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Items: 14

1.

De novo DNA synthesis using polymerase-nucleotide conjugates.

Palluk S, Arlow DH, de Rond T, Barthel S, Kang JS, Bector R, Baghdassarian HM, Truong AN, Kim PW, Singh AK, Hillson NJ, Keasling JD.

Nat Biotechnol. 2018 Aug;36(7):645-650. doi: 10.1038/nbt.4173. Epub 2018 Jun 18.

2.

SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.

Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE.

Science. 2015 Jun 19;348(6241):1361-5. doi: 10.1126/science.aaa5264.

3.

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.

Dror RO, Green HF, Valant C, Borhani DW, Valcourt JR, Pan AC, Arlow DH, Canals M, Lane JR, Rahmani R, Baell JB, Sexton PM, Christopoulos A, Shaw DE.

Nature. 2013 Nov 14;503(7475):295-9. doi: 10.1038/nature12595. Epub 2013 Oct 13.

PMID:
24121438
4.

The dynamic process of β(2)-adrenergic receptor activation.

Nygaard R, Zou Y, Dror RO, Mildorf TJ, Arlow DH, Manglik A, Pan AC, Liu CW, Fung JJ, Bokoch MP, Thian FS, Kobilka TS, Shaw DE, Mueller L, Prosser RS, Kobilka BK.

Cell. 2013 Jan 31;152(3):532-42. doi: 10.1016/j.cell.2013.01.008.

5.

High-resolution crystal structure of human protease-activated receptor 1.

Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK.

Nature. 2012 Dec 20;492(7429):387-92. doi: 10.1038/nature11701. Epub 2012 Dec 9.

6.

Structure and dynamics of the M3 muscarinic acetylcholine receptor.

Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK.

Nature. 2012 Feb 22;482(7386):552-6. doi: 10.1038/nature10867.

7.

Activation mechanism of the β2-adrenergic receptor.

Dror RO, Arlow DH, Maragakis P, Mildorf TJ, Pan AC, Xu H, Borhani DW, Shaw DE.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18684-9. doi: 10.1073/pnas.1110499108. Epub 2011 Oct 26.

8.

Pathway and mechanism of drug binding to G-protein-coupled receptors.

Dror RO, Pan AC, Arlow DH, Borhani DW, Maragakis P, Shan Y, Xu H, Shaw DE.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13118-23. doi: 10.1073/pnas.1104614108. Epub 2011 Jul 21.

9.

Structure and function of an irreversible agonist-β(2) adrenoceptor complex.

Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK.

Nature. 2011 Jan 13;469(7329):236-40. doi: 10.1038/nature09665.

10.

The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functions.

Charest-Marcotte A, Dufour CR, Wilson BJ, Tremblay AM, Eichner LJ, Arlow DH, Mootha VK, Giguère V.

Genes Dev. 2010 Mar 15;24(6):537-42. doi: 10.1101/gad.1871610. Epub 2010 Mar 1.

11.

A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis.

Baughman JM, Nilsson R, Gohil VM, Arlow DH, Gauhar Z, Mootha VK.

PLoS Genet. 2009 Aug;5(8):e1000590. doi: 10.1371/journal.pgen.1000590. Epub 2009 Aug 14. Erratum in: PLoS Genet. 2010;6(3). doi: 10.1371/annotation/36fe7624-0904-46d4-a013-4be6195245c4.

12.

Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations.

Dror RO, Arlow DH, Borhani DW, Jensen MØ, Piana S, Shaw DE.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4689-94. doi: 10.1073/pnas.0811065106. Epub 2009 Mar 3.

13.

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.

Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P.

Nature. 2007 Nov 29;450(7170):736-40.

PMID:
18046414
14.

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.

Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM.

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6570-5. Epub 2004 Apr 20. Erratum in: Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10405.

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