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Individual brain organoids reproducibly form cell diversity of the human cerebral cortex.

Velasco S, Kedaigle AJ, Simmons SK, Nash A, Rocha M, Quadrato G, Paulsen B, Nguyen L, Adiconis X, Regev A, Levin JZ, Arlotta P.

Nature. 2019 Jun;570(7762):523-527. doi: 10.1038/s41586-019-1289-x. Epub 2019 Jun 5.


Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex.

Zonouzi M, Berger D, Jokhi V, Kedaigle A, Lichtman J, Arlotta P.

Cell Rep. 2019 Jun 4;27(10):2799-2808.e3. doi: 10.1016/j.celrep.2019.05.018.


Cell diversity in the human cerebral cortex: from the embryo to brain organoids.

Arlotta P, Paşca SP.

Curr Opin Neurobiol. 2019 Jun;56:194-198. doi: 10.1016/j.conb.2019.03.001. Epub 2019 Apr 30. Review.


Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics.

Adam Y, Kim JJ, Lou S, Zhao Y, Xie ME, Brinks D, Wu H, Mostajo-Radji MA, Kheifets S, Parot V, Chettih S, Williams KJ, Gmeiner B, Farhi SL, Madisen L, Buchanan EK, Kinsella I, Zhou D, Paninski L, Harvey CD, Zeng H, Arlotta P, Campbell RE, Cohen AE.

Nature. 2019 May;569(7756):413-417. doi: 10.1038/s41586-019-1166-7. Epub 2019 May 1.


Studying the Brain in a Dish: 3D Cell Culture Models of Human Brain Development and Disease.

Brown J, Quadrato G, Arlotta P.

Curr Top Dev Biol. 2018;129:99-122. doi: 10.1016/bs.ctdb.2018.03.002. Epub 2018 May 2. Review.


Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission.

Nehme R, Zuccaro E, Ghosh SD, Li C, Sherwood JL, Pietilainen O, Barrett LE, Limone F, Worringer KA, Kommineni S, Zang Y, Cacchiarelli D, Meissner A, Adolfsson R, Haggarty S, Madison J, Muller M, Arlotta P, Fu Z, Feng G, Eggan K.

Cell Rep. 2018 May 22;23(8):2509-2523. doi: 10.1016/j.celrep.2018.04.066.


The ethics of experimenting with human brain tissue.

Farahany NA, Greely HT, Hyman S, Koch C, Grady C, Pașca SP, Sestan N, Arlotta P, Bernat JL, Ting J, Lunshof JE, Iyer EPR, Hyun I, Capestany BH, Church GM, Huang H, Song H.

Nature. 2018 Apr;556(7702):429-432. doi: 10.1038/d41586-018-04813-x. No abstract available.


Organoids required! A new path to understanding human brain development and disease.

Arlotta P.

Nat Methods. 2018 Jan 3;15(1):27-29. doi: 10.1038/nmeth.4557.


Present and future of modeling human brain development in 3D organoids.

Quadrato G, Arlotta P.

Curr Opin Cell Biol. 2017 Dec;49:47-52. doi: 10.1016/ Epub 2017 Dec 8. Review.


Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease.

Kim J, Hughes EG, Shetty AS, Arlotta P, Goff LA, Bergles DE, Brown SP.

J Neurosci. 2017 Sep 13;37(37):9037-9053. doi: 10.1523/JNEUROSCI.0811-17.2017. Epub 2017 Aug 17.


Cell diversity and network dynamics in photosensitive human brain organoids.

Quadrato G, Nguyen T, Macosko EZ, Sherwood JL, Min Yang S, Berger DR, Maria N, Scholvin J, Goldman M, Kinney JP, Boyden ES, Lichtman JW, Williams ZM, McCarroll SA, Arlotta P.

Nature. 2017 May 4;545(7652):48-53. doi: 10.1038/nature22047. Epub 2017 Apr 26.


Editorial overview: Developmental neuroscience 2017.

Arlotta P, Vanderhaeghen P.

Curr Opin Neurobiol. 2017 Feb;42:A1-A4. doi: 10.1016/j.conb.2017.01.003. Epub 2017 Jan 20. No abstract available.


The promises and challenges of human brain organoids as models of neuropsychiatric disease.

Quadrato G, Brown J, Arlotta P.

Nat Med. 2016 Nov;22(11):1220-1228. doi: 10.1038/nm.4214. Epub 2016 Oct 26.


Adult axolotls can regenerate original neuronal diversity in response to brain injury.

Amamoto R, Huerta VG, Takahashi E, Dai G, Grant AK, Fu Z, Arlotta P.

Elife. 2016 May 9;5. pii: e13998. doi: 10.7554/eLife.13998.


Stressed out? Healing Tips for Newly Reprogrammed Neurons.

Quadrato G, Zhang AC, Arlotta P.

Cell Stem Cell. 2016 Mar 3;18(3):297-9. doi: 10.1016/j.stem.2016.02.008.


Seq-ing the cortex one neuron at a time.

Chen HH, Arlotta P.

Nat Neurosci. 2016 Feb;19(2):179-81. doi: 10.1038/nn.4230. No abstract available.


Homeotic Transformations of Neuronal Cell Identities.

Arlotta P, Hobert O.

Trends Neurosci. 2015 Dec;38(12):751-762. doi: 10.1016/j.tins.2015.10.005. Review.


Instructing Perisomatic Inhibition by Direct Lineage Reprogramming of Neocortical Projection Neurons.

Ye Z, Mostajo-Radji MA, Brown JR, Rouaux C, Tomassy GS, Hensch TK, Arlotta P.

Neuron. 2015 Nov 4;88(3):475-83. doi: 10.1016/j.neuron.2015.10.006.


Diversity Matters: A Revised Guide to Myelination.

Tomassy GS, Dershowitz LB, Arlotta P.

Trends Cell Biol. 2016 Feb;26(2):135-147. doi: 10.1016/j.tcb.2015.09.002. Epub 2015 Oct 3. Review.


Generating neuronal diversity in the mammalian cerebral cortex.

Lodato S, Arlotta P.

Annu Rev Cell Dev Biol. 2015;31:699-720. doi: 10.1146/annurev-cellbio-100814-125353. Epub 2015 Sep 11. Review.


Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain.

Goff LA, Groff AF, Sauvageau M, Trayes-Gibson Z, Sanchez-Gomez DB, Morse M, Martin RD, Elcavage LE, Liapis SC, Gonzalez-Celeiro M, Plana O, Li E, Gerhardinger C, Tomassy GS, Arlotta P, Rinn JL.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6855-62.


Building blocks of the cerebral cortex: from development to the dish.

Harris J, Tomassy GS, Arlotta P.

Wiley Interdiscip Rev Dev Biol. 2015 Sep-Oct;4(5):529-44. doi: 10.1002/wdev.192. Epub 2015 Apr 29. Review.


Seven actionable strategies for advancing women in science, engineering, and medicine.

Smith KA, Arlotta P, Watt FM; Initiative on Women in Science and Engineering Working Group, Solomon SL.

Cell Stem Cell. 2015 Mar 5;16(3):221-4. doi: 10.1016/j.stem.2015.02.012.


DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex.

Molyneaux BJ, Goff LA, Brettler AC, Chen HH, Hrvatin S, Rinn JL, Arlotta P.

Neuron. 2015 Jan 21;85(2):275-288. doi: 10.1016/j.neuron.2014.12.024. Epub 2014 Dec 31. Erratum in: Neuron. 2016 Jan 6;89(1):235.


Cerebral cortex assembly: generating and reprogramming projection neuron diversity.

Lodato S, Shetty AS, Arlotta P.

Trends Neurosci. 2015 Feb;38(2):117-25. doi: 10.1016/j.tins.2014.11.003. Epub 2014 Dec 17. Review.


Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons.

Lodato S, Molyneaux BJ, Zuccaro E, Goff LA, Chen HH, Yuan W, Meleski A, Takahashi E, Mahony S, Rinn JL, Gifford DK, Arlotta P.

Nat Neurosci. 2014 Aug;17(8):1046-54. doi: 10.1038/nn.3757. Epub 2014 Jul 6.


Brains in metamorphosis: reprogramming cell identity within the central nervous system.

Arlotta P, Berninger B.

Curr Opin Neurobiol. 2014 Aug;27:208-14. doi: 10.1016/j.conb.2014.04.007. Epub 2014 May 4. Review.


Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex.

Tomassy GS, Berger DR, Chen HH, Kasthuri N, Hayworth KJ, Vercelli A, Seung HS, Lichtman JW, Arlotta P.

Science. 2014 Apr 18;344(6181):319-24. doi: 10.1126/science.1249766.


Development-inspired reprogramming of the mammalian central nervous system.

Amamoto R, Arlotta P.

Science. 2014 Jan 31;343(6170):1239882. doi: 10.1126/science.1239882. Review.


Multiple knockout mouse models reveal lincRNAs are required for life and brain development.

Sauvageau M, Goff LA, Lodato S, Bonev B, Groff AF, Gerhardinger C, Sanchez-Gomez DB, Hacisuleyman E, Li E, Spence M, Liapis SC, Mallard W, Morse M, Swerdel MR, D'Ecclessis MF, Moore JC, Lai V, Gong G, Yancopoulos GD, Frendewey D, Kellis M, Hart RP, Valenzuela DM, Arlotta P, Rinn JL.

Elife. 2013 Dec 31;2:e01749. doi: 10.7554/eLife.01749.


Reshaping the brain: direct lineage conversion in the nervous system.

Amamoto R, Arlotta P.

F1000Prime Rep. 2013 Sep 2;5:33. doi: 10.12703/P5-33. Review.


The quest for myelin in the adult brain.

Zuccaro E, Arlotta P.

Nat Cell Biol. 2013 Jun;15(6):572-5. doi: 10.1038/ncb2750. Epub 2013 May 5.


Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo.

Rouaux C, Arlotta P.

Nat Cell Biol. 2013 Feb;15(2):214-21. doi: 10.1038/ncb2660. Epub 2013 Jan 20.


A sip of GABA for the cerebral cortex.

Tomassy GS, Lodato S, Arlotta P.

Neuron. 2013 Jan 9;77(1):1-3. doi: 10.1016/j.neuron.2012.12.026. Erratum in: Neuron. 2013 Mar 6;77(5):993.


A radial glia-specific role of RhoA in double cortex formation.

Cappello S, Böhringer CR, Bergami M, Conzelmann KK, Ghanem A, Tomassy GS, Arlotta P, Mainardi M, Allegra M, Caleo M, van Hengel J, Brakebusch C, Götz M.

Neuron. 2012 Mar 8;73(5):911-24. doi: 10.1016/j.neuron.2011.12.030.


Programming and reprogramming neuronal subtypes in the central nervous system.

Rouaux C, Bhai S, Arlotta P.

Dev Neurobiol. 2012 Jul;72(7):1085-98. doi: 10.1002/dneu.22018. Review.


Developmental Controls are Re-Expressed during Induction of Neurogenesis in the Neocortex of Young Adult Mice.

Sohur US, Arlotta P, Macklis JD.

Front Neurosci. 2012 Feb 6;6:12. doi: 10.3389/fnins.2012.00012. eCollection 2012.


Cell replacement therapies for nervous system regeneration.

López-Bendito G, Arlotta P.

Dev Neurobiol. 2012 Feb;72(2):145-52. doi: 10.1002/dneu.20897. Review.


Loss of COUP-TFI alters the balance between caudal ganglionic eminence- and medial ganglionic eminence-derived cortical interneurons and results in resistance to epilepsy.

Lodato S, Tomassy GS, De Leonibus E, Uzcategui YG, Andolfi G, Armentano M, Touzot A, Gaztelu JM, Arlotta P, Menendez de la Prida L, Studer M.

J Neurosci. 2011 Mar 23;31(12):4650-62. doi: 10.1523/JNEUROSCI.6580-10.2011.


Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex.

Lodato S, Rouaux C, Quast KB, Jantrachotechatchawan C, Studer M, Hensch TK, Arlotta P.

Neuron. 2011 Feb 24;69(4):763-79. doi: 10.1016/j.neuron.2011.01.015.


Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription.

Zhang F, Cong L, Lodato S, Kosuri S, Church GM, Arlotta P.

Nat Biotechnol. 2011 Feb;29(2):149-53. doi: 10.1038/nbt.1775. Epub 2011 Jan 19.


Fezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo.

Rouaux C, Arlotta P.

Nat Neurosci. 2010 Nov;13(11):1345-7. doi: 10.1038/nn.2658. Epub 2010 Oct 17.


Development and regeneration of projection neuron subtypes of the cerebral cortex.

Tomassy GS, Lodato S, Trayes-Gibson Z, Arlotta P.

Sci Prog. 2010;93(Pt 2):151-69. Review.


Untangling the cortex: Advances in understanding specification and differentiation of corticospinal motor neurons.

Shoemaker LD, Arlotta P.

Bioessays. 2010 Mar;32(3):197-206. doi: 10.1002/bies.200900114. Review.


Novel subtype-specific genes identify distinct subpopulations of callosal projection neurons.

Molyneaux BJ, Arlotta P, Fame RM, MacDonald JL, MacQuarrie KL, Macklis JD.

J Neurosci. 2009 Sep 30;29(39):12343-54. doi: 10.1523/JNEUROSCI.6108-08.2009.


Molecular development of corticospinal motor neuron circuitry.

Molyneaux BJ, Arlotta P, Macklis JD.

Novartis Found Symp. 2007;288:3-15; discussion 15-20, 96-8. Review.


SOX5 controls the sequential generation of distinct corticofugal neuron subtypes.

Lai T, Jabaudon D, Molyneaux BJ, Azim E, Arlotta P, Menezes JR, Macklis JD.

Neuron. 2008 Jan 24;57(2):232-47. doi: 10.1016/j.neuron.2007.12.023.


Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum.

Arlotta P, Molyneaux BJ, Jabaudon D, Yoshida Y, Macklis JD.

J Neurosci. 2008 Jan 16;28(3):622-32. doi: 10.1523/JNEUROSCI.2986-07.2008.


Neuronal subtype specification in the cerebral cortex.

Molyneaux BJ, Arlotta P, Menezes JR, Macklis JD.

Nat Rev Neurosci. 2007 Jun;8(6):427-37. Review.


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