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Items: 1 to 50 of 93

1.

[Chemical targeting of DNA and histone methylation in cancer: Novelties, hopes and promises].

Bon C, Erdmann D, Halby L, Arimondo PB.

Bull Cancer. 2019 Oct;106(10):823-833. doi: 10.1016/j.bulcan.2019.08.001. Epub 2019 Sep 12. French. No abstract available.

PMID:
31522746
2.

Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells.

Zwergel C, Schnekenburger M, Sarno F, Battistelli C, Manara MC, Stazi G, Mazzone R, Fioravanti R, Gros C, Ausseil F, Florean C, Nebbioso A, Strippoli R, Ushijima T, Scotlandi K, Tripodi M, Arimondo PB, Altucci L, Diederich M, Mai A, Valente S.

Clin Epigenetics. 2019 May 6;11(1):68. doi: 10.1186/s13148-019-0663-8.

3.

The Many Faces of EpigeneticsOxford, December 2017.

Arimondo PB, Barberousse A, Pontarotti G.

Epigenetics. 2019 Jun;14(6):623-631. doi: 10.1080/15592294.2019.1595298. Epub 2019 Apr 17.

4.

Demethylation by low-dose 5-aza-2'-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma.

Desjobert C, Carrier A, Delmas A, Marzese DM, Daunay A, Busato F, Pillon A, Tost J, Riond J, Favre G, Etievant C, Arimondo PB.

Clin Epigenetics. 2019 Jan 16;11(1):9. doi: 10.1186/s13148-018-0600-2.

5.

Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells.

Franchini DM, Lanvin O, Tosolini M, Patras de Campaigno E, Cammas A, Péricart S, Scarlata CM, Lebras M, Rossi C, Ligat L, Pont F, Arimondo PB, Laurent C, Ayyoub M, Despas F, Lapeyre-Mestre M, Millevoi S, Fournié JJ.

Cell Rep. 2019 Jan 2;26(1):94-107.e7. doi: 10.1016/j.celrep.2018.12.014.

6.

Assembly of the Entire Carbon Backbone of a Stereoisomer of the Antitumor Marine Natural Product Hemicalide.

Lecourt C, Dhambri S, Yamani K, Boissonnat G, Specklin S, Fleury E, Hammad K, Auclair E, Sablé S, Grondin A, Arimondo PB, Sautel F, Massiot G, Meyer C, Cossy J, Sorin G, Lannou MI, Ardisson J.

Chemistry. 2019 Feb 21;25(11):2745-2749. doi: 10.1002/chem.201806327. Epub 2019 Jan 25.

PMID:
30600846
7.

Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers.

Lascano S, Lopez M, Arimondo PB.

Chem Rec. 2018 Dec;18(12):1854-1876. doi: 10.1002/tcr.201800133. Epub 2018 Dec 10. Review.

PMID:
30537358
8.

Identification of novel quinazoline derivatives as potent antiplasmodial agents.

Bouchut A, Rotili D, Pierrot C, Valente S, Lafitte S, Schultz J, Hoglund U, Mazzone R, Lucidi A, Fabrizi G, Pechalrieu D, Arimondo PB, Skinner-Adams TS, Chua MJ, Andrews KT, Mai A, Khalife J.

Eur J Med Chem. 2019 Jan 1;161:277-291. doi: 10.1016/j.ejmech.2018.10.041. Epub 2018 Oct 17.

PMID:
30366254
9.

A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy.

Manara MC, Valente S, Cristalli C, Nicoletti G, Landuzzi L, Zwergel C, Mazzone R, Stazi G, Arimondo PB, Pasello M, Guerzoni C, Picci P, Nanni P, Lollini PL, Mai A, Scotlandi K.

Mol Cancer Ther. 2018 Sep;17(9):1881-1892. doi: 10.1158/1535-7163.MCT-17-0818. Epub 2018 Jun 29.

10.

The past and presence of gene targeting: from chemicals and DNA via proteins to RNA.

Geel TM, Ruiters MHJ, Cool RH, Halby L, Voshart DC, Andrade Ruiz L, Niezen-Koning KE, Arimondo PB, Rots MG.

Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748). pii: 20170077. doi: 10.1098/rstb.2017.0077. Review.

11.

Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.

Halby L, Marechal N, Pechalrieu D, Cura V, Franchini DM, Faux C, Alby F, Troffer-Charlier N, Kudithipudi S, Jeltsch A, Aouadi W, Decroly E, Guillemot JC, Page P, Ferroud C, Bonnefond L, Guianvarc'h D, Cavarelli J, Arimondo PB.

Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748). pii: 20170072. doi: 10.1098/rstb.2017.0072.

12.

The DNMT3A R882H mutant displays altered flanking sequence preferences.

Emperle M, Rajavelu A, Kunert S, Arimondo PB, Reinhardt R, Jurkowska RZ, Jeltsch A.

Nucleic Acids Res. 2018 Apr 6;46(6):3130-3139. doi: 10.1093/nar/gky168.

13.

Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches.

Sabatino M, Rotili D, Patsilinakos A, Forgione M, Tomaselli D, Alby F, Arimondo PB, Mai A, Ragno R.

J Comput Aided Mol Des. 2018 Mar;32(3):435-458. doi: 10.1007/s10822-018-0096-z. Epub 2018 Jan 15.

PMID:
29335872
14.

Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors.

Rondelet G, Fleury L, Faux C, Masson V, Dubois J, Arimondo PB, Willems L, Wouters J.

Future Med Chem. 2017 Sep;9(13):1465-1481. doi: 10.4155/fmc-2017-0074. Epub 2017 Aug 10.

PMID:
28795598
15.

Rational Design of Bisubstrate-Type Analogues as Inhibitors of DNA Methyltransferases in Cancer Cells.

Halby L, Menon Y, Rilova E, Pechalrieu D, Masson V, Faux C, Bouhlel MA, David-Cordonnier MH, Novosad N, Aussagues Y, Samson A, Lacroix L, Ausseil F, Fleury L, Guianvarc'h D, Ferroud C, Arimondo PB.

J Med Chem. 2017 Jun 8;60(11):4665-4679. doi: 10.1021/acs.jmedchem.7b00176. Epub 2017 May 23.

PMID:
28463515
16.

DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge.

Castillo-Aguilera O, Depreux P, Halby L, Arimondo PB, Goossens L.

Biomolecules. 2017 Jan 5;7(1). pii: E3. doi: 10.3390/biom7010003. Review.

17.

DNA methyltransferase inhibitors in cancer: From pharmacology to translational studies.

Pechalrieu D, Etievant C, Arimondo PB.

Biochem Pharmacol. 2017 Apr 1;129:1-13. doi: 10.1016/j.bcp.2016.12.004. Epub 2016 Dec 9. Review.

PMID:
27956110
18.

DNA Methyltransferase Inhibitors: Development and Applications.

Lopez M, Halby L, Arimondo PB.

Adv Exp Med Biol. 2016;945:431-473. Review.

PMID:
27826847
19.

Identification of epigenetic factors regulating the mesenchyme to epithelium transition by RNA interference screening in breast cancer cells.

Gregoire JM, Fleury L, Salazar-Cardozo C, Alby F, Masson V, Arimondo PB, Ausseil F.

BMC Cancer. 2016 Aug 31;16:700. doi: 10.1186/s12885-016-2683-5.

20.

Identification and optimization of hydrazone-gallate derivatives as specific inhibitors of DNA methyltransferase 3A.

Erdmann A, Menon Y, Gros C, Masson V, Aussagues Y, Ausseil F, Novosad N, Schambel P, Baltas M, Arimondo PB.

Future Med Chem. 2016;8(4):373-80. doi: 10.4155/fmc.15.192. Epub 2016 Mar 15.

PMID:
26976348
21.

Design and synthesis of new non nucleoside inhibitors of DNMT3A.

Erdmann A, Menon Y, Gros C, Molinier N, Novosad N, Samson A, Gregoire JM, Long C, Ausseil F, Halby L, Arimondo PB.

Bioorg Med Chem. 2015 Sep 1;23(17):5946-53. doi: 10.1016/j.bmc.2015.06.066. Epub 2015 Jul 10.

PMID:
26220519
22.

DNA Methylation Analysis of ChIP Products at Single Nucleotide Resolution by Pyrosequencing®.

Moison C, Assemat F, Daunay A, Arimondo PB, Tost J.

Methods Mol Biol. 2015;1315:315-33. doi: 10.1007/978-1-4939-2715-9_22.

PMID:
26103908
23.

Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2'-deoxycytidine in human leukemic KG1 cells.

Vispé S, Deroide A, Davoine E, Desjobert C, Lestienne F, Fournier L, Novosad N, Bréand S, Besse J, Busato F, Tost J, De Vries L, Cussac D, Riond J, Arimondo PB.

Oncotarget. 2015 Jun 20;6(17):15265-82.

24.

Combined analysis of DNA methylation and cell cycle in cancer cells.

Desjobert C, El Maï M, Gérard-Hirne T, Guianvarc'h D, Carrier A, Pottier C, Arimondo PB, Riond J.

Epigenetics. 2015;10(1):82-91. doi: 10.1080/15592294.2014.995542. Epub 2015 Jan 23.

25.

New insights on the mechanism of quinoline-based DNA Methyltransferase inhibitors.

Gros C, Fleury L, Nahoum V, Faux C, Valente S, Labella D, Cantagrel F, Rilova E, Bouhlel MA, David-Cordonnier MH, Dufau I, Ausseil F, Mai A, Mourey L, Lacroix L, Arimondo PB.

J Biol Chem. 2015 Mar 6;290(10):6293-302. doi: 10.1074/jbc.M114.594671. Epub 2014 Dec 18.

26.

Targeting DNA methylation with small molecules: what's next?

Erdmann A, Halby L, Fahy J, Arimondo PB.

J Med Chem. 2015 Mar 26;58(6):2569-83. doi: 10.1021/jm500843d. Epub 2014 Dec 4. Review.

PMID:
25406944
27.

Cytisine-like alkaloids from Ormosia hosiei Hemsl. & E.H. Wilson.

Pouny I, Batut M, Vendier L, David B, Yi S, Sautel F, Arimondo PB, Massiot G.

Phytochemistry. 2014 Nov;107:97-101. doi: 10.1016/j.phytochem.2014.07.022. Epub 2014 Aug 26.

PMID:
25172516
28.

Challenges in developing novel DNA methyltransferases inhibitors for cancer therapy.

Guianvarc'h D, Arimondo PB.

Future Med Chem. 2014 Jul;6(11):1237-40. doi: 10.4155/fmc.14.82. No abstract available.

PMID:
25162996
29.

Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity.

Rotili D, Tarantino D, Marrocco B, Gros C, Masson V, Poughon V, Ausseil F, Chang Y, Labella D, Cosconati S, Di Maro S, Novellino E, Schnekenburger M, Grandjenette C, Bouvy C, Diederich M, Cheng X, Arimondo PB, Mai A.

PLoS One. 2014 May 8;9(5):e96941. doi: 10.1371/journal.pone.0096941. eCollection 2014.

30.

Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation.

Rilova E, Erdmann A, Gros C, Masson V, Aussagues Y, Poughon-Cassabois V, Rajavelu A, Jeltsch A, Menon Y, Novosad N, Gregoire JM, Vispé S, Schambel P, Ausseil F, Sautel F, Arimondo PB, Cantagrel F.

ChemMedChem. 2014 Mar;9(3):590-601. doi: 10.1002/cmdc.201300420.

31.

Synergistic chromatin repression of the tumor suppressor gene RARB in human prostate cancers.

Moison C, Assemat F, Daunay A, Tost J, Guieysse-Peugeot AL, Arimondo PB.

Epigenetics. 2014 Apr;9(4):477-82. doi: 10.4161/epi.27869. Epub 2014 Feb 3.

32.

Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells.

Valente S, Liu Y, Schnekenburger M, Zwergel C, Cosconati S, Gros C, Tardugno M, Labella D, Florean C, Minden S, Hashimoto H, Chang Y, Zhang X, Kirsch G, Novellino E, Arimondo PB, Miele E, Ferretti E, Gulino A, Diederich M, Cheng X, Mai A.

J Med Chem. 2014 Feb 13;57(3):701-13. doi: 10.1021/jm4012627. Epub 2014 Jan 15.

33.

Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1.

Asgatay S, Champion C, Marloie G, Drujon T, Senamaud-Beaufort C, Ceccaldi A, Erdmann A, Rajavelu A, Schambel P, Jeltsch A, Lequin O, Karoyan P, Arimondo PB, Guianvarc'h D.

J Med Chem. 2014 Jan 23;57(2):421-34. doi: 10.1021/jm401419p. Epub 2014 Jan 9.

PMID:
24328113
34.

Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies.

Gros C, Chauvigné L, Poulet A, Menon Y, Ausseil F, Dufau I, Arimondo PB.

Nucleic Acids Res. 2013 Oct;41(19):e185. doi: 10.1093/nar/gkt753. Epub 2013 Aug 25.

35.

Dichapetalins from Dichapetalum species and their cytotoxic properties.

Long C, Aussagues Y, Molinier N, Marcourt L, Vendier L, Samson A, Poughon V, Chalo Mutiso PB, Ausseil F, Sautel F, Arimondo PB, Massiot G.

Phytochemistry. 2013 Oct;94:184-91. doi: 10.1016/j.phytochem.2013.03.023. Epub 2013 Apr 22.

PMID:
23618620
36.

DNA methylation associated with polycomb repression in retinoic acid receptor β silencing.

Moison C, Senamaud-Beaufort C, Fourrière L, Champion C, Ceccaldi A, Lacomme S, Daunay A, Tost J, Arimondo PB, Guieysse-Peugeot AL.

FASEB J. 2013 Apr;27(4):1468-78. doi: 10.1096/fj.12-210971. Epub 2013 Jan 8.

PMID:
23299856
37.

Identification of novel inhibitors of DNA methylation by screening of a chemical library.

Ceccaldi A, Rajavelu A, Ragozin S, Sénamaud-Beaufort C, Bashtrykov P, Testa N, Dali-Ali H, Maulay-Bailly C, Amand S, Guianvarc'h D, Jeltsch A, Arimondo PB.

ACS Chem Biol. 2013 Mar 15;8(3):543-8. doi: 10.1021/cb300565z. Epub 2013 Jan 11.

PMID:
23294304
38.

DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies.

Fahy J, Jeltsch A, Arimondo PB.

Expert Opin Ther Pat. 2012 Dec;22(12):1427-42. doi: 10.1517/13543776.2012.729579. Epub 2012 Oct 3. Review.

PMID:
23033952
39.

Epigenetics.

Arimondo PB, Egger G, Tost J.

Biochimie. 2012 Nov;94(11):2191-2. doi: 10.1016/j.biochi.2012.09.003. Epub 2012 Sep 11. No abstract available.

PMID:
22982039
40.

DNA methylation inhibitors in cancer: recent and future approaches.

Gros C, Fahy J, Halby L, Dufau I, Erdmann A, Gregoire JM, Ausseil F, Vispé S, Arimondo PB.

Biochimie. 2012 Nov;94(11):2280-96. doi: 10.1016/j.biochi.2012.07.025. Epub 2012 Aug 11. Review.

PMID:
22967704
41.

Semisynthetic neoboutomellerone derivatives as ubiquitin-proteasome pathway inhibitors.

Beck J, Guminski Y, Long C, Marcourt L, Derguini F, Plisson F, Grondin A, Vandenberghe I, Vispé S, Brel V, Aussagues Y, Ausseil F, Arimondo PB, Massiot G, Sautel F, Cantagrel F.

Bioorg Med Chem. 2012 Jan 15;20(2):819-31. doi: 10.1016/j.bmc.2011.11.066. Epub 2011 Dec 8.

PMID:
22206869
42.

Rapid synthesis of new DNMT inhibitors derivatives of procainamide.

Halby L, Champion C, Sénamaud-Beaufort C, Ajjan S, Drujon T, Rajavelu A, Ceccaldi A, Jurkowska R, Lequin O, Nelson WG, Guy A, Jeltsch A, Guianvarc'h D, Ferroud C, Arimondo PB.

Chembiochem. 2012 Jan 2;13(1):157-65. doi: 10.1002/cbic.201100522. Epub 2011 Dec 14.

PMID:
22170584
43.

Sequence-specific base pair mimics are efficient topoisomerase IB inhibitors.

Vekhoff P, Duca M, Guianvarc'h D, Benhida R, Arimondo PB.

Biochemistry. 2012 Jan 10;51(1):43-51. doi: 10.1021/bi2012959. Epub 2011 Dec 23.

PMID:
22124209
44.

DNA methyltransferase assays.

Jurkowska RZ, Ceccaldi A, Zhang Y, Arimondo PB, Jeltsch A.

Methods Mol Biol. 2011;791:157-77. doi: 10.1007/978-1-61779-316-5_13.

PMID:
21913079
45.

Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters.

Bensasson RV, Zoete V, Jossang A, Bodo B, Arimondo PB, Land EJ.

Free Radic Biol Med. 2011 Oct 1;51(7):1406-10. doi: 10.1016/j.freeradbiomed.2011.06.021. Epub 2011 Jun 23.

PMID:
21745563
46.

Commercial reverse transcriptase as source of false-positive strand-specific RNA detection in human cells.

Moison C, Arimondo PB, Guieysse-Peugeot AL.

Biochimie. 2011 Oct;93(10):1731-7. doi: 10.1016/j.biochi.2011.06.005. Epub 2011 Jun 15.

PMID:
21689721
47.

C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development.

Ceccaldi A, Rajavelu A, Champion C, Rampon C, Jurkowska R, Jankevicius G, Sénamaud-Beaufort C, Ponger L, Gagey N, Ali HD, Tost J, Vriz S, Ros S, Dauzonne D, Jeltsch A, Guianvarc'h D, Arimondo PB.

Chembiochem. 2011 Jun 14;12(9):1337-45. doi: 10.1002/cbic.201100130. Epub 2011 Jun 1.

PMID:
21633996
48.

Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.

Pitts SL, Jablonksy MJ, Duca M, Dauzonne D, Monneret C, Arimondo PB, Anklin C, Graves DE, Osheroff N.

Biochemistry. 2011 Jun 7;50(22):5058-66. doi: 10.1021/bi200531q. Epub 2011 May 13.

49.

Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts.

Le Breton C, Hennion M, Arimondo PB, Hyrien O.

PLoS One. 2011 Apr 15;6(4):e18554. doi: 10.1371/journal.pone.0018554.

50.

Introduction "DNA and chromosomes: Physical and biological approaches".

Braslau A, van Noort J, Arimondo PB.

Biochimie. 2010 Dec;92(12):v-vi. doi: 10.1016/S0300-9084(10)00386-X. No abstract available.

PMID:
21130300

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