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Items: 1 to 50 of 99

1.

Comparative disposition and metabolism of paraherquamide in sheep, gerbils, and dogs.

Aloysius HA, Elipe MV, Arison BH, Faidley TD, Michael BF, Blizzard TA, Thompson DR, Shoop WL, Tschirret-Guth RA.

Drug Metab Dispos. 2008 Aug;36(8):1659-69. doi: 10.1124/dmd.107.019430. Epub 2008 May 27.

PMID:
18505789
2.

Characterization of two cyclic metabolites of sitagliptin.

Liu DQ, Arison BH, Stearns RA, Kim D, Vincent SH.

Drug Metab Dispos. 2007 Apr;35(4):521-4. Epub 2007 Jan 12.

PMID:
17220240
3.

Metabolism and disposition of a potent and selective GABA-Aalpha2/3 receptor agonist in healthy male volunteers.

Polsky-Fisher SL, Vickers S, Cui D, Subramanian R, Arison BH, Agrawal NG, Goel TV, Vessey LK, Murphy MG, Lasseter KC, Simpson RC, Vega JM, Rodrigues AD.

Drug Metab Dispos. 2006 Jun;34(6):1004-11. Epub 2006 Mar 1.

PMID:
16510541
4.

In vitro and in vivo metabolism of a potent and selective integrin alpha v beta 3 antagonist in rats, dogs, and monkeys.

Cui D, Subramanian R, Shou M, Yu X, Wallace MA, Braun MP, Arison BH, Yergey JA, Prueksaritanont T.

Drug Metab Dispos. 2004 Aug;32(8):848-61.

PMID:
15258111
5.

A novel lipid hydroperoxide-derived modification to arginine.

Oe T, Lee SH, Silva Elipe MV, Arison BH, Blair IA.

Chem Res Toxicol. 2003 Dec;16(12):1598-605.

PMID:
14680374
6.

Metabolism of rofecoxib in vitro using human liver subcellular fractions.

Slaughter D, Takenaga N, Lu P, Assang C, Walsh DJ, Arison BH, Cui D, Halpin RA, Geer LA, Vyas KP, Baillie TA.

Drug Metab Dispos. 2003 Nov;31(11):1398-408.

PMID:
14570773
7.

Characterization of 2'-deoxycytidine adducts derived from 4-oxo-2-nonenal, a novel lipid peroxidation product.

Pollack M, Oe T, Lee SH, Silva Elipe MV, Arison BH, Blair IA.

Chem Res Toxicol. 2003 Jul;16(7):893-900.

PMID:
12870892
8.

1H-NMR studies on a potent and selective antagonist at human melanocortin receptor 4 (hMC-4R).

Victoria Silva Elipe M, Mosley RT, Bednarek MA, Arison BH.

Biopolymers. 2003 Apr;68(4):512-27.

PMID:
12666176
9.

Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins.

Singh R, Silva Elipe MV, Pearson PG, Arison BH, Wong BK, White R, Yu X, Burgey CS, Lin JH, Baillie TA.

Chem Res Toxicol. 2003 Feb;16(2):198-207.

PMID:
12588191
10.

Pharmacokinetics and metabolism of a RAS farnesyl transferase inhibitor in rats and dogs: in vitro-in vivo correlation.

Singh R, Chen IW, Jin L, Silva MV, Arison BH, Lin JH, Wong BK.

Drug Metab Dispos. 2001 Dec;29(12):1578-87.

PMID:
11717177
11.

Metabolites of caspofungin acetate, a potent antifungal agent, in human plasma and urine.

Balani SK, Xu X, Arison BH, Silva MV, Gries A, DeLuna FA, Cui D, Kari PH, Ly T, Hop CE, Singh R, Wallace MA, Dean DC, Lin JH, Pearson PG, Baillie TA.

Drug Metab Dispos. 2000 Nov;28(11):1274-8.

PMID:
11038152
12.

A Tethered Porphyrin Dimer with π Overlap of a Single Pyrrole Ring.

Knapp S, Vasudevan J, Emge TJ, Arison BH, Potenza JA, Schugar HJ.

Angew Chem Int Ed Engl. 1998 Sep 18;37(17):2368-2370. doi: 10.1002/(SICI)1521-3773(19980918)37:17<2368::AID-ANIE2368>3.0.CO;2-K.

PMID:
29710963
13.

Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2.

Yang L, Berk SC, Rohrer SP, Mosley RT, Guo L, Underwood DJ, Arison BH, Birzin ET, Hayes EC, Mitra SW, Parmar RM, Cheng K, Wu TJ, Butler BS, Foor F, Pasternak A, Pan Y, Silva M, Freidinger RM, Smith RG, Chapman K, Schaeffer JM, Patchett AA.

Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10836-41.

14.

Metabolism of MK-499, a class III antiarrhythmic agent, in rats and dogs.

Vickers S, Duncan CA, Slaughter DE, Arison BH, Greber T, Olah TV, Vyas KP.

Drug Metab Dispos. 1998 May;26(5):388-95.

PMID:
9571219
15.

Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes.

Zeng Z, Andrew NW, Arison BH, Luffer-Atlas D, Wang RW.

Xenobiotica. 1998 Mar;28(3):313-21.

PMID:
9574819
16.

Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile.

Balani SK, Xu X, Pratha V, Koss MA, Amin RD, Dufresne C, Miller RR, Arison BH, Doss GA, Chiba M, Freeman A, Holland SD, Schwartz JI, Lasseter KC, Gertz BJ, Isenberg JI, Rogers JD, Lin JH, Baillie TA.

Drug Metab Dispos. 1997 Nov;25(11):1282-7.

PMID:
9351905
17.

In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s.

Prueksaritanont T, Gorham LM, Ma B, Liu L, Yu X, Zhao JJ, Slaughter DE, Arison BH, Vyas KP.

Drug Metab Dispos. 1997 Oct;25(10):1191-9.

PMID:
9321523
18.

Orally active inhibitors of human leukocyte elastase. III. Identification and characterization of metabolites of L-694,458 by liquid chromatography-tandem mass spectrometry.

Luffer-Atlas D, Vincent SH, Painter SK, Arison BH, Stearns RA, Chiu SH.

Drug Metab Dispos. 1997 Aug;25(8):940-52.

PMID:
9280402
19.

Chemical and biological characterization of two FK506 analogs produced by targeted gene disruption in Streptomyces sp. MA6548.

Shafiee A, Motamedi H, Dumont FJ, Arison BH, Miller RR.

J Antibiot (Tokyo). 1997 May;50(5):418-23.

20.

Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol.

Bostedor RG, Karkas JD, Arison BH, Bansal VS, Vaidya S, Germershausen JI, Kurtz MM, Bergstrom JD.

J Biol Chem. 1997 Apr 4;272(14):9197-203.

21.

Disposition and metabolism of finasteride in dogs.

Carlin JR, Christofalo P, Arison BH, Ellsworth RE, Rosegay A, Miller RR, Chiu SH, VandenHeuvel WJ.

Drug Metab Dispos. 1997 Jan;25(1):100-9.

PMID:
9010636
22.

Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.

Motamedi H, Shafiee A, Cai SJ, Streicher SL, Arison BH, Miller RR.

J Bacteriol. 1996 Sep;178(17):5243-8.

23.

Metabolites of L-735,524, a potent HIV-1 protease inhibitor, in human urine.

Balani SK, Arison BH, Mathai L, Kauffman LR, Miller RR, Stearns RA, Chen IW, Lin JH.

Drug Metab Dispos. 1995 Feb;23(2):266-70.

PMID:
7736923
24.

Biotransformation of finasteride (MK-0906) by Selenastrum capricornutum (green algae).

Venkataramani ES, Carlin JR, Dolling U, Christofalo P, Magliette RJ, Arison BH, Stearns RA.

Ann N Y Acad Sci. 1994 Nov 30;745:51-60.

PMID:
7832532
25.

Metabolism of 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2 (1H)-one (L-696,229), an HIV-1 reverse transcriptase inhibitor, by rat liver slices and in humans.

Balani SK, Kauffman LR, Arison BH, Olah TV, Goldman ME, Varga SL, O'Brien JA, Ramjit HG, Rooney CS, Hoffman JM, et al.

Drug Metab Dispos. 1994 Mar-Apr;22(2):200-5.

PMID:
7516852
26.

Evidence for a 1,2-hydride shift in the microsomal metabolism of the heterocycle L-158,338, a nonpeptide angiotensin II receptor antagonist.

Stearns RA, Miller RR, Arison BH, Rosegay A, Smith JL, Mantlo NB, Chiu SH.

Drug Metab Dispos. 1993 Jul-Aug;21(4):670-6.

PMID:
8104127
27.

A cofactor for thienamycin biosynthesis produced by a blocked mutant of Streptomyces cattleya.

Chen TS, Arison BH, Ruby CL, Dombrowski AW, Inamine ES.

J Ind Microbiol. 1993 Jan;12(1):66-7. No abstract available.

PMID:
7763903
28.

Metabolism of a new HIV-1 reverse transcriptase inhibitor, 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one (L-696,229), in rat and liver slices.

Balani SK, Pitzenberger SM, Kauffman LR, Arison BH, Ramjit HG, Goldman ME, O'Brien JA, King JD, Hoffman JM, Rooney CS, et al.

Drug Metab Dispos. 1992 Nov-Dec;20(6):869-76.

PMID:
1283569
29.

Microbial transformation of immunosuppressive compounds. II. Specific desmethylation of 13-methoxy group of FK 506 and FR 900520 by an unidentified Actinomycete ATCC 53828 [corrected].

Chen TS, Arison BH, Wicker LS, Inamine ES.

J Antibiot (Tokyo). 1992 Apr;45(4):577-80. No abstract available. Erratum in: J Antibiot (Tokyo) 1992 Jun;45(6):C-2.

30.
31.

HIV-1 protease inhibitory activity of L-694,746, a novel metabolite of L-689,502.

Lingham RB, Arison BH, Colwell LF, Hsu A, Dezeny G, Thompson WJ, Garrity GM, Gagliardi MM, Hartner FW, Darke PL, et al.

Biochem Biophys Res Commun. 1991 Dec 31;181(3):1456-61.

PMID:
1764098
32.

Metabolism of the platelet-activating factor antagonist (+/-)-trans-2-(3'-methoxy-5'-methylsulphonyl-4'-propoxyphenyl)-5-(3",4" ,5"- trimethoxyphenyl)tetrahydrofuran (L-659,989) in rhesus monkeys.

Thomson KL, Chang MN, Bugianesi RL, Ponpipom MM, Arison BH, Hucker HB, Sweeney BM, White SD, Chabala JC.

Xenobiotica. 1991 May;21(5):613-25.

PMID:
1949894
33.

Synthesis of a deuterium-labeled cortisol for the study of its rate of 11 beta-hydroxy dehydrogenation in man.

Linberg L, Wang JZ, Arison BH, Ulick S.

J Steroid Biochem Mol Biol. 1991 Mar;38(3):351-7.

PMID:
2009227
34.

[Neolignans from Piper polysyphorum C.DC].

Ma Y, Han GQ, Li CL, Cheng JR, Arison BH, Hwang SB.

Yao Xue Xue Bao. 1991;26(5):345-50. Chinese.

PMID:
1957684
35.

Purification and identification of dTDP-oleandrose, the precursor of the oleandrose units of the avermectins.

Schulman MD, Acton SL, Valentino DL, Arison BH.

J Biol Chem. 1990 Oct 5;265(28):16965-70.

36.

Detailed study of oxidative esterification and elimination reactions undergone by a steroidal 17 alpha-benzoyloxy-20-oxo-21-aldehyde.

Lewbart ML, Annan RS, Arison BH, Springer JP, Gould SR.

J Pharm Sci. 1990 May;79(5):373-8.

PMID:
2352154
37.

3-Methylpseudouridine as a fermentation product.

Nielsen JB, Arison BH.

J Antibiot (Tokyo). 1989 Aug;42(8):1248-52.

38.

Metabolism of kadsurenone and 9,10-dihydrokadsurenone in rhesus monkeys and rat liver microsomes.

Thompson KL, Chang MN, Chabala JC, Chiu SH, Eline D, Hucker HB, Sweeney BM, White SD, Arison BH, Smith JL.

Drug Metab Dispos. 1988 Sep-Oct;16(5):737-43.

PMID:
2906599
39.

Metabolism of lovastatin by rat and human liver microsomes in vitro.

Greenspan MD, Yudkovitz JB, Alberts AW, Argenbright LS, Arison BH, Smith JL.

Drug Metab Dispos. 1988 Sep-Oct;16(5):678-82.

PMID:
2906589
40.

Identification and possible role of D-mannitol and 2-O-methyl-chiro-inositol (quebrachitol) in Eimeria tenella.

Schmatz DM, Arison BH, Dashkevicz MP, Liesch JM, Turner MJ.

Mol Biochem Parasitol. 1988 May;29(1):29-36.

PMID:
3133561
41.

[Studies on the chemical constituents of Piper hancei Maxim (II)].

Li SM, Han GQ, Arison BH, Chang MN.

Yao Xue Xue Bao. 1987 Mar;22(3):196-202. Chinese. No abstract available.

PMID:
3661206
42.

Metabolic disposition of ivermectin in tissues of cattle, sheep, and rats.

Chiu SH, Sestokas E, Taub R, Buhs RP, Green M, Sestokas R, Vandenheuvel WJ, Arison BH, Jacob TA.

Drug Metab Dispos. 1986 Sep-Oct;14(5):590-600.

PMID:
2876867
43.

Biosynthesis of fluorothreonine and fluoroacetic acid by the thienamycin producer, Streptomyces cattleya.

Sanada M, Miyano T, Iwadare S, Williamson JM, Arison BH, Smith JL, Douglas AW, Liesch JM, Inamine E.

J Antibiot (Tokyo). 1986 Feb;39(2):259-65.

44.

The structure of efrotomycin.

Dewey RS, Arison BH, Hannah J, Shih DH, Albers-Schönberg G.

J Antibiot (Tokyo). 1985 Dec;38(12):1691-8.

45.

Carnitine and glucuronic acid conjugates of pivalic acid.

Vickers S, Duncan CA, White SD, Ramjit HG, Smith JL, Walker RW, Flynn H, Arison BH.

Xenobiotica. 1985 Jun;15(6):453-8.

PMID:
4036169
46.
47.

Urinary metabolites of the antiprotozoal agent cis-3a,4,5,6,7,7a- hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole in the rat.

VandenHeuvel WJ, Arison BH, Flynn H, Gatto GJ, Mertel HE, Wislocki PG.

J Pharm Sci. 1984 Dec;73(12):1731-4.

PMID:
6527245
48.

The pterin component of the molybdenum cofactor. Structural characterization of two fluorescent derivatives.

Johnson JL, Hainline BE, Rajagopalan KV, Arison BH.

J Biol Chem. 1984 May 10;259(9):5414-22.

49.

Drug residue formation from ronidazole, a 5-nitroimidazole. V. Cysteine adducts formed upon reduction of ronidazole by dithionite or rat liver enzymes in the presence of cysteine.

Wislocki PG, Bagan ES, Vandenheuvel WJ, Walker RW, Alvaro RF, Arison BH, Lu AY, Wolf FJ.

Chem Biol Interact. 1984 Apr;49(1-2):13-25.

PMID:
6722933
50.

[R-(Z)]-4-amino-3-chloro-2-pentenedioic acid, a new antibiotic. Fermentation, isolation and characterization.

Chaiet L, Arison BH, Monaghan RL, Springer JP, Smith JL, Zimmerman SB.

J Antibiot (Tokyo). 1984 Mar;37(3):207-10.

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