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Identification of reference genes suitable for RT-qPCR studies of murine gastrulation and patterning.

Barratt KS, Diamand KEM, Arkell RM.

Mamm Genome. 2018 Oct;29(9-10):656-662. doi: 10.1007/s00335-018-9769-0. Epub 2018 Aug 9.


CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype.

Candido JB, Morton JP, Bailey P, Campbell AD, Karim SA, Jamieson T, Lapienyte L, Gopinathan A, Clark W, McGhee EJ, Wang J, Escorcio-Correia M, Zollinger R, Roshani R, Drew L, Rishi L, Arkell R, Evans TRJ, Nixon C, Jodrell DI, Wilkinson RW, Biankin AV, Barry ST, Balkwill FR, Sansom OJ.

Cell Rep. 2018 May 1;23(5):1448-1460. doi: 10.1016/j.celrep.2018.03.131.


ZIC2 in Holoprosencephaly.

Barratt KS, Arkell RM.

Adv Exp Med Biol. 2018;1046:269-299. doi: 10.1007/978-981-10-7311-3_14. Review.


Overview of Rodent Zic Genes.

Diamand KEM, Barratt KS, Arkell RM.

Adv Exp Med Biol. 2018;1046:179-207. doi: 10.1007/978-981-10-7311-3_10. Review.


Zic2 mutation causes holoprosencephaly via disruption of NODAL signalling.

Houtmeyers R, Tchouate Gainkam O, Glanville-Jones HA, Van den Bosch B, Chappell A, Barratt KS, Souopgui J, Tejpar S, Arkell RM.

Hum Mol Genet. 2016 Sep 15;25(18):3946-3959. doi: 10.1093/hmg/ddw235. Epub 2016 Jul 27.


Does elective parathyroidectomy for primary hyperparathyroidism affect renal function? A prospective cohort study.

Egan RJ, Dewi F, Arkell R, Ansell J, Zouwail S, Scott-Coombes D, Stechman M.

Int J Surg. 2016 Mar;27:138-41. doi: 10.1016/j.ijsu.2016.01.072. Epub 2016 Jan 23.


APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease.

Vélez JI, Lopera F, Sepulveda-Falla D, Patel HR, Johar AS, Chuah A, Tobón C, Rivera D, Villegas A, Cai Y, Peng K, Arkell R, Castellanos FX, Andrews SJ, Silva Lara MF, Creagh PK, Easteal S, de Leon J, Wong ML, Licinio J, Mastronardi CA, Arcos-Burgos M.

Mol Psychiatry. 2016 Jul;21(7):916-24. doi: 10.1038/mp.2015.177. Epub 2015 Dec 1.


Correction: Mutation of the Diamond-Blackfan Anemia Gene Rps7 in Mouse Results in Morphological and Neuroanatomical Phenotypes.

Watkins-Chow DE, Cooke J, Pidsley R, Edwards A, Slotkin R, Leeds KE, Mullen R, Baxter LL, Campbell TG, Salzer MC, Biondini L, Gibney G, Tuy FP, Chelly J, Morris HD, Riegler J, Lythgoe MF, Arkell RM, Loreni F, Flint J, Pavan WJ, Keays DA.

PLoS Genet. 2015 Nov 19;11(11):e1005682. doi: 10.1371/journal.pgen.1005682. eCollection 2015 Nov. No abstract available.


Flightless I is a key regulator of the fibroproliferative process in hypertrophic scarring and a target for a novel antiscarring therapy.

Cameron AM, Turner CT, Adams DH, Jackson JE, Melville E, Arkell RM, Anderson PJ, Cowin AJ.

Br J Dermatol. 2016 Apr;174(4):786-94. doi: 10.1111/bjd.14263. Epub 2016 Jan 9.


Fibroblast-specific upregulation of Flightless I impairs wound healing.

Turner CT, Waters JM, Jackson JE, Arkell RM, Cowin AJ.

Exp Dermatol. 2015 Sep;24(9):692-7. doi: 10.1111/exd.12751. Epub 2015 Jul 14.


The role of Zic genes in inner ear development in the mouse: Exploring mutant mouse phenotypes.

Chervenak AP, Bank LM, Thomsen N, Glanville-Jones HC, Jonathan S, Millen KJ, Arkell RM, Barald KF.

Dev Dyn. 2014 Nov;243(11):1487-98. doi: 10.1002/dvdy.24186. Epub 2014 Sep 16.


The Zic2 gene directs the formation and function of node cilia to control cardiac situs.

Barratt KS, Glanville-Jones HC, Arkell RM.

Genesis. 2014 Jun;52(6):626-35. doi: 10.1002/dvg.22767. Epub 2014 Mar 17.


Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering.

Kopecki Z, Yang GN, Arkell RM, Jackson JE, Melville E, Iwata H, Ludwig RJ, Zillikens D, Murrell DF, Cowin AJ.

J Pathol. 2014 Apr;232(5):541-52. doi: 10.1002/path.4323. Epub 2014 Feb 5.


Attenuation of flightless I improves wound healing and enhances angiogenesis in a murine model of type 1 diabetes.

Ruzehaji N, Kopecki Z, Melville E, Appleby SL, Bonder CS, Arkell RM, Fitridge R, Cowin AJ.

Diabetologia. 2014 Feb;57(2):402-12. doi: 10.1007/s00125-013-3107-6. Epub 2013 Nov 29.


Wnt signalling in mouse gastrulation and anterior development: new players in the pathway and signal output.

Arkell RM, Fossat N, Tam PP.

Curr Opin Genet Dev. 2013 Aug;23(4):454-60. doi: 10.1016/j.gde.2013.03.001. Epub 2013 Apr 19. Review.


Successful whole embryo culture with commercially available reagents.

Glanville-Jones HC, Woo N, Arkell RM.

Int J Dev Biol. 2013;57(1):61-7. doi: 10.1387/ijdb.120098ra.


The influence of Flightless I on Toll-like-receptor-mediated inflammation in a murine model of diabetic wound healing.

Ruzehaji N, Mills SJ, Melville E, Arkell R, Fitridge R, Cowin AJ.

Biomed Res Int. 2013;2013:389792. doi: 10.1155/2013/389792. Epub 2013 Feb 18.


A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation.

Ahmed JN, Ali RG, Warr N, Wilson HM, Bellchambers HM, Barratt KS, Thompson AJ, Arkell RM.

Dis Model Mech. 2013 May;6(3):755-67. doi: 10.1242/dmm.011668. Epub 2013 Feb 21.


Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease.

Caruana G, Farlie PG, Hart AH, Bagheri-Fam S, Wallace MJ, Dobbie MS, Gordon CT, Miller KA, Whittle B, Abud HE, Arkell RM, Cole TJ, Harley VR, Smyth IM, Bertram JF.

PLoS One. 2013;8(3):e55429. doi: 10.1371/journal.pone.0055429. Epub 2013 Mar 1.


The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis.

Houtmeyers R, Souopgui J, Tejpar S, Arkell R.

Cell Mol Life Sci. 2013 Oct;70(20):3791-811. doi: 10.1007/s00018-013-1285-5. Epub 2013 Feb 27. Review.


Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes.

Watkins-Chow DE, Cooke J, Pidsley R, Edwards A, Slotkin R, Leeds KE, Mullen R, Baxter LL, Campbell TG, Salzer MC, Biondini L, Gibney G, Phan Dinh Tuy F, Chelly J, Morris HD, Riegler J, Lythgoe MF, Arkell RM, Loreni F, Flint J, Pavan WJ, Keays DA.

PLoS Genet. 2013;9(1):e1003094. doi: 10.1371/journal.pgen.1003094. Epub 2013 Jan 31. Erratum in: PLoS Genet. 2015 Nov;11(11):e1005682.


High resolution melt analysis (HRMA); a viable alternative to agarose gel electrophoresis for mouse genotyping.

Thomsen N, Ali RG, Ahmed JN, Arkell RM.

PLoS One. 2012;7(9):e45252. doi: 10.1371/journal.pone.0045252. Epub 2012 Sep 19.


Zinc fingers of the cerebellum (Zic): transcription factors and co-factors.

Ali RG, Bellchambers HM, Arkell RM.

Int J Biochem Cell Biol. 2012 Nov;44(11):2065-8. doi: 10.1016/j.biocel.2012.08.012. Epub 2012 Aug 14. Review.


Initiating head development in mouse embryos: integrating signalling and transcriptional activity.

Arkell RM, Tam PP.

Open Biol. 2012 Mar;2(3):120030. doi: 10.1098/rsob.120030.


Overexpression of the Flii gene increases dermal-epidermal blistering in an autoimmune ColVII mouse model of epidermolysis bullosa acquisita.

Kopecki Z, Arkell RM, Strudwick XL, Hirose M, Ludwig RJ, Kern JS, Bruckner-Tuderman L, Zillikens D, Murrell DF, Cowin AJ.

J Pathol. 2011 Nov;225(3):401-13. doi: 10.1002/path.2973. Epub 2011 Sep 26.


Mouse strains for the ubiquitous or conditional overexpression of the Flii gene.

Thomsen N, Chappell A, Ali RG, Jones T, Adams DH, Matthaei KI, Campbell HD, Cowin AJ, Arkell RM.

Genesis. 2011 Aug;49(8):681-8. doi: 10.1002/dvg.20735. Epub 2011 Jul 22.


Regulation of focal adhesions by flightless i involves inhibition of paxillin phosphorylation via a Rac1-dependent pathway.

Kopecki Z, O'Neill GM, Arkell RM, Cowin AJ.

J Invest Dermatol. 2011 Jul;131(7):1450-9. doi: 10.1038/jid.2011.69. Epub 2011 Mar 24.


Decreased expression of Flightless I, a gelsolin family member and developmental regulator, in early-gestation fetal wounds improves healing.

Lin CH, Waters JM, Powell BC, Arkell RM, Cowin AJ.

Mamm Genome. 2011 Jun;22(5-6):341-52. doi: 10.1007/s00335-011-9320-z. Epub 2011 Mar 13.


Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo.

Fossat N, Jones V, Khoo PL, Bogani D, Hardy A, Steiner K, Mukhopadhyay M, Westphal H, Nolan PM, Arkell R, Tam PP.

Development. 2011 Feb;138(4):667-76. doi: 10.1242/dev.052803. Epub 2011 Jan 12.


Regeneration of hair follicles is modulated by flightless I (Flii) in a rodent vibrissa model.

Waters JM, Lindo JE, Arkell RM, Cowin AJ.

J Invest Dermatol. 2011 Apr;131(4):838-47. doi: 10.1038/jid.2010.393. Epub 2010 Dec 30.


Extracellular growth factors and mitogens cooperate to drive mitochondrial biogenesis.

Echave P, Machado-da-Silva G, Arkell RS, Duchen MR, Jacobson J, Mitter R, Lloyd AC.

J Cell Sci. 2009 Dec 15;122(Pt 24):4516-25. doi: 10.1242/jcs.049734. Epub 2009 Nov 17. Erratum in: J Cell Sci. 2009 Dec 15;122(Pt 24):4584.


Upregulation of PKD1L2 provokes a complex neuromuscular disease in the mouse.

Mackenzie FE, Romero R, Williams D, Gillingwater T, Hilton H, Dick J, Riddoch-Contreras J, Wong F, Ireson L, Powles-Glover N, Riley G, Underhill P, Hough T, Arkell R, Greensmith L, Ribchester RR, Blanco G.

Hum Mol Genet. 2009 Oct 1;18(19):3553-66. doi: 10.1093/hmg/ddp304. Epub 2009 Jul 4.


Attenuation of Flightless I, an actin-remodelling protein, improves burn injury repair via modulation of transforming growth factor (TGF)-beta1 and TGF-beta3.

Adams DH, Ruzehaji N, Strudwick XL, Greenwood JE, Campbell HD, Arkell R, Cowin AJ.

Br J Dermatol. 2009 Aug;161(2):326-36. doi: 10.1111/j.1365-2133.2009.09296.x. Epub 2009 Jun 9.


Flightless I regulates hemidesmosome formation and integrin-mediated cellular adhesion and migration during wound repair.

Kopecki Z, Arkell R, Powell BC, Cowin AJ.

J Invest Dermatol. 2009 Aug;129(8):2031-45. doi: 10.1038/jid.2008.461. Epub 2009 Feb 12.


Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation.

Warr N, Powles-Glover N, Chappell A, Robson J, Norris D, Arkell RM.

Hum Mol Genet. 2008 Oct 1;17(19):2986-96. doi: 10.1093/hmg/ddn197. Epub 2008 Jul 9.


Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance.

Goldsworthy M, Hugill A, Freeman H, Horner E, Shimomura K, Bogani D, Pieles G, Mijat V, Arkell R, Bhattacharya S, Ashcroft FM, Cox RD.

Diabetes. 2008 Aug;57(8):2234-44. doi: 10.2337/db07-0337. Epub 2008 May 13.


DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5.

Arkell RS, Dickinson RJ, Squires M, Hayat S, Keyse SM, Cook SJ.

Cell Signal. 2008 May;20(5):836-43. doi: 10.1016/j.cellsig.2007.12.014. Epub 2007 Dec 27.


Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling.

Ybot-Gonzalez P, Gaston-Massuet C, Girdler G, Klingensmith J, Arkell R, Greene ND, Copp AJ.

Development. 2007 Sep;134(17):3203-11.


Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.

Garrick D, Sharpe JA, Arkell R, Dobbie L, Smith AJ, Wood WG, Higgs DR, Gibbons RJ.

PLoS Genet. 2006 Apr;2(4):e58. Epub 2006 Apr 21.


Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport.

Carlton JG, Bujny MV, Peter BJ, Oorschot VM, Rutherford A, Arkell RS, Klumperman J, McMahon HT, Cullen PJ.

J Cell Sci. 2005 Oct 1;118(Pt 19):4527-39.


Dissecting the genetic complexity of human 6p deletion syndromes by using a region-specific, phenotype-driven mouse screen.

Bogani D, Willoughby C, Davies J, Kaur K, Mirza G, Paudyal A, Haines H, McKeone R, Cadman M, Pieles G, Schneider JE, Bhattacharya S, Hardy A, Nolan PM, Tripodis N, Depew MJ, Chandrasekara R, Duncan G, Sharpe PT, Greenfield A, Denny P, Brown SD, Ragoussis J, Arkell RM.

Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12477-82. Epub 2005 Aug 18.


CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+.

Liu Q, Walker SA, Gao D, Taylor JA, Dai YF, Arkell RS, Bootman MD, Roderick HL, Cullen PJ, Lockyer PJ.

J Cell Biol. 2005 Jul 18;170(2):183-90. Epub 2005 Jul 11.


An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse.

Blewitt ME, Vickaryous NK, Hemley SJ, Ashe A, Bruxner TJ, Preis JI, Arkell R, Whitelaw E.

Proc Natl Acad Sci U S A. 2005 May 24;102(21):7629-34. Epub 2005 May 12.


New semidominant mutations that affect mouse development.

Bogani D, Warr N, Elms P, Davies J, Tymowska-Lalanne Z, Goldsworthy M, Cox RD, Keays DA, Flint J, Wilson V, Nolan P, Arkell R.

Genesis. 2004 Oct;40(2):109-117.


Organization and evolution of a gene-rich region of the mouse genome: a 12.7-Mb region deleted in the Del(13)Svea36H mouse.

Mallon AM, Wilming L, Weekes J, Gilbert JG, Ashurst J, Peyrefitte S, Matthews L, Cadman M, McKeone R, Sellick CA, Arkell R, Botcherby MR, Strivens MA, Campbell RD, Gregory S, Denny P, Hancock JM, Rogers J, Brown SD.

Genome Res. 2004 Oct;14(10A):1888-901. Epub 2004 Sep 13.


Overlapping and distinct expression domains of Zic2 and Zic3 during mouse gastrulation.

Elms P, Scurry A, Davies J, Willoughby C, Hacker T, Bogani D, Arkell R.

Gene Expr Patterns. 2004 Sep;4(5):505-11.


Zic2 is required for neural crest formation and hindbrain patterning during mouse development.

Elms P, Siggers P, Napper D, Greenfield A, Arkell R.

Dev Biol. 2003 Dec 15;264(2):391-406.


Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse.

Curtin JA, Quint E, Tsipouri V, Arkell RM, Cattanach B, Copp AJ, Henderson DJ, Spurr N, Stanier P, Fisher EM, Nolan PM, Steel KP, Brown SD, Gray IC, Murdoch JN.

Curr Biol. 2003 Jul 1;13(13):1129-33.


Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse.

Murdoch JN, Henderson DJ, Doudney K, Gaston-Massuet C, Phillips HM, Paternotte C, Arkell R, Stanier P, Copp AJ.

Hum Mol Genet. 2003 Jan 15;12(2):87-98.


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