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Structure of the C1 complex of complement.

Arlaud GJ, Gaboriaud C, Ling WL, Thielens NM.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5766-E5767. doi: 10.1073/pnas.1703977114. Epub 2017 Jul 12. No abstract available.


Classical complement pathway components C1r and C1s: purification from human serum and in recombinant form and functional characterization.

Rossi V, Bally I, Lacroix M, Arlaud GJ, Thielens NM.

Methods Mol Biol. 2014;1100:43-60. doi: 10.1007/978-1-62703-724-2_4.


The serine protease domain of MASP-3: enzymatic properties and crystal structure in complex with ecotin.

Gaboriaud C, Gupta RK, Martin L, Lacroix M, Serre L, Teillet F, Arlaud GJ, Rossi V, Thielens NM.

PLoS One. 2013 Jul 4;8(7):e67962. doi: 10.1371/journal.pone.0067962. Print 2013.


Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites.

Bally I, Ancelet S, Moriscot C, Gonnet F, Mantovani A, Daniel R, Schoehn G, Arlaud GJ, Thielens NM.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8650-5. doi: 10.1073/pnas.1304894110. Epub 2013 May 6.


Structure and properties of the Ca(2+)-binding CUB domain, a widespread ligand-recognition unit involved in major biological functions.

Gaboriaud C, Gregory-Pauron L, Teillet F, Thielens NM, Bally I, Arlaud GJ.

Biochem J. 2011 Oct 15;439(2):185-93. doi: 10.1042/BJ20111027. Review.


Enzymatically modified low-density lipoprotein is recognized by c1q and activates the classical complement pathway.

Arlaud GJ, Biro A, Ling WL.

J Lipids. 2011;2011:376092. doi: 10.1155/2011/376092. Epub 2011 Mar 9.


M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules.

Gout E, Moriscot C, Doni A, Dumestre-Pérard C, Lacroix M, Pérard J, Schoehn G, Mantovani A, Arlaud GJ, Thielens NM.

J Immunol. 2011 May 15;186(10):5815-22. doi: 10.4049/jimmunol.1100180. Epub 2011 Apr 13.


X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism.

Chouquet A, Païdassi H, Ling WL, Frachet P, Houen G, Arlaud GJ, Gaboriaud C.

PLoS One. 2011 Mar 15;6(3):e17886. doi: 10.1371/journal.pone.0017886.


Investigations on the C1q-calreticulin-phosphatidylserine interactions yield new insights into apoptotic cell recognition.

Païdassi H, Tacnet-Delorme P, Verneret M, Gaboriaud C, Houen G, Duus K, Ling WL, Arlaud GJ, Frachet P.

J Mol Biol. 2011 Apr 29;408(2):277-90. doi: 10.1016/j.jmb.2011.02.029. Epub 2011 Feb 23.


Proteins of the innate immune system crystallize on carbon nanotubes but are not activated.

Ling WL, Biro A, Bally I, Tacnet P, Deniaud A, Doris E, Frachet P, Schoehn G, Pebay-Peyroula E, Arlaud GJ.

ACS Nano. 2011 Feb 22;5(2):730-7. doi: 10.1021/nn102400w. Epub 2011 Jan 7.


The human c1q globular domain: structure and recognition of non-immune self ligands.

Gaboriaud C, Frachet P, Thielens NM, Arlaud GJ.

Front Immunol. 2012 Jan 6;2:92. doi: 10.3389/fimmu.2011.00092. eCollection 2011.


Structural and functional characterization of the recombinant human mitochondrial trifunctional protein.

Fould B, Garlatti V, Neumann E, Fenel D, Gaboriaud C, Arlaud GJ.

Biochemistry. 2010 Oct 5;49(39):8608-17. doi: 10.1021/bi100742w. Epub 2010 Sep 8.


Direct interaction between CD91 and C1q.

Duus K, Hansen EW, Tacnet P, Frachet P, Arlaud GJ, Thielens NM, Houen G.

FEBS J. 2010 Sep;277(17):3526-37. doi: 10.1111/j.1742-4658.2010.07762.x.


Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex.

Brier S, Pflieger D, Le Mignon M, Bally I, Gaboriaud C, Arlaud GJ, Daniel R.

J Biol Chem. 2010 Oct 15;285(42):32251-63. doi: 10.1074/jbc.M110.149112. Epub 2010 Jun 30.


Cutting edge: C1q binds deoxyribose and heparan sulfate through neighboring sites of its recognition domain.

Garlatti V, Chouquet A, Lunardi T, Vivès R, Païdassi H, Lortat-Jacob H, Thielens NM, Arlaud GJ, Gaboriaud C.

J Immunol. 2010 Jul 15;185(2):808-12. doi: 10.4049/jimmunol.1000184. Epub 2010 Jun 14.


Complement protein C1q forms a complex with cytotoxic prion protein oligomers.

Erlich P, Dumestre-Pérard C, Ling WL, Lemaire-Vieille C, Schoehn G, Arlaud GJ, Thielens NM, Gagnon J, Cesbron JY.

J Biol Chem. 2010 Jun 18;285(25):19267-76. doi: 10.1074/jbc.M109.071860. Epub 2010 Apr 21.


Structural insights into the recognition properties of human ficolins.

Garlatti V, Martin L, Lacroix M, Gout E, Arlaud GJ, Thielens NM, Gaboriaud C.

J Innate Immun. 2010;2(1):17-23. doi: 10.1159/000233475. Epub 2009 Aug 6. Review.


Functional characterization of the recombinant human C1 inhibitor serpin domain: insights into heparin binding.

Rossi V, Bally I, Ancelet S, Xu Y, Frémeaux-Bacchi V, Vivès RR, Sadir R, Thielens N, Arlaud GJ.

J Immunol. 2010 May 1;184(9):4982-9. doi: 10.4049/jimmunol.0902016. Epub 2010 Mar 29.


Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin.

Gout E, Garlatti V, Smith DF, Lacroix M, Dumestre-Pérard C, Lunardi T, Martin L, Cesbron JY, Arlaud GJ, Gaboriaud C, Thielens NM.

J Biol Chem. 2010 Feb 26;285(9):6612-22. doi: 10.1074/jbc.M109.065854. Epub 2009 Dec 23.


Analysis of human C1q by combined bottom-up and top-down mass spectrometry: detailed mapping of post-translational modifications and insights into the C1r/C1s binding sites.

Pflieger D, Przybylski C, Gonnet F, Le Caer JP, Lunardi T, Arlaud GJ, Daniel R.

Mol Cell Proteomics. 2010 Apr;9(4):593-610. doi: 10.1074/mcp.M900350-MCP200. Epub 2009 Dec 14.


Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation.

Hair PS, Gronemus JQ, Crawford KB, Salvi VP, Cunnion KM, Thielens NM, Arlaud GJ, Rawal N, Krishna NK.

Mol Immunol. 2010 Jan;47(4):792-8. doi: 10.1016/j.molimm.2009.10.006. Epub 2009 Nov 6.


How phagocytes track down and respond to apoptotic cells.

Paidassi H, Tacnet-Delorme P, Arlaud GJ, Frachet P.

Crit Rev Immunol. 2009;29(2):111-30. Review.


Identification of the C1q-binding Sites of Human C1r and C1s: a refined three-dimensional model of the C1 complex of complement.

Bally I, Rossi V, Lunardi T, Thielens NM, Gaboriaud C, Arlaud GJ.

J Biol Chem. 2009 Jul 17;284(29):19340-8. doi: 10.1074/jbc.M109.004473. Epub 2009 May 27.


The lectin-like activity of human C1q and its implication in DNA and apoptotic cell recognition.

Païdassi H, Tacnet-Delorme P, Lunardi T, Arlaud GJ, Thielens NM, Frachet P.

FEBS Lett. 2008 Sep 3;582(20):3111-6. doi: 10.1016/j.febslet.2008.08.001. Epub 2008 Aug 12.


Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins.

Teillet F, Gaboriaud C, Lacroix M, Martin L, Arlaud GJ, Thielens NM.

J Biol Chem. 2008 Sep 12;283(37):25715-24. doi: 10.1074/jbc.M803551200. Epub 2008 Jul 2.


C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition.

Païdassi H, Tacnet-Delorme P, Garlatti V, Darnault C, Ghebrehiwet B, Gaboriaud C, Arlaud GJ, Frachet P.

J Immunol. 2008 Feb 15;180(4):2329-38.


Trimeric reassembly of the globular domain of human C1q.

Tacnet P, Cheong EC, Goeltz P, Ghebrehiwet B, Arlaud GJ, Liu XY, Lesieur C.

Biochim Biophys Acta. 2008 Mar;1784(3):518-29. doi: 10.1016/j.bbapap.2007.12.005. Epub 2007 Dec 15.


The chaperone and potential mannan-binding lectin (MBL) co-receptor calreticulin interacts with MBL through the binding site for MBL-associated serine proteases.

Pagh R, Duus K, Laursen I, Hansen PR, Mangor J, Thielens N, Arlaud GJ, Kongerslev L, Højrup P, Houen G.

FEBS J. 2008 Feb;275(3):515-26. doi: 10.1111/j.1742-4658.2007.06218.x. Epub 2008 Jan 3.


Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch.

Garlatti V, Martin L, Gout E, Reiser JB, Fujita T, Arlaud GJ, Thielens NM, Gaboriaud C.

J Biol Chem. 2007 Dec 7;282(49):35814-20. Epub 2007 Sep 26.


Deciphering complement mechanisms: the contributions of structural biology.

Arlaud GJ, Barlow PN, Gaboriaud C, Gros P, Narayana SV.

Mol Immunol. 2007 Sep;44(16):3809-22. Review.


Assembly of C1 and the MBL- and ficolin-MASP complexes: structural insights.

Gaboriaud C, Teillet F, Gregory LA, Thielens NM, Arlaud GJ.

Immunobiology. 2007;212(4-5):279-88. Epub 2006 Dec 20. Review.


Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases: the essential role of Lys55.

Teillet F, Lacroix M, Thiel S, Weilguny D, Agger T, Arlaud GJ, Thielens NM.

J Immunol. 2007 May 1;178(9):5710-6.


Complement protein C1q induces maturation of human dendritic cells.

Csomor E, Bajtay Z, Sándor N, Kristóf K, Arlaud GJ, Thiel S, Erdei A.

Mol Immunol. 2007 Jul;44(13):3389-97. Epub 2007 Mar 26.


Studies on the interactions between C-reactive protein and complement proteins.

Bíró A, Rovó Z, Papp D, Cervenak L, Varga L, Füst G, Thielens NM, Arlaud GJ, Prohászka Z.

Immunology. 2007 May;121(1):40-50. Epub 2007 Jan 18.


Structural insights into the innate immune recognition specificities of L- and H-ficolins.

Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Endo Y, Fujita T, Fontecilla-Camps JC, Arlaud GJ, Thielens NM, Gaboriaud C.

EMBO J. 2007 Jan 24;26(2):623-33. Epub 2007 Jan 11.


Modified low density lipoproteins differentially bind and activate the C1 complex of complement.

Biró A, Thielens NM, Cervenák L, Prohászka Z, Füst G, Arlaud GJ.

Mol Immunol. 2007 Feb;44(6):1169-77. Epub 2006 Aug 30.


Molecular organization of human Ficolin-2.

Hummelshoj T, Thielens NM, Madsen HO, Arlaud GJ, Sim RB, Garred P.

Mol Immunol. 2007 Jan;44(4):401-11. Epub 2006 Apr 3.


Evidence that complement protein C1q interacts with C-reactive protein through its globular head region.

McGrath FD, Brouwer MC, Arlaud GJ, Daha MR, Hack CE, Roos A.

J Immunol. 2006 Mar 1;176(5):2950-7.


Interactions of the extracellular matrix proteoglycans decorin and biglycan with C1q and collectins.

Groeneveld TW, Oroszlán M, Owens RT, Faber-Krol MC, Bakker AC, Arlaud GJ, McQuillan DJ, Kishore U, Daha MR, Roos A.

J Immunol. 2005 Oct 1;175(7):4715-23.


Functional role of the linker between the complement control protein modules of complement protease C1s.

Bally I, Rossi V, Thielens NM, Gaboriaud C, Arlaud GJ.

J Immunol. 2005 Oct 1;175(7):4536-42.


Complement protein C1q recognizes a conformationally modified form of the prion protein.

Blanquet-Grossard F, Thielens NM, Vendrely C, Jamin M, Arlaud GJ.

Biochemistry. 2005 Mar 22;44(11):4349-56.


Mass spectrometry analysis of the oligomeric C1q protein reveals the B chain as the target of trypsin cleavage and interaction with fucoidan.

Tissot B, Gonnet F, Iborra A, Berthou C, Thielens N, Arlaud GJ, Daniel R.

Biochemistry. 2005 Feb 22;44(7):2602-9.


C1q and tumor necrosis factor superfamily: modularity and versatility.

Kishore U, Gaboriaud C, Waters P, Shrive AK, Greenhough TJ, Reid KB, Sim RB, Arlaud GJ.

Trends Immunol. 2004 Oct;25(10):551-61. Review.


Structure and activation of the C1 complex of complement: unraveling the puzzle.

Gaboriaud C, Thielens NM, Gregory LA, Rossi V, Fontecilla-Camps JC, Arlaud GJ.

Trends Immunol. 2004 Jul;25(7):368-73. Review. No abstract available.


The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin.

Gregory LA, Thielens NM, Matsushita M, Sorensen R, Arlaud GJ, Fontecilla-Camps JC, Gaboriaud C.

J Biol Chem. 2004 Jul 9;279(28):29391-7. Epub 2004 Apr 26.


Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2.

Zundel S, Cseh S, Lacroix M, Dahl MR, Matsushita M, Andrieu JP, Schwaeble WJ, Jensenius JC, Fujita T, Arlaud GJ, Thielens NM.

J Immunol. 2004 Apr 1;172(7):4342-50.

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