P, Ainsworth HC, Sergeant S, Chilton FH, Israel E.

Springerplus. 2014 Nov 6;3:661. doi: 10.1186/2193-1801-3-661. eCollection 2014.

4.

Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis.

Rothenberg ME, Wen T, Greenberg A, Alpan O, Enav B, Hirano I, Nadeau K, Kaiser S, Peters T, Perez A, Jones I, Arm JP, Strieter RM, Sabo R, Gunawardena KA.

J Allergy Clin Immunol. 2015 Feb;135(2):500-7. doi: 10.1016/j.jaci.2014.07.049. Epub 2014 Sep 13.

PMID:
25226850
5.

Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects.

Arm JP, Bottoli I, Skerjanec A, Floch D, Groenewegen A, Maahs S, Owen CE, Jones I, Lowe PJ.

Clin Exp Allergy. 2014 Nov;44(11):1371-85. doi: 10.1111/cea.12400.

6.

Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics.

Arm JP, Boyce JA, Wang L, Chhay H, Zahid M, Patil V, Govindarajulu U, Ivester P, Weaver KL, Sergeant S, Israel E, Chilton FH.

Lipids Health Dis. 2013 Oct 2;12:141. doi: 10.1186/1476-511X-12-141.

7.

Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia.

Degousee N, Kelvin DJ, Geisslinger G, Hwang DM, Stefanski E, Wang XH, Danesh A, Angioni C, Schmidt H, Lindsay TF, Gelb MH, Bollinger J, Payré C, Lambeau G, Arm JP, Keating A, Rubin BB.

J Biol Chem. 2011 Oct 14;286(41):35650-62. doi: 10.1074/jbc.M111.262733. Epub 2011 Aug 17.

8.

A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis.

Boilard E, Lai Y, Larabee K, Balestrieri B, Ghomashchi F, Fujioka D, Gobezie R, Coblyn JS, Weinblatt ME, Massarotti EM, Thornhill TS, Divangahi M, Remold H, Lambeau G, Gelb MH, Arm JP, Lee DM.

EMBO Mol Med. 2010 May;2(5):172-87. doi: 10.1002/emmm.201000072.

9.

Group V secreted phospholipase A2 contributes to LPS-induced leukocyte recruitment.

Lapointe S, Brkovic A, Cloutier I, Tanguay JF, Arm JP, Sirois MG.

J Cell Physiol. 2010 Jul;224(1):127-34. doi: 10.1002/jcp.22106.

PMID:
20232296
10.

Effect of dietary fatty acids on inflammatory gene expression in healthy humans.

Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, Chilton FH.

J Biol Chem. 2009 Jun 5;284(23):15400-7. doi: 10.1074/jbc.M109.004861. Epub 2009 Apr 9.

11.

Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans.

Balestrieri B, Maekawa A, Xing W, Gelb MH, Katz HR, Arm JP.

J Immunol. 2009 Apr 15;182(8):4891-8. doi: 10.4049/jimmunol.0803776.

12.

Induced loss of Syk in human basophils by non-IgE-dependent stimuli.

MacGlashan DW Jr, Ishmael S, MacDonald SM, Langdon JM, Arm JP, Sloane DE.

J Immunol. 2008 Mar 15;180(6):4208-17.

13.

Mechanisms by which botanical lipids affect inflammatory disorders.

Chilton FH, Rudel LL, Parks JS, Arm JP, Seeds MC.

Am J Clin Nutr. 2008 Feb;87(2):498S-503S. Review.

PMID:
18258646
14.

Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells.

Tedla N, Lee CW, Borges L, Geczy CL, Arm JP.

J Leukoc Biol. 2008 Feb;83(2):334-43. Epub 2007 Nov 12.

PMID:
17998301
15.

Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized mice.

Muñoz NM, Meliton AY, Arm JP, Bonventre JV, Cho W, Leff AR.

J Immunol. 2007 Oct 1;179(7):4800-7.

16.
17.

Down-regulation of leucocyte immunoglobulin-like receptor expression in the synovium of rheumatoid arthritis patients after treatment with disease-modifying anti-rheumatic drugs.

Huynh OA, Hampartzoumian T, Arm JP, Hunt J, Borges L, Ahern M, Smith M, Geczy CL, McNeil HP, Tedla N.

Rheumatology (Oxford). 2007 May;46(5):742-51. Epub 2007 Jan 3.

PMID:
17202177
18.

Pseudolipasin A is a specific inhibitor for phospholipase A2 activity of Pseudomonas aeruginosa cytotoxin ExoU.

Lee VT, Pukatzki S, Sato H, Kikawada E, Kazimirova AA, Huang J, Li X, Arm JP, Frank DW, Lory S.

Infect Immun. 2007 Mar;75(3):1089-98. Epub 2006 Dec 18.

19.
20.

Group V sPLA2: classical and novel functions.

Balestrieri B, Arm JP.

Biochim Biophys Acta. 2006 Nov;1761(11):1280-8. Epub 2006 Jul 28. Review.

PMID:
16945583
21.

Human mast cell-derived gelatinase B (matrix metalloproteinase-9) is regulated by inflammatory cytokines: role in cell migration.

Di Girolamo N, Indoh I, Jackson N, Wakefield D, McNeil HP, Yan W, Geczy C, Arm JP, Tedla N.

J Immunol. 2006 Aug 15;177(4):2638-50.

22.

Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis.

Balestrieri B, Hsu VW, Gilbert H, Leslie CC, Han WK, Bonventre JV, Arm JP.

J Biol Chem. 2006 Mar 10;281(10):6691-8. Epub 2006 Jan 1.

23.

Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition.

Sloane DE, Tedla N, Awoniyi M, Macglashan DW Jr, Borges L, Austen KF, Arm JP.

Blood. 2004 Nov 1;104(9):2832-9. Epub 2004 Jul 8.

PMID:
15242876
24.

Leukotriene generation and clinical implications.

Arm JP.

Allergy Asthma Proc. 2004 Jan-Feb;25(1):37-42. Review.

PMID:
15055561
25.

Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption.

Satake Y, Diaz BL, Balestrieri B, Lam BK, Kanaoka Y, Grusby MJ, Arm JP.

J Biol Chem. 2004 Apr 16;279(16):16488-94. Epub 2004 Feb 4.

26.

Phospholipase A(2).

Diaz BL, Arm JP.

Prostaglandins Leukot Essent Fatty Acids. 2003 Aug-Sep;69(2-3):87-97. Review.

PMID:
12895591
27.

Asthma or not? The value of flow volume loops in evaluating airflow obstruction.

Lin DA, Arm JP.

Allergy Asthma Proc. 2003 Mar-Apr;24(2):107-10.

PMID:
12776443
28.

Participation of cytosolic phospholipase A2 in eicosanoid generation by mouse bone marrow-derived mast cells.

Diaz BL, Fujishima H, Sapirstein A, Bonventre JV, Arm JP.

Adv Exp Med Biol. 2002;507:41-6. Review. No abstract available.

PMID:
12664562
29.

Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7.

Tedla N, Bandeira-Melo C, Tassinari P, Sloane DE, Samplaski M, Cosman D, Borges L, Weller PF, Arm JP.

Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1174-9. Epub 2003 Jan 14.

30.

Leukotriene receptors and aspirin sensitivity.

Arm JP, Austen KF.

N Engl J Med. 2002 Nov 7;347(19):1524-6. No abstract available.

PMID:
12421897
31.

The co-expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium.

Tedla N, Gibson K, McNeil HP, Cosman D, Borges L, Arm JP.

Am J Pathol. 2002 Feb;160(2):425-31.

32.
33.

A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells.

Ho IC, Arm JP, Bingham CO 3rd, Choi A, Austen KF, Glimcher LH.

J Biol Chem. 2001 May 25;276(21):18321-6. Epub 2001 Mar 12.

34.

Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4.

Liu WR, Kim J, Nwankwo C, Ashworth LK, Arm JP.

Immunogenetics. 2000 Jul;51(8-9):659-69.

PMID:
10941837
36.

Low molecular weight group IIA and group V phospholipase A(2) enzymes have different intracellular locations in mouse bone marrow-derived mast cells.

Bingham CO 3rd, Fijneman RJ, Friend DS, Goddeau RP, Rogers RA, Austen KF, Arm JP.

J Biol Chem. 1999 Oct 29;274(44):31476-84.

37.

Cytosolic phospholipase A2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells.

Fujishima H, Sanchez Mejia RO, Bingham CO 3rd, Lam BK, Sapirstein A, Bonventre JV, Austen KF, Arm JP.

Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4803-7.

39.
41.

Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35.

Penrose JF, Spector J, Baldasaro M, Xu K, Boyce J, Arm JP, Austen KF, Lam BK.

J Biol Chem. 1996 May 10;271(19):11356-61.

42.

Sorting out the cytokines of asthma.

Drazen JM, Arm JP, Austen KF.

J Exp Med. 1996 Jan 1;183(1):1-5. No abstract available.

43.
44.

Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells.

Murakami M, Austen KF, Bingham CO 3rd, Friend DS, Penrose JF, Arm JP.

J Biol Chem. 1995 Sep 29;270(39):22653-6.

48.

Cytokine regulation of mast cell protease phenotype and arachidonic acid metabolism.

Murakami M, Arm JP, Austen KF.

Ann N Y Acad Sci. 1994 Nov 15;744:84-98. Review. No abstract available.

PMID:
7825865
50.

Effect of the 5-lipoxygenase inhibitor ZD2138 on aspirin-induced asthma.

Nasser SM, Bell GS, Foster S, Spruce KE, MacMillan R, Williams AJ, Lee TH, Arm JP.

Thorax. 1994 Aug;49(8):749-56.

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